SYNTHETICS (News 2010-2019)

SYNTHETICS and COMPOUNDS THAT AFFECT the ENDOCANNABINOID SYSTEM (ECS) News Articles 2010-2019

(Due to the limited number of early articles, there are no date restrictions)

ACEA/ARACHIDONYL-2′-CHLOROETHYLAMIDE (Changes into AM-404, Which Stops Anandamide Breakdown, and the Extra Anandamide Eases Pain)
AJULEMIC ACID/AjA/IP-751/HU-239/CT-3 (Analog of Δ8-THC-11-oic acid, Mechanism of Action Not Established, See also JBT-101)
AM-111/D-JNKI-1/XG-102 (Blocks the MAPK-JNK Signal Pathway)
AM-251 (GPR 55 Agonist, CB1 Antagonist/Inverse Agonist) 
AM-404 (Cannabinoid Transport Inhibitor, Slows Destruction of Anandamide. The body makes it from acetaminophen. See also ACETAMINOPHEN)
AM-630 (CB2 Inverse Agonist)
AM-1172 (Anandamide Transport Inhibitor)
AM-1241 (CB2 Agonist)
AM-1346 (CB1 Agonist)
AM-1710 (CB2 Agonist)
AM-6538 (Strong Antagonist of CB1 Receptors that “Freezes” Them For Easier Study)
BIA 10-2474 (Failed FAAH inhibitor, Prevents Breakdown of Anandamide, Can Be Fatal)
CANNABINOR (CB2 Agonist)
CB-65 (CB2 Agonist)
CP-47,497 (CB1 and CB2 Agonist)
CP-55,940 (CB1, CB2 and GPR55 Agonist)
FUBINACA GROUP
GP-1A (CB2 Agonist)
HU-210 (CB1 and CB2 Agonist Over 100 Times Stronger Than THC)

HU-211/DEXANABINOL/DEXANABINONE/SINNABIDOL/ETS-2101/PA 50211/PRS 211007 (CB2 Agonist)
HU-308 (CB2 Agonist)
HU-910/LISINOPRIL (CB2 Agonist)
HU-914 (CB2 Agonist)
IBUPROFEN (Blocks Breakdown of Anandamide Which is What Actually Relieves Your Pain)
J-147 (CB1 Antagonist Derived from Curcumin)
JBT-101/RESUNAB
JD-5037 (CB1 Agonist With Limited Brain Penetration)
JWH-015 (CB2 and GPR-55 Agonist, Mildly Activates CB1 Receptors)
JWH-018 (CB1 Agonist)
JWH-073 (CB1 and CB2 Agonist)
JWH-122 (CB1 Agonist)
JWH-133/3-(1_1_-dimethylbutyl)-1-deoxy-_8-THC (CB2 Agonist)
JWH-200 (CB1 Agonist)
JWH-210 (CB1 Agonist)
JZL-184 (Blocks Breakdown of 2-AG)
KN38-7271/BAY38-7271 (CB1 and CB2 Agonist)
MAB-CHMINACA
MARINOL/DRONABINOL (Synthetic THC, CB1 and CB2 Agonist)
MDA-7 (Strong CB2 Agonist)
MDA-19 (Strong CB2 Agonist)
NABILONE/CESAMET (Synthetic THC, CB1 and CB2 Agonist)
RIMONABANT/ACOMPLIA/SR141716/SR1 (CB1 and CB2 Antagonist, GPR-55 Agonist, Failed Weight Loss Drug, sort of an “anti-THC”)
Ro 61-8048 (Blocks the THC “High”)
“SPICE”/SCRAs (Various Synthetic Cannabinoid Mixtures, See Also AM, HU, JWH and CP Series – Some Have Caused Fatalities, Unlike Natural Cannabis)
SYNDROS (Orally Administered Liquid Formulation of Dronabinol [Synthetic THC], Schedule II)
TM-38837 (Mostly Peripherally Restricted CB1 Antagonist)
TRICOR/FENOFIBRATE (Works by Activating CB2 Receptors, Partial CB1 Agonist)
URB-597/KDS-4103 (Slows Cannabinoid Destruction in the Body, Not the Brain)
URB-937 (Slows Cannabinoid Destruction)
VCE-004.8 (Semi-synthetic CB2 Activator)
WIN-55,212-2 (CB1 and CB2 Agonist, Stronger Than THC but Usually Acts in a Similar Fashion)
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ACEA/ARACHIDONYL-2′-CHLOROETHYLAMIDE
Study: Cannabis Agonists Produce Anti-Cancer Effects In Human Liver Cancer Cells (news–2012) https://norml.org/news/2012/10/11/study-cannabis-agonists-produce-anti-cancer-effects-in-human-liver-cancer-cells
Anti-Cancer Effects In Human Liver Cancer Cells Produced By Cannabis Agonists (news–2012) http://cb65.com/anti-cancer-effects-in-human-liver-cancer-cells-produced-by-cannabis-agonists-2/


ACETAMINOPHEN/PARACETAMOL/TYLENOL
Tylenol’s Analgesic Effect is Mediated By Cannabinoid Receptors (news – 2014) http://sclabs.com/about-blog/item/61-tylenol-s-analgesic-effect-is-mediated-by-cannabinoid-receptors.html
Acetaminophen or Paracetamol: Pain Relief and Precautions (news – 2016) https://healdove.com/health-care-industry/Acetaminophen-or-Paracetamol-How-Does-it-Provide-Pain-Relief


AJULEMIC ACID/AjA/IP-751/HU-239/CT-3
Marijuana-Derived Compound Targets Pain, Inflammation (news-2002) http://www.sciencedaily.com/releases/2002/08/020822071026.htm
Marijuana-Derived Drug Suppresses Bladder Overactivity And Irritation In Animal Models (news-2005) http://www.sciencedaily.com/releases/2005/09/050906080225.htm
Marijuana-Derived Drug Suppresses Bladder Pain In Animal Models (news-2006) http://www.sciencedaily.com/releases/2006/05/060521103039.htm
Letter: Preclinical assessment of abuse liability of ajulemic acid (letter-2007)
http://www.cannabis-med.org/english/journal/en_2007_01_2.pdf
Cannabinoids, Dupuytren, and Orphan Drugs (news – 2017) https://dupuytrens.org/cannabinoids-dupuytren-and-orphan-drugs/


AM-111/D-JNKI-1/XG-102
Otoprotective Effect of AM-111 Also Shown In Model of Cochlear Ischemia (news–2010) https://www.biospace.com/article/releases/auris-medical-ag-release-otoprotective-effect-of-am-111-also-shown-in-model-of-cochlear-ischemia-/
Analysis: Drugmakers step up search for hearing loss medicines (news–2012)
http://www.reuters.com/article/2012/12/02/us-hearing-medicines-idUSBRE8B102H20121202
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AM-251
Cannabidiol (CBD) as an Anti-Arrhythmic – the Role of the CB1 Receptors (news–2010)
http://cannabisclinicians.org/2011/cannabidiol-cbd-as-an-anti-arrhythmic-the-role-of-the-cb1-receptors/


AM-404
Aging & Medical Marijuana (booklet – undated) http://www.safeaccessnow.org/aging_booklet
Easing anxiety with anandamide (news–2004) http://www.rsc.org/chemistryworld/Issues/2004/July/anandamide.asp
Talking Tylenol… yes, more cannabinoid analgesia (news–2008) https://juniorprof.wordpress.com/2008/05/16/talking-tylenol-yes-more-cannabinoid-analgesia/
Tylenol’s Analgesic Effect is Mediated By Cannabinoid Receptors (news–2014) https://www.sclabs.com/tylenol-s-analgesic-effect-is-mediated-by-cannabinoid-receptors/


AM-630
Cannabinoid Trans-Caryophyllene Protects Brain Cells From Ischemia (news–2013)
http://www.medicalnewstoday.com/articles/256799.php
Activation of cortical type 2 cannabinoid receptors ameliorates ischemic brain injury (news–2013) http://www.sciencedaily.com/releases/2013/02/130221141140.htm


AM-1172
New molecule may be basis for drugs that battle overeating and drug dependency (news–2004) http://www.sciencedaily.com/releases/2004/05/040517072118.htm
Easing anxiety with anandamide (news–2004) https://www.chemistryworld.com/news/easing-anxiety-with-anandamide/3001375.article
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AM-1241
New Compound That Acts On Peripheral Receptors May Be Promising Treatment For  Some Nerve Pain (news-2003) http://www.sciencedaily.com/releases/2003/08/030812073750.htm


AM-1346
Synthetic Cannabinoid May Aid Fertility In Smokers (news-2006) http://www.medicalnewstoday.com/articles/58063.php
Marijuana-like Chemical Can Restore Sperm Function Lost to Tobacco Abuse (news-2006) http://www.rxpgnews.com/specialtopics/article_5093.shtml
Cannabis-based boost for smokers’ suffering sperm (news–forum re-post-2006) https://www.420magazine.com/forums/am-1346-a/144336-cannabis-based-boost-smokers-suffering-sperm.html
Scientist Discovers New Molecule to Treat Chronic Pain (news-2008) https://news.northeastern.edu/2008/08/11/makryannisnewmolecule/


AM-1710
An alternative to medical marijuana for pain? (news–2015) http://medicalxpress.com/news/2015-03-alternative-medical-marijuana-pain.html


AM-6538
Harvesting Benefits from Cannabinoids (article–2016) http://www.cell.com/cell/fulltext/S0092-8674(16)31675-0
ShanghaiTech Scientists Resolve the Structure of the Human “Marijuana Receptor” (news–2016) http://www.prnewswire.com/news-releases/shanghaitech-scientists-resolve-the-structure-of-the-humanmarijuana-receptor-300347438.html
Structure of primary cannabinoid receptor is revealed (news–2016) https://www.eurekalert.org/pub_releases/2016-10/niod-sop102016.php


BIA 10-2474/BIOTRIAL
French drug trial leaves one brain dead and five critically ill (news–2015) https://www.theguardian.com/world/2016/jan/15/french-drug-trial-one-person-in-coma-and-five-critically-ill
French drug trial turns disastrous, leaving 1 brain dead and 5 hospitalized [Updated] (news–2016) https://arstechnica.com/science/2016/01/french-drug-trial-turns-disastrous-leaving-1-brain-dead-and-5-hospitalized/
Researchers question design of fatal French clinical trial. (news – 2016) https://www.nature.com/news/researchers-question-design-of-fatal-french-clinical-trial-1.19221
Will Death in French Drug Trial Lead to Tighter Phase 1 Rules? (news – 2016) https://www.painresearchforum.org/news/63317-will-death-french-drug-trial-lead-tighter-phase-1-rules
Animal Test Details Emerge in French Drug Trial Death (news–2016) https://www.pcrm.org/news/ethical-science/animal-test-details-emerge-french-drug-trial-death
High Doses Of Experimental Drug Implicated In Botched French Study. (news – 2016) https://www.npr.org/sections/health-shots/2016/03/09/469786037/high-doses-of-experimental-drug-implicated-in-botched-french-study?utm_medium=RSS&utm_campaign=world?utm_medium=RSS&utm_campaign=world Botched French Drug Trial Followed Rules But Lacked ‘Common Sense’ (news–2016) https://www.npr.org/sections/health-shots/2016/05/03/475867184/botched-french-drug-trial-followed-rules-but-lacked-common-sense
A Clinical Disaster in France (news–2016) https://blogs.sciencemag.org/pipeline/archives/2016/01/15/a-clinical-disaster-in-france
French company bungled clinical trial that led to a death and illness, report says (news–2016) https://www.sciencemag.org/news/2016/02/french-company-bungled-clinical-trial-led-death-and-illness-report-says
What we know so far about the clinical trial disaster in France (news–2016) https://www.sciencemag.org/news/2016/01/what-we-know-so-far-about-clinical-trial-disaster-france
More details emerge on fateful French drug trial (news–2016) https://www.sciencemag.org/news/2016/01/more-details-emerge-fateful-french-drug-trial
France tightens rules in wake of fatal clinical trial (news–2016) https://www.sciencemag.org/news/2016/01/more-details-emerge-fateful-french-drug-trial
FDA Sees No General Safety Risk With FAAH Inhibitors (news–2016) https://www.medpagetoday.com/neurology/generalneurology/59666?pop=0&ba=1&xid=tmd-md&hr=trendMD
From Pot to FAAH: Exploiting the Endocannabinoid System (news–2016) https://www.medpagetoday.com/neurology/generalneurology/56011

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CANNABINOR
Cannabinoid Receptor Agonist Significantly Reduces Post-Operative Pain, Study Says (news–2007) http://norml.org/news/2007/04/26/cannabinoid-receptor-agonist-significantly-reduces-post-operative-painstudy-says


CB–65
Study: Cannabis Agonists Produce Anti-Cancer Effects In Human Liver Cancer Cells (news–2012) http://norml.org/news/2012/10/11/study-cannabis-agonists-produce-anti-cancer-effects-in-human-liver-cancer-cells
Anti-Cancer Effects In Human Liver Cancer Cells Produced By Cannabis Agonists (news–2012) http://cb65.com/anti-cancer-effects-in-human-liver-cancer-cells-produced-by-cannabis-agonists-2/


CP-47,497
A Synthetic Solution for a Legal 4:20 (news–2009) http://www.popsci.com/scitech/article/2009-04/synthetic-solution-legal-420
THIS ISN’T YOUR MOTHER’S SPICE (news-2010) http://www.mapinc.org/drugnews/v10/n497/a07.html?1173
Now, There’s a Test for That – Norchem’s “Fake Marijuana” Test Reveals Significantly
Increased Abuse of Spice/K2 (news-2010) https://www.globenewswire.com/news-release/2010/11/18/1183266/0/en/Now-There-s-a-Test-for-That-Norchem-s-Fake-Marijuana-Test-Reveals-Significantly-Increased-Abuse-of-Spice-K2.html
Chemicals Used in “Spice” and “K2” Type Products Now Under Federal Control and Regulation (news–2011) https://www.dea.gov/press-releases/2011/03/01/chemicals-used-spice-and-k2-type-products-now-under-federal-control-and
Outlawing ‘Legal Highs:’ Can Emergency Bans Hinder Drug Development? (news–2011)
http://healthland.time.com/2011/02/23/outlawing-legal-highs-can-emergency-bans-hinder-drug-development/
Getting up to speed with the public health and regulatory challenges posed by new psychoactive substances in the information age (editorial–2013) http://onlinelibrary.wiley.com/doi/10.1111/
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CP-55,940
Endocannabinoids — The Brain’s Cannabis — Demonstrate Novel Modes Of Action To Stress (news-2005) http://www.sciencedaily.com/releases/2005/07/050720065810.htm
Study: Cannabinoids Attenuate Hyperactivity and Weight Loss in Anorexia (news–2017) https://thejointblog.com/study-cannabinoids-attenuate-hyperactivity-weight-loss-anorexia/


FUBINACA GROUP
‘Fake pot’ causing zombielike effects is 85 times more potent than marijuana (news–2016) http://www.cnn.com/2016/12/16/health/zombie-synthetic-marijuana/index.html


GP-1A
Severity of acute cystitis may be cut with cannabinoid agonist (news–forum re-post-2011) https://forum.grasscity.com/threads/severity-of-acute-cystitis-may-be-cut-with-cannabinoid-agonist.1463384/#post-23639559


HU-210
Cannabinoids spell relief in colon inflammation (news–2004) https://www.mpg.de/496761/pressRelease20040506?filter_order=L
Is cannabis good for your brain? (news-2005) https://arstechnica.com/science/2005/10/1529/
Study Shows Marijuana Promotes Neuron Growth (news-2005) http://english.ohmynews.com/articleview/article_view.asp?menu=c10400&no=253377&rel_no=1
Marijuana May Grow Neurons in the Brain (news-2005) https://www.medpagetoday.com/Psychiatry/AnxietyStress/1934
Surprising Brain Effects From Pot-Like Drug (news–2005) https://www.webmd.com/mental-health/news/20051013/surprising-brain-effects-from-pot-like-drug
Marijuana might cause new cell growth in the brain (news–2005) https://www.newscientist.com/article/dn8155-marijuana-might-cause-new-cell-growth-in-the-brain/
A Cooling Effect From Cannabis? (news-2005) https://beyondthc.com/the-cooling-effect-of-cannabis/
Now, There’s a Test for That — Norchem’s “Fake Marijuana” Test Reveals Significantly Increased Abuse of Spice/K2 (news-2010) https://www.globenewswire.com/news-release/2010/11/18/1183266/0/en/Now-There-s-a-Test-for-That-Norchem-s-Fake-Marijuana-Test-Reveals-Significantly-Increased-Abuse-of-Spice-K2.html
Cannabinoids for the Treatment of Neuropathic Pain (news–2012) https://www.medscape.com/viewarticle/739103_3
Getting up to speed with the public health and regulatory challenges posed by new psychoactive substances in the information age (editorial–2013) https://onlinelibrary.wiley.com/doi/full/10.1111/add.12287
Study: Cannabis May Help Reduce Brain Damage Caused By Ischemic Strokes (news–2014) https://www.medicaljane.com/2014/12/31/marijuana-may-reduce-brain-damage-caused-by-strokes/
Medicinal Marijuana vs Retinitis Pigmentosa and Eye Disease (news–2015) http://www.mrstinkysgreengarden.com/2015/01/medicinal-marijuana-vs-retinitis.html


HU-211/DEXANABINOL/DEXANABINONE/SINNABIDOL/ETS-2101/PA 50211/PRS 211007
Scientists Develop Prototype Drug To Prevent Osteoporosis Based On Cannabinoids Produced By Body (news-2006) https://www.sciencedaily.com/releases/2006/01/060104232013.htm
Latest Studies Imply That Cannabinoids Are Protective Against Alcohol-Induced Brain Damage (news–2011) https://blog.norml.org/2011/09/06/latest-studies-imply-that-cannabinoids-are-protective-against-alcohol-induced-brain-damage/
Marijuana might cause new cell growth in the brain (news–2005) https://www.newscientist.com/article/dn8155-marijuana-might-cause-new-cell-growth-in-the-brain/
Clinical trial evaluates synthetic cannabinoid as brain cancer treatment (click “cancel” for article–2012) https://health.ucsd.edu/news/releases/Pages/2012-09-25-cannabinoids-may-treat-brain-cancer.aspx
Cannabinoid May Treat Brain Cancer (news–2012) https://www.sciencedaily.com/releases/2012/09/120925142557.htm
e-Therapeutics announces continuation of ETS2101 phase I trial in brain cancer (news–2014) https://www.news-medical.net/news/20140107/e-Therapeutics-announces-continuation-of-ETS2101-phase-I-trial-in-brain-cancer.aspx


HU-308
Activation of CB2 receptor attenuates bone loss in osteoporosis (news-2006) http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=210#2
Endocannabinoids, cannabinoid receptors and inflammatory stress: an interview with Dr. Pál Pacher (link to PDF – interview – 2007) http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.510.3426
Protection from osteoarthritis may lie in our own joints, study suggests. (news – 2014) https://www.sciencedaily.com/releases/2014/05/140518092722.htm 


HU-910/LISINOPRIL
Cannabis could treat traumatic brain injury, Israeli researchers say (news – 2017) http://www.timesofisrael.com/cannabis-could-treat-traumatic-brain-injury-israeli-researchers-say/


HU-914
Cannabis could treat traumatic brain injury, Israeli researchers say (news–2017) http://www.timesofisrael.com/cannabis-could-treat-traumatic-brain-injury-israeli-researchers-say/


IBUPROFEN
Scripps Research Scientists Discover Inflammation Is Controlled Differently in Brain and Other Tissues (news–2011) https://www.scripps.edu/news/press/2011/20111020cravatt.html
Preventing marijuana-induced memory problems with over-the-counter painkillers (news–2013) https://medicalxpress.com/news/2013-11-marijuana-induced-memory-problems-over-the-counter-painkillers.html
What ailments does medical marijuana help? (news–2015) https://www.mnn.com/health/fitness-well-being/stories/what-ailments-does-medical-marijuana-help 


J-147
Medical marijuana has potential as Alzheimer’s treatment, study says (news–2016) https://kfor.com/2016/07/25/medical-marijuana-has-potential-as-alzheimers-treatment-study-says/
Cannabinoids remove plaque-forming Alzheimer’s proteins from brain cells (news–2016) https://www.sciencedaily.com/releases/2016/06/160629095609.htm


JBT-101/RESUNAB
Corbus Pharmaceuticals’ Investigational Scleroderma Drug Takes Novel Approach To Treating Inflammation. (news – 2016) https://sclerodermanews.com/2015/03/16/corbus-pharmaceuticals-investigational-scleroderma-drug-takes-novel-approach-treating-
inflammation/

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JD-5037
New Drug Could Help Maintain Long-Term Weight Loss (news–2012) http://www.sciencedaily.com/releases/2012/07/120726122116.htm


JWH-015
Now, There’s a Test for That — Norchem’s “Fake Marijuana” Test Reveals Significantly Increased Abuse of Spice/K2 (news-2010) https://www.globenewswire.com/news-release/2010/11/18/1183266/0/en/Now-There-s-a-Test-for-That-Norchem-s-Fake-Marijuana-
Test-Reveals-Significantly-Increased-Abuse-of-Spice-K2.html Latest blood test detects 12 popular synthetic cannabinoids in “fake pot” (news–2011) https://www.businesswire.com/news/home/20110720005281/en/Latest-blood-test-detects-12-popular-synthetic#.VZnGiPlwtB8
Chemicals Used in “Spice” and “K2” Type Products Now Under Federal Control and Regulation (news–2011) https://www.dea.gov/press-releases/2011/03/01/chemicals-used-spice-and-k2-type-products-now-under-federal-control-and
Study: Medical Cannabis May Inhibit The Spread Of Prostate Cancer (news–2014) https://www.medicaljane.com/2014/01/17/study-medical-cannabis-may-inhibit-the-spread-of-prostate-cancer


JWH-018
A Synthetic Solution for a Legal 4:20 (news–2009) https://www.popsci.com/scitech/article/2009-04/synthetic-solution-legal-420/
FAQ: K2, Spice Gold, and Herbal ‘Incense’ (news-2010) https://www.webmd.com/mental-health/addiction/news/20100305/k2-spice-gold-herbal-incense-faq#1
THIS ISN’T YOUR MOTHER’S SPICE (news-2010) http://www.mapinc.org/drugnews/v10/n497/a07.html?1173
Fake Weed, Real Drug: K2 Causing Hallucinations in Teens (news–2010) https://www.livescience.com/6149-fake-weed-real-drug-k2-causing-hallucinations-teens.html
Outlawing ‘Legal Highs:’ Can Emergency Bans Hinder Drug Development? (news–2011) http://healthland.time.com/2011/02/23/outlawing-legal-highs-can-emergency-bans-hinder-drug-development/
Latest blood test detects 12 popular synthetic cannabinoids in “fake pot” (news–2011) https://www.businesswire.com/news/home/20110720005281/en/Latest-blood-test-detects-12-popular-synthetic#.VZnGiPlwtB8
‘Fake Marijuana’ May Trigger Heart Trouble in Teens (news–2011) http://usatoday30.usatoday.com/news/health/story/health/story/2011-11-09/Fake-marijuana-may-trigger-heart-trouble-in-teens/51133266/1
Synthetic cannabis (article–2012) https://tidsskriftet.no/en/2012/10/synthetic-cannabis
Clemson University professor created synthetic marijuana for abuse research (news–2012) https://www.nola.com/news/crime_police/article_103e3218-bec0-521d-ae84-c266a7d765d1.html
Wyoming kidney failure outbreak linked to designer ‘blueberry spice’ drug, aka ‘legal marijuana’ (news–2012) https://www.naturalnews.com/035181_spice_recreational_drugs_kidney_failure.html
Blueberry “spice” in Wyoming linked to cases of renal failure (news–2012) http://www.thepoisonreview.com/2012/03/03/blueberry-spice-in-wyoming-linked-to-cases-of-renal-failure/
New health concerns about ‘fake pot’ in US (news–2012) https://medicalxpress.com/news/2012-03-health-fake-pot.html
Tachycardia followed by bradycardia after smoking the synthetic cannabinoid “K9″ (news–2012) http://www.thepoisonreview.com/2012/05/22/tachycardia-followed-by-bradycardia-after-smoking-the-synthetic-cannabinoid-k9/
Getting up to speed with the public health and regulatory challenges posed by new psychoactive substances in the information age (editorial  013) https://onlinelibrary.wiley.com/doi/full/10.1111/add.12287
Cannabinoids Found to Reduce 90% of Skin Cancer in Just 20 Weeks, According to New Study (news–2013) https://thejointblog.com/cannabinoids-found-to-reduce-90-of-skin-cancer-in-just-20-weeks-according-to-new-study/
Japanese Study Shows Cannabinoids Inhibit Tumor Growth (news–2014) https://www.medicaljane.com/2013/07/27/study-shows-cannabinoids-inhibit-tumor-growth/
How this chemist unwittingly helped spawn the synthetic drug industry (news–2015) https://www.washingtonpost.com/local/social-issues/how-a-chemist-unwittingly-helped-spawn-the-synthetic-drug-epidemic/2015/08/09/94454824-3633-11e5-9739-170df8af8eb9_story.html?utm_term=.b426a6f719c0

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JWH-073
Now, There’s a Test for That — Norchem’s “Fake Marijuana” Test Reveals Significantly Increased Abuse of Spice/K2 (news-2010) https://www.globenewswire.com/news-release/2010/11/18/1183266/0/en/Now-There-s-a-Test-for-That-Norchem-s-Fake-Marijuana-Test-Reveals-Significantly-Increased-Abuse-of-Spice-K2.html
Outlawing ‘Legal Highs:’ Can Emergency Bans Hinder Drug Development? (news–2011) http://healthland.time.com/2011/02/23/outlawing-legal-highs-can-emergency-bans-hinder-drug-development/
Latest blood test detects 12 popular synthetic cannabinoids in “fake pot” (news–2011) https://www.businesswire.com/news/home/20110720005281/en/Latest-blood-test-detects-12-popular-synthetic#.VZnGiPlwtB8
‘Fake Marijuana’ May Trigger Heart Trouble in Teens (news–2011) http://usatoday30.usatoday.com/news/health/story/health/story/2011-11-09/Fake-marijuana-may-trigger-heart-trouble-in-teens/51133266/1
Chemicals Used in “Spice” and “K2” Type Products Now Under Federal Control and Regulation (news–2011) https://www.dea.gov/press-releases/2011/03/01/chemicals-used-spice-and-k2-type-products-now-under-federal-control-and
NMS Labs & Cerilliant Announce Identification Of Major Metabolite Of The Synthetic Cannabinoid JWH-073 (news–2011) https://www.medicalnewstoday.com/releases/226597.php
Clemson University professor created synthetic marijuana for abuse research (news–2012) https://www.nola.com/news/crime_police/article_103e3218-bec0-521d-ae84-c266a7d765d1.html
Tachycardia followed by bradycardia after smoking the synthetic cannabinoid “K9″ (news–2012) http://www.thepoisonreview.com/2012/05/22/tachycardia-followed-by-bradycardia-after-smoking-the-synthetic-cannabinoid-k9/
How this chemist unwittingly helped spawn the synthetic drug industry (news–2015) https://www.washingtonpost.com/local/social-issues/how-a-chemist-unwittingly-helped-spawn-the-synthetic-drug-epidemic/2015/08/09/94454824-3633-11e5-9739-170df8af8eb9_story.html?utm_term=.b426a6f719c0

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JWH-122
Cannabinoids Found to Reduce 90% of Skin Cancer in Just 20 Weeks, According to New Study (news–2013) http://thejointblog.com/cannabinoids-found-to-reduce-90-of-skin-cancer-in-just-20-weeks-according-to-new-study/
Japanese Study Shows Cannabinoids Inhibit Tumor Growth (news–2014) https://www.medicaljane.com/2013/07/27/study-shows-cannabinoids-inhibit-tumor-growth/
Testing: Three Kings Day bread laced with ‘substantial’ amount of synthetic pot (news–2015) http://www.ocregister.com/2015/01/14/testing-three-kings-day-bread-laced-with-substantial-amount-of-synthetic-pot/


JWH-133/3-(1_1_-dimethylbutyl)-1-deoxy-_8-THC
Cannabinoids inhibit glioma cell invasion in brain cancer studies (news–forum repost-2010) https://www.420magazine.com/forums/glioma-cancer/144892-cannabinoids-inhibit-glioma-cell-invasion-brain-cancer-studies.html
Outlawing ‘Legal Highs:’ Can Emergency Bans Hinder Drug Development? (news–2011) http://healthland.time.com/2011/02/23/outlawing-legal-highs-can-emergency-bans-hinder-drug-development/
Can marijuana curb cocaine addiction? (news–2011) https://theweek.com/articles/482924/marijuana-curb-cocaine-addiction
Drugs Related to Cannabis Have Pain-Relieving Potential for Osteoarthritis (news–2014) https://www.sciencedaily.com/releases/2014/01/140107092825.htm
Synthetic cannabinoid molecule created for osteoarthritis (news–2014) https://www.news-medical.net/news/20140107/Synthetic-cannabinoid-molecule-created-for-osteoarthritis.aspx
Study: Cannabis Plays A Key Role In Pancreatic Cancer Treatment (news–2014) https://www.medicaljane.com/2014/01/29/study-cannabinoids-could-play-a-role-in-pancreatic-cancer-treatment
Study: Cannabinoid Use in the Treatment of Osteoarthritis Pain (news–2015) https://www.medicaljane.com/2015/01/26/cannabinoid-use-in-the-treatment-of-osteoarthritis-pain/


JWH-200
Outlawing ‘Legal Highs:’ Can Emergency Bans Hinder Drug Development? (news–2011) http://healthland.time.com/2011/02/23/outlawing-legal-highs-can-emergency-bans-hinder-drugdevelopment/
How this chemist unwittingly helped spawn the synthetic drug industry (news–2015)
http://www.washingtonpost.com/local/social-issues/how-a-chemist-unwittingly-helped-spawn-thesynthetic-drug-epidemic/2015/08/09/94454824-3633-11e5-9739-170df8af8eb9_story.html


JWH-210
Cannabinoids Found to Reduce 90% of Skin Cancer in Just 20 Weeks, According to New Study (news–2013) http://thejointblog.com/cannabinoids-found-to-reduce-90-of-skin-cancer-in-just-20-weeks-according-to-new-study/
Study: Cannabinoids Offer Treatment For Severe Lung Disease (news–2013) http://www.leafscience.com/2013/11/21/study-cannabinoids-offer-treatment-severe-lung-disease/
Japanese Study Shows Cannabinoids Inhibit Tumor Growth (news–2014) https://www.medicaljane.com/2013/07/27/study-shows-cannabinoids-inhibit-tumor-growth/
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JZL-184
Understanding the Effects of Endogenous Cannabinoids (news–2008) http://arstechnica.com/science/2008/11/understanding-the-effects-of-endogenous-cannabinoids/


KN38-7271/BAY38-7271
Breakthrough in treatment of Traumatic Brain Injury: KeyNeurotek’s clinical study reaches primary endpoint and shows significant increase in survival (news-2009)
http://www.drugs.com/clinical_trials/breakthrough-traumatic-brain-injury-keyneurotek-s-clinical-studyreaches-primary-endpoint-shows-8667.html


MAB-CHMINACA
Authorities may know common link between synthetic pot illnesses nationwide (news–2015) http://www.mcall.com/news/nationworld/pennsylvania/mc-us-synthetic-marijuana-hospitalization-spike-20150508-story.html?track=rss


MARINOL/DRONABINOL
Schedule III Cannabinoids (encyclopedia entry) http://www.chemie.de/lexikon/e/Cannabinoids/
Aging & Medical Marijuana (booklet – undated) http://www.safeaccessnow.org/aging_booklet
CANNABIS AND MARINOL IN THE TREATMENT OF MIGRAINE HEADACHE (abst-undated) http://www.druglibrary.org/schaffer/hemp/migrn2.htm

Marinol vs. Marijuana: Politics, Science, and Popular Culture (article–1997) http://www.naturallyhealingmd.com/marinol-vs-marijuana-politics-science-and-popular-culture/
The Science of Marijuana (book–2000) http://www.green215.com/sites/all/files/education_articles/Science%20Cannabis.pdf
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Ganja medicine in Jamaica (news–2000) http://cifas.us/ganja-medicine-in-jamaica-2/ Healing Haze? (news-2001) https://www.scientificamerican.com/article/healing-haze/
http://www.scientificamerican.com/article.cfm?id=healing-haze

Marinol Death Sentence: Oregon Man Denied Liver Transplant Because of Prescription – He’s Not the Only One (news–2003) http://stopthedrugwar.org/chronicle-old/299/notransplant.shtml
Marijuana Research (news–2004)  http://www.scientificamerican.com/article/marijuana-research/
Dronabinol can’t replace medical marijuana (article-2005) https://www.managedcaremag.com/archives/2005/8/dronabinol-cant-replace-medical-marijuana 
Testimony of Terry Jacobs to FDA – why he prefers for medical marijuana to Marinol (testimony–forum repost-2005) https://www.420magazine.com/community/threads/testimony-of-terry-jacobs
-to-fda-why-he-prefers-for-medical-marijuana-to- marinol.147441/ 

Cannabis Chemicals May Alleviate Post-Eating Stomach Cramps (news–2006) http://www.bio-medicine.org/medicine-news/Cannabis-Chemicals-May-Alleviate-Post-Eating-StomachCramps-15219-1/
Big Pharma’s Strange Holy Grail: Cannabis Without Euphoria? (news-2006) http://www.mapinc.org/drugnews/v06.n899.a05.html
ACG: Cannabinoid Activator Mellows Out Colon (news-2006) http://www.medpagetoday.com/MeetingCoverage/ACG/4410
Letter: Cannabinoid medicines and the need for the scientific method (letter–2007)
http://www.cannabis-med.org/data/pdf/en_2007_02_3.pdf
Improvement in Refractory Obsessive Compulsive Disorder With Dronabinol (letter-2008) http://ajp.psychiatryonline.org/doi/full/10.1176/appi.ajp.2007.07061016
Medical use of cannabinoids does not cause an increase in serious adverse health effects (news-2008) http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=272
THC can improve symptoms of schizophrenia (article–2009) http://www.cannabis-med.org/data/pdf/en_2009_04_1_0.pdf
Does the Pot Pill Work? (news-2009) http://www.cbsnews.com/news/does-the-pot-pill-work/ 
The FDA has written documentation that patients can overdose on Marinol and that it can be lethal (news–forum repost-2009) https://www.420magazine.com/community/threads/the-fda-has-written-documentation-that-patients-can-overdose-on-marinol.173318/ 
Science: Dramatic improvement of neuromyotonia (Isaacs’ syndrome) with THC in a case report (news–2010) http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=337
Nature’s (Legal) Cannabinoids (news-2010) http://www.mapinc.org/drugnews/v10/n126/a04.html?1194
Oral THC Reduces Aggressive Behavior In Patients With Refractory Psychosis, Study Says (news-2010) http://norml.org/news/2010/12/09/oral-thc-reduces-aggressive-behavior-in-patients-with-refractory-psychosis-study-says
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What Are Prescription Drugs That Are a Substitute for Marijuana? (news–2011) http://www.livestrong.com/article/137065-what-are-prescription-drugs-that-are-substitute-marijuana/#ixzz21Ia1dVQG
Science: THC effective in trichotillomania symptoms in a pilot study (news–2011) http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=348
DRONABINOL capsule [Watson Laboratories, Inc.] (monograph-2012)
http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5bbac0b1-ddc2-400b-8e0d-1e1d484720ca
Can medical marijuana help rheumatoid arthritis? (news–2012) http://www.health.com/health/condition-article/0,,20499017,00.html
Cannabinoids for the Treatment of Neuropathic Pain (news–2012) https://www.medscape.com/viewarticle/739103_3
Can cannabinoid drug used for nausea in chemotherapy relieve sleep apnea? (news–2012) http://medicalxpress.com/news/2012-06-cannabinoid-drug-nausea-chemotherapy-relieve.html
Suspected Dronabinol Withdrawal in an Elderly Cannabis-Naive Medically Ill Patient (letter–2013) https://ajp.psychiatryonline.org/doi/full/10.1176/appi.ajp.2013.13010059
Medicinal Cannabis and Painful Sensory Neuropathy (editorial–2013) https://journalofethics.ama-assn.org/article/medicinal-cannabis-and-painful-sensory-neuropathy/2013-05  
Medical Marijuana: Consortium of Multiple Sclerosis Centers (news–2013) http://www.msviews.org/msviewsandnews4/index.php/2012-05-28-00-15-54/2012-07-04-00-19-28/610-medical-marajuana-consortium-of-multiple-sclerosis-centers
Maine Mom Fights Son’s Autistic Episodes With Marinol (news–2013) http://www.marijuana.com/news/2013/04/maine-mom-fights-sons-autistic-episodes-with-marinol/
Science/Human: THC reduces sleep apnoea in small clinical study (news–2013) http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=392&search_pattern=2013#2
Report on Medical Cannabis Research History- What the Science Says (article–2014) https://www.safeaccessnow.org/medical_cannabis_research_what_does_the_evidence_say
Marijuana Saved My Life: An Abbreviated Dope Diary (news–2014) https://www.thestreet.com/story/12785216/1/marijuana-saved-my-life-abbreviated-dope-diary.html
3 Prescription Drugs You Didn’t Know Come From Marijuana (news–2014) https://www.fool.com/investing/general/2014/03/16/3-prescription-drugs-you-didnt-know-come-from-mari.aspx
The Entourage Effect: Why Whole Cannabis Is Better (news–2014) https://unitedpatientsgroup.com/blog/2014/04/22/the-entourage-effect-why-whole-cannabis-is-better
Health Benefits Of Medical Marijuana: 3 Major Ways Cannabis Helps Sick People Live Normal Lives (news–2014) https://www.medicaldaily.com/health-benefits-medical-marijuana-3-major-ways-cannabis-helps-sick-people-live-normal-lives-
283388
New Study Suggests THC Can Treat Non-Cardiac Chest Pain (news–2014) https://thejointblog.com/new-study-suggests-thc-can-treat-non-cardiac-chest-pain/
Novel way for treating non-cardiac chest pain due to esophageal hypersensitivity (news–2014) https://www.news-medical.net/news/20141022/Novel-way-for-treating-non-cardiac-chest-pain-due-to-esophageal-
hypersensitivity.aspx Marijuana Is a Wonder Drug When It Comes to the Horrors of Chemo (news–2015) https://www.newsweek.com/2015/07/31/keep-toke-alive-356032.html
Huge New Review Shows What Medical Marijuana May (and May Not) Help (news–2015) https://www.yahoo.com/lifestyle/huge-new-review-shows-what-medical-marijuana-may-122209836947.html
Marijuana flips appetite switch in brain (news–2015) https://www.nature.com/news/marijuana-flips-appetite-switch-in-brain-1.16957
Part Two: The Role of Phytocannabinoids in ASD Therapy (autism) (article–2015) https://www.medicaljane.com/2015/06/17/part-two-the-role-of-phytocannabinoids-in-asd-therapy/
FDA OKs Cannabis-Based Ovarian Cancer Treatment (news–2016) http://www.cannabestmedical.com/cannabest-medical-blog/2015/6/22/fda-oks-cannabis-based-ovarian-cancer-treatment
The Science behind the DEA’s Long War on Marijuana (news–2016) https://www.scientificamerican.com/article/the-science-behind-the-dea-s-long-war-on-marijuana/
Weeding out the truth: Cannabis-based medications for cancer patients (news–2016) https://www.mcmasteroptimalaging.org/blog/detail/blog/2016/07/11/weeding-out-the-truth-cannabis-based-medications-for-cancer-patients
Cannabis and Cannabinoids (PDQ®): Patient Version (full–2017) https://www.ncbi.nlm.nih.gov/books/NBK65875/
Some of the Parts: Is Marijuana’s “Entourage Effect” Scientifically Valid? (news–2017) https://www.scientificamerican.com/article/some-of-the-parts-is-marijuana-rsquo-s-ldquo-entourage-effect-rdquo-scientifically-valid/
Grandmother with terminal cancer jailed for prescribed medical marijuana (news–2017) https://theweek.com/speedreads/696918/grandmother-terminal-cancer-jailed
-prescribed-medical-marijuana
The Endocannabinoid System: A Beginner’s Guide (news–2017) https://www.leafscience.com/2017/03/17/the-endocannabinoid-system-a-beginners-guide/
Mormon Church Opposing Utah Medical Marijuana Initiative Owns $1 Billion Worth of Big Pharma Stocks (news–2018) https://www.civilized.life/articles/mormon-church-big-pharma-stocks/ 


MDA-7
Cannabinoid Receptor Stimulator Reverses Symptoms of Alzheimer’s Disease in Animal Model (news–2012) https://www.labmedica.com/bioresearch/articles/294742494/cannabinoid-receptor-stimulator-reverses-symptoms-of-alzheimers-disease-in-animal-model.html
Researchers investigating potential drug for treatement of Alzheimer’s disease (news–2012) http://medicalxpress.com/news/2012-08-potential-drug-treatement-alzheimer-disease.html


MDA-19
Studies demonstrate analgesic properties of synthetic cannabinoid (news–2010) http://www.news-medical.net/news/20100702/Studies-demonstrate-analgesic-properties-of-syntheticcannabinoid.aspx
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NABILONE/CESAMET
The Science of Marijuana (book–2000) http://www.green215.com/sites/all/files/education_articles/Science%20Cannabis.pdf
Nabilone Could Treat Chorea and Irritability in Huntington’s Disease (letter-2006) http://neuro.psychiatryonline.org/doi/full/10.1176/jnp.2006.18.4.553
A Look At FDA-OK’d ‘Marijuana’ Drug (news–2006) https://www.cbsnews.com/news/a-look-at-fda-okd-marijuana-drug/  
2nd synthetic marijuana drug OK’d for chemo effects (news–2006) http://www.usatoday.com/news/health/2006-05-16-marijuana-drug_x.htm
Cesamet, THC and chemotherapy (news–2006) http://www.sciencebase.com/science-blog/cesamet-thc.html
Cesamet (nabilone) capsule (info page-2007) http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=bb582d64-0f51-11df-8a39-0800200c9a66
Synthetic Cannabis for Fibromyalgia Pain? (news–forum re-post-2007) https://www.420magazine.com/forums/fibromyalgia/155086-synthetic-cannabis-fibromyalgia-pain.html
Nabilone relieves many advanced Ca symptoms (news-2007) http://www.highbeam.com/doc/1G1-178441488.html
Nabilone for the treatment of paraneoplastic night sweats: a report of four cases (abst–2008) http://www.ncbi.nlm.nih.gov/pubmed/18715188
Science: Nabilone effective in the treatment of night sweats of four patients with advanced cancer (news–2008) http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=277
Marijuana-Based Drug Reduces Fibromyalgia Pain, Study Suggests (news-2008) http://www.sciencedaily.com/releases/2008/02/080217214547.htm
Marijuana Derivative Called Effective in Fibromyalgia (news-forum re-post-2008) https://www.420magazine.com/forums/fibromyalgia/155094-marijuana
CESAMET® CII (nabilone) Capsules For Oral Administration (archived drug label-2010) http://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=16800
What Are Prescription Drugs That Are a Substitute for Marijuana? (news–2011) http://www.livestrong.com/article/137065-what-are-prescription-drugs-that-are-substitutemarijuana/#ixzz21Ia1dVQG
Study: Synthetic THC Analogue Mitigates Diabetic Neuropathy, Is ‘Well Tolerated’ In
Patients (news–2012) http://norml.org/news/2012/09/20/study-synthetic-thc-analogue-mitigates-diabetic-neuropathy-is-well-tolerated-in-patients
New drug offers novel pain management therapy for diabetics (news-2012) http://www.thefreelibrary.com/New+drug+offers+novel+pain+management+therapy+for+diabetics.-a0306899453
Synthetic cannabinoid could treat pain in diabetes patients (news–2012) http://www.news-medical.net/news/20121108/Synthetic-cannabinoid-could-treat-pain-in-diabetes-patients.aspx
Cannabinoids for the Treatment of Neuropathic Pain (news–2012) https://www.medscape.com/viewarticle/739103_3
Drug offers new pain management therapy for diabetics (news–2012) http://medicalxpress.com/news/2012-10-drug-pain-therapy-diabetics.html
Can medical marijuana help rheumatoid arthritis? (news–2012) http://www.health.com/health/condition-article/0,,20499017,00.html
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The Fibromyalgia Drugs Your Doctor (Probably) Knows Nothing About (news–2013) https://www.prohealth.com/library/the-fibromyalgia-drugs-your-doctor-probably-knows-nothing-about-31397?site=articles
Senior Focus: Should marijuana be legalized for end of life care? (news–2013) https://www.stltoday.com/lifestyles/health-med-fit/6814b63f-d758-5500-9507-a908a5b20c01.html
Nabilone (Cesamet) For Fibromyalgia and Chronic Fatigue Syndrome (news–2013) http://www.cortjohnson.org/drugs-for-fibromyalgia/nabilone-cesamet-fibromyalgia-chronic-fatiguesyndrom/
Report On Medical Cannabis Research, What the Science Says (article–2014) http://www.safeaccessnow.org/medical_cannabis_research_what_does_the_evidence_say
3 Prescription Drugs You Didn’t Know Come From Marijuana (news–2014) http://www.fool.com/investing/general/2014/03/16/3-prescription-drugs-you-didnt-know-come-from-mari.aspx
Health Benefits Of Medical Marijuana: 3 Major Ways Cannabis Helps Sick People Live Normal Lives (news–2014) http://www.medicaldaily.com/health-benefits-medical-marijuana-3-major-ways-cannabis-helps-sick-people-live-normal-lives-283388
Marijuana Is a Wonder Drug When It Comes to the Horrors of Chemo (news–2015) http://www.newsweek.com/2015/07/31/keep-toke-alive-356032.html
Using Medical Cannabis in an Oncology Practice (article–2016) https://www.cancernetwork.com/oncology-journal/using-medical-cannabis-oncology-practice
Can Cannabis-Based Medicine Cure Sleep Apnea? (news–2016) https://merryjane.com/news/can-cannabis-based-medicine-cure-sleep-apnea
Weeding out the truth: Cannabis-based medications for cancer patients (news–2016) https://www.mcmasteroptimalaging.org/blog/detail/blog/2016/07/11/weeding-out-the-truth-cannabis-based-medications-for-cancer-patients
The Pain Management Journey. (Hereditary Multiple Exotoses) (news–2016) https://www.mhecoalition.org/single-post/2016/07/31/The-Pain-Management-Journey
Cannabis and Cannabinoids (PDQ®): Patient Version (full–2017) https://www.ncbi.nlm.nih.gov/books/NBK65875/


RIMONABANT/ACOMPLIA/SR141716/SR1
Big Pharma’s Strange Holy Grail: Cannabis Without Euphoria? (news-2006) http://www.mapinc.org/drugnews/v06.n899.a05.html
European watchdog warns about dangers of Acomplia (news-2007) https://www.news-medical.net/news/2007/07/21/27891.aspx
Three Long-Term Diet Pills Show Poor Performance, Study Suggests (news-2007) https://www.sciencedaily.com/releases/2007/11/071116094804.htm
F.D.A. Panel Rejects Drug for Obesity (news-2007) https://www.nytimes.com/2007/06/14/business/14drugs.html
Risk of psychiatric side effects is approximately doubled in patients taking Acomplia (news-2008) https://www.medicinenews.net/article/risk-of-psychiatric-side-effects-is-approximately-doubled-in-patients-taking-acomplia
Caution Urged With New Anti-Obesity Drug In Kids (news-2008) https://www.sciencedaily.com/releases/2008/05/080507133326.htm
Weeding out the highs of medical marijuana (news–2008) https://www.sciencedaily.com/releases/2008/07/080714192555.htm
Suicides in other trials led to early termination of trial into effects of weight loss drug rimonabant on cardiovascular outcomes (CRESCENDO study) (news–2010) https://www.eurekalert.org/pub_releases/2010-08/l-sio081110.php
Risk of suicide spurs rimonabant trial to end (news–2010) https://www.thefreelibrary.com/Risk+of+suicide+spurs+rimonabant+trial+to+end.-a0238838571

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Experimental obesity drug avoids brain effects that troubled predecessors (news–2010) https://medicalxpress.com/news/2010-07-experimental-obesity-drug-brain-effects.html http://phys.org/news197905295.html
Smoking marijuana not linked to obesity: study (news–2011) http://www.reuters.com/article/2011/09/09/us-marijuana-obesity-idUSTRE7886TT20110909
Part of placebo effect ascribed to cannabinoids (news–2011) http://arstechnica.com/science/2011/10/is-the-placebo-effect-partially-caused-by-cannabinoids/
Endocannabinoids Pitch In for Placebo Effect (news–2011) https://www.painresearchforum.org/news/10072-endocannabinoids-pitch-placebo-effect
New therapy for fragile X chromosome syndrome discovered (news–2013) https://www.sciencedaily.com/releases/2013/04/130410082413.htm
Marijuana may help blood sugar control, study says (news–2014) https://www.diabeteshealth.com/marijuana-may-help-blood-sugar-control-study-says/
Why so munchy? Cannabis shown to ramp up sense of smell (news–2014) https://www.newscientist.com/article/dn25018-why-so-munchy-cannabis-shown-to-ramp-up-sense-of-smell/
M
arijuana flips appetite switch in brain (news–2015) https://www.nature.com/news/marijuana-flips-appetite-switch-in-brain-1.16957
Harvesting Benefits from Cannabinoids (article–2016) http://www.cell.com/cell/fulltext/S0092-8674(16)31675-0
M
ind Over Matter Over Mind: Cannabinoids and the Placebo Effect (news–2017) https://www.alternet.org/2017/02/mind-over-mater-over-mind-endocannabinoids-placebo-effect/
Cannabis Treatment for Hypertension (news–2017) https://www.hcmagazine.com/cannabis-treatment-for-hypertension/
Health effects of eating marijuana is subject of a new study (news/abst–2019) https://neurosciencenews.com/eating-marijuana-health-14681/
The Endocannabinoid System and the Gut (news–2019) https://todayspractitioner.com/cannabis/the-endocannabinoid-system-and-the-gut/


Ro 61-8048
Scientists Have Found A Way To Make Marijuana Un-Fun (news–2013) http://www.popsci.com/article/science/scientists-have-found-way-make-marijuana-un-fun


“SPICE”/SCRAs
A Synthetic Solution for a Legal 4:20 (news–2009) http://www.popsci.com/scitech/article/2009-04/synthetic-solution-legal-420

Synthetic cannabis mimic found in herbal incense (news–2009) https://www.chemistryworld.com/news/synthetic-cannabis-mimic-found-in-herbal-incense/3003869.article
Fake Weed, Real Drug: K2 Causing Hallucinations in Teens (news–2010) https://www.livescience.com/6149-fake-weed-real-drug-k2-causing-hallucinations-teens.html
THIS ISN’T YOUR MOTHER’S SPICE (news-2010) http://www.mapinc.org/drugnews/v10/n497/a07.html?1173
Now, There’s a Test for That — Norchem’s “Fake Marijuana” Test Reveals Significantly Increased Abuse of Spice/K2 (news-2010) https://www.globenewswire.com/news-release/2010/11/18/1183266/0/en/Now-There-s-a-Test-for-That-Norchem-s-Fake-Marijuana-Test-Reveals-Significantly-Increased-Abuse-of-Spice-K2.html
FAQ: K2, Spice Gold, and Herbal ‘Incense’ (news-2010) https://www.webmd.com/mental-health/addiction/news/20100305/k2-spice-gold-herbal-incense-faq#1
Inhaled Incense “K2” May Cause Heart Damage (news–forum re-post–2010) https://www.420magazine.com/forums/heart-disease-cardiovascular/171816-inhaled-incense-k2-may-cause-heart-damage.html
Outlawing ‘Legal Highs:’ Can Emergency Bans Hinder Drug Development? (news–2011) http://healthland.time.com/2011/02/23/outlawing-legal-highs-can-emergency-bans-hinder-drug-development/
1 in 9 high school seniors using synthetic marijuana (news–2011) http://thechart.blogs.cnn.com/2011/12/14/1-in-9-high-school-seniors-using-synthetic-marijuana/
‘Fake Marijuana’ May Trigger Heart Trouble in Teens (news–2011) http://usatoday30.usatoday.com/news/health/story/health/story/2011-11-09/Fake-marijuana-may-trigger-heart-trouble-in-teens/51133266/1
Texas teens had heart attacks after smoking K2 (news–2011) https://www.reuters.com/article/us-teens-heart-attacks-smoking/texas-teens-had-heart-attacks-after-smoking-k2-idUSTRE7A66TN20111107
Chemicals Used in “Spice” and “K2” Type Products Now Under Federal Control and Regulation (news–2011) https://www.dea.gov/press-releases/2011/03/01/chemicals-used-spice-and-k2-type-products-now-under-federal-control-and
Latest blood test detects 12 popular synthetic cannabinoids in “fake pot” (news–2011) https://www.businesswire.com/news/home/20110720005281/en/Latest-blood-test-detects-12-popular-synthetic#.VZnGiPlwtB8
New tests for ‘legal marijuana,’ ‘bath salts’ and other emerging designer drugs (news–2011) https://phys.org/news/2011-08-legal-marijuana-salts-emerging-drugs.html
Synthetic cannabis linked to extended psychosis (news–2011) https://medicalxpress.com/news/2011-05-synthetic-cannabis-linked-psychosis.html
Synthetic cannabis (article–2012) https://tidsskriftet.no/en/2012/10/synthetic-cannabis
‘Hammer Head’ ‘incense’ blamed for seizure of youth in Le Roy (news–2012) https://www.thebatavian.com/howard-owens/hammer-head-incense-blamed-seizure-youth-le-roy/29983
Synthetic marijuana linked to 11,406 of 4.9M drug-related ED visits in 2010 (news–2012) http://www.news-medical.net/news/20121206/Synthetic-marijuana-linked-to-11406-of-49M-drug-related-ED-visits-in-2010.aspx

Clemson University professor created synthetic marijuana for abuse research (news–2012) https://www.nola.com/news/crime_police/article_103e3218-bec0-521d-ae84-c266a7d765d1.html
Why K2 is Pimps’ Choice for Controlling Young Sex Workers (news–2012) https://blogs.scientificamerican.com/white-noise/why-k2-is-pimps-choice-for-controlling-young-sex-workers/?redirect=1
Outbreak of kidney failure in Wyoming linked to “Spice” (news–2012) https://www.reuters.com/article/us-spice-illness-wyoming/outbreak-of-kidney-failure-in-wyoming-linked-to-spice-idUSTRE82204T20120303
Wyoming kidney failure outbreak linked to designer ‘blueberry spice’ drug, aka ‘legal marijuana’ (news–2012) https://www.naturalnews.com/035181_spice_recreational_drugs_kidney_failure.html
Blueberry “spice” in Wyoming linked to cases of renal failure (news–2012) http://www.thepoisonreview.com/2012/03/03/blueberry-spice-in-wyoming-linked-to-cases-of-renal-failure/
New health concerns about ‘fake pot’ in US (news–2012) https://medicalxpress.com/news/2012-03-health-fake-pot.html
Tachycardia followed by bradycardia after smoking the synthetic cannabinoid “K9″ (news–2012) http://www.thepoisonreview.com/2012/05/22/tachycardia-followed-by-bradycardia-after-smoking-the-synthetic-cannabinoid-k9/
Synthetic marijuana sent more than 11,400 people to ER in 2010 (news–2012) https://www.cbsnews.com/news/synthetic-marijuana-sent-more-than-11400-people-to-er-in-2010/
Synthetic cannabinoid use in New Zealand: a recent rebound (news–2012) https://www.nzma.org.nz/journal/read-the-journal/all-issues/2010-2019/2012/vol-125-no-1364/letter-schep
With Labs Pumping Out Legal Highs, China Is the New Front in the Global Drug War (news–2013) http://world.time.com/2013/09/02/with-labs-pumping-out-legal-highs-china-is-the-new-front-in-the-global-drugs-war/
Teen narrowly escapes death after smoking synthetic marijuana (news–2013) https://www.cnn.com/2013/02/04/health/synthetic-marijuana-irpt/index.html
Synthetic Marijuana Dangerous for Kidneys (news–2013) https://www.sciencedaily.com/releases/2013/02/130208124553.htm
Study: Consumers Prefer Natural Cannabis Over Synthetic ‘Marijuana’ Herbal Products (news–2013) https://norml.org/news/2013/01/10/study-consumers-prefer-natural-cannabis-over-synthetic-marijuana-herbal-products
Synthetic Marijuana Harms Kidneys of 16 Users, CDC Reports (news-2013) https://news.yahoo.com/synthetic-marijuana-harms-kidneys-16-users-cdc-reports-170208780.html
Synthetic drugs carry risk of kidney damage (news-2013) http://www.stuff.co.nz/timaru-herald/news/8558914/Synthetic-drugs-carry-risk-of-kidney-damage
High K2 use rate among psych unit patients (news-2013) https://www.odt.co.nz/news/national/high-k2-use-rate-among-psych-unit-patients
‘Legal high’ users turn to real thing (news–2013) https://www.odt.co.nz/news/national/legal-high-users-turn-real-thing
Survey: Teens using synthetic drugs less often (news-2013) https://news.yahoo.com/survey-teens-using-synthetic-drugs-less-often-050311100.html
Synthetic Marijuana Added to Defense Department Drug Testing (news–2013) https://drugfree.org/learn/drug-and-alcohol-news/synthetic-marijuana-added-to-defense-department-drug-testing/
Smoking “spice” associated with stroke in healthy, young adults (news–2013) https://www.medicalnewstoday.com/releases/269132.php
Synthetic Marijuana Lands Thousands of Young People in the ER, Especially Young Males (news–2013) https://www.drugabuse.gov/related-topics/trends-statistics/infographics/synthetic-marijuana-lands-thousands-young-people-in-er-
especially-young-males
Synthetic Drug Use Skyrocketing, Targeting Young Users (news–2014) https://blogs.psychcentral.com/science-addiction/2014/06/synthetic-drug-use-skyrocketing-targeting-young-users/
Study identifies teens at-risk for synthetic marijuana use (news–2015) https://medicalxpress.com/news/2015-03-teens-at-risk-synthetic-marijuana.html#nRlv
Synthetic pot linked to kidney injury (news–2015) https://www.webmd.com/mental-health/addiction/news/20150330/synthetic-pot-linked-to-kidney-injury
7 possible deaths linked to spice (news–2015) https://www.wlbt.com/story/28853152/7-possible-deaths-linked-to-spice/
Synthetic ‘marijuana’ isn’t pot, isn’t safe (news–2015) https://www.washingtontimes.com/news/2015/may/6/nina-radcliff-synthetic-marijuana-isnt-pot-isnt-sa/?utm_source=RSS_Feed&utm_medium=RSS Calls to Poison Control Centers Linked to Synthetic Marijuana Spike 229%, CDC Says (news–2015) https://abcnews.go.com/Health/calls-poison-control-centers-linked-synthetic-marijuana-spike/story?id=31703572
Synthetic drugs: evidence that they can cause cancer (news–2015) https://www.sciencedaily.com/releases/2015/04/150416083746.htm
A stunning number of new ‘legal high’ drugs are being discovered (news–2015) https://www.businessinsider.com/new-legal-high-drugs-are-being-discovered-2015-6#ixzz3gHaeROGT
Deaths triple from synthetic marijuana in US (news–2015) https://medicalxpress.com/news/2015-06-deaths-triple-synthetic-marijuana.html
How this chemist unwittingly helped spawn the synthetic drug industry (news–2015) https://www.washingtonpost.com/local/social-issues/how-a-chemist-unwittingly-helped-spawn-the-synthetic-drug-epidemic/2015/08/09/94454824-3633-11e5-9739-170df8af8eb9_story.html?utm_term=.b426a6f719c0
Thousands Hospitalized This Year Due to Fake Weed (news–2015) https://www.scientificamerican.com/article/thousands-hospitalized-this-year-due-to-fake-weed/
Study identifies teens at-risk for synthetic marijuana use (news–2015) https://medicalxpress.com/news/2015-03-teens-at-risk-synthetic-marijuana.html#nRlv
High Times: Taking A Look at the Marijuana Receptor (news/abst–2016) https://neurosciencenews.com/thc-cannabinoid-receptor-5316/
Scientists Closer to Understanding Why Weed Gets Us High (news–2016) https://www.laweekly.com/scientists-closer-to-understanding-why-weed-gets-us-high/
‘Fake pot’ causing zombielike effects is 85 times more potent than marijuana (news–2016) https://www.cnn.com/2016/12/16/health/zombie-synthetic-marijuana/index.html
Please, don’t call it fake weed (news–2016) https://www.insidescience.org/news/please-dont-call-it-fake-weed
How Cannabis Prohibition Created a More Dangerous Alternative (news–2016) https://www.marijuanatimes.org/how-cannabis-prohibition-created-a-more-dangerous-alternative/
Amputee: K2 ‘takes away my pain’ (news–2017) https://www.nzherald.co.nz/nz/news/article.cfm?c_id=1&objectid=10850580
Zombie weed: Don’t let the name fool you, police say, this is serious (news–2017) https://www.gazettextra.com/archives/zombie-weed-don-t-let-the-name-fool-you-police/article_be229a67-4dcf-54ee-9283-93e5037b99ab.html
Synthetic Marijuana May Make You More Violent, Study Says (news–2017) https://www.ibtimes.com/synthetic-marijuana-may-make-you-more-violent-study-says-2507355
Synthetic marijuana shows lethal side effects. (news–2017) https://www.jhunewsletter.com/article/2017/04/synthetic-marijuana-shows-lethal-side-effects/
Genetic factors may contribute to adverse effects produced by synthetic cannabinoids (news–2017) https://www.sciencedaily.com/releases/2017/04/170424141359.htm
Synthetic marijuana linked to 6 cases of severe bleeding in Illinois (news–2018) https://fox2now.com/2018/03/28/synthetic-marijuana-linked-to-6-cases-of-severe-bleeding-in-illinois/
Two deaths, 54 other cases of severe bleeding tied to fake weed in Illinois (news–2018) https://www.cnn.com/2018/04/02/health/fake-weed-illinois-death-bn/index.html
Army: Vaping oils blamed for 2 deaths, 60 hospitalizations (news–2018) https://krcrtv.com/news/nation-world/army-vaping-oils-blamed-for-2-deaths-60-hospitalizations
America’s Rotten Drug Laws Encourage ‘Synthetic Marijuana’ Use (news–2018) https://cannabisnow.com/americas-rotten-drug-laws-encourage-synthetic-marijuana-use/#comment-182892
Synthetic Marijuana Now the Top Killer in Florida Prisons. This drug is turning Florida inmates into ‘zombies.’ It’s fueling a record death toll (news–2018) https://www.miamiherald.com/news/special-reports/florida-prisons/article215642855.html
Fake Weed Is Making People Bleed From Their Eyes and Ears (new  2019) https://www.yahoo.com/lifestyle/fake-weed-making-people-bleed-212600630.html
SUGARS Diet & the Endocannabinoid System: Food for Thought (news–2017) https://www.projectcbd.org/food-for-thought-diet-cannabis-and-the-endocannabinoid-system


SYNDROS
INSYS is Targeting a $700 Million Market With Syndros (news–2015) https://marketexclusive.com/insys/
Syndros (news–2016) https://syndros.com/
The DEA claims that synthetic THC is safer than the natural stuff in regular marijuana (news–2017) https://www.digitaltrends.com/cool-tech/dea-synethetic-marijuana-safer-than-weed/#ixzz4cjWy6hsb
A pharma company that spent $500,000 trying to keep pot illegal just got DEA approval for synthetic marijuana (news–2017) https://www.washingtonpost.com/amphtml/news/wonk/wp/2017/03/24/a-pharma-company-that-spent-500000-trying-to-keep-pot-illegal-just -got-dea-approval-for-synthetic-marijuana
Schedules of Controlled Substances: Placement of FDA-Approved Products of Oral Solutions Containing Dronabinol [(-)-delta-9-trans-tetrahydrocannabinol (delta-9-THC)] in Schedule II (news–2017) https://www.federalregister.gov/documents/2017/03/23/2017-05809/schedules-of-controlled-substances-placement-of-fda-approved-products-of-oral-solutions-containing
A New Marijuana Medicine Gets DEA Scheduling, but It’s Not All Good News (news–2017) https://www.fool.com/investing/2017/03/24/a-new-marijuana-medicine-gets-dea-scheduling-but-i.aspx
Some of the Parts: Is Marijuana’s “Entourage Effect” Scientifically Valid? (news–2017) https://www.scientificamerican.com/article/some-of-the-parts-is-marijuana-rsquo-s-ldquo-entourage-effect-rdquo-scientifically-valid/


TM-38837
Experimental obesity drug avoids brain effects that troubled predecessors (news–2010) https://medicalxpress.com/news/2010-07-experimental-obesity-drug-brain-effects.html
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TRICOR/FENOFIBRATE
Common cholesterol drug stimulates the same receptors as marijuana (news–2015) https://medicalxpress.com/news/2015-04-common-cholesterol-drug-receptors-marijuana.html


URB-597/KDS-4103
Marijuana’s Distant Relative May Be The Next Prozac; Chemical Reduces Anxiety Using Novel Nerve System In Body (news-2002) https://www.sciencedaily.com/releases/2002/12/021202071928.htm
Blocking the destruction of endocannabinoids (news–2005) https://arstechnica.com/science/2005/12/2106/
Marijuana-Like Brain Chemicals Work As Antidepressant (news-2007) https://www.sciencedaily.com/releases/2007/11/071105120556.htm
Parkinsons’ Helped By Marijuana-Like Chemicals In Brain (news–2007) https://www.medicalnewstoday.com/releases/62616.php
http://www.medicalnewstoday.com/releases/62616.php
Enhancing Activity Of Marijuana-Like Chemicals In Brain Helps Treat Parkinson’s Symptoms In Mice (news-2007) https://www.sciencedaily.com/releases/2007/02/070207171915.htm
Potential First-in-Class Compound, Reveals New Approach to the Treatment of Pain (D3) (news–2010) https://www.drugs.com/clinical_trials/potential-first-class-compound-reveals-new-approach-pain-d3-10133.html
A new drug that kills pain like marijuana, without getting you stoned (news–2010) https://io9.gizmodo.com/a-new-drug-that-kills-pain-like-marijuana-without-gett-5643337
Potential Pain Medication Targets Peripheral Nerves (news–2012) https://archives.drugabuse.gov/news-events/nida-notes/2012/09/potential-pain-medication-targets-peripheral-nerves
Uncovering the Neurological Differences Between the Sexes (news–2015) https://neurosciencenews.com/sex-differences-hippocampus-2421/ 


URB-937
New Drug Kills Pain by Boosting Body’s Naturally Occurring Marijuana-Like Compound (news–2010) https://www.popsci.com/science/article/2010-09/new-drug-boosts-marijuana-compound-reducing-pain-after-injuries/
Compound boosts marijuana-like chemical in the body to relieve pain at injury site (news-2010) https://www.eurekalert.org/pub_releases/2010-09/uoc–cbm092010.php
Research Reaps Reefer Madness (news–2010) https://www.newuniversity.org/2010/10/23/research-reaps-reefer-madness/
Cannabinoids for the Treatment of Neuropathic Pain (news–2012) https://www.medscape.com/viewarticle/739103_3

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VCE-004.8
Dupuytren’s Contracture and Cannabis (news–2016) https://www.uweblesching.com/blog/dupuytren-s-contracture-and-cannabis


WIN-55,212-2
Pot Shrinks Tumors; Government Knew in ’74 (news-2001) http://cannabisnews.com/news/9/thread9211.shtml
Marijuana-like compounds may aid array of debiliating conditions ranging from Parkinson’s to pain (news–2004) https://www.eurekalert.org/pub_releases/2004-10/sfn-mcm102604.php
Cannabinoids, in combination with (NSAIDS), produce a synergistic analgesic effect (news-2006) https://norml.org/news/2006/02/16/cannabinoids-enhance-analgesic-effects-of-anti-inflammatory-drugs-study-says
Synthetic form of THC is an effective anti-depressant at low doses (news-2007) https://www.news-medical.net/news/2007/10/24/31666.aspx
Cannabis: Potent Anti-Depressant In Low Doses, Worsens Depression At High Doses (news-2007) https://www.sciencedaily.com/releases/2007/10/071023183937.htm
Could Marijuana Substance Help Prevent Or Delay Memory Impairment In The Aging Brain? (news-2008) https://www.sciencedaily.com/releases/2008/11/081119120141.htm
Marijuana may be good for the aging brain (news-2008) https://www.news-medical.net/news/2008/11/19/43212.aspx
Marijuana reduces memory impairment (news-2008) https://www.news-medical.net/news/2008/11/19/43212.aspx
Cannabinoids for the Treatment of Neuropathic Pain (news–2012) https://www.medscape.com/viewarticle/739103_3
Marijuana’s Memory Paradox (news-forum repost 2013) https://ehealthforum.com/health/interesting-t164409.html
How this chemist unwittingly helped spawn the synthetic drug industry (news–2015) https://www.washingtonpost.com/local/social-issues/how-a-chemist-unwittingly-helped-spawn-the-synthetic-drug-epidemic/2015/08/09/94454824-3633-11e5-9739-170df8af8eb9_story.html?utm_term=.b426a6f719c0
Marijuana may help delay Alzheimer’s symptoms (news–2016) https://psychcentral.com/lib/marijuana-may-help-delay-alzheimers-symptoms/
Roll joints, not dice: Could cannabis be used to ‘cure’ problem gamblers? (news–2016) https://metro.co.uk/2016/03/02/roll-joint-not-dice-could-cannabis-be-used-to-cure-problem-gamblers-5728367

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Updated 12 October, 2019