T-W (Synthetics Pre-2010)

SYNTHETICS and COMPOUNDS THAT AFFECT the ENDOCANNABINOID SYSTEM Pre-2010

TARANBANT / MK-0364 (CB1 Inverse Agonist, Weight Loss Drug)
URB-532 (Slows Cannabinoid Destruction)
URB-597 / KDS-4103 (Slows Cannabinoid Destruction in the Body, Not the Brain)
URB-602 (Stops Breakdown of Anandamide and 2-AG)
URB-754 (Slows Cannabinoid Destruction)
URB-937 (Slows Cannabinoid Destruction)
WIN 55,212-2 (CB1 and CB2 Agonist)
WWL-70 (Prevents Breakdown of 2-AG)


TARANBANT / MK-0364
The discovery of taranabant, a selective cannabinoid-1 receptor inverse agonist for the treatment of obesity (full–2008) http://onlinelibrary.wiley.com/doi/10.1002/ardp.200700255/pdf
Taranabant, a novel cannabinoid type 1 receptor inverse agonist (abst–2008) http://www.ncbi.nlm.nih.gov/pubmed/18821475
Cannabinoid-1 receptor inverse agonists: current understanding of mechanism of action and unanswered questions (full–2009) http://www.nature.com/ijo/journal/v33/n9/full/ijo2009132a.html
Influence of taranabant, a cannabinoid-1 receptor inverse agonist, on pharmacokinetics and pharmacodynamics of warfarin (abst–2009) http://www.ncbi.nlm.nih.gov/pubmed/18989636
Central side-effects of therapies based on CB1 cannabinoid receptor agonists and antagonists: focus on anxiety and depression (abst–2009) http://www.ncbi.nlm.nih.gov/pubmed/19285266


URB-532
The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity (full–2005) http://www.jlr.org/content/46/2/342.long
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URB-597 / KDS-4103
Marijuana’s Distant Relative May Be The Next Prozac; Chemical Reduces Anxiety Using Novel Nerve System In Body (news-2002) http://www.sciencedaily.com/releases/2002/12/021202071928.htm
Cannabis’ Potential Exciting Researchers in Treatment of ALS, Parkinson’s Disease -URB597 (news-2004) http://www.illinoisnorml.org/index2.php?option=com_content&do_pdf=1&id=104
Antidepressant-like Activity and Modulation of Brain Monoaminergic Transmission by Blockade of Anandamide Hydrolysis (full–2005) http://www.pnas.org/content/102/51/18620.long
Blocking the destruction of endocannabinoids (news–2005) http://arstechnica.com/science/2005/12/2106/
Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models (full–2006) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1751298/?tool=pmcentrez
Effects of endocannabinoid neurotransmission modulators on brain stimulation reward (abst–2006) http://www.ncbi.nlm.nih.gov/pubmed/16953388
Endocannabinoid Degradation and Oxidative Defense Mechanisms Determine Anandamide-induced Cell Death in Liver Cell Populations (abst–2006) https://www.thieme-connect.com/ejournals/abstract/10.1055/s-2006-931661
The Endogenous Cannabinoid Anandamide Produces δ-9-Tetrahydrocannabinol-Like Discriminative and Neurochemical Effects That Are Enhanced by Inhibition of Fatty Acid Amide Hydrolase but Not by Inhibition of Anandamide Transport (full-2007) http://jpet.aspetjournals.org/content/321/1/370.full
Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson’s disease: role of CB1 and TRPV1 receptors (full-2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128772/?tool=pmcentrez
The CB1 Cannabinoid Receptor Mediates Excitotoxicity-induced Neural Progenitor Proliferation and Neurogenesis (full-2007) http://www.jbc.org/content/282/33/23892.full
The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3′-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice (full-2007) http://jpet.aspetjournals.org/content/322/1/236.long
Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress (abst–2007) http://www.ncbi.nlm.nih.gov/pubmed/17511970
Marijuana-Like Brain Chemicals Work As Antidepressant (news–2007) http://www.sciencedaily.com/releases/2007/11/071105120556.htm
Parkinsons’ Helped By Marijuana-Like Chemicals In Brain (news–2007) http://www.medicalnewstoday.com/releases/62616.php
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Enhancing Activity Of Marijuana-Like Chemicals In Brain Helps Treat Parkinson’s Symptoms In Mice (news-2007) http://www.sciencedaily.com/releases/2007/02/070207171915.htm
Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats (full–2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697765/?tool=pmcentrez
Pharmacological enhancement of endocannabinoid signaling reduces the cholinergic toxicity of diisopropylfluorophosphate (full–2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659532/
An endocannabinoid signaling system modulates anxiety-like behavior in male Syrian hamsters (full–2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694060/
Inhibition of anandamide hydrolysis by URB597 reverses abuse-related behavior and neurochemical effects of nicotine in rats (full–2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663803/?tool=pubmed
The FAAH inhibitor URB-597 ameliorates cannabinoid withdrawal in mice (abst–2008) http://www.fasebj.org/cgi/content/meeting_abstract/22/1_MeetingAbstracts/711.6?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=720&resourcetype=HWCIT
Targeting endocannabinoid degradation protects against experimental colitis in mice: involvement of CB1 and CB2 receptors (abst–2008) http://www.ncbi.nlm.nih.gov/pubmed/18493729
Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain (full-2009) http://jpet.aspetjournals.org/content/330/3/902.full?sid=af53ea87-ab4b-426e-9c7e-8f750e9c4a17
Processing cardiovascular information in the vlPAG during electroacupuncture in rats: roles of endocannabinoids and GABA (full–2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692771/#!po=4.54545
Long-term consequences of URB597 administration during adolescence on cannabinoid CB1 receptor binding in brain areas (abst–2009) http://www.sciencedirect.com/science/article/pii/S0006899308030588


URB-602
Pharmacological enhancement of endocannabinoid signaling reduces the cholinergic toxicity of diisopropylfluorophosphate (full–2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659532/
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URB-754
The CB1 Cannabinoid Receptor Mediates Excitotoxicity-induced Neural Progenitor Proliferation and Neurogenesis (full-2007) http://www.jbc.org/content/282/33/23892.full


URB-937
UC Irvine discovery part of growing pharma effort to create new class of drugs (news–2007) http://archive.today.uci.edu/news/release_detail.asp?key=1631


WIN 55,212-2
Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells (full-1992) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC525583/
Cross-tolerance between delta-9-tetrahydrocannabinol and the cannabimimetic agents, CP 55,940, WIN 55,212-2 and anandamide (full–1993) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175863/?tool=pmcentrez&page=1
(+)-WIN 55,212-2, a novel cannabinoid receptor agonist, exerts antidystonic effects in mutant dystonic hamsters (abst-1994) http://www.ncbi.nlm.nih.gov/pubmed/7698178
Cannabinoid Receptor Agonists Protect Cultured Rat Hippocampal Neurons from Excitotoxicity (full-1998) http://molpharm.aspetjournals.org/content/54/3/459.full
Loss of Cannabinoid Receptor Binding and Messenger Rna Levels and Cannabinoid Agonist-stimulated [35s]guanylyl-5’o-(Thio)-triphosphate Binding in the Basal Ganglia of Aged Rats (abst-1998) http://www.ncbi.nlm.nih.gov/pubmed/9578396?dopt=Abstract
Cannabinoids and Neuroprotection in Global and Focal Cerebral Ischemia and in Neuronal Cultures (full–1999) http://www.jneurosci.org/cgi/content/full/19/8/2987?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT
The role of cannabinoid receptors in intestinal motility, defaecation and diarrhoea in rats (abst-1999) http://www.ncbi.nlm.nih.gov/pubmed/10611417
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Involvement of Cannabinoid Receptors in the Intraocular Pressure-Lowering Effects of WIN55212-2 (full-2000) http://jpet.aspetjournals.org/content/292/1/136.long
Cannabinoids might reduce spasticity in multiple sclerosis (full–2000) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1117698/?tool=pmcentrez
Effects of cannabinoid receptor agonists on neuronally-evoked contractions of urinary bladder tissues isolated from rat, mouse, pig, dog, monkey and human (full-2000) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1571997/?tool=pmcentrez
Central and peripheral cannabinoid modulation of gastrointestinal transit in physiological states or during the diarrhoea induced by croton oil (full–2000) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1572019&tool=pmcentrez
Modulation of peristalsis by cannabinoid CB1 ligands in the isolated guinea-pig ileum (full-2000) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1571902&tool=pmcentrez
Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation (full-2000) http://depts.washington.edu/stellalb/images/Nature2000.pdf
Behaviroal, pharmacological, and molecular characterization of an amphibian cannabinoid receptor (full–2000) http://onlinelibrary.wiley.com/doi/10.1046/j.1471-4159.2000.0750413.x/full
Delta(9)-tetrahydrocannabinol and synthetic cannabinoids prevent emesis produced by the cannabinoid CB(1) receptor antagonist/inverse agonist SR 141716A (full–2001) http://www.nature.com/npp/journal/v24/n2/full/1395605a.html
The synthetic cannabinoid WIN55,212-2 attenuates hyperalgesia and allodynia in a rat model of neuropathic pain (full-2001) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1572814&tool=pmcentrez
The cannabinoid CB1 receptor antagonist SR 141716A reverses the antiemetic and motor depressant actions of WIN 55, 212-2 (full–2001) http://www.nature.com/npp/journal/v24/n2/full/1395605a.html
The cannabinoid agonist WIN55,212-2 suppresses opioid-induced emesis in ferrets (link to PDF-2001) http://journals.lww.com/anesthesiology/Fulltext/2001/05000/The_Cannabinoid_Agonist_WIN55,212_2_Suppresses.29.aspx
Increased Severity of Stroke in CB1 Cannabinoid Receptor Knock-Out Mice (full–2002) http://www.jneurosci.org/cgi/content/full/22/22/9771?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT
Contrasting effects of WIN 55212-2 on motility of the rat bladder and uterus (full–2002) http://www.jneurosci.org/content/22/16/7147.long
CB1 Receptors in the Preoptic Anterior Hypothalamus Regulate WIN 55212-2 [(4,5-Dihydro-2-methyl-4(4-morpholinylmethyl)-1-(1-naphthalenyl-carbonyl)-6H-pyrrolo[3,2,1ij]quinolin-6-one]-Induced Hypothermia (full-2002) http://jpet.aspetjournals.org/content/301/3/963.full
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A Peripheral Mechanism for CB1 Cannabinoid Receptor-Dependent Modulation of Feeding (full-2002) http://www.jneurosci.org/content/22/21/9612.full
Influence of the CB1 receptor antagonist, AM 251, on the regional haemodynamic effects of WIN-55212-2 or HU 210 in conscious rats (full-2002) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573379/?tool=pmcentrez
The potent emetogenic effects of the endocannabinoid, 2-AG (2-arachidonoylglycerol) are blocked by delta(9)-tetrahydrocannabinol and other cannnabinoids (full–2002) http://jpet.aspetjournals.org/content/300/1/34.long
Evidence for functional CB1 cannabinoid receptor expressed in the rat thyroid (full–2002) http://www.eje-online.org/content/147/2/255.full.pdf+html
Effects of pharmacological manipulations of cannabinoid receptors on severity of dystonia in a genetic model of paroxysmal dyskinesia (abst-2002) http://www.ncbi.nlm.nih.gov/pubmed/12421641
Inhibition of tumor angiogenesis by cannabinoids (full–2003) http://www.fasebj.org/cgi/reprint/02-0795fjev1?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=cannabis&andorexactfulltext=and&searchid=1&FIRSTINDEX=20&sortspec=relevance&resourcetype=HWCIT
The Endogenous Cannabinoid System Regulates Seizure Frequency and Duration in a Model of Temporal Lobe Epilepsy (full–2003) http://jpet.aspetjournals.org/content/307/1/129.full?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=160&resourcetype=HWCIT
Immunoregulation of a viral model of multiple sclerosis using the synthetic cannabinoid R(+)WIN55,212 (full-2003) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC152941/?tool=pmcentrez
Cannabinoid receptor type 1 modulates excitatory and inhibitory neurotransmission in mouse colon (full–2003) http://ajpgi.physiology.org/content/286/1/G110.full?sid=fc6948f0-78cf-405c-981b-afaa05ee417c
Effect of WIN 55212-2, a Cannabinoid Receptor Agonist, on Aqueous Humor Dynamics in Monkeys (link to PDF–2003) http://archopht.ama-assn.org/cgi/content/full/121/1/87?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=marihuana&searchid=1&FIRSTINDEX=640&resourcetype=HWCIT
The cannabinoid agonist WIN 55, 212-2 increases nociception threshold in cholestatic rats: implications for the treatment of the pruritus of cholestasis (abst–2003) http://www.ncbi.nlm.nih.gov/pubmed/13679241
Cannabinoids: Defending the Epileptic Brain (full–2004) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1176332/?tool=pmcentrez
The effect of WIN 55,212-2, a cannabinoid agonist, on tactile allodynia in diabetic rats (abst–2004) http://www.ncbi.nlm.nih.gov/pubmed/15519750
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Marijuana-like compounds may aid array of debiliating conditions ranging from Parkinson’s to pain (news–2004) http://www.eurekalert.org/pub_releases/2004-10/sfn-mcm102604.php
Enhancing Cannabinoid Neurotransmission Augments the Extinction of Conditioned Fear (full-2005) http://www.nature.com/npp/journal/v30/n3/full/1300655a.html
Effects of cannabinoids on colonic muscle contractility and tension in guinea pigs (full–2005) https://www.jstage.jst.go.jp/article/jnms/72/1/72_1_43/_pdf
Effects of cannabinoid treatment on Chagas disease pathogenesis: balancing inhibition of parasite invasion and immunosuppression (full–2005) http://onlinelibrary.wiley.com/doi/10.1111/j.1462-5822.2005.00577.x/pdf
The cannabinoid receptor agonist WIN 55212-2 inhibits neurogenic inflammations in airway tissues (full–2005) https://www.jstage.jst.go.jp/article/jphs/98/1/98_1_77/_pdf
Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma (full–2005) http://www.sciencedirect.com/science/article/pii/S0014579305013803
Systemic administration of WIN 55,212-2 increases norepinephrine release in the rat frontal cortex (abst-2005) http://www.ncbi.nlm.nih.gov/pubmed/15927549
Cannabinoids down-regulate PI3K/Akt and Erk signalling pathways and activate proapoptotic function of Bad protein (abst–2005) http://www.ncbi.nlm.nih.gov/pubmed/15451022
Cannabinoid Receptor-Mediated Apoptosis Induced by R(+)-Methanandamide and Win55,212-2 Is Associated with Ceramide Accumulation and p38 Activation in Mantle Cell Lymphoma (full-2006) http://molpharm.aspetjournals.org/content/70/5/1612.full
Increasing cannabinoid levels by pharmacological and genetic manipulation delay disease progression in SOD1 mice (full-2006) http://www.fasebj.org/cgi/content/full/20/7/1003
Activation of G-proteins in brain by endogenous and exogenous cannabinoids (full–2006) http://www.ncbi.nlm.nih.gov/pubmed/16584117
Effects of a Cannabinoid Agonist on Spinal Nociceptive Neurons in a Rodent Model of Neuropathic Pain (full-2006) http://jn.physiology.org/cgi/content/full/96/6/2984
The Endocannabinoid System Controls Key Epileptogenic Circuits in the Hippocampus (full–2006) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1769341/?tool=pmcentrez
Antinociceptive effect of cannabinoid agonist WIN 55,212–2 in rats with a spinal cord injury (full-2006) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1861843/?tool=pmcentrez
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Activation of the Cannabinoid Type-1 Receptor Mediates the Anticonvulsant Properties of Cannabinoids in the Hippocampal Neuronal Culture Models of Acquired Epilepsy and Status Epilepticus (full–2006) http://jpet.aspetjournals.org/content/317/3/1072.full?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=320&resourcetype=HWCIT#ref-list-1
Cannabinoid Receptor Agonist-induced Apoptosis of Human Prostate Cancer Cells LNCaP Proceeds through Sustained Activation of ERK1/2 Leading to G1 Cell Cycle Arrest (full-2006) http://www.jbc.org/content/281/51/39480.full
Sphingosine and its analog, the immunosuppressant 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol, interact with the CB1 cannabinoid receptor (full–2006) http://molpharm.aspetjournals.org/content/70/1/41.long
Modulation of paraoxon toxicity by the cannabinoid receptor agonist WIN 55,212-2 (abst–2006) http://www.ncbi.nlm.nih.gov/pubmed/16956707
Cannabinoid receptors as a target for therapy of ovarian cancer (abst–2006) http://www.aacrmeetingabstracts.org/cgi/content/abstract/2006/1/1084?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=560&resourcetype=HWCIT
Arthritis and cannabinoids: HU-210 and Win-55,212-2 prevent IL-1alpha-induced matrix degradation in bovine articular chondrocytes in-vitro (abst-2006) http://www.ncbi.nlm.nih.gov/pubmed/16536902
The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells (abst-2006) http://www.ncbi.nlm.nih.gov/pubmed/16458258
Characterization of the neuroprotective effect of the cannabinoid agonist WIN-55212 in an in vitro model of hypoxic-ischemic brain damage in newborn rats (abst–2006) http://www.ncbi.nlm.nih.gov/pubmed/16864698
Role of cannabinoid receptor agonists in mechanisms of suppression of central pain syndrome (abst–2006) http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=17369898&dopt=abstractplus
Cannabinoids, in combination with (NSAIDS), produce a synergistic analgesic effect (news-2006) http://www.norml.org/index.cfm?Group_ID=6819
Continuous infusion of the cannabinoid WIN 55,212–2 to the site of a peripheral nerve injury reduces mechanical and cold hypersensitivity (full-2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2013951/?tool=pmcentrez
The phytocannabinoid Δ9-tetrahydrocannabivarin modulates inhibitory neurotransmission in the cerebellum (full–2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2438968/
Antinociceptive effect of cannabinoid agonist WIN 55,212–2 in rats with a spinal cord injury (full-2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1861843/?tool=pmcentrez
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Activation of cannabinoid CB1 and CB2 receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats (full–2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190028/?tool=pubmed
Cannabinoids elicit antidepressant-like behavior and activate serotonergic neurons through the medial prefrontal cortex (full-2007) http://www.jneurosci.org/cgi/content/full/27/43/11700
Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of chronic brain inflammation (full-2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852513/?tool=pmcentrez
Antinociceptive Synergy Between the Cannabinoid Receptor Agonist WIN 55,212-2 and Bupivacaine in the Rat Formalin Test (full–2007) http://journals.lww.com/anesthesia-analgesia/Fulltext/2007/03000/Antinociceptive_Synergy_Between_the_Cannabinoid.50.aspx
Cardiovascular effects of cannabinoids in conscious spontaneously hypertensive rats (full-2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190006/?tool=pmcentrez
Cross-sensitization and cross-tolerance between exogenous cannabinoid antinociception and endocannabinoid-mediated stress-induced analgesia (full–2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771679/?tool=pubmed
CANNABINOID-INDUCED HYPERPHAGIA: CORRELATION WITH INHIBITION OF PROOPIOMELANOCORTIN NEURONS? (full–2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720321/?tool=pmcentrez
Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson’s disease: role of CB1 and TRPV1 receptors (full-2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128772/?tool=pmcentrez
Cannabinoid self-administration in rats: sex differences and the influence of ovarian function (full-2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190022/
Development of pharmacoresistance to benzodiazepines but not cannabinoids in the hippocampal neuronal culture model of status epilepticus (full-2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2094113/?tool=pmcentrez
Control of spasticity in a multiple sclerosis model is mediated by CB1, not CB2, cannabinoid receptors (full-2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189718/?tool=pubmed
Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of chronic brain inflammation (full-2007) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1852513&tool=pmcentrez
CB1 receptors mediate the analgesic effects of cannabinoids on colorectal distension-induced visceral pain in rodents (full–2007) http://www.jneurosci.org/content/29/5/1554.long
Subchronic cannabinoid agonist (WIN 55,212-2) treatment during cocaine abstinence alters subsequent cocaine seeking behavior (full-2007) http://www.nature.com/npp/journal/v32/n11/pdf/1301365a.pdf
The synthetic cannabinoids attenuate allodynia and hyperalgesia in a rat model of trigeminal neuropathic pain (abst–2007) http://www.ncbi.nlm.nih.gov/pubmed/17572451
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Cannabinoid receptors agonist WIN-55,212-2 inhibits angiogenesis, metastasis and tumor growth of androgen-sensitive prostate cancer cell CWR22R{nu}1 xenograft in athymic nude mice (abst–2007) http://www.aacrmeetingabstracts.org/cgi/content/meeting_abstract/2007/1_Annual_Meeting/2195?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=720&resourcetype=HWCIT
Pharmacological analysis of cannabinoid-induced inhibition of gastric mucosal damage and gastric motility (abst–2007) https://www.thieme-connect.com/ejournals/abstract/10.1055/s-2007-982722
Characterization of cannabinoid-binding sites in zebrafish brain (abst–2007) http://www.frontiersin.org/publications/17178193
Additive Effects of Timolol and Cannabinoids on Intraocular Pressure in a Rat Glaucoma Model (abst–2007) http://abstracts.iovs.org/cgi/content/abstract/48/5/4807?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=560&resourcetype=HWCIT
Synthetic form of THC is an effective anti-depressant at low doses (news–2007) http://www.news-medical.net/news/2007/10/24/31666.aspx?page=2
Cannabis: Potent Anti-Depressant In Low Doses, Worsens Depression At High Doses (news-2007) http://www.sciencedaily.com/releases/2007/10/071023183937.htm
Chronic cannabinoid administration in vivo compromises extinction of fear memory (full-2008) http://learnmem.cshlp.org/content/15/12/876.long
Topical WIN55212-2 Alleviates Intraocular Hypertension in Rats Through a CB1 Receptor-Mediated Mechanism of Action (full-2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637200/?tool=pmcentrez
Pharmacological enhancement of endocannabinoid signaling reduces the cholinergic toxicity of diisopropylfluorophosphate (full–2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659532/
Attenuation of Experimental Autoimmune Hepatitis by Exogenous and Endogenous Cannabinoids: Involvement of Regulatory T Cells (full–2008) http://molpharm.aspetjournals.org/content/74/1/20.full?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=320&resourcetype=HWCIT#content-block
Peripheral Cannabinoids Attenuate Carcinoma Induced Nociception in Mice (full-2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771220/
Role of activated endocannabinoid system in regulation of cellular cholesterol metabolism in macrophages (full–2008) http://cardiovascres.oxfordjournals.org/content/81/4/805.full?sid=7d2438c4-a727-410f-870d-4a971695b4fb
Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats (full-2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697765/?tool=pmcentrez
The influence of mast cell mediators on migration of SW756 cervical carcinoma cells (full–2008) https://www.jstage.jst.go.jp/article/jphs/106/2/106_FP0070736/_pdf
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Cannabinoid 2 receptor induction by IL-12 and its potential as a therapeutic target for the treatment of anaplastic thyroid carcinoma (full–2008) http://www.nature.com/cgt/journal/v15/n2/full/7701101a.html
An endocannabinoid signaling system modulates anxiety-like behavior in male Syrian hamsters (full–2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694060/
Differential effects of repeated low dose treatment with the cannabinoid agonist WIN 55,212-2 in experimental models of bone cancer pain and neuropathic pain (abst-2008) http://www.ncbi.nlm.nih.gov/pubmed/18611408
Cannabinoid receptor agonists inhibit growth and metastasis of breast cancer (abst–2008) http://www.aacrmeetingabstracts.org/cgi/content/meeting_abstract/2008/1_Annual_Meeting/4081?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=480&resourcetype=HWCIT
New neuron production can be increased in the hippocampus of aged rats following cannabinoid treatment (abst–2008) http://www.ncbi.nlm.nih.gov/pubmed/18197164
Scientists are High on Idea that Cannabis Reduces Memory Impairment (news–2008) http://www.physorg.com/news146320102.html
Could Marijuana Substance Help Prevent Or Delay Memory Impairment In The Aging Brain? (news-2008) http://www.sciencedaily.com/releases/2008/11/081119120141.htm
WIN55,212-2, a Cannabinoid Receptor Agonist, Protects Against Nigrostriatal Cell Loss in the MPTP Mouse Model of Parkinson’s Disease (full–2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755595/?tool=pmcentrez
Sustained antinociceptive effect of cannabinoid receptor agonist WIN 55,212-2 over time in rat model of neuropathic spinal cord injury pain (full–2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743245/?tool=pmcentrez
Cannabinoid-1 (CB1) receptors regulate colonic propulsion by acting at motor neurons within the ascending motor pathways in mouse colon (full–2009) http://ajpgi.physiology.org/cgi/content/full/296/1/G119?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=160&resourcetype=HWCIT
Cannabinoid Receptor Activation in the Basolateral Amygdala Blocks the Effects of Stress on the Conditioning and Extinction of Inhibitory Avoidance (full-2009) http://www.jneurosci.org/cgi/content/full/29/36/11078?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=Dr.+Irit+Akirav+&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT
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Effects of the cannabinoid CB1 receptor antagonist rimonabant on distinct measures of impulsive behavior in rats (full–2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1915592/?tool=pubmed
Endocannabinoids in the rat basolateral amygdala enhance memory consolidation and enable glucocorticoid modulation of memory (full-2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660732/?tool=pmcentrez
Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer (full-2009) http://mct.aacrjournals.org/content/8/11/3117.full
Cannabinoids inhibit fibrogenesis in diffuse systemic sclerosis fibroblasts (full-2009) http://rheumatology.oxfordjournals.org/content/48/9/1050.full
Prolonged exposure to WIN55,212-2 causes downregulation of the CB1 receptor and the development of tolerance to its anticonvulsant effects in the hippocampal neuronal culture model of acquired epilepsy (full–2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757117/?tool=pubmed
Cannabinoid agonist WIN-55,212-2 partially restores neurogenesis in the aged rat brain (full-2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011092/?tool=pubmed
Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesis (abst–2009) http://www.ncbi.nlm.nih.gov/pubmed/19385063
EFFECTIVENESS OF A CANNABINOID AGONIST TO MODIFY THE ALTERED MECHANOSENSITIVITY OF A-DELTA FIBERS AFTER ANTITUMORAL TREATMENT (abst–2009) http://www.efic-congress.org/showabstract.php?abstract=169
The CB1/CB2 receptor agonist WIN-55,212-2 reduces viability of human Kaposi’s sarcoma cells in vitro (abst-2009) http://www.ncbi.nlm.nih.gov/pubmed/19539619


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Monoacylglycerol lipase limits the duration of endocannabinoid-mediated depolarization-induced suppression of excitation in autaptic hippocampal neurons (full–2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784730/
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