+ Studies in 2000-2009 List
* Studies in Pre-2000 List
EBOLA
ECZEMA +
EDEMA*+
EHLERS-DANLOS SYNDROME +
EMBRYOS/FETAL DEVELOPMENT/PLACENTAL DEVELOPMENT +
ENCEPHALITIS +
ENCEPHALOMYELITIS/EAE*+
ENDOMETRIOSIS +
ENTOURAGE EFFECT (See PHYTOCANNABINOIDS and ENDOCANNABINOIDS)
EPILEPSY/SEIZURES* (See Also EPIDIOLEX in PHYTOCANNABINOIDS)
ESSENTIAL TREMOR
EXERCISE and the ENDOCANNABINOID SYSTEM*+
EBOLA
CBD Protective Against Ebola Virus (article-2014) http://cannabisdigest.ca/cbd-protective-ebola-virus/
ECZEMA
Hemp Oil Benefits for Skin (news–2010) http://www.livestrong.com/article/137621-hemp-oil-benefits-skin/
Hemp Seed Oil for Skin (news–2010) http://www.livestrong.com/article/340189-hemp-seed-oil-for-skin/
The Cannabis Closet: Severe Eczema (anecdotal–2010) http://andrewsullivan.theatlantic.com/the_daily_dish/2010/05/the-cannabis-closet-severe-eczema.html
Hemp Seed Oil For Eczema – Cures From The Inside Out (news/anecdotal–2012) http://www.theweedblog.com/hemp-seed-oil-for-eczema-cures-from-the-inside-out/
Epigenetic Control of Skin Differentiation Genes by Phytocannabinoids (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23869687
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EDEMA
The cannabinoid receptor-2 is involved in allergic inflammation (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22525379
Activation of Cannabinoid CB2 Receptor-Mediated AMPK/CREB Pathway Reduces Cerebral Ischemic Injury (abst-2013) http://www.ncbi.nlm.nih.gov/pubmed/23414569
Sex differences in anti-allodynic, anti-hyperalgesic and anti-edema effects of Δ9-tetrahydrocannabinol in the rat (abst-2013) http://www.ncbi.nlm.nih.gov/pubmed/23707295
Activation of cannabinoid CB2 receptor-mediated AMPK/CREB pathway reduces cerebral ischemic injury (abst-2013) http://www.ncbi.nlm.nih.gov/pubmed/23414569
Activation of cortical type 2 cannabinoid receptors ameliorates ischemic brain injury (news-2013) http://www.sciencedaily.com/releases/2013/02/130221141140.htm
Cannabinoid Trans-Caryophyllene Protects Brain Cells From Ischemia (news-2013) http://www.medicalnewstoday.com/articles/256799.php
Cannabinoid type 2 receptor stimulation attenuates brain edema by reducing cerebral leukocyte infiltration following subarachnoid hemorrhage in rats. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24819918
Cannabinoid Receptor Type 2 Agonist Attenuates Apoptosis by Activation of Phosphorylated CREB-Bcl-2 Pathway After Subarachnoid Hemorrhage in Rats. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/25058046
Peripheral neurobiologic mechanisms of antiallodynic effect of warm water immersion therapy on persistent inflammatory pain (abst-2014) http://www.ncbi.nlm.nih.gov/pubmed/25079058
Cannabinoid CB2 receptor stimulation attenuates brain edema and neurological deficits in a germinal matrix hemorrhage rat model (abst-2015) http://www.ncbi.nlm.nih.gov/pubmed/25625355
Changes in cannabinoid receptors, aquaporin 4 and vimentin expression after traumatic brain injury in adolescent male mice. Association with edema and neurological deficit (full – 2015) http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0128782
Minocycline Attenuates Neonatal Germinal-Matrix-Hemorrhage-Induced Neuroinflammation and Brain Edema by Activating Cannabinoid Receptor 2 (abst – 2015) http://www.ncbi.nlm.nih.gov/pubmed/25833102
Cannabinoid receptor 2 attenuates microglial accumulation and brain injury following germinal matrix hemorrhage via ERK dephosphorylation in vivo and in vitro (abst – 2015) http://www.ncbi.nlm.nih.gov/pubmed/25963415
EHLERS-DANLOS SYNDROME
Ehlers-Danlos Syndrome (anecdotal/news-2010) http://andrewsullivan.theatlantic.com/the_daily_dish/2010/05/the-cannabis-closet-chronic-joint-pain.html
The Cannabis Closet: Chronic Joint Pain (anecdotal/news-2010) http://www.theatlantic.com/daily-dish/archive/2010/05/the-cannabis-closet-chronic-joint-pain/187292/
Schneider: Lansing mom says son’s legal marijuana use unfairly stigmatized (anecdotal/news-2010) http://marijuanaevaluations.wordpress.com/2010/06/28/schneider-lansing-mom-says-sons-legal-marijuanause-unfairly-stigmatized/
Medicinal Marijuana: A Patient-Driven Phenomenon (anecdotal/news – 2010) http://www.npr.org/templates/story/story.php?storyId=127773447
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Patient’s Corner – Pat Cavanaugh (p. 4-anecdotal/news-2011) http://issuu.com/whoisitguy/docs/releaf_july_2011?mode=embed&viewModeresentation&layout=http%3A%2F%2Fskin.issuu.com%2Fv%2Flight%2Flayout.xml&showFlipBtn=true
Panelists debate state of medical marijuana in RI (news-2012) http://www.browndailyherald.com/2012/04/05/panelists-debate-state-of-medical-marijuana-in-ri/
I Was Totally Against Drug Use Until I Needed Medical Marijuana (news-2012) http://www.xojane.com/healthy/ehlers-danlos-syndrome-medical-marijuana
EMBRYOS/FETAL DEVELOPMENT/PLACENTAL DEVELOPMENT
The Maternal Lifestyle Study: Sleep Problems in Children with Prenatal Substance Exposure (full-2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917192/?tool=pubmed
A prospective study on intrauterine cannabis exposure and fetal blood flow (abst-2010) http://www.ncbi.nlm.nih.gov/pubmed/20451334
Prenatal tobacco, marijuana, stimulant, and opiate exposure: outcomes and practice implications (full-2011)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188826/?tool=pubmed
Modulation of the novel cannabinoid receptor – GPR55 – during rat fetoplacental development (full-2011)
http://www.placentajournal.org/article/S0143-4004%2811%2900110-X/fulltext
Uncovering a role for endocannabinoid signaling in autophagy in preimplantation mouse embryos (full-2012) http://molehr.oxfordjournals.org/content/19/2/93.full
Immunity and early pregnancy events: are endocannabinoids the missing link? (abst-2012) http://www.ncbi.nlm.nih.gov/pubmed/23177537
Embryonic diapause in humans: time to consider? (full-2013) http://www.rbej.com/content/11/1/92
Reduced expression of brain cannabinoid receptor 1 (Cnr1) is coupled with an increased complementary micro-RNA (miR-26b) in a mouse model of fetal alcohol spectrum disorders. (full – 2013) http://www.clinicalepigeneticsjournal.com/content/5/1/14
Endocannabinoid crosstalk between placenta and maternal fat in a baboon model (Papio spp.) of obesity (full-2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827983/
Implantation failure in mice with a disruption in Phospholipase C beta 1 gene: lack of embryonic attachment, aberrant steroid hormone signalling and defective endocannabinoid metabolism (full-2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632219/
Long-term consequences of perinatal fatty acid amino hydrolase inhibition (abst-2013) http://onlinelibrary.wiley.com/doi/10.1111/bph.12500/abstract
Behavioral Responses to Acute and Sub-chronic Administration of the Synthetic Cannabinoid JWH-018 in Adult Mice Prenatally Exposed to Corticosterone (abst-2013) http://www.ncbi.nlm.nih.gov/pubmed/23296549
Gene-Specific Disruption of Endocannabinoid Receptor 1 (cnr1a) by Ethanol Probably Leads to the Development of Fetal Alcohol Spectrum Disorder (FASD) Phenotypes in Japanese Rice Fish (Oryzias latipes) Embryogenesis (abst-2014) http://www.ncbi.nlm.nih.gov/pubmed/25251458
Fatty Acid Binding Protein-4 is expressed in the mouse placental labyrinth, yet is dispensable for placental triglyceride accumulation and fetal growth (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25096952
Lipid abundance in zebrafish embryos is regulated by complementary actions of the Endocannabinoid System and Retinoic Acid Pathway (full-2015) http://press.endocrine.org/doi/pdf/10.1210/EN.2015-1315
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Use of paracetamol during pregnancy and child neurological development (abst-2015) http://www.ncbi.nlm.nih.gov/pubmed/25851072
Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development via PGE2 and P-selectin Activity (abst–2015)
http://www.ncbi.nlm.nih.gov/pubmed/25931248
Long-term consequences of perinatal and adolescent cannabinoid exposure on neural and psychological processes (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25960036
Anandamide restricts uterine stromal differentiation and is critical for complete decidualization (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25960165
Dynamics of expression and localization of the cannabinoid system in granulosa cells during oocyte nuclear maturation (abst–2015)
http://www.ncbi.nlm.nih.gov/pubmed/26144572
Endocannabinoid signaling in female reproductive events: a potential therapeutic target? (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26126134
Gestation Related Gene Expression of the Endocannabinoid Pathway in Rat Placenta (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26229240
ENCEPHALITIS
A synthetic cannabinoid agonist promotes oligodendrogliogenesis during viral encephalitis in rats (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981070/?toolubmed
Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain: an intravital microscopy study (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034694/?toolmcentrez
Gadolinium-HU-308-incorporated micelles (full–2011) http://www.ncbi.nlm.nih.gov/books/NBK54067/pdf/CB2R-Gd-Micelles.pdf
Prospects for cannabinoid therapies in viral encephalitis (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24021420
ENCEPHALOMYELITIS/EAE
Administration of 2-arachidonoylglycerol ameliorates both acute and chronic Experimental Autoimmune Encephalomyelitis (abst–2011) http://www.unboundmedicine.com/medline/ebm/record/21406188/abstract/Administration_of_2_arachidonoylglycerol_ameliorates_both_acute_and_chronic_Experimental_Autoimmune_Encephalomyelitis_
Evaluation of the Effects of Sativex (THC BDS: CBD BDS) on Inhibition of Spasticity in a Chronic Relapsing Experimental Allergic Autoimmune Encephalomyelitis: A Model of Multiple Sclerosis (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423911/pdf/ISRN.NEUROLOGY2012-802649.pdf
Cannabinoid receptor-2-selective agonists improve recovery in experimental autoimmune encephalomyelitis (abst–2012) http://www.jimmunol.org/cgi/content/meeting_abstract/188/1_MeetingAbstracts/116.7?maxtoshow=&hits=25&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=130&sortspec=date&resourcetype=HWCIT
Cannabinoids ameliorate disease progression in a model of multiple sclerosis in mice, acting preferentially through CB(1) receptor-mediated anti-inflammatory effects (abst-2012) http://www.ncbi.nlm.nih.gov/pubmed/22342378
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Cannabinoid receptor 2 agonists inhibit migration of activated dendritic cells via modulation of MMP-9 (abst–2012) http://www.jimmunol.org/cgi/content/meeting_abstract/188/1_MeetingAbstracts/173.23?maxtoshow=&hits=25&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=130&sortspec=date&resourcetype=HWCIT
Genetic Background Can Result in a Marked or Minimal Effect of Gene Knockout (GPR55 and CB2 Receptor) in Experimental Autoimmune Encephalomyelitis Models of Multiple Sclerosis (full–2013) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0076907
Multiple sclerosis and the blood-central nervous system barrier (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562587/
Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: A role for A2A receptors (full–2013) http://www.sciencedirect.com/science/article/pii/S0969996113001939
Selective CB2 receptor activation ameliorates EAE by reducing Th17 differentiation and immune cell accumulation in the CNS (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24342422
Pre- and postsynaptic type-1 cannabinoid receptors control the alterations of glutamate transmission in experimental autoimmune encephalomyelitis. (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24440366
Activating Cannabinoid Receptor 2 Alleviates Pathogenesis of Experimental Autoimmune Encephalomyelitis Via Activation of Autophagy and Inhibiting NLRP3 Inflammasome (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25417929
Neuroprotection in Experimental Autoimmune Encephalomyelitis and Progressive Multiple Sclerosis by Cannabis-Based Cannabinoids (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25537576
Interaction between the protective effects of cannabidiol and palmitoylethanolamide in experimental model of multiple sclerosis in C57BL/6 mice (abst–2015) http://www.sciencedirect.com/science/article/pii/S0306452215000858
Cannabidiol, a non-psychoactive cannabinoid, leads to EGR2-dependent anergy in activated encephalitogenic T cells (full–2015)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363052/
Interaction between the protective effects of cannabidiol and palmitoylethanolamide in experimental model of multiple sclerosis in C57BL/6 mice (abst–2015) http://www.sciencedirect.com/science/article/pii/S0306452215000858
Activation of Cannabinoid CB2 receptors Reduces Hyperalgesia in an Experimental Autoimmune Encephalomyelitis Mouse Model of Multiple Sclerosis (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25849525
Neuroprotection in Experimental Autoimmune Encephalomyelitis and Progressive Multiple Sclerosis by Cannabis-Based Cannabinoids (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25537576
Activation of CB2 receptor is required for the therapeutic effect of ABHD6 inhibition in experimental autoimmune encephalomyelitis (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26189763
ENDOMETRIOSIS
Antiproliferative effects of cannabinoid agonists on deep infiltrating endometriosis (full-2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993285/
Effect of palmitoylethanolamide-polydatin combination on chronic pelvic pain associated with endometriosis: preliminary observations (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/20176435
Endocannabinoid involvement in endometriosis (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/20833475
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Cannabinoids May Provide Treatment for Endometriosis (news–2011) http://greencrosscenter.com/marijuana-card-doctor/2011/10/cannabinoids-may-provide-treatment-forendometriosis/
Δ9-Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells (full–2012) http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01497.x/full
The molecular connections between the cannabinoid system and endometriosis (full–2012) http://molehr.oxfordjournals.org/content/18/12/563.full
Progesterone-dependent regulation of endometrial cannabinoid receptor type 1 (CB1-R) expression is disrupted in women with endometriosis and in isolated stromal cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462249/
β-Caryophyllene causes regression of endometrial implants in a rat model of endometriosis without affecting fertility (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23353590
Administration of micronized palmitoylethanolamide (PEA)-transpolydatin in the treatment of chronic pelvic pain in women affected by endometriosis: preliminary results (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24051945
The adjuvant use of N-palmitoylethanolamine and transpolydatin in the treatment of endometriotic pain (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23415738
Magnolol inhibits LPS-induced inflammatory response in uterine epithelial cells : magnolol inhibits LPS-induced inflammatory response (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23515857
EPILEPSY/SEIZURES
Alterations of endocannabinoids in cerebrospinal fluid of dogs with epileptic seizure disorder (full–2013) http://www.biomedcentral.com/content/pdf/1746-6148-9-262.pdf
Marijuana, endocannabinoids, and epilepsy: Potential and challenges for improved therapeutic intervention (full-2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3332149/
Cannabidivarin (CBDV) suppresses pentylenetetrazole (PTZ)-induced increases in epilepsy-related gene expression (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840466/
Therapeutic potential of cannabinoid medicines. (full – 2013) http://onlinelibrary.wiley.com/doi/10.1002/dta.1529/full
Cannabis and other illicit drug use in epilepsy patients. (full – 2013) http://onlinelibrary.wiley.com/doi/10.1111/ene.12081/full
Medical Marijuana Coverage Still Lost in the Legal Weeds (article – 2013) http://www.managedcaremag.com/linkout/2013/1/23
Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment resistant epilepsy (abst–2013) http://www.sciencedirect.com/science/article/pii/S1525505013004629
The Role of CB1-Receptors in the Proconvulsant Effect of Leptin on Penicillin-Induced Epileptiform Activity in Rats (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23521910
The role of potassium BK channels in anticonvulsant effect of cannabidiol in pentylenetetrazole and maximal electroshock models of seizure in mice (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/23644464
Cannabinoid 1 receptor as therapeutic target in preventing chronic epilepsy (abst–2013) http://www.fasebj.org/cgi/content/meeting_abstract/27/1_MeetingAbstracts/660.2?sid=eea722c0-971c-4daa-8b8c-38c0c63c19ad
The du2J mouse model of ataxia and absence epilepsy has deficient cannabinoid CB1 receptor-mediated signalling (abst-2013) http://www.ncbi.nlm.nih.gov/pubmed/23732642
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The role of α2-adrenoceptors in the anti-convulsant effects of cannabinoids on pentylenetetrazole-induced seizure threshold in mice. (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/23756131
CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/23860329
Effects of WIN 55,212-2 mesylate on the anticonvulsant action of lamotrigine, oxcarbazepine, pregabalin and topiramate against maximal electroshock-induced seizures in mice. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/24161913
Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism. (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/23902406
Epidiolex – GW Pharmaceuticals (drug development page-2013) http://www.gwpharm.com/Epidiolex.aspx
Science/Animal: CBD inhibits the activity of a certain liver enzyme (news-2013) http://www.cannabismed.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=391&search_pattern=2013#10
Cannabis Anti-Convulsant Shakes up Epilepsy Treatment (news-2013) http://www.thecompassionchronicles.com/2013/01/26/cannabis-anti-convulsant-shakes-up-epilepsytreatment/
New cannabis discovery could lead to better treatments for epilepsy (news-2013) http://www.reading.ac.uk/news-and-events/releases/PR464765.aspx
Parents of epileptic N.J. tot lament medical marijuana delays (news-2013) http://articles.philly.com/2013-06-24/news/40148313_1_marijuana-law-marijuana-card-dispensary
Medical Marijuana for Kids? Some Praise Results While Others Worry About Risks (news-2013) http://www.cnbc.com/id/100876423
New therapy for fragile X chromosome syndrome discovered (news-2013) http://www.sciencecodex.com/new_therapy_for_fragile_x_chromosome_syndrome_discovered-110170
Charlotte’s Web Of Suffering: Six-Year-Old Colorado Girl With Dravet Syndrome Finds Relief From Marijuana High In CBD (news-2013) http://www.marijuana.com/news/2013/06/charlottes-web-of-suffering-six-year-old-colorado-girl-withdravet-syndrome-finds-relief-from-marijuana-high-in-cbd/
Toronto family hopes for access to controversial treatment to cure baby’s rare epilepsy (news-2013) http://globalnews.ca/news/714104/toronto-family-hopes-for-access-to-controversial-treatment-to-curebabys-rare-epilepsy/
New Study: Cannabinoids Protect the Brain and Heart From Injury (news-2013) http://www.science20.com/news_articles/thc_can_prevent_brain_damage_study-113512
Families of children with epilepsy moving to Colorado, drawn by success of marijuana oil (news-2013) http://gazette.com/families-of-children-with-epilepsy-moving-to-colorado-drawn-by-success-of-marijuanaoil/article/1507895#AZpGzkjtp6Hzx785.99
Families migrate to Colorado for marijuana miracle (news – 2013) http://www.denverpost.com/fitness/ci_24498723/families-migrate-colorado-marijuana-miracle?source=rss
Comes Now Epidiolex (FDA approves IND studies of CBD) (news – 2013) http://www.beyondthc.com/comes-now-epidiolex-fda-approves-ind-studies-of-cbd/
Pharmaceuticals Provides Update on Orphan Program in Childhood Epilepsy for Epidiolex® (news – 2013) http://www.gwpharm.com/GW%20Pharmaceuticals%20Provides%20Update%20on%20Orphan%20Program%20in%20Childhood%20Epilepsy%20for%20Epidiolex.aspx
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Cannabis-Based Epilepsy Drug Approved For Clinical Trials (news – 2013) http://www.medicaljane.com/2013/10/23/cannabis-based-epilepsy-drug-approved-for-clinical-trials/
OBTAINING EPIDIOLEX™ IN THE U.S. (news – 2013) http://www.dravetfoundation.org/dravet-syndrome/consider-dravet/obtaining-epidiolex
‘Crazy Monkey’ Poisons Man and Dog: Human and canine seizures due to PB-22, a novel synthetic cannabinoid (full – 2014) http://informahealthcare.com/doi/full/10.3109/15563650.2014.925562
Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders (full – 2014) http://onlinelibrary.wiley.com/doi/10.1111/epi.12631/full
Effects of WIN 55,212-2 (a non-selective cannabinoid CB1 and CB 2 receptor agonist) on the protective action of various classical antiepileptic drugs in the mouse 6 Hz psychomotor seizure model (full–2014) http://download.springer.com/static/pdf/828/art%253A10.1007%252Fs00702-014-1173-7.pdf?auth66=1393191519_d7b51017bd9f9b481c18158f0312786b&ext=.pdf
Modulation of pilocarpine-induced seizures by cannabinoid receptor 1 (full–2014) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0095922
Endogenous Signaling by Omega-3 Docosahexaenoic Acid-derived Mediators Sustains Homeostatic Synaptic and Circuitry Integrity. (full – 2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180614/
Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders (full – 2014) http://onlinelibrary.wiley.com/doi/10.1111/epi.12631/full
Astrocytic expression of cannabinoid type 1 receptor in rat and human sclerotic hippocampi. (full – 2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097232/
Presynaptic mechanisms of neuronal plasticity and their role in epilepsy. (full – 2014) http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00164/full
The Comprehensive Report on the Cannabis Extract Movement and the Use of Cannabis Extracts to Treat Diseases (report – 2014) http://www.slideshare.net/TheHempSolution/comprehensive-report-on-the-cannabis-extract-movement
Cannabinoids for epilepsy. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24595491
Voltage-gated sodium (NaV) channel blockade by plant cannabinoids does not confer anticonvulsant effects per se. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24642454
Anticonvulsant Effects of N-Arachidonoyl-Serotonin, a Dual FAAH Enzyme and TRPV1 Channel Blocker, on Experimental Seizures: The Roles of Cannabinoid CB1 Receptors and TRPV1 Channels. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24674273
Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24854329
The case for assessing cannabidiol in epilepsy. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24854434
The case for medical marijuana in epilepsy. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24854149
Cannabinoids for epilepsy: is marijuana an effective treatment for epilepsy? (abst – 2014) http://iospress.metapress.com/content/p50752072175783q/?p=00368d67a25c414b9e1ecc38b534bdfc&pi=14
ABHD6 Blockade Exerts Antiepileptic Activity in PTZ-Induced Seizures and in Spontaneous Seizures in R6/2 Mice. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/25033180
The non-psychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/25029033
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The potential of antiseizure drugs and agents that act on novel molecular targets as antiepileptogenic treatments. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24671870
Distinct modulation of the endocannabinoid system upon kainic acid-induced in vivo seizures and in vitro epileptiform bursting. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/25064144
An Ingredient of Pot May Help People with Epilepsy (news – 2014) http://www.scientificamerican.com/article/an-ingredient-of-pot-may-help-people-with-epilepsy/
Federal red tape ties up marijuana research (news – 2014) http://www.nature.com/news/federal-red-tape-ties-up-marijuana-research-1.14926
This Family Had To Fire Their Doctor To Get Medical Marijuana For Their Son (news – 2014) http://www.huffingtonpost.com/2014/03/25/epilepsy-medical-marijuana_n_5022008.html
Marijuana tested as treatment for children with epilepsy (news – 2014) http://www.sfgate.com/health/article/Marijuana-tested-as-treatment-for-children-with-5246372.php?cmpid=twitter-mobile
UCSF-led study gathers data on safety, tolerability of purified cannabinoid for children with epilepsy (news – 2014) http://www.news-medical.net/news/20140205/UCSF-led-study-gathers-data-on-safety-tolerability-ofpurified-cannabinoid-for-children-with-epilepsy.aspx
Bid to Expand Medical Marijuana Business Faces Federal Hurdles (news – 2014) http://www.nytimes.com/2014/08/24/us/bid-to-expand-medical-marijuana-business-faces-federal-hurdles.html?_r=0
Federal marijuana bill would legalize some cannabis strains (news-2014) http://www.cnn.com/2014/07/28/health/federal-marijuana-bill/index.html
Low or No THC, High CBD Medical Marijuana Bills: Leaving Most Patients Behind (news-2014) http://www.mpp.org/assets/documents/low-or-no-thc-high-cbd.html
Desperate Journey (news-2014) http://extras.denverpost.com/stateofhope/
Marijuana research hampered by access from government and politics, scientists say (news-2014) http://www.washingtonpost.com/national/health-science/marijuana-research-hampered-by-access-from-government-and-politics-scientists-say/2014/03/21/6065eb88-a47d-11e3-84d4-e59b1709222c_story.html
Augmented Inhibition from Cannabinoid-Sensitive Interneurons Diminishes CA1 Output after Traumatic Brain Injury (full-2015) http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00435/full
Muscarinic M1 receptor and cannabinoid CB1 receptor do not modulate paraoxon induced seizures (full-2015) http://onlinelibrary.wiley.com/doi/10.1002/prp2.100/full
Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents (abst – 2015) http://www.ncbi.nlm.nih.gov/pubmed/25560837
Pentylenetetrazol-induced seizure-like behavior and neural hyperactivity in the medicinal leech (abst-2015) http://www.ncbi.nlm.nih.gov/pubmed/25572075
Neuroprotective effects of trans-caryophyllene against kainic Acid induced seizure activity and oxidative stress in mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25417010
Effects of WIN 55,212-2 (a synthetic cannabinoid CB1 and CB2 receptor agonist) on the anticonvulsant activity of various novel antiepileptic drugs against 6 Hz-induced psychomotor seizures in mice. (abst – 2015) http://www.ncbi.nlm.nih.gov/pubmed/25592741
How Medical Marijuana’s Chemicals May Protect Cells (news – 2015) http://www.scientificamerican.com/article/how-medical-marijuana-s-chemicals-may-protect-cells/
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Fatty Acid Binding Proteins (FABPs) are Intracellular Carriers for Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD) (full–2015)
http://www.jbc.org/content/early/2015/02/09/jbc.M114.618447.long
Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine (full – 2015) http://www.hindawi.com/journals/mi/2015/523418/
Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423390/
Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents. (full – 2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284516/
Interaction between Cannabinoid Compounds and Capsazepine in Protection against Acute Pentylenetetrazole-induced Seizure in Mice (full–2015)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499434/
Phytocannabinoids and epilepsy (full–2015) http://onlinelibrary.wiley.com/doi/10.1111/jcpt.12235/full
Impaired 2-AG signaling in hippocampal glutamatergic neurons: aggravation of anxietylike behavior and unaltered seizure susceptibility (full–2015) http://ijnp.oxfordjournals.org/content/ijnp/early/2015/07/29/ijnp.pyv091.full.pdf
Cannabinoids: is there a potential treatment role in epilepsy? (full – 2015) http://informahealthcare.com/doi/pdf/10.1517/14656566.2015.1074181
Neuroprotective effects of trans-caryophyllene against kainic Acid induced seizure activity and oxidative stress in mice (abst–2015)
http://www.ncbi.nlm.nih.gov/pubmed/25417010
Effects of WIN 55,212-2 (a synthetic cannabinoid CB1 and CB2 receptor agonist) on the anticonvulsant activity of various novel antiepileptic drugs against 6 Hz-induced psychomotor seizures in mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25592741
Options for pharmacoresistant epilepsy in children: when medications don’t work (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25658218
A Common Source Outbreak of Severe Delirium Associated with Exposure to the Novel Synthetic Cannabinoid ADB-PINACA (abst–2015)
http://www.ncbi.nlm.nih.gov/pubmed/25726258
Attenuation of kainic acid-induced status epilepticus by inhibition of endocannabinoid transport and degradation in guinea pigs (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25769371
Homer Protein-Metabotropic Glutamate Receptor Binding Regulates Endocannabinoid Signaling and Affects Hyperexcitability in a Mouse Model of Fragile X Syndrome (abst – 2015) http://www.ncbi.nlm.nih.gov/pubmed/25740522
Marijuana: A Time-Honored but Untested Treatment for Epilepsy. (abst – 2015) http://www.ncbi.nlm.nih.gov/pubmed/25715711
Inhibition of monoacylglycerol lipase mediates a cannabinoid 1-receptor dependent delay of kindling progression in mice. (abst – 2015)
http://www.ncbi.nlm.nih.gov/pubmed/25796567
Withdrawal Seizures Seen In the Setting of Synthetic Cannabinoid Abuse (abst – 2015) http://www.ajemjournal.com/article/S0735-6757%2815%2900169-2/abstract
Parental reporting of response to oral cannabis extracts for treatment of refractory epilepsy. (abst – 2015) http://www.ncbi.nlm.nih.gov/pubmed/25845492
The role of cannabinoids and leptin in neurological diseases. (abst – 2015) http://www.ncbi.nlm.nih.gov/pubmed/25880465
Pure cannabidiol in the treatment of malignant migrating partial seizures in infancy: a case report. (abst – 2015) http://www.ncbi.nlm.nih.gov/pubmed/25882081
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Weeding out bad waves: towards selective cannabinoid circuit control in epilepsy (abst – 2015) http://www.ncbi.nlm.nih.gov/pubmed/25891509
Influence of arachidonyl-2′-chloroethylamide, a selective cannabinoid CB1 receptor agonist, on the anticonvulsant and acute side-effect potentials of clobazam, lacosamide and pregabalin in the maximal electroshock-induced seizure model and chimney test in mice (abst-2015) http://www.ncbi.nlm.nih.gov/pubmed/25904357
Long-term disease-modifying effect of the endocannabinoid agonist WIN55,212-2 in a rat model of audiogenic epilepsy (abst-2015) http://www.ncbi.nlm.nih.gov/pubmed/25933961
Enhancement of endocannabinoid signalling protects against cocaine-induced neurotoxicity (abst-2015) http://www.ncbi.nlm.nih.gov/pubmed/25933444
Perceived efficacy of cannabidiol-enriched cannabis extracts for treatment of pediatric epilepsy: A potential role for infantile spasms and Lennox-Gastaut syndrome (abst – 2015) http://www.ncbi.nlm.nih.gov/pubmed/25935511
JWH-018 impairs sensorimotor functions in mice. (abst – 2015) http://www.ncbi.nlm.nih.gov/pubmed/25987201
Cannabinoid and nitric oxide signaling interplay in the modulation of hippocampal hyperexcitability: Study on electrophysiological and behavioral models of temporal lobe epilepsy in the rat. (abst – 2015) http://www.ncbi.nlm.nih.gov/pubmed/26135674
Changes over time of cannabinoid receptor 1 in hippocampus of status epilepticus rats (abst-2015) http://www.ncbi.nlm.nih.gov/pubmed/26168676
ACEA (a highly selective cannabinoid CB1 receptor agonist) stimulates hippocampal neurogenesis in mice treated with antiepileptic drugs (abst-2015) http://www.ncbi.nlm.nih.gov/pubmed/26225920
How Medical Marijuana’s Chemicals May Protect Cells (news-2015) http://www.scientificamerican.com/article/how-medical-marijuana-s-chemicals-may-protect-cells/
Many States Mulling Medical Marijuana Bills (news-2015) http://www.webmd.com/mental-health/news/20150212/states-medical-marijuana-legislation
Oshawa woman says marijuana helped curb her constant seizures (news-2015) http://toronto.ctvnews.ca/oshawa-woman-says-marijuana-helped-curb-her-constant-seizures-1.2246708
What ailments does medical marijuana help? (news-2015) http://www.mnn.com/health/fitness-well-being/stories/what-ailments-does-medical-marijuana-help 10 diseases where medical marijuana could have impact (news-2015) http://www.cnn.com/2015/04/15/health/marijuana-medical-advances/index.html
The Science Behind Sanjay Gupta’s WEED 3 (news-2015) http://blog.sfgate.com/smellthetruth/2015/04/21/the-science-behind-sanjay-guptas-weed-3/
Big Pharma-Produced Cannabis Is Likely Coming to the U.S. (news-2015) http://www.huffingtonpost.com/alice-oleary-randall/medical-cannabis-issue-th_b_7925956.html
Study confirms safety of cannabis drug CBD (news-2015) https://www.epilepsy.org.uk/news/news/study-confirms-safety-cannabis-drug-cbd-64709
Science Seeks to Unlock Marijuana’s Secrets (news-2015) http://ngm.nationalgeographic.com/2015/06/marijuana/sides-text
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ESSENTIAL TREMOR
Retired Flint couple sees the light on medical marijuana (news-2014) http://www.mlive.com/news/flint/index.ssf/2014/04/retired_flint_couple_sees_the.html
EXERCISE and the ENDOCANNABINOID SYSTEM
Endocannabinoids and voluntary activity in mice: runner’s high and long-term consequences in emotional behaviors (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/20353785
Aerobic Exercise Training Reduces Cannabis Craving and Use in Non-Treatment Seeking Cannabis-Dependent Adults (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050879/?toolmcentrez
Adipose tissue endocannabinoid system gene expression: depot differences and effects of diet and exercise (full–2011) http://www.lipidworld.com/content/10/1/194
High-performance sport, marijuana, and cannabimimetics (full–2011) http://jat.oxfordjournals.org/content/35/9/624.long
Effects of exercise stress on the endocannabinoid system in humans under field conditions (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/22101870
Naloxone and rimonabant reduce the reinforcing properties of exercise in rats (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21707193
Intense exercise increases circulating endocannabinoid and BDNF levels in humans— Possible implications for reward and depression (abst–2011) http://www.psyneuen-journal.com/article/PIIS0306453011002873/abstract?rss=yes
Cure for the Munchies? Exercise Cuts Marijuana Cravings (news–2011) http://healthland.time.com/2011/03/09/cure-for-the-munchies-exercise-cuts-marijuana-cravings/
Exercise can reduce cannabis use in persons who don’t want to stop (news–2011) http://www.news-medical.net/news/20110304/Exercise-can-reduce-cannabis-use-in-persons-who-dontwant-to-stop.aspx
The role of the endocannabinoid system in skeletal muscle and metabolic adaptations to exercise: potential implications for the treatment of obesity (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22943701
Wired to run: exercise-induced endocannabinoid signaling in humans and cursorial mammals with implications for the ‘runner’s high’ (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22442371
Exercise-induced endocannabinoid signaling is modulated by intensity (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22990628
Ventral Tegmental Area Cannabinoid Type-1 Receptors Control Voluntary Exercise Performance (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/23237313
‘Runner’s High’ may have played role in evolutionary history of humans (news–2012) http://in.news.yahoo.com/runners-high-may-played-role-evolutionary-history-humans-105030765.html
It hurts so good: the runner’s high (news–2012) http://blogs.scientificamerican.com/scicurious-brain/2012/03/12/it-hurts-so-good-the-runners-high/
Voluntary Running in Young Adult Mice Reduces Anxiety-Like Behavior and Increases the Accumulation of Bioactive Lipids in the Cerebral Cortex (full–2013) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0081459
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The effects of caffeine, nicotine, ethanol, and tetrahydrocannabinol on exercise performance (full–2013) http://www.nutritionandmetabolism.com/content/10/1/71
A role for the endocannabinoid system in exercise-induced spatial memory enhancement in mice (full–2013) http://www.ncbi.nlm.nih.gov/pubmed/24115292
Exercise Addiction- Diagnosis, Bio-Psychological Mechanisms and Treatment Issues (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24001300
Exercise increases plasma THC concentrations in regular cannabis users (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24018317
The endocannabinoid system mediates aerobic exercise-induced antinociception in rats (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24148812
Why resolutions about taking up physical activity are hard to keep (news–2013) http://www.thefreelibrary.com/Why+resolutions+about+taking+up+physical+activity+are+hard+to+keep.-a0313904638
London Zoo: No runner’s high for ferrets (news–2013) http://azdailysun.com/news/local/43054478-b68d-11e2-b97e-001a4bcf887a.html
Do Dogs Get Runner’s High? (news – 2013) http://news.discovery.com/animals/pets/do-dogs-experience-runners-high-130514.htm
One Toke, Many Hits: Exercise Could Trigger Additional High for Marijuana Users (news-2013) http://healthland.time.com/2013/09/17/one-toke-many-hits-exercise-could-trigger-additional-high-formarijuana-users/
Care and Feeding of the Endocannabinoid System: A Systematic Review of Potential Clinical Interventions that Upregulate the Endocannabinoid System. (full – 2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951193/
Physical activity and the endocannabinoid system: an overview (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24526057
Physical activity and cannabis cessation (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24629045
Fasting and exercise increase plasma cannabinoid levels in THC pre-treated rats: an examination of behavioural consequences (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24696079
Effect of dronabinol therapy on physical activity in anorexia nervosa: a randomised, controlled trial. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24890912
Acute Resistance Exercise Induces Antinociception by Activation of the Endocannabinoid System in Rats. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24977916
Effects of Two Different Specific Neck Exercise Interventions on Palmitoylethanolamide and Stearoylethanolamide Concentrations in the Interstitium of the Trapezius Muscle in Women with Chronic Neck Shoulder Pain (abst – 2014) http://onlinelibrary.wiley.com/doi/10.1111/pme.12486/abstract
Mechanisms of Exercise-Induced Hypoalgesia (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/25261342
The fatty acid amide hydrolase in lymphocytes from sedentary and active subjects (abst – 2014)http://www.ncbi.nlm.nih.gov/pubmed/23793235
Molecular Basis for the Improvement in Muscle Metaboreflex and Mechanoreflex Control in Exercise-Trained Humans with Chronic Heart Failure (abst-2014) http://www.ncbi.nlm.nih.gov/pubmed/25305179
Marijuana’s Surprising Effects On Athletic Performance (news-2015) http://finance.yahoo.com/news/marijuanas-surprising-effects-athletic-performance-183230768.html;_ylt=AwrTWVV1Z8BUa1EAyA_QtDMD
Marijuana’s Surprising Effects On Athletic Performance (news-2015) http://finance.yahoo.com/news/marijuanas-surprising-effects-athletic-performance-183230768.html;_ylt=AwrTWVV1Z8BUa1EAyA_QtDMD
Cannabinoid Receptor 1 and Acute Resistance Exercise – In vivo and In vitro Studies in Human Skeletal Muscle (abst-2015) http://www.ncbi.nlm.nih.gov/pubmed/25796352
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Marijuana’s Surprising Effects On Athletic Performance (news-2015) http://finance.yahoo.com/news/marijuanas-surprising-effects-athletic-performance-183230768.html;_ylt=AwrTWVV1Z8BUa1EAyA_QtDMD
Smoking marijuana may help athletic performance (news-2015) http://www.washingtonpost.com/national/health-science/smoking-marijuana-may-help-athleticperformance/2015/02/06/f0ea7b1c-a71d-11e4-a06b-9df2002b86a0_story.html?wprss=rss_national
Marijuana Finds Popularity Among An Unlikely Group (news-2015) http://finance.yahoo.com/news/marijuana-finds-popularity-among-unlikely-131100410.html;_ylt=AwrSyCT5PdpUwEkA4UPQtDMD
Olympic athlete pushes for pot gold (news-2015) http://www.bclocalnews.com/national/300827901.html
Granny Storm Crow's List 