K-S (Synthetics 2010+)

SYNTHETICS and COMPOUNDS THAT AFFECT the ECS 2010-2015

KM-233 (CB2 Agonist)
KML-29 (Stops Production of MAGL, Preventing Breakdown of 2-AG)
KN38-7271 / BAY38-7271 (CB1 and CB2 Agonist)
LBP-1 (CB1 Agonist with a Minimal High)
LEI-105 (Potent, Highly Selective, Reversible Dual DAGL-α/DAGL-β Inhibitor)
LY3038404 HCl (Highly Selective CB2 Agonist)
MAB-CHMINACA
MAM-2201 (CB1 and CB2 Agonist, Hybrid of JWH-122 and AM-2201)
MARINOL / DRONABINOL (Synthetic THC, CB1 and CB2 Agonist)
MDA-7 (Strong CB2 Agonist)
MDA-19 (Strong CB2 Agonist)
MJN-110 (Blocks Breakdown of 2-AG)
MK-0364 (See TARANABANT)
ML-193 (GPR-55 Antagonist)
MM-433593 (Inhibits FAAH Thus Increasing Anandamide)
MT-178 (CB2 Agonist)
NABILONE / CESAMET (Synthetic THC, CB1 and CB2 Agonist)
NESS0327 (CB1 Antagonist)
NMP-7 (CB2 Agonist)
NMP-181 (CB2 Agonist)
NS TYR (Anandamide Analog)
O-1602 (Cannabidiol Analog, GPR18 and GPR55 Agonist)
O-1663 (Acts Like Combination of THC and CBD)
O-1812 (Stable Analog of Anandamide)
O-1918 (GPR18 Antagonist)
O-1966 (CB2 Agonist)
O-2050 (CB1 Antagonist)
O-2545 (CB1 Agonist)
OMDM-2 (Blocks Re-uptake of Endocannabinoids)
ORG-27569 (Enhances Agonist-Binding Affinity to CB1)
PB-22 / QUPIC / ‘CRAZY MONKEY’ / ‘PSYCLONE’
PF-3845 (Blocks Breakdown of Anandamide)
PF-04457845 (Blocks Breakdown of Anandamide)
4(PM49) (CB1 Partial Agonist)
PSN-632408 (GPR 119 Agonist)
QUPIC (See PB-22)
R-FLURBIPROFEN (May Help Restore More Normal Endocannabinoid Levels)
RHC-80267
RIMONABANT / ACOMPLIA / SR141716 / SR1 (CB1 and CB2 Antagonist, Failed Weight Loss Drug)
R(+)-METHANANANDAMIDE / AM-356 (More Stable Anandamide Analog)
Ro 61-8048 (Blocks THC ‘High’)
RQ-00202730 (Strong CB2 Agonist)
RWJ-400065 (CB2 Agonist)
S-444823 (CB1 and CB2 Agonist)
S-777469 (CB2 Agonist)
SA-57 (Dual FAAH-MAGL Inhibitor)
SAB-378 (Activates Peripheral CB1 and CB2 Receptors, No ‘High’)
SAD-448 (Activates Peripheral CB1 Receptors, No ‘High’)
SAR-127303 (Prevents Breakdown of 2-AG)
SMM–189 (CB2 Inverse Agonist)
SPICE-NEWS (Various Synthetic Cannabinoid Mixtures, See Also AM, HU, JWH and CP series)
SPICE-STUDIES (Various Synthetic Cannabinoid Mixtures, See Also AM, HU, JWH and CP Series)
SR-144528
SURINABANT / SR 147778
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KM-233
Synthesis of Novel Cannabinoid Ligands and Their Use as Anti-Glioma and Anti-Inflammatory Agents (full–2010) http://etd.uthsc.edu/WORLD-ACCESS/Gurley/2010-030-Gurley.pdf
Mechanism of anti-glioma activity and in vivo efficacy of the cannabinoid ligand KM-233 (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22875710


KML-29
In vivo characterization of the highly selective monoacylglycerol lipase inhibitor KML29: Antinociceptive activity without cannabimimetic side effects (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23848221
Comparative biochemical characterization of the monoacylglycerol lipase inhibitor KML29 in brain, spinal cord, liver, spleen, fat and muscle tissue (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25497453
Postnatal ethanol exposure alters levels of 2-arachidonylglycerol-metabolizing enzymes and pharmacological inhibition of monoacylglycerol (MAGL) does not cause neurodegeneration in neonatal mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25857698


KN38-7271 / BAY38-7271
Early Survival of Comatose Patients after Severe Traumatic Brain Injury with the Dual Cannabinoid CB1/CB2 Receptor Agonist KN38-7271: A Randomized, Double-Blind, Placebo-Controlled Phase II Trial (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22696266
Cannabinoid Receptor Subtypes 1 and 2 Mediate Long-Lasting Neuroprotection and Improve Motor Behaviour Deficits After Transient Focal Cerebral Ischemia (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/23069763


LBP-1
Low brain penetrant CB1 receptor agonists for the treatment of neuropathic pain (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/22421020


LEI-105
A highly selective, reversible inhibitor identified by comparative chemoproteomics modulates diacylglycerol lipase activity in neurons (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26083464


LY3038404 HCl
Cannabinoid receptor 2 agonist attenuates pain related behavior in rats with chronic alcohol / high fat diet induced pancreatitis (full–2014) http://www.molecularpain.com/content/10/1/66


MAB-CHMINACA
Postmortem distribution of MAB-CHMINACA in body fluids and solid tissues of a human cadaver (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26257834
Authorities may know common link between synthetic pot illnesses nationwide (news–2015) http://www.mcall.com/news/nationworld/pennsylvania/mc-us-synthetic-marijuana-hospitalization-spike-20150508-story.html?track=rss
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MAM-2201
Cytotoxicity of synthetic cannabinoids on primary neuronal cells of the forebrain: the involvement of cannabinoid CB1 receptors and apoptotic cell death (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24211273
Identification and quantification of synthetic cannabinoids in ‘spice-like’ herbal mixtures: A snapshot of the German situation in the autumn of 2012 (full–2014) http://onlinelibrary.wiley.com/doi/10.1002/dta.1499/full
LC-QTOF-MS as a superior strategy to immunoassay for the comprehensive analysis of synthetic cannabinoids in urine (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24424965
Driving under the influence of synthetic cannabinoids (“Spice”): a case series (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/23636569
MAM-2201 (Analytically Confirmed) Intoxication After “Synthacaine” Consumption (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24530110
Determination of major metabolites of MAM-2201 and JWH-122 in in vitro and in vivo studies to distinguish their intake (abst–2014)
http://www.ncbi.nlm.nih.gov/pubmed/25195129
Urinary prevalence, metabolite detection rates, temporal patterns and evaluation of suitable LC-MS/MS targets to document synthetic cannabinoid intake in US military urine specimens (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25263309
Simultaneous determination of five naphthoylindole-based synthetic cannabinoids and metabolites and their deposition in human and rat hair (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25282599
A Synthetic Cannabinoid MAM-2201 Potently Suppresses Synaptic Transmission via Activation of Presynaptic CB1 Receptors and Reduces Synaptically-Evoked Intracellular Ca2+ Transients in Cerebellar Purkinje Cells (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25747605
Metabolome disruption of the rat cerebrum induced by the acute toxic effects of the synthetic cannabinoid MAM-2201 (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26032255


MARINOL / DRONABINOL
Use of dronabinol (delta-9-THC) in autism: A prospective single-case-study with an early infantile autistic child (full–2010) http://www.cannabis-med.org/data/pdf/en_2010_04_1.pdf
Delta9-tetrahydrocannabivarin testing may not have the sensitivity to detect marijuana use among individuals ingesting dronabinol (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815025/?tool=pubmed
DEA- Listing of Approved Drug Products Containing Dronabinol in Schedule III (full–2010) http://www.deadiversion.usdoj.gov/fed_regs/rules/2010/fr1101.htm
Dramatic improvement of refractory Isaacs’ syndrome after treatment with dronabinol (1st page–2010) http://www.deepdyve.com/lp/elsevier/dramatic-improvement-of-refractory-isaacs-syndrome-after-treatment-kuk1Dc3xDe
Effect of dronabinol on central neuropathic pain after spinal cord injury: a pilot study (abst–2010) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=313
Efficacy and tolerability of high-dose dronabinol maintenance in HIV-positive marijuana smokers: a controlled laboratory study (abst–2010) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=316
Dronabinol for the treatment of unspecific pain, restlessness and spasticity in neuropaediatrics (abst–2010) https://www.thieme-connect.com/ejournals/abstract/10.1055/s-0030-1265622
Science: Dramatic improvement of neuromyotonia (Isaacs’ syndrome) with THC in a case report (news–2010) http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=337
Nature’s (Legal) Cannabinoids (news-2010) http://www.mapinc.org/drugnews/v10/n126/a04.html?1194
Oral THC Reduces Aggressive Behavior In Patients With Refractory Psychosis, Study Says (news-2010) http://www.norml.org/index.cfm?Group_ID=8419
Pharmacogenetic Trial of a Cannabinoid Agonist Shows Reduced Fasting Colonic Motility in Patients with Non-Constipated Irritable Bowel Syndrome (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202649/
Combined effects of acute, very-low-dose ethanol and delta(9)-tetrahydrocannabinol in healthy human volunteers (full-2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018238/
Dronabinol for the treatment of cannabis dependence: a randomized, double-blind, placebo-controlled trial (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154755/
Room-temperature stable dronabinol formulations – Patent NZ555701 (A) ― 2011-05-27 (full–2011) http://worldwide.espacenet.com/publicationDetails/description?CC=NZ&NR=555701A&KC=A&FT=D&ND=3&date=20110527&DB=EPODOC&locale=en_EP
Antagonist-elicited cannabis withdrawal in humans (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717344/
Dronabinol, a cannabinoid agonist, reduces hair pulling in trichotillomania: a pilot study (abst–2011) http://www.unboundmedicine.com/medline/ebm/record/21590520/abstract/Dronabinol_a_cannabinoid_agonist_reduces_hair_pulling_in_trichotillomania:_a_pilot_study_
Cannabinoids in children (abst–2011) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=295
Drunk versus drugged: How different are the drivers? (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21925803
What Are Prescription Drugs That Are a Substitute for Marijuana? (news–2011) http://www.livestrong.com/article/137065-what-are-prescription-drugs-that-are-substitute-marijuana/#ixzz21Ia1dVQG
Science: THC effective in trichotillomania symptoms in a pilot study (news–2011) http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=348
Is Pot Good For You? (news–2011) http://www.time.com/time/magazine/article/0,9171,1003570,00.html
Endocannabinoids in nervous system health and disease: the big picture in a nutshell (full–2012) http://rstb.royalsocietypublishing.org/content/367/1607/3193.full
Tolerance to Effects of High-Dose Oral {Delta}9-Tetrahydrocannabinol and Plasma Cannabinoid Concentrations in Male Daily Cannabis Smokers (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584989/
The Therapeutic Potential of Cannabis and Cannabinoids (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442177/
Can oral fluid cannabinoid testing monitor medication compliance and/or cannabis smoking during oral THC and oromucosal Sativex administration? (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612560/
The dose effects of short-term dronabinol (oral THC) maintenance in daily cannabis users (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546149/
Irritable Bowel Syndrome: Methods, Mechanisms, and Pathophysiology. Genetic epidemiology and pharmacogenetics in irritable bowel syndrome (full–2012) http://ajpgi.physiology.org/content/302/10/G1075
Effects of delta-9-tetrahydrocannabinol on evaluation of emotional images (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664416/
Genetic Epidemiology and Pharmacogenetics in Irritable Bowel Syndrome (full-2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362100/
Randomized pharmacodynamic and pharmacogenetic trial of dronabinol effects on colon transit in irritable bowel syndrome-diarrhea (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775711/
DRONABINOL capsule [Watson Laboratories, Inc.] (monograph–2012) http://dailymed.nlm.nih.gov/dailymed/mobile/lookup.cfm?setid=1f1af798-17d5-47d0-b129-21d4aa1eb125
Subjective, cognitive and cardiovascular dose-effect profile of nabilone and dronabinol in marijuana smokers (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22260337
Heat Exposure of Cannabis sativa Extracts Affects the Pharmacokinetic and Metabolic Profile in Healthy Male Subjects (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22411724
Cannabinoids in the treatment of chemotherapy-induced nausea and vomiting (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22491047
Effects of dronabinol on morphine-induced dopamine-related behavioral effects in animals (abst–2012) http://onlinelibrary.wiley.com/doi/10.1002/syn.21586/abstract
Side Effects of the Marinol Pill (news–2012) http://www.livestrong.com/article/90879-side-effects-marinol-pill/
Can medical marijuana help rheumatoid arthritis? (news–2012) http://healthyliving.msn.com/diseases/rheumatoid-arthritis/can-medical-marijuana-help-rheumatoid-arthritis-1
Can cannabinoid drug used for nausea in chemotherapy relieve sleep apnea? (news–2012) http://medicalxpress.com/news/2012-06-cannabinoid-drug-nausea-chemotherapy-relieve.html
Proof of concept trial of dronabinol in obstructive sleep apnea (full–2013) http://www.frontiersin.org/Sleep_Disorders/10.3389/fpsyt.2013.00001/full
The pharmacologic and clinical effects of medical cannabis (full–2013) http://onlinelibrary.wiley.com/doi/10.1002/phar.1187/full
Pharmacokinetic and Pharmacodynamic Profile of Supratherapeutic Oral Doses of Δ9 -THC in Cannabis Users (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691290/
Cannabinoid facilitation of fear extinction memory recall in humans (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445738/
Towards a better Cannabis drug (full–2013) http://onlinelibrary.wiley.com/doi/10.1111/bph.12400/full
The medical use of cannabis for reducing morbidity and mortality in patients with HIV/AIDS (full–2013) http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD005175.pub3/full
Suspected Dronabinol Withdrawal in an Elderly Cannabis-Naive Medically Ill Patient (letter–2013) http://ajp.psychiatryonline.org/article.aspx?articleid=1700628
Medicinal Cannabis and Painful Sensory Neuropathy (editorial–2013) http://virtualmentor.ama-assn.org/2013/05/oped1-1305.html
Simultaneous and sensitive LC–MS/MS determination of tetrahydrocannabinol and metabolites in human plasma (abst–2013) http://link.springer.com/article/10.1007/s00216-012-6501-x
Comparison of the Analgesic Effects of Dronabinol and Smoked Marijuana In Daily Marijuana Smokers (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23609132
Acyl migration evaluation in monoacylglycerols from Echium plantagineum seed oil and Marinol (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23287502
Dronabinol Treatment of Refractory Nausea and Vomiting Related to Peritoneal Carcinomatosis (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24052427
Plasma Cannabinoid Concentrations During Dronabinol Pharmacotherapy for Cannabis Dependence (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24067260
Intranodose ganglion injections of dronabinol attenuate serotonin-induced apnea in Sprague-Dawley rat (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24121138
The Subjective Psychoactive Effects of Oral Dronabinol Studied in a Randomized, Controlled Crossover Clinical Trial For Pain (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24281276
Synthetic cannabis: a comparison of patterns of use and effect profile with natural cannabis in a large global sample (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23291209
Medical Marijuana: Consortium of Multiple Sclerosis Centers (news–2013) http://www.msviews.org/msviewsandnews4/index.php/2012-05-28-00-15-54/2012-07-04-00-19-28/610-medical-marajuana-consortium-of-multiple-sclerosis-centers
Maine Mom Fights Son’s Autistic Episodes With Marinol (news–2013) http://www.marijuana.com/news/2013/04/maine-mom-fights-sons-autistic-episodes-with-marinol/
Pharmaceutical Cannabis Produces Similar High, Study Finds (news–2013) http://www.leafscience.com/2013/12/04/pharmaceutical-cannabis-produces-similar-high-study-finds/
Science/Human: THC reduces sleep apnoea in small clinical study (news–2013) http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=392&search_pattern=2013#2
Cannabis pill better than smoking for pain (news–2013) http://www.rheumatologyupdate.com.au/latest-news/cannabis-pill-better-than-smoking-for-pain
Getting high on the endocannabinoid system (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997295/
Dronabinol in severe, enduring anorexia nervosa: A randomized controlled trial (full–2014) http://onlinelibrary.wiley.com/doi/10.1002/eat.22173/full
Dronabinol and chronic pain: importance of mechanistic considerations (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24819592
Fibromyalgia (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24365316
Effect of dronabinol therapy on physical activity in anorexia nervosa: a randomised, controlled trial (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24890912
(Mo1121) Cannabinoid Use Decreases ED Utilization in a Gastroenterology Clinic Population (abst–2014) http://www.gastrojournal.org/article/S0016-5085%2814%2962037-0/pdf
(Mo1121) Cannabinoid Use Decreases ED Utilization in a Gastroenterology Clinic Population (abst–2014) http://www.gastrojournal.org/article/S0016-5085%2814%2962037-0/pdf
(Mo1122) Prevalence and Characterization of Cannabinoid Use in Patients With Gastrointestinal Disorders (abst–2014) http://www.gastrojournal.org/article/S0016-5085%2814%2962037-0/pdf
Marijuana In A Pill? Why Patients Might Be Better Off Smoking It (news–2014) http://www.leafscience.com/2014/01/19/marijuana-pill-patients-might-better-smoking/
Marijuana Saved My Life: An Abbreviated Dope Diary (news–2014) http://www.mainstreet.com/article/family/family-health/marijuana-saved-my-life-abbreviated-dope-diary?puc=yahoo&cm_ven=YAHOO
3 Prescription Drugs You Didn’t Know Come From Marijuana (news–2014) http://www.fool.com/investing/general/2014/03/16/3-prescription-drugs-you-didnt-know-come-from-mari.aspx
Marijuana Benefits MS Patients as Other Remedies Fail (news–2014) http://www.bloomberg.com/news/2014-03-24/marijuana-benefits-ms-patients-as-other-remedies-fail.html
Health Benefits Of Medical Marijuana: 3 Major Ways Cannabis Helps Sick People Live Normal Lives (news–2014) http://www.medicaldaily.com/health-benefits-medical-marijuana-3-major-ways-cannabis-helps-sickpeople-live-normal-lives-283388
Temple Study Suggests a Novel Approach for Treating Non-Cardiac Chest Pain (news–2014) http://www.templehealth.org/content/news.htm?view=34&inCtx5news_id=1132&inCtx4pg=0&news=2
Novel way for treating non-cardiac chest pain due to esophageal hypersensitivity (news–2014) http://www.news-medical.net/news/20141022/Novel-way-for-treating-non-cardiac-chest-pain-due-toesophageal-hypersensitivity.aspx
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The successful use of dronabinol for failure to thrive secondary to intestinal dysmotility (full–2015) http://www.casereports.com/article/S2210-2612%2815%2900219-9/pdf
Current Status and Future of Cannabis Research (full–2015) http://cannabisclinicians.org/wp-content/uploads/2015/05/Russo-et-al-Current-status-and-future-ofcannabis-research-Clin-Researcher-2015.pdf
Pharmacogenetics in irritable bowel syndrome (full–2015) http://informahealthcare.com/doi/pdf/10.1517/17425255.2015.1048223
The effects of dronabinol during detoxification and the initiation of treatment with extended release naltrexone (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26187456
Changes in IGF-I, urinary free cortisol and adipokines during dronabinol therapy in anorexia nervosa: Results from a randomised, controlled trial (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26248813
Do Cannabinoid Receptor Agonists Have A Role In The Intensive Care Unit? … Totally Dude! (abst–2015) http://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2015.191.1_MeetingAbstracts.A1657
A state-of-the-art review of the management and treatment of taste and smell alterations in adult oncology patients (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26162535
Marijuana Is a Wonder Drug When It Comes to the Horrors of Chemo (news–2015) http://www.newsweek.com/2015/07/31/keep-toke-alive-356032.html
Huge New Review Shows What Medical Marijuana May (and May Not) Help (news–2015) https://www.yahoo.com/health/huge-new-review-shows-what-medical-marijuana-may-122209836947.html


MDA-7
Prevention of Paclitaxel-Induced Neuropathy Through Activation of the Central Cannabinoid Type 2 Receptor System (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334436/
Cannabinoid Receptor Stimulator Reverses Symptoms of Alzheimer’s Disease in Animal Model (news–2012) http://www.biotechdaily.com/?option=com_article&Itemid=294742494
Researchers investigating potential drug for treatement of Alzheimer’s disease (news–2012) http://medicalxpress.com/news/2012-08-potential-drug-treatement-alzheimer-disease.html
Activation of the CB(2) receptor system reverses amyloid-induced memory deficiency (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/22795792
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In vivo efficacy of enabling formulations based on hydroxypropyl-β-cyclodextrins, micellar preparation, and liposomes for the lipophilic cannabinoid CB2 agonist, MDA7 (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23192786
Spinal gene expression profiling and pathways analysis of a CB2 agonist (MDA7)-targeted prevention of paclitaxel-induced neuropathy (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24361916


MDA-19
Pharmacological characterization of a novel cannabinoid ligand, MDA19, for treatment of neuropathic pain (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253719/
Studies demonstrate analgesic properties of synthetic cannabinoid (news–2010) http://www.news-medical.net/news/20100702/Studies-demonstrate-analgesic-properties-of-synthetic-cannabinoid.aspx


MJN-110
Selective monoacylglycerol lipase inhibitors: Antinociceptive vs. cannabimimetic effects in mice (full–2015) http://jpet.aspetjournals.org/content/early/2015/03/11/jpet.114.222315.long
For whom the endocannabinoid tolls: Modulation of innate immune function and implications for psychiatric disorders (abst–2015) http://www.sciencedirect.com/science/article/pii/S027858461500055X


ML-193
The Lysophosphatidylinositol Receptor GPR55 Modulates Pain Perception in the Periaqueduactal Grey (full–2015) http://molpharm.aspetjournals.org/content/early/2015/05/12/mol.115.099333.long
Central administration of GPR55 receptor agonist and antagonist modulates anxietyrelated behaviors in rats (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25620584
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MM-433593
Metabolism and disposition of MM-433593, a selective FAAH-1 inhibitor, in monkeys (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186420/


MT-178
Antinociceptive effects of the selective CB2 agonist MT178 in inflammatory and chronic rodent pain models (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23518609


NABILONE / CESAMET
The Effects of Nabilone on Sleep in Fibromyalgia: Results of a Randomized Controlled Trial (full-2010) http://journals.lww.com/anesthesia-analgesia/Fulltext/2010/02000/The_Effects_of_Nabilone_on_Sleep_in_Fibromyalgia_.56.aspx
CESAMET® CII (nabilone) Capsules For Oral Administration (archived drug label–2010) http://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=16800
A randomized, double-blinded, crossover pilot study assessing the effect of nabilone on spasticity in persons with spinal cord injury (abst-2010) http://www.ncbi.nlm.nih.gov/pubmed/20434606
An Open-Label Comparison of Nabilone and Gabapentin as Adjuvant Therapy or Monotherapy in the Management of Neuropathic Pain in Patients with Peripheral Neuropathy (abst–2010) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=311
Refractory CRPS Patients Discontinue Opiates With Cannabinoid Treatment (news–2010) http://www.braatah.com/refractory-crps-patients-discontinue-opiates-with-cannabinoid-treatment/
Refractory CRPS Patients Discontinue Opiates With Cannabinoid Treatment (news–2010) http://www.braatah.com/refractory-crps-patients-discontinue-opiates-with-cannabinoid-treatment/
What Are Prescription Drugs That Are a Substitute for Marijuana? (news–2011) http://www.livestrong.com/article/137065-what-are-prescription-drugs-that-are-substitute-marijuana/#ixzz21Ia1dVQG
The Therapeutic Potential of Cannabis and Cannabinoids (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442177/
CADTH Rapid Response Report: Cannabinoids for the treatment of post-traumatic stress disorder (full–2012) http://www.cadth.ca/media/pdf/htis/july-2012/RC0368%20Cannabinoids%20Final.pdf
Endocannabinoids in nervous system health and disease: the big picture in a nutshell (full–2012) http://rstb.royalsocietypublishing.org/content/367/1607/3193.full
Subjective, cognitive and cardiovascular dose-effect profile of nabilone and dronabinol in marijuana smokers (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22260337
Cannabinoids in the treatment of chemotherapy-induced nausea and vomiting (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22491047
A Randomized, Double-Blind, Placebo Controlled, Parallel Assignment, Flexible Dose, Efficacy Study of Nabilone as Adjuvant in the Treatment of Diabetic Peripheral Neuropathic Pain Using an Enriched Enrollment Randomized Withdrawal Design (S38.003) (abst–2012) http://www.neurology.org/cgi/content/meeting_abstract/78/1_MeetingAbstracts/S38.003?maxtoshow=&hits=25&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=180&sortspec=date&resourcetype=HWCIT
An enriched-enrolment, randomized withdrawal, flexible-dose, double-blind, placebo-controlled, parallel assignment efficacy study of nabilone as adjuvant in the treatment of diabetic peripheral neuropathic pain (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22921260
Study: Synthetic THC Analogue Mitigates Diabetic Neuropathy, Is ‘Well Tolerated’ In Patients (news–2012) http://norml.org/news/2012/09/20/study-synthetic-thc-analogue-mitigates-diabetic-neuropathy-is-well-tolerated-in-patients
New drug offers novel pain management therapy for diabetics (news–2012) http://www.thefreelibrary.com/New+drug+offers+novel+pain+management+therapy+for+diabetics.-a0306899453
Synthetic cannabinoid could treat pain in diabetes patients (news–2012) http://www.medwirenews.com/57/102248/Diabetes/Synthetic_cannabinoid_could_treat_pain_in_diabetes_patients_.html
Drug offers new pain management therapy for diabetics (news–2012) http://medicalxpress.com/news/2012-10-drug-pain-therapy-diabetics.html
Can medical marijuana help rheumatoid arthritis? (news–2012) http://healthyliving.msn.com/diseases/rheumatoid-arthritis/can-medical-marijuana-help-rheumatoid-arthritis-1
Nabilone decreases marijuana withdrawal and a laboratory measure of marijuana relapse (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682150/
Combined antiproliferative effects of the aminoalkylindole WIN55,212-2 and radiation in breast cancer cells (full–2013) http://jpet.aspetjournals.org/content/early/2013/11/20/jpet.113.205120.long
The pharmacologic and clinical effects of medical cannabis (full–2013) http://onlinelibrary.wiley.com/doi/10.1002/phar.1187/full
Transdermal delivery of cannabidiol Patent 8435556 (full–2013) https://www.google.com/patents/US8435556
The use of cannabinoids in chronic pain (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23893276
Synthetic cannabis: a comparison of patterns of use and effect profile with natural cannabis in a large global sample (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23291209
The Fibromyalgia Drugs Your Doctor (Probably) Knows Nothing About (news–2013) http://www.prohealth.com/library/showArticle.cfm?libid=18225&site=articles
Use of a Synthetic Cannabinoid in a Correctional Population for Posttraumatic Stress Disorder-Related Insomnia and Nightmares, Chronic Pain, Harm Reduction, and Other Indications: A Retrospective Evaluation (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24987795
Combined antiproliferative effects of the aminoalkylindole WIN55,212-2 and radiation in breast cancer cells (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24259678
Marijuana In A Pill? Why Patients Might Be Better Off Smoking It (news–2014) http://www.leafscience.com/2014/01/19/marijuana-pill-patients-might-better-smoking/
3 Prescription Drugs You Didn’t Know Come From Marijuana (news–2014) http://www.fool.com/investing/general/2014/03/16/3-prescription-drugs-you-didnt-know-come-from-mari.aspx
Nabilone as an Adjunctive to Gabapentin for Multiple Sclerosis-Induced Neuropathic Pain: A Randomized Controlled Trial (full–2015) http://onlinelibrary.wiley.com/doi/10.1111/pme.12569/full
Promising cannabinoid-based therapies for Parkinson’s disease: motor symptoms to neuroprotection (full–2015) http://www.molecularneurodegeneration.com/content/pdf/s13024-015-0012-0.pdf
The efficacy of nabilone, a synthetic cannabinoid, in the treatment of PTSD-associated nightmares: A preliminary randomized, double-blind, placebo-controlled cross-over design study (full–2015) http://www.psyneuen-journal.com/article/S0306-4530%2814%2900413-2/fulltext
The effectiveness of cannabinoids in the management of chronic nonmalignant neuropathic pain: a systematic review (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25635955
Investigational drugs under development for the treatment of PTSD (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25773140
Marijuana Is a Wonder Drug When It Comes to the Horrors of Chemo (news–2015) http://www.newsweek.com/2015/07/31/keep-toke-alive-356032.html


NESS0327
Docosahexaenoyl ethanolamide improves glucose uptake and alters endocannabinoid system gene expression in proliferating and differentiating C2C12 myoblasts (full–2014) http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00100/full
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Multiple Forms of Endocannabinoid and Endovanilloid Signaling Regulate the Tonic Control of GABA Release (full–2015) http://www.jneurosci.org/content/35/27/10039.full?sid=7e769d1b-9b77-42fe-92d0-8b337b34b9b6


NMP-7
Analgesic effect of a mixed T-type channel inhibitor/CB2 receptor agonist (full–2013) http://www.molecularpain.com/content/9/1/32
NMP-7 inhibits chronic inflammatory and neuropathic pain via block of Cav3.2 T-type calcium channels and activation of CB2 receptors (full–2014) http://www.molecularpain.com/content/pdf/1744-8069-10-77.pdf


NMP-181
Analgesic effect of a mixed T-type channel inhibitor/CB2 receptor agonist (full–2013) http://www.molecularpain.com/content/9/1/32


NS TYR
N-stearoyltyrosine protects primary cortical neurons against Aβ(1-40)-induced injury through inhibiting endocannabinoid degradation (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25637682


O-1602
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2 (full–2010) http://pharmrev.aspetjournals.org/content/62/4/588.full.pdf+html
A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans (full–2011) http://joe.endocrinology-journals.org/content/211/2/177.long
A novel CB receptor GPR55 and its ligands are involved in regulation of gut movement in rodents (full–2011) http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2982.2011.01742.x/full
A novel CB receptor GPR55 and its ligands are involved in regulation of gut movement in rodents (full–2011) http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2982.2011.01742.x/full
The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55 (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21683763
The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116968/
The atypical cannabinoid O-1602 shows antitumorigenic effects in colon cancer cells and reduces tumor growth in a colitis-associated colon cancer model (full–2012) http://www.biomedcentral.com/content/pdf/2050-6511-13-S1-A23.pdf
GPR18 in microglia: implications for the CNS and endocannabinoid system signaling (full–2012) http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02019.x/full
Evidence for the Putative Cannabinoid Receptor (GPR55)-Mediated Inhibitory Effects on Intestinal Contractility in Mice (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548934/
siRNA knockdown of GPR18 receptors in BV-2 microglia attenuates N-arachidonoyl glycine-induced cell migration (full–2012) http://www.jmolecularsignaling.com/content/7/1/10
The atypical cannabinoid O-1602 stimulates food intake and adiposity in rats (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/21981246
The atypical cannabinoid O-1602 increases hind paw sensitisation in the chronic constriction injury model of neuropathic pain (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22227298
The Atypical Cannabinoid O-1602: Targets, Actions, and the Central Nervous System (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22831390
O-1602, an atypical cannabinoid, inhibits tumor growth in colitis-associated colon cancer through multiple mechanisms (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529923/
Role of endogenous cannabinoid system in the gut (full–2013) http://www.actaps.com.cn/qikan/manage/wenzhang/2013-4-12.pdf
A role for O-1602 and G protein-coupled receptor GPR55 in the control of colonic motility in mice (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677091/
A GPR18-based signaling system regulates IOP in murine eye (ful–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687663/
Regulation of cell proliferation by GPR55/cannabinoid receptors using (R,R’)-4’-methoxy-1-naphthylfenoterol in rat C6 glioma cell line (abst–2013) http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=695437a2-7613-4bef-8697-2294df2da859&cKey=18ba6eb0-2c5f-4004-a56f-2d1f450e2ed1&mKey=9b2d28e7-24a0-466f-a3c9-07c21f6e9bc9
Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/22850623
(R,R’)-4’-methoxy-1-naphthylfenoterol Inhibits GPR55 signaling and the modulation of motility in human cancer cells (abst–2013) http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=25370896-7d13-4f15-be76-f664d79b577d&cKey=87b7fec1-45cc-42b7-aca7-48c6b1d42773&mKey=9b2d28e7-24a0-466f-a3c9-07c21f6e9bc9
Evaluation of the insulin releasing and antihyperglycaemic activities of GPR55 lipid agonists using clonal beta-cells, isolated pancreatic islets and mice (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23992544
Cannabinoid Effects on β Amyloid Fibril and Aggregate Formation, Neuronal and Microglial-Activated Neurotoxicity In Vitro (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24030360
Anticancer activity of anandamide in human cutaneous melanoma cells (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24041928
Increase of mesenchymal stem cell migration by Cannabidiol via activation of p42/44 MAPK (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24304686
(R,R’)-4′-Methoxy-1-naphthylfenoterol Targets GPR55-mediated Ligand Internalization and Impairs Cancer Cell Motility (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24355564
Cannabinoids inhibit cholinergic contraction in human airways through prejunctional CB1 receptors (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24467410
Activation of GPR18 by Cannabinoid compounds: A tale of biased agonism (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24762058
Activation of GPR55 Receptors Exacerbates oxLDL-Induced Lipid Accumulation and Inflammatory Responses, while Reducing Cholesterol Efflux from Human Macrophages (full–2015) http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0126839
Pharmacological profiling of the hemodynamic effects of cannabinoid ligands: a combined in vitro and in vivo approach (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492759/
Central administration of GPR55 receptor agonist and antagonist modulates anxiety related behaviors in rats (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25620584
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O-1663
Targeting multiple cannabinoid antitumor pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24910342


O-1918
Endothelium-dependent mechanisms of the vasodilatory effect of the endocannabinoid, anandamide, in the rat pulmonary artery (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22627170
A GPR18-based signaling system regulates IOP in murine eye (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687663/
Mechanisms of endothelium-dependent relaxation evoked by anandamide in isolated human pulmonary arteries (full–2014) http://download.springer.com/static/pdf/387/art%253A10.1007%252Fs00210-014-0961-9.pdf?auth66=1396559334_2a7771f3b0767a5092c7c4a570374992&ext=.pdf
Vascular targets for cannabinoids: animal and human studies (full–2014) http://onlinelibrary.wiley.com/doi/10.1111/bph.12560/full
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Activation of GPR18 by Cannabinoid compounds: A tale of biased agonism (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24762058
The GPR55 agonist lysophosphatidylinositol mediates vasorelaxation of the rat mesenteric resistance artery and induces calcium release in rat mesenteric artery endothelial cells (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25652040
A role for GPR55 in human placental venous endothelial cells (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25869640


O-1966
Modulation of inflammatory responses by a cannabinoid-2-selective agonist after spinal cord injury (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235339/
Acute effects of a selective cannabinoid-2 receptor agonist on neuroinflammation in a murine model of traumatic brain injury (abst–2011) http://www.unboundmedicine.com/medline/ebm/record/21332427/abstract/Acute_effects_of_a_selective_cannabinoid_2_receptor_agonist_on_neuroinflammation_in_a_murine_model_of_traumatic_brain_injury_
Activation of cannabinoid receptor 2 attenuates leukocyte-endothelial cell interactions and blood-brain barrier dysfunction under inflammatory conditions (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325902/
A cannabinoid type 2 receptor agonist attenuates blood-brain barrier damage and neurodegeneration in a murine model of traumatic brain injury (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22903455
O-1602, an atypical cannabinoid, inhibits tumor growth in colitis-associated colon cancer through multiple mechanisms (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529923/
Attenuation of HIV-1 replication in macrophages by cannabinoid receptor 2 agonists (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629438/
Effect of cannabinoid CB2 receptor agonism on learning and memory in a mouse model of photothrombosis (abst–2013) http://www.fasebj.org/cgi/content/meeting_abstract/27/1_MeetingAbstracts/1097.4?sid=eea722c0-971c-4daa-8b8c-38c0c63c19ad
Cannabinoid receptor type-2 stimulation, blockade, and deletion alters the vascular inflammatory responses to traumatic brain injury (full–2014)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248435/
A selective cannabinoid CB2 agonist attenuates damage and improves memory retention following stroke in mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26032254
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O-2050
Hypothalamic 2-arachidonoylglycerol regulates multistage process of high-fat diet preferences (full–2012) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0038609
Angiotensin II induces vascular endocannabinoid release, which attenuates its vasoconstrictor effect via CB1 cannabinoid receptors (full–2012) http://www.jbc.org/content/early/2012/07/11/jbc.M112.346296.full.pdf+html
Structural analogs of pyrazole and sulfonamide cannabinoids: Effects on acute food intake in mice (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586205/
The complex effects of cannabinoids on insulin secretion from rat isolated islets of Langerhans (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23499687
O-2050 facilitates noradrenaline release and increases the CB1 receptor inverse agonistic effect of rimonabant in the guinea pig hippocampus (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24853577


O-2545
Cannabinoid agonists rearrange synaptic vesicles at excitatory synapses and depress motoneuron activity in vivo (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25595101


OMDM-2
Activity-based anorexia in C57/BL6 mice: effects of the phytocannabinoid, Delta9-tetrahydrocannabinol (THC) and the anandamide analogue, OMDM-2 (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/20471226
A new strategy to block tumor angiogenesis by inhibiting endocannabinoid inactivation (abst–2013) http://www.fasebj.org/cgi/content/meeting_abstract/27/1_MeetingAbstracts/1105.6?sid=eea722c0-971c-4daa-8b8c-38c0c63c19ad
The administration of endocannabinoid uptake inhibitors OMDM-2 or VDM-11 promotes sleep and decreases extracellular levels of dopamine in rats (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23238438
For whom the endocannabinoid tolls: Modulation of innate immune function and implications for psychiatric disorders (abst–2015) http://www.sciencedirect.com/science/article/pii/S027858461500055X


ORG-27569
Parameterization of Org27569: An allosteric modulator of the cannabinoid CB(1) G protein-coupled receptor (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145811/
Allosteric modulator ORG27569 induces CB1 cannabinoid receptor high affinity agonist binding state, receptor internalization, and Gi protein-independent ERK1/2 kinase activation (full–2012) http://www.ncbi.nlm.nih.gov/pubmed/22343625
A key agonist-induced conformational change in the cannabinoid receptor CB1 is blocked by the allosteric ligand Org 27569 (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460482/
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Distinct roles of β-arrestin 1 and β-arrestin 2 in ORG27569-induced biased signaling and internalization of the cannabinoid receptor one (CB1) (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617280/
Real-time characterisation of Cannabinoid Receptor 1 (CB1 ) allosteric modulators reveals novel mechanism of action (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23937487
Optimization of Chemical Functionalities of Indole-2-Carboxamides to Improve Allosteric Parameters for the Cannabinoid Receptor 1 (CB1) (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24635495
Allosteric Modulation of a Cannabinoid G Protein-coupled Receptor BINDING SITE ELUCIDATION AND RELATIONSHIP TO G PROTEIN SIGNALING (abst–2014) http://www.jbc.org/content/289/9/5828.abstract?sid=9a3f2c47-b737-4ecc-b47c-2f6edbe16774
Optimization of Chemical Functionalities of Indole-2-Carboxamides to Improve Allosteric Parameters for the Cannabinoid Receptor 1 (CB1) (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203403/
Effects of the cannabinoid CB1 receptor allosteric modulator ORG 27569 on reinstatement of cocaine- and methamphetamine-seeking behavior in rats (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25169627
Biased Agonism and Biased Allosteric Modulation at the CB1 Cannabinoid Receptor (full–2015) http://molpharm.aspetjournals.org/content/early/2015/06/04/mol.115.099192.long


PB-22 / QUPIC / ‘CRAZY MONKEY’ / ‘PSYCLONE’
‘Crazy Monkey’ Poisons Man and Dog: Human and canine seizures due to PB-22, a novel synthetic cannabinoid (full–2014) http://informahealthcare.com/doi/full/10.3109/15563650.2014.925562
The effects of bioisosteric fluorine in synthetic cannabinoid designer drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135 (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25921407
Δ9-Tetrahydrocannabinol-like effects of novel synthetic cannabinoids found on the gray market (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26061356
Psyclones: a roller coaster of life? Hidden synthetic cannabinoids and stimulants in apparently harmless products (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26216561
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PF-3845
Inhibition of monoacylglycerol lipase (MAGL) attenuates NSAID-induced gastric hemorrhages in mice (full–2011) http://jpet.aspetjournals.org/content/early/2011/06/09/jpet.110.175778.long
The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423256/
The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717616/
Dual Inhibition of Endocannabinoid Catabolic Enzymes Produces Enhanced Anti-Withdrawal Effects in Morphine-Dependent Mice (full–2013) http://www.ncbi.nlm.nih.gov/pubmed/23303065
Selective inhibition of FAAH produces antidiarrheal and antinociceptive effect mediated by endocannabinoids and cannabinoid-like fatty acid amides (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24460851
Toward modulation of the endocannabinoid system for treatment of gastrointestinal disease: FAAHster but not “higher” (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24641009
Endocannabinoid contribution to Δ9-tetrahydrocannabinol discrimination in rodents (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24858366
The fatty acid amide hydrolase inhibitor PF-3845 promotes neuronal survival, attenuates inflammation and improves functional recovery in mice with traumatic brain injury (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24937045
Full FAAH inhibition combined with partial monoacylglycerol lipase inhibition: Augmented and sustained antinociceptive effects with negligible cannabimimetic side effects in mice (full–2015) http://jpet.aspetjournals.org/content/early/2015/05/20/jpet.115.222851.long
Multiple Forms of Endocannabinoid and Endovanilloid Signaling Regulate the Tonic Control of GABA Release (full–2015)
http://www.jneurosci.org/content/35/27/10039.full?sid=7e769d1b-9b77-42fe-92d0-8b337b34b9b6
Endocannabinoid Catabolic Enzymes Play Differential Roles in Thermal Homeostasis in Response to Environmental or Immune Challenge (full–2015) http://link.springer.com/article/10.1007/s11481-015-9593-1
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PF-04457845
Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738192/
A Systems Pharmacology Perspective on the Clinical Development of Fatty Acid Amide Hydrolase Inhibitors for Pain (full–2014) http://www.nature.com/psp/journal/v3/n1/full/psp201372a.html
2012 Division of Medicinal Chemistry Award Address: Trekking the Cannabinoid Road: A Personal Perspective (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064474/
The FAAH inhibitor PF-04457845 has THC-like rewarding and reinstatement effects in squirrel monkeys and increases dopamine levels in the nucleus accumbens shell in rats (abst–2014) http://www.fasebj.org/content/28/1_Supplement/838.6.abstract?sid=db987fd0-3ef0-4796-aff6-4103f0c84daf
Blocking of fatty acid amide hydrolase activity with PF-04457845 in human brain: a positron emission tomography study with the novel radioligand [11C]CURB (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26082009


4(PM49)
Synthetic cannabinoid quinones: Preparation, in-vitro antiproliferative effects and in-vivo prostate antitumor activity (abst–2013) http://www.sciencedirect.com/science/article/pii/S0223523413006247


PSN-632408
Direct activation of the proposed anti-diabetic receptor, GPR119 in cardiomyoblasts decreases markers of muscle metabolic activity (abst–2015) http://www.sciencedirect.com/science/article/pii/S0303720715000106


R-FLURBIPROFEN
R-Flurbiprofen Reduces Neuropathic Pain in Rodents by Restoring Endogenous Cannabinoids (full-2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869361/
R-flurbiprofen, a novel nonsteroidal anti-inflammatory drug, decreases cell proliferation and induces apoptosis in pituitary adenoma cells in vitro (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/21938529
R-flurbiprofen improves tau, but not Aß pathology in a triple transgenic model of Alzheimer’s disease (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863610/
R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice (full–2014) http://embomolmed.embopress.org/content/6/11/1398.long


RHC-80267
Disease-Modifying Effects of RHC80267 and JZL184 in a Pilocarpine Mouse Model of Temporal Lobe Epilepsy (abst–2014) http://onlinelibrary.wiley.com/doi/10.1111/cns.12302/abstract
A Basal Tone of 2-Arachidonoylglycerol Contributes to Early Oligodendrocyte Progenitor Proliferation by Activating Phosphatidylinositol 3-Kinase (PI3K)/AKT and the Mammalian Target of Rapamycin (MTOR) Pathways (full–2015) http://link.springer.com/article/10.1007/s11481-015-9609-x/fulltext.html


RIMONABANT / ACOMPLIA / SR141716 / SR1
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2 (full–2010) http://pharmrev.aspetjournals.org/content/62/4/588.full.pdf+html
Therapeutical use of the cannabinoids in psychiatry (full–2010) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462010000500009&lng=en&nrm=iso&tlng=en
GPR55 ligands promote receptor coupling to multiple signalling pathways (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931561/?tool=pubmed
Rehashing endocannabinoid antagonists: can we selectively target the periphery to safely treat obesity and type 2 diabetes? (full–2010) http://www.jci.org/articles/view/44099?search%5Babstract_text%5D=&search%5Barticle_text%5D=cannabinoid&search%5Bauthors_text%5D=&search%5Bfpage%5D=&search%5Btitle_text%5D=&search%5Bvolume%5D=
Perspectives of CB1 Antagonist in Treatment of Obesity: Experience of RIO-Asia (full–2010) http://www.hindawi.com/journals/jobes/2011/957268/
Central and peripheral consequences of the chronic blockade of CB1 cannabinoid receptor with rimonabant or taranabant (full–2010) http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2009.06549.x/full
Energetic Metabolism and Human Sperm Motility: Impact of CB1 Receptor Activation (full–2010) http://endo.endojournals.org/content/151/12/5882.full
The Effects of Rimonabant on Brown Adipose Tissue in Rat: Implications for Energy Expenditure (full-2010) http://onlinelibrary.wiley.com/doi/10.1038/oby.2008.509/full
The Endocannabinoid System Tonically Regulates Inhibitory Transmission and Depresses the Effect of Ethanol in Central Amygdala (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904853/
Rimonabant-induced Delta9-tetrahydrocannabinol withdrawal in rhesus monkeys: discriminative stimulus effects and other withdrawal signs (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912042/pdf/zpt347.pdf
Anxiety-like effects of SR141716-precipitated delta9-tetrahydrocannabinol withdrawal in mice in the elevated plus-maze (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923489/
Reduced neural response to reward following 7 days treatment with the cannabinoid CB1 antagonist rimonabant in healthy volunteers (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/20426883
Suicides in other trials led to early termination of trial into effects of weight loss drug rimonabant on cardiovascular outcomes (CRESCENDO study) (news–2010) http://www.eurekalert.org/pub_releases/2010-08/l-sio081110.php
Risk of suicide spurs rimonabant trial to end (news–2010) http://www.thefreelibrary.com/Risk+of+suicide+spurs+rimonabant+trial+to+end.-a0238838571
Experimental obesity drug avoids brain effects that troubled predecessors (news–2010) http://phys.org/news197905295.html
Endocannabinoid system protects against cryptogenic seizures (full–2011) http://www.if-pan.krakow.pl/pjp/pdf/2011/1_165.pdf
Intracellular Cannabinoid Type 1 (CB1) Receptors Are Activated by Anandamide (full–2011) http://www.jbc.org/content/286/33/29166.full
Pharmacological activation/inhibition of the cannabinoid system affects alcohol withdrawal-induced neuronal hypersensitivity to excitotoxic insults (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158793/
CB(1) -independent mechanisms of Δ(9) -THCV, AM251 and SR141716 (rimonabant) (full–2011) http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2710.2011.01284.x/full
Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164582/
Sex Differences in Cannabinoid 1 vs. Cannabinoid 2 Receptor-Selective Antagonism of Antinociception Produced by Δ9-Tetrahydrocannabinol and CP55,940 in the Rat (full–2011) http://jpet.aspetjournals.org/content/340/3/787.full
The central cannabinoid CB1 receptor is required for diet-induced obesity and rimonabant’s antiobesity effects in mice (full–2011) http://onlinelibrary.wiley.com/doi/10.1038/oby.2011.250/full
Chronic Δ⁹-tetrahydrocannabinol treatment in rhesus monkeys: differential tolerance and cross-tolerance among cannabinoids (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051379/pdf/bph0162-1060.pdf
Psychiatric adverse effects of rimonobant in adults with Prader Willi syndrome (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038245/
CB1 receptors mediate rimonabant-induced pruritic responses in mice: investigation of locus of action (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606913/
Bioactivation Pathways of the Cannabinoid Receptor 1 Antagonist Rimonabant (full–2011) http://dmd.aspetjournals.org/content/39/10/1823.long
Effects of Chronic Oral Rimonabant Administration on Energy Budgets of Diet-Induced Obese C57BL/6 Mice (full–2011) http://www.ncbi.nlm.nih.gov/pubmed/22173576
Antagonist-elicited cannabis withdrawal in humans (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717344/
The role of the cannabinoid system in the pathogenesis and treatment of alcohol dependence (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21934185
The CB-1 Receptor Antagonist Rimonabant Modulates the Interaction Between Adipocytes and Pancreatic Beta-Cells in Vitro (abst–2011) https://www.thieme-connect.com/ejournals/abstract/10.1055/s-0030-1261963
The identification of rimonabant polymorphs, sibutramine and analogues of both in counterfeit Acomplia bought on the internet (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/20828968
Pro-epileptic effects of the cannabinoid receptor antagonist SR141716 in a model of audiogenic epilepsy (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21733658
Neuropsychiatric adverse effects of centrally acting antiobesity drugs (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21951371
Effects of the cannabinoid antagonist SR 141716 on sexual and motor behavior in receptive female rats (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21848907
A role for the ventral hippocampal endocannabinoid system in fear-conditioned analgesia and fear responding in the presence of nociceptive tone in rats (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21864979
CB1 cannabinoid receptor mediates glucocorticoid effects on hormone secretion induced by volume and osmotic changes (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/22211674
Naloxone and rimonabant reduce the reinforcing properties of exercise in rats (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21707193
Nonopioid placebo analgesia is mediated by CB1 cannabinoid receptors (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21963514
Smoking marijuana not linked to obesity: study (news–2011) http://www.reuters.com/article/2011/09/09/us-marijuana-obesity-idUSTRE7886TT20110909
Part of placebo effect ascribed to cannabinoids (news–2011) http://arstechnica.com/science/2011/10/is-the-placebo-effect-partially-caused-by-cannabinoids/
To Be or Not To Be—Obese (full–2012) http://endo.endojournals.org/content/152/10/3592.long
The effects of fasting duration on gastric emptying in man, an exploration of the role of the endocannabinoid system and inter-individual responsiveness (full–2012) http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2982.2012.01954.x/full
Probing the Interaction of SR141716A with the CB1 Receptor (full–2012) http://www.jbc.org/content/287/46/38741.full.pdf+html
The cannabinoid CB1 receptor antagonists rimonabant (SR141716) and AM251 directly potentiate GABAA receptors (full–2012) http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01405.x/full
Relationships between glucose, energy intake and dietary composition in obese adults with type 2 diabetes receiving the cannabinoid 1 (CB1) receptor antagonist, rimonabant (full–2012) http://www.nutritionj.com/content/11/1/50
Anandamide regulates the expression of GnRH1, GnRH2, and GnRH-Rs in frog testis (full–2012) http://ajpendo.physiology.org/content/303/4/E475.long
GPR18 in microglia: implications for the CNS and endocannabinoid system signaling (full–2012)http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02019.x/full
Angi otensin II induces vascular endocannabinoid release, which attenuates its vasoconstrictor effect via CB1 cannabinoid receptors (full–2012) http://www.jbc.org/content/early/2012/07/11/jbc.M112.346296.full.pdf+html
The role of CB2 receptor ligands in human eosinophil function (full–2012) http://www.biomedcentral.com/content/pdf/2050-6511-13-S1-A13.pdf
Hypothalamic CB1 Cannabinoid Receptors Regulate Energy Balance in Mice (full–2012) http://press.endocrine.org/doi/full/10.1210/en.2012-1405
The cannabinoid receptor CB1 modulates the signaling properties of the lysophosphatidylinositol receptor GPR55 (full–2012) http://www.jbc.org/content/early/2012/11/16/jbc.M112.364109.long
Rimonabant eliminates responsiveness to workload changes in a time-constrained food-reinforced progressive ratio procedure in rats (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387812/
Endocannabinoid signaling in female reproduction (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382454/
Extinction learning of rewards in the rat: is there a role for CB1 receptors? (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161161/
Pharmacological modulation of the endocannabinoid signalling alters binge-type eating behaviour in female rats (full–2012) http://onlinelibrary.wiley.com/doi/10.1111/bph.12014/full
Structural analogs of pyrazole and sulfonamide cannabinoids: Effects on acute food intake in mice (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586205/
Ghrelin-Induced Orexigenic Effect in Rats Depends on the Metabolic Status and Is Counteracted by Peripheral CB1 Receptor Antagonism (full–2013) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0060918
Novel Insights Into CB1 Cannabinoid Receptor Signaling: A Key Interaction Identified Between EC3-Loop and TMH2 (full–2013) http://jpet.aspetjournals.org/content/early/2013/02/21/jpet.112.201046.long
Astroglial CB1 cannabinoid receptors regulate leptin signaling in mouse brain astrocytes (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854987/
Diuretic effects of cannabinoids (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533417/
Cannabinoid signaling and liver therapeutics (full–2013) http://www.journal-of-hepatology.eu/article/S0168-8278%2813%2900212-2/fulltext
Bladder function in a cannabinoid receptor type 1 knock-out mouse (full–2013) http://onlinelibrary.wiley.com/doi/10.1111/bju.12350/full
Stimulatory and Inhibitory Roles of Brain 2-Arachidonoylglycerol in Bombesin-Induced Central Activation of Adrenomedullary Outflow in Rats (full–2013) https://www.jstage.jst.go.jp/article/jphs/121/2/121_12208FP/_pdf
Rimonabant effects on anxiety induced by simulated public speaking in healthy humans: a preliminary report (full–2013) http://onlinelibrary.wiley.com/doi/10.1002/hup.2374/full
Phencyclidine-induced social withdrawal results from deficient stimulation of cannabinoid CB1 receptors: implications for schizophrenia (full – 2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717536/
Activation of the sympathetic nervous system mediates hypophagic and anxiety-like effects of CB1 receptor blockade (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607008/
Reduced Food Intake is the Major Contributor to the Protective Effect of Rimonabant on Islet in Established Obesity-Associated Type 2 Diabetes (full–2013) http://www.eymj.org/DOIx.php?id=10.3349/ymj.2013.54.5.1127
Endocannabinoids as markers of sperm quality: hot spots (full–2013) http://www.frontiersin.org/Journal/10.3389/fendo.2013.00169/full
The Gastric CB1 Receptor Modulates Ghrelin Production through the mTOR Pathway to Regulate Food Intake (full–2013) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0080339
WIN55, 212-2 promotes differentiation of oligodendrocyte precursor cells and improve remyelination through regulation of the phosphorylation level of the ERK 1/2 via cannabinoid receptor 1 after stroke-induced demyelination (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23148948
Cannabis and Δ(9)-tetrahydrocannabinol (THC) for weight loss? (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23410498
Novel antiobesity agents: Synthesis and pharmacological evaluation of analogues of Rimonabant and of LH21 (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23434135
Additive effect of rimonabant and citalopram on extracellular serotonin levels monitored with in vivo microdialysis in rat brain (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23562616
The inverse agonist of CB1 receptor SR141716 blocks compulsive eating of palatable food (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23587012
Effects of CB1 receptor blockade on monosodium glutamate induced hypometabolic and hypothalamic obesity in rats (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23620336
Synergetic Insulin Sensitizing Effect of Rimonabant and BGP-15 in Zucker-Obes Rats (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23640247
Infusion of cannabidiol into infralimbic cortex facilitates fear extinction via CB1 receptors (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23643693
Effects of the cannabinoid 2 receptor-selective agonist GW405833 in assays of acute pain-stimulated and paindepressed behavior in rats (abst–2013) http://www.fasebj.org/cgi/content/meeting_abstract/27/1_MeetingAbstracts/886.9?sid=eea722c0-971c-4daa-8b8c-38c0c63c19ad
Sex differences in anti-allodynic, anti-hyperalgesic and anti-edema effects of Δ9-tetrahydrocannabinol in the rat (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23707295
Blockade of cannabinoid receptors reduces inflammation, leukocyte accumulation and neovascularization in a model of sponge-induced inflammatory angiogenesis (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23722450
Dysregulation of Cannabinoid CB1 Receptor and Associated Signaling Networks in Brains of Cocaine Addicts and Cocaine-Treated Rodents (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23727505
Rimonabant precipitates anxiety in rats withdrawn from palatable food: role of the central amygdale (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23793355
The Role of the Endocannabinoid System in Eating Disorders: Neurochemical and Behavioural Preclinical Evidence (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23829365
Low dose naloxone attenuates the pruritic but not anorectic response to rimonabant in male rats (abst – 2013)http://www.ncbi.nlm.nih.gov/pubmed/23142959
CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23860329
2-arachidonoylglycerol interferes with lithium-induced vomiting in the house musk shrew, Suncus murinus (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23958470
Anandamide transport inhibition by ARN272 attenuates nausea-induced behaviour in rats, and vomiting in shrews (Suncus murinus) (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23991698
Expression of the cannabinoid receptor type 1 in the pituitary of rabbits and its role in the control of LH secretion (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24099736
The combination of oral L-DOPA/rimonabant for effective dyskinesia treatment and cytological preservation in a rat model of Parkinson’s disease and L-DOPA-induced dyskinesia (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24196024
Endocannabinoids underlie reconsolidation of hedonic memories in Wistar rats (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24247477
Endocannabinoid Signaling in Hypothalamic-Pituitary-Adrenocortical Axis Recovery Following Stress: Effects of Indirect Agonists and Comparison of Male and Female Mice (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24316201
Tetrahydrocannabinolic acid reduces nausea-induced conditioned gaping in rats and vomiting in Suncus murinus (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23889598
Glutamate spillover drives endocannabinoid production and inhibits GABAergic transmission in the Substantia Nigra pars compacta (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24334069
The CB1 receptor mediates the peripheral effects of ghrelin on AMPK activity but not on growth hormone release (abst–2013) http://www.fasebj.org/content/27/12/5112.abstract?sid=7a3e6978-9a8c-4319-bca1-9f80fed2445f
Low brain CB1 receptor occupancy by a second generation CB1 receptor antagonist TM38837 in comparison with rimonabant in nonhuman primates: A PET study (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24293119
Islet cannabinoid receptors: cellular distribution and biological function (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24005231
New therapy for fragile X chromosome syndrome discovered (news–2013) http://www.sciencecodex.com/new_therapy_for_fragile_x_chromosome_syndrome_discovered-110170
Getting high on the endocannabinoid system (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997295/
Involvement of the Cannabinoid CB1 Receptor in Modulation of Dopamine Output in the Prefrontal Cortex Associated with Food Restriction in Rats (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954872/
Vascular targets for cannabinoids: animal and human studies (full–2014) http://onlinelibrary.wiley.com/doi/10.1111/bph.12560/full
2012 Division of Medicinal Chemistry Award Address: Trekking the Cannabinoid Road: A Personal Perspective (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064474/
Oleoylethanolamide: a novel potential pharmacological alternative to cannabinoid antagonists for the control of appetite (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996326/
Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders (full–2014) http://onlinelibrary.wiley.com/doi/10.1111/epi.12631/full
Prolonged monoacylglycerol lipase blockade causes equivalent CB1-receptor mediated adaptations in FAAH wild type and knockout mice (full–2014) http://jpet.aspetjournals.org/content/early/2014/05/21/jpet.114.212753.long
Δ9-tetrahydrocannabinol prevents methamphetamine-induced neurotoxicity (full–2014) http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0098079&representation=PDF
Effects of cannabinoid drugs on the deficit of prepulse inhibition of startle in an animal model of schizophrenia: the SHR strain (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915876/
Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934591/
The Endocannabinoid System – Back to the Scene of Cardiometabolic Risk Factors Control? (full–2014) https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0034-1375653
Early increase of cannabinoid receptor density after experimental traumatic brain injury in the newborn piglet (link to PDF–2014) http://www.ncbi.nlm.nih.gov/pubmed/24993629
Rimonabant’s reductive effects on high densities of food reinforcement, but not palatability, in lean and obese Zucker rats (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24398820
Evaluation of WIN 55,212-2 self-administration in rats as a potential cannabinoid abuse liability model (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24412835
CB1 blockade-induced weight loss over 48 weeks decreases liver fat in proportion to weight loss in humans (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/22828945
Cannabinoids inhibit cholinergic contraction in human airways through prejunctional CB1 receptors (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24467410
Microinjection of 2-arachidonoyl glycerol into the rat ventral hippocampus differentially modulates contextually induced fear, depending on a persistent pain state (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24494683
Guineensine is a novel inhibitor of endocannabinoid uptake showing cannabimimetic behavioral effects in BALB/c mice (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24412246
Micromolar concentrations of rimonabant directly inhibits delta opioid receptor specific ligand binding and agonist-induced G-protein activity (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24508403
Modulation of Fear Memory by Dietary Polyunsaturated Fatty Acids via Cannabinoid Receptors (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24518289
Effects of cannabinoid and vanilloid drugs on positive and negative-like symptoms on an animal model of schizophrenia: The SHR strain (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24556469
Evaluation of sex differences in cannabinoid dependence (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24582909
Involvement of cannabinoid receptor-1 activation in mitochondrial depolarizing effect of lipopolysaccharide in human spermatozoa (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24692267
Cannabinoid receptor type 1 receptors on GABAergic vs. glutamatergic neurons differentially gate sex-dependent social interest in mice (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24698342
The CB1 Receptor as an Important Mediator of Hedonic Reward Processing (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24718372
Anandamide attenuates haloperidol-induced vacuous chewing movements in rats (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24747871
Inhibition of Peripheral Fatty Acid Amide Hydrolase Depresses Activities of Bladder Mechanosensitive Nerve Fibers of the Rat (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24746881
Ultramicronized palmitoylethanolamide normalizes intestinal motility in a murine model of post-inflammatory accelerated transit: involvement of CB1 receptors and TRPV1 (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24818658
O-2050 facilitates noradrenaline release and increases the CB1 receptor inverse agonistic effect of rimonabant in the guinea pig hippocampus (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24853577
In vivo effects of synthetic cannabinoids JWH-018 and JWH-073 and phytocannabinoid Δ9-THC in mice: inhalation versus intraperitoneal injection (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24857780
Cannabinoids negatively modulate striatal glutamate and dopamine release and behavioural output of acute d-amphetamine (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24867330
The endocannabinoid anandamide regulates the peristaltic reflex by reducing neuro-neuronal and neuro-muscular neurotransmission in ascending myenteric reflex pathways in rats (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24911079
The endocannabinoid system and appetite: relevance for food reward (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24933167
Haloperidol and rimonabant increase delay discounting in rats fed high-fat and standard-chow diets (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25000488
CB1 receptor antagonism in the granular insular cortex or somatosensory area facilitates consolidation of object recognition memory (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25004406
Allosteric Modulation of a Cannabinoid G Protein-coupled Receptor BINDING SITE ELUCIDATION AND RELATIONSHIP TO G PROTEIN SIGNALING (abst–2014) http://www.jbc.org/content/289/9/5828.abstract?sid=9a3f2c47-b737-4ecc-b47c-2f6edbe16774
Ultralow doses of cannabinoid drugs protect the mouse brain from inflammation-induced cognitive damage (abst–2014) http://onlinelibrary.wiley.com/doi/10.1002/jnr.23452/abstract
Functional consequences of synthetic cannabinoid metabolites and CYP2C9 polymorphisms (abst–2014) http://www.fasebj.org/content/28/1_Supplement/838.4.abstract?sid=467bb529-0ecc-4ddc-af27-3f56f520a102
The FAAH inhibitor PF-04457845 has THC-like rewarding and reinstatement effects in squirrel monkeys and increases dopamine levels in the nucleus accumbens shell in rats (abst–2014) http://www.fasebj.org/content/28/1_Supplement/838.6.abstract?sid=db987fd0-3ef0-4796-aff6-4103f0c84daf
The potential of antiseizure drugs and agents that act on novel molecular targets as antiepileptogenic treatments (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24671870
Endocannabinoid Influence on Partner Preference in Female Rats (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25042777
Distinct modulation of the endocannabinoid system upon kainic acid-induced in vivo seizures and in vitro epileptiform bursting (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25064144
Marijuana may help blood sugar control, study says (news–2014) http://www.philly.com/philly/health/diabetes/Marijuana_may_help_blood_sugar_control_study_says.html
Cocaine-induced endocannabinoid release modulates behavioral and neurochemical sensitization in mice (full–2015) http://onlinelibrary.wiley.com/doi/10.1111/adb.12080/full
Role for Endogenous BDNF in Endocannabinoid-Mediated Long-Term Depression at Neocortical Inhibitory Synapses (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415885/
Cannabinoid receptor CB1 regulates STAT3 activity and its expression dictates the responsiveness to SR141716 treatment in human glioma patients’ cells (full–2015) http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D
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Biased Agonism and Biased Allosteric Modulation at the CB1 Cannabinoid Receptor  (full–2015) http://molpharm.aspetjournals.org/content/early/2015/06/04/mol.115.099192.long
A cannabinoid receptor agonist N-arachidonoyl dopamine inhibits adipocyte differentiation in human mesenchymal stem cells (full–2015)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428713/
Role of the endogenous cannabinoid system in nicotine addiction: novel insights (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373509/
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Endocannabinoid Catabolic Enzymes Play Differential Roles in Thermal Homeostasis in Response to Environmental or Immune Challenge (full–2015) http://tinyurl.com/jq67ymz
Hormonal status and age differentially affect tolerance to the disruptive effects of delta-9-tetrahydrocannabinol (Δ(9)-THC) on learning in female rats (full–2015) http://journal.frontiersin.org/article/10.3389/fphar.2015.00133/full
Homeostatic regulation of brain functions by endocannabinoid signaling (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468750/
Proapoptotic effect of endocannabinoids in prostate cancer cells (link to PDF–2015) http://www.spandidos-publications.com/10.3892/or.2015.3746
Effects of acute and repeated dosing of the synthetic cannabinoid CP55,940 on intracranial self-stimulation in mice (abst–2015)
http://www.sciencedirect.com/science/article/pii/S0376871615000423
Combined inhibition of monoacylglycerol lipase and cyclooxygenases synergistically reduces neuropathic pain in mice (abst–2015) http://onlinelibrary.wiley.com/doi/10.1111/bph.13012/abstract
Targeting cannabinoid receptor-2 pathway by phenylacetylamide suppresses the proliferation of human myeloma cells through mitotic dysregulation and cytoskeleton disruption (abst–2015) http://onlinelibrary.wiley.com/doi/10.1002/mc.22251/abstract
Effects of Fatty Acid Amide Hydrolase (FAAH) Inhibitors in Non-Human Primate Models of Nicotine Reward and Relapse (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25754762
Spinal neuronal cannabinoid receptors mediate urodynamic effects of systemic fatty acid amide hydrolase (FAAH) inhibition in rats (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25788026
Targeting cannabinoid receptor-2 pathway by phenylacetylamide suppresses the proliferation of human myeloma cells through mitotic dysregulation and cytoskeleton disruption (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25640641
Cannabinoid Receptor Interacting Protein 1a (CRIP1a) Modulates CB1 Receptor Signaling and Regulation (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25657338
Anandamide Drives Cell Cycle Progression through CB1 Receptors in a Rat Model of Synchronized Liver Regeneration (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25684344
The GPR55 agonist lysophosphatidylinositol mediates vasorelaxation of the rat mesenteric resistance artery and induces calcium release in rat mesenteric artery endothelial cells (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25652040
Rimonabant inhibits proliferation, collagen secretion and induces apoptosis in hepatic stellate cells (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25713910
Simultaneous inhibition of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) shares discriminative stimulus effects with ∆9-THC in mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25711338
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A PET study comparing receptor occupancy by five selective cannabinoid 1 receptor antagonists in non-human primates (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25791528
Effects of URB597 as an inhibitor of fatty acid amide hydrolase on WIN55, 212-2-induced learning and memory deficits in rats (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25689415
CB 1Cannabinoid Receptor Agonist Inhibits Matrix Metalloproteinase Activity in Spinal Cord Injury: A Possible Mechanism of Improved Recovery (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25881484
Anti Proliferative and Pro Apoptotic Effects of Flavonoid Quercetin Are Mediated by CB1 Receptor in Human Colon Cancer Cell Lines (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25893829
Role of cannabinoidergic system on food intake in neonatal layer-type chicken (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25902906
Inhibition of FAAH reduces nitroglycerin-induced migraine-like pain and trigeminal neuronal hyperactivity in mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25910421
Distinct roles of the endocannabinoids anandamide and 2-arachidonoylglycerol in social behavior and emotionality at different developmental ages in rats (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25914159
Epigenetic and Proteomic Expression Changes Promoted by Eating Addictive-like Behavior (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25944409
The endocannabinoid system and associative learning and memory in zebrafish (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25956869
Cannabinoid-Induced Chemotaxis in Bovine Corneal Epithelial Cells (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26024113
Microstructural analysis of rat ethanol and water drinking patterns using a modified operant self-administration model (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26037631
Endocannabinoid and nitric oxide interaction mediates food intake in neonatal chicken (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26053311
Modulatory effects by CB1 receptors on rat spinal locomotor networks after sustained application of agonists or antagonists (abst–2015)
http://www.ncbi.nlm.nih.gov/pubmed/26126926
Roles for the endocannabinoid system in ethanol-motivated behavior (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26123153
Influence of rimonabant treatment on peripheral blood mononuclear cells; flow cytometry analysis and gene expression profiling (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26157624
A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26161824
The impact of gonadal hormones on cannabinoid dependence (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26237318
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R(+)-METHANANANDAMIDE / AM-356
Energetic Metabolism and Human Sperm Motility: Impact of CB1 Receptor Activation (full–2010) http://endo.endojournals.org/content/151/12/5882.full
Anandamide capacitates bull spermatozoa through CB1 and TRPV1 activation (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037938/?tool=pubmed
Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1 (full–2011) http://www.fasebj.org/content/26/4/1535.long
Pharmacological elevation of anandamide impairs short-term memory by altering the neurophysiology in the hippocampus (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156972/
Effects of Cannabinoid Agonists on Sheep Sphincter of Oddi in vitro (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21921665
Anandamide Induces Sperm Release from Oviductal Epithelia through Nitric Oxide Pathway in Bovines (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281848/?tool=pubmed
Uncovering a role for endocannabinoid signaling in autophagy in preimplantation mouse embryos (full–2012) http://molehr.oxfordjournals.org/content/19/2/93.full
Neonatal DSP-4 Treatment Modifies Antinociceptive Effects of the CB(1) Receptor Agonist Methanandamide in Adult Rats (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526738/
GPR18 in microglia: implications for the CNS and endocannabinoid system signaling (full–2012) http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02019.x/full
Contrasting effects of different cannabinoid receptor ligands on mouse ingestive behavior (abst–2012) http://www.unboundmedicine.com/medline/ebm/record/22772336/abstract/Contrasting_effects_of_different_cannabinoid_receptor_ligands_on_mouse_ingestive_behaviour_
Long-term treatment with methanandamide attenuates LPS-induced periodontitis in rats (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22581275
Activation of Type 1 Cannabinoid Receptor (CB1R) Promotes Neurogenesis in Murine Subventricular Zone Cell Cultures (full–2013) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0063529
Anandamide modulates human sperm motility: implications for men with asthenozoospermia and oligoasthenoteratozoospermia (full–2013) http://humrep.oxfordjournals.org/content/28/8/2058.long
Diuretic effects of cannabinoids (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533417/
Endocannabinoids as markers of sperm quality: hot spots (full–2013) http://www.frontiersin.org/Journal/10.3389/fendo.2013.00169/full
Role of cannabinoid and vanilloid receptors in invasion of human breast carcinoma cells (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23394450
A new strategy to block tumor angiogenesis by inhibiting endocannabinoid inactivation (abst–2013) http://www.fasebj.org/cgi/content/meeting_abstract/27/1_MeetingAbstracts/1105.6?sid=eea722c0-971c-4daa-8b8c-38c0c63c19ad
Diuretic effects of cannabinoid agonists in mice (abst–2013) http://www.sciencedirect.com/science/article/pii/S0014299913007176
Repositioning therapy for thyroid cancer: new insights on established medications (full–2014) http://erc.endocrinology-journals.org/content/21/3/R183.long
Involvement of PAR-4 in Cannabinoid-Dependent Sensitization of Osteosarcoma Cells to TRAIL-Induced Apoptosis (full–2014) http://www.ijbs.com/v10p0466.htm
2012 Division of Medicinal Chemistry Award Address: Trekking the Cannabinoid Road: A Personal Perspective (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064474/
Identification of a Pharmacological Target for Genioglossus Reactivation throughout Sleep (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902869/
Cannabinoids inhibit angiogenic capacities of Endothelial cells via release of Tissue inhibitor of matrix metalloproteinases-1 from lung cancer cells (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24976505
Ligand Activation of Cannabinoid Receptors Attenuates Hypertrophy of Neonatal Rat Cardiomyocytes (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24979612
CANNABINOIDS INCREASE LUNG CANCER CELL LYSIS BY LYMPHOKINE-ACTIVATED KILLER CELLS VIA UPREGULATION OF ICAM-1 (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25069049
Biased Agonism and Biased Allosteric Modulation at the CB1 Cannabinoid Receptor (full–2015) http://molpharm.aspetjournals.org/content/early/2015/06/04/mol.115.099192.long
Bi-directional CB1 receptor-mediated cardiovascular effects of cannabinoids in anaesthetized rats: role of the paraventricular nucleus (full–2015) http://www.jpp.krakow.pl/journal/archive/06_15/pdf/343_06_15_article.pdf
Proapoptotic effect of endocannabinoids in prostate cancer cells (link to PDF– 2015) http://www.spandidos-publications.com/10.3892/or.2015.3746
Synthetic and endogenous cannabinoids protect retinal neurons from AMPA excitotoxicity in vivo, via activation of CB1 receptors: Involvement of PI3K/Akt and MEK/ERK signaling pathways (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25989217


Ro 61-8048
Scientists Have Found A Way To Make Marijuana Un-Fun (news–2013) http://www.popsci.com/article/science/scientists-have-found-way-make-marijuana-un-fun


RQ-00202730
Identification of a highly potent and selective CB2 agonist, RQ-00202730, for the treatment of irritable bowel syndrome (abst–2014)
http://www.ncbi.nlm.nih.gov/pubmed/25499880


S-444823
Discovery of S-444823, a potent CB1/CB2 dual agonist as an antipruritic agent (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22421019
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S-777469
Discovery of S-777469: an orally available CB2 agonist as an antipruritic agent (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22444677
Non-clinical evaluation of the metabolism, pharmacokinetics and excretion of S-777469, a new cannabinoid receptor 2 selective agonist (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/23763649
S-777469, a Novel Cannabinoid Type 2 Receptor Agonist, Suppresses Itch-Associated Scratching Behavior in Rodents through Inhibition of Itch Signal Transmission (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25721168


SA-57
Delta-9 tetrahydrocannabinol (THC) and endocannabinoid degradative enzyme inhibitors attenuate intracranial self-stimulation (ICSS) in mice (full–2014) http://jpet.aspetjournals.org/content/early/2014/11/14/jpet.114.218677.long
Simultaneous inhibition of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) shares discriminative stimulus effects with ∆9-THC in mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25711338


SAB-378
Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone (SAB378), a peripherally restricted cannabinoid CB1/CB2 receptor agonist, inhibits gastrointestinal motility but has no effect on experimental colitis in mice (full–2010) http://jpet.aspetjournals.org/content/334/3/973.long
Control of spasticity in a multiple sclerosis model using central nervous system-excluded CB1 cannabinoid receptor agonists (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24121462
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SAD-448
Control of spasticity in a multiple sclerosis model using central nervous system-excluded CB1 cannabinoid receptor agonists (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24121462


SAR-127303
Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284516/


SMM–189
Motor, Visual and Emotional Deficits in Mice after Closed-Head Mild Traumatic Brain Injury Are Alleviated by the Novel CB2 Inverse Agonist SMM-189 (full–2015) http://www.mdpi.com/1422-0067/16/1/758/htm


SPICE-NEWS
Inhaled Incense “K2” May Cause Heart Damage (news–2010) http://drwes.blogspot.com/2010/08/inhaled-incense-k2-may-cause-heart.html
The New Cannabinoids (news–2010) http://www.wellsphere.com/drug-addiction-article/the-new-cannabinoids/1247426
Outlawing ‘Legal Highs:’ Can Emergency Bans Hinder Drug Development? (news–2011) http://healthland.time.com/2011/02/23/outlawing-legal-highs-can-emergency-bans-hinder-drug-development/
1 in 9 high school seniors using synthetic marijuana (news–2011) http://thechart.blogs.cnn.com/2011/12/14/1-in-9-high-school-seniors-using-synthetic-marijuana/
‘Fake Marijuana’ May Trigger Heart Trouble in Teens (news–2011) http://usatoday30.usatoday.com/news/health/story/health/story/2011-11-09/Fake-marijuana-may-trigger-heart-trouble-in-teens/51133266/1
Texas teens had heart attacks after smoking K2 (news–2011) http://www.reuters.com/article/2011/11/07/us-teens-heart-attacks-smoking-idUSTRE7A66TN20111107
Chemicals Used in “Spice” and “K2” Type Products Now Under Federal Control and Regulation (news–2011) http://www.justice.gov/dea/pubs/pressrel/pr030111.html
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Synthetic cannabis linked to extended psychosis (news–2011) http://medicalxpress.com/news/2011-05-synthetic-cannabis-linked-psychosis.html
‘Hammer Head’ ‘incense’ blamed for seizure of youth in Le Roy (news–2012) http://thebatavian.com/howard-owens/hammer-head-incense-blamed-seizure-youth-le-roy/29983
Synthetic marijuana was created strictly for research at Clemson (news – 2012) http://www.timesnews.net/article/9042095/synthetic-marijuana-was-created-strictly-for-research-at-clemson
Why K2 is Pimps’ Choice for Controlling Young Sex Workers (news–2012) http://blogs.scientificamerican.com/white-noise/2012/09/17/why-k2-is-pimps-choice-for-controlling-young-sex-workers/
Outbreak of kidney failure in Wyoming linked to “Spice” (news–2012) http://www.reuters.com/article/2012/03/03/us-spice-illness-wyoming-idUSTRE82204T20120303
‘Spice’-y Party Drugs Can Lead to the ED (news–2012) http://www.medpagetoday.com/EmergencyMedicine/EmergencyMedicine/32690
Wyoming kidney failure outbreak linked to designer ‘blueberry spice’ drug, aka ‘legal marijuana’ (news–2012) http://www.naturalnews.com/035181_spice_recreational_drugs_kidney_failure.html
Blueberry “spice” in Wyoming linked to cases of renal failure (news–2012) http://www.thepoisonreview.com/2012/03/03/blueberry-spice-in-wyoming-linked-to-cases-of-renal-failure/
New health concerns about ‘fake pot’ in US (news–2012) http://medicalxpress.com/news/2012-03-health-fake-pot.html
Tachycardia followed by bradycardia after smoking the synthetic cannabinoid “K9″ (news–2012) http://www.thepoisonreview.com/2012/05/22/tachycardia-followed-by-bradycardia-after-smoking-the-synthetic-cannabinoid-k9/
Synthetic marijuana sent more than 11,400 people to ER in 2010 (news–2012) http://www.cbsnews.com/8301-204_162-57557080/synthetic-marijuana-sent-more-than-11400-people-to-er-in-2010/
With Labs Pumping Out Legal Highs, China Is the New Front in the Global Drug War (news–2013) http://world.time.com/2013/09/02/with-labs-pumping-out-legal-highs-china-is-the-new-front-in-the-global-drugs-war/
Teen narrowly escapes death after smoking synthetic marijuana (news–2013) http://www.cnn.com/2013/02/04/health/synthetic-marijuana-irpt/index.html?iref=allsearch
Synthetic Marijuana Dangerous for Kidneys (news–2013) http://www.sciencedaily.com/releases/2013/02/130208124553.htm
Study: Consumers Prefer Natural Cannabis Over Synthetic ‘Marijuana’ Herbal Products (news–2013) http://norml.org/news/2013/01/10/study-consumers-prefer-natural-cannabis-over-synthetic-marijuana-herbal-products
Synthetic Marijuana Harms Kidneys of 16 Users, CDC Reports (news–2013) http://news.yahoo.com/synthetic-marijuana-harms-kidneys-16-users-cdc-reports-170208780.html
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Synthetic cannabis: how it’s made, what’s in it (news–2013) http://www.3news.co.nz/Synthetic-cannabis-how-its-made-whats-in-it/tabid/423/articleID/297471/Default.aspx
Death link to synthetic cannabis (news–2013) http://www.nzherald.co.nz/nz/news/article.cfm?c_id=1&objectid=10882473&ref=rss
Synthetic drugs carry risk of kidney damage (news–2013) http://www.stuff.co.nz/timaru-herald/news/8558914/Synthetic-drugs-carry-risk-of-kidney-damage
High K2 use rate among psych unit patients (news 2013) http://www.odt.co.nz/news/national/262756/high-k2-use-rate-among-psych-unit-patients
‘Legal high’ users turn to real thing (news-2013) http://www.odt.co.nz/news/national/266889/legal-high-users-turn-real-thing
Survey: Teens using synthetic drugs less often (news–2013) http://news.yahoo.com/survey-teens-using-synthetic-drugs-less-often-050311100.html;_ylt=AwrSyCRcGbJSljYA1CTQtDMD
Synthetic Marijuana Added to Defense Department Drug Testing (news–2013) http://www.drugfree.org/join-together/drugs/synthetic-marijuana-added-to-defense-department-drug-testing
Smoking “spice” associated with stroke in healthy, young adults (news–2013) http://www.medicalnewstoday.com/releases/269132.php
Synthetic Drug Use Skyrocketing, Targeting Young Users (news–2014) http://blogs.psychcentral.com/science-addiction/2014/06/synthetic-drug-use-skyrocketing-targeting-young-users/
Study identifies teens at-risk for synthetic marijuana use (news–2015) http://www.sciencedaily.com/releases/2015/03/150302091659.htm
Synthetic pot linked to kidney injury (news–2015) http://www.newschannel10.com/story/28652118/synthetic-pot-linked-to-kidney-injury
7 possible deaths linked to spice (news–2015) http://www.msnewsnow.com/story/28853152/7-possible-deaths-linked-to-spice
Synthetic ‘marijuana’ isn’t pot, isn’t safe (news–2015) http://www.washingtontimes.com/news/2015/may/6/nina-radcliff-synthetic-marijuana-isnt-pot-isntsa/?utm_source=RSS_Feed&utm_medium=RSS
Calls to Poison Control Centers Linked to Synthetic Marijuana Spike 229%, CDC Says (news–2015) http://abcnews.go.com/Health/calls-poison-control-centers-linked-synthetic-marijuanaspike/story?id=31703572
Synthetic drugs: evidence that they can cause cancer (news–2015) http://www.alphagalileo.org/ViewItem.aspx?ItemId=151742&CultureCode=en
A stunning number of new ‘legal high’ drugs are being discovered (news–2015) http://www.businessinsider.com/new-legal-high-drugs-are-being-discovered-2015-6#ixzz3gHaeROGT
Deaths triple from synthetic marijuana in US (news–2015) http://medicalxpress.com/news/2015-06-deaths-triple-synthetic-marijuana.html
How this chemist unwittingly helped spawn the synthetic drug industry (news–2015)
http://www.washingtonpost.com/local/social-issues/how-a-chemist-unwittingly-helped-spawn-thesynthetic-drug-epidemic/2015/08/09/94454824-3633-11e5-9739-170df8af8eb9_story.html
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SPICE-STUDIES
Atypical diabetic ketoacidosis: case report (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342127/
Cardiovascular side effects related with use of synthetic cannabinoids “bonzai” : two case reports (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462325/
Synthetic cannabis-induced mania (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369931/
Synthetic cannabinoids as a cause for black carbonaceous bronchoalveolar lavage (full–2015) http://casereports.bmj.com/content/2015/bcr-2015-211391.full.pdf
Legal highs: staying on top of the flood of novel psychoactive substances (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521440/
Notes from the Field: Increase in Reported Adverse Health Effects Related to Synthetic Cannabinoid Use – United States, January-May 2015 (report–2015) http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6422a5.htm
Spice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25584561
The adverse health effects of synthetic cannabinoids with emphasis on psychosis-like effects (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25586398
Synthetic cannabinoid withdrawal: A new demand on detoxification services (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25588420
A Synthetic Cannabinoid MAM-2201 Potently Suppresses Synaptic Transmission via Activation of Presynaptic CB1 Receptors and Reduces Synaptically-Evoked Intracellular Ca2+ Transients in Cerebellar Purkinje Cells (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25747605
Synthetic cannabinoid use in a nationally representative sample of US high school seniors (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25736618
A Common Source Outbreak of Severe Delirium Associated with Exposure to the Novel Synthetic Cannabinoid ADB-PINACA (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25726258
Risk of emergency medical treatment following consumption of cannabis or synthetic cannabinoids in a large global sample (abst–2015)
http://www.ncbi.nlm.nih.gov/pubmed/25759401
Synthetic cannabinoid use in a nationally representative sample of US high school seniors (abst–2015) http://www.drugandalcoholdependence.com/article/S0376-8716%2815%2900079-4/abstract
Genotoxic properties of representatives of alkylindazoles and aminoalkyl-indoles which are consumed as synthetic cannabinoids (abst–2015)
http://www.ncbi.nlm.nih.gov/pubmed/25792264
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Withdrawal Seizures Seen In the Setting of Synthetic Cannabinoid Abuse (abst–2015) http://www.ajemjournal.com/article/S0735-6757%2815%2900169-2/abstract
Synthetic cannabinoids pharmacokinetics and detection methods in biological matrices (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25853390
Synthetic cannabinoids: spread, addiction biology & current perspective of personal health hazard (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25893495
Case reports of synthetic cannabinoid XLR-11 associated fatalities (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25979131
JWH-018 impairs sensorimotor functions in mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25987201
Thalamic and Cerebellar Gray Matter Volume Reduction in Synthetic Cannabinoids Users (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26021304
K2 and Spice use among a cohort of college students in southeast region of the USA (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26030768
Δ9-Tetrahydrocannabinol-like effects of novel synthetic cannabinoids found on the gray market (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26061356
“Legal Highs” – An Emerging Epidemic of Novel Psychoactive Substances (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26070762
Synthetic Cannabinoids (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26132518
Quantitation of Synthetic Cannabinoids in Plant Materials Using High Performance Liquid Chromatography with UV Detection (Validated Method) (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26175160
Hyperthermia and severe rhabdomyolysis from synthetic cannabinoids (abst–2015) http://www.ajemjournal.com/article/S0735-6757%2815%2900490-8/abstract
Myocardial Ischemia Secondary to Synthetic Cannabinoid (K2) Use in Pediatric Patients (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26165442
Psyclones: a roller coaster of life? Hidden synthetic cannabinoids and stimulants in apparently harmless products (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26216561
A New Threat: Synthetic Marijuana Associated Lung Disease (abst–2015) http://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2015.191.1_MeetingAbstracts.A4684
“Spice” Can Really Heat Things Up (abst–2015) http://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2015.191.1_MeetingAbstracts.A4600
Acute Eosinophilic Pneumonia With Respiratory Failure Induced By ‘Bonzai’ (Synthetic Cannabinoid) Inhalation (abst–2015) http://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2015.191.1_MeetingAbstracts.A1496
K2 and Spice use among a cohort of college students in southeast region of the USA (abst–2015) http://informahealthcare.com/doi/abs/10.3109/00952990.2015.1043438
Teenage Cardiac Arrest Following Abuse of Synthetic Cannabis (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26256565


SR-144528
CB2 Cannabinoid Receptors Promote Neural Progenitor Cell Proliferation via mTORC1 Signaling (full–2011) http://www.jbc.org/content/287/2/1198.full
N-arachidonoyl–serine is neuroprotective after traumatic brain injury by reducing apoptosis (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170948/
The effects of peptide and lipid endocannabinoids on arthritic pain at the spinal level (full–2012) http://journals.lww.com/anesthesia-analgesia/Fulltext/2012/06000/The_Effects_of_Peptide_and_Lipid_Endocannabinoids.30.aspx
Stabilization of Functional Recombinant Cannabinoid Receptor CB2 in Detergent Micelles and Lipid Bilayers (full–2013) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0046290
Endocannabinoids as markers of sperm quality: hot spots (full–2013) http://www.frontiersin.org/Journal/10.3389/fendo.2013.00169/full
Novel antiobesity agents: Synthesis and pharmacological evaluation of analogues of Rimonabant and of LH21 (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23434135
Characterisation of cannabinoid-induced relief of neuropathic pain in a rat model of cisplatin-induced neuropathy (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23454533
Effects of the cannabinoid 2 receptor-selective agonist GW405833 in assays of acute pain-stimulated and paindepressed behavior in rats (abst–2013) http://www.fasebj.org/cgi/content/meeting_abstract/27/1_MeetingAbstracts/886.9?sid=eea722c0-971c-4daa-8b8c-38c0c63c19ad
Sex differences in anti-allodynic, anti-hyperalgesic and anti-edema effects of Δ9-tetrahydrocannabinol in the rat (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23707295
Blockade of cannabinoid receptors reduces inflammation, leukocyte accumulation and neovascularization in a model of sponge-induced inflammatory angiogenesis (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23722450
Blockade of cannabinoid CB1 and CB2 receptors does not prevent the antipruritic effect of systemic paracetamol (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24399199
Cannabinoids inhibit cholinergic contraction in human airways through prejunctional CB1 receptors (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24467410
Detailed characterization of the endocannabinoid system in human macrophages and foam cells, and anti-inflammatory role of type-2 cannabinoid receptor (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24529123
Inhibition of Peripheral Fatty Acid Amide Hydrolase Depresses Activities of Bladder Mechanosensitive Nerve Fibers of the Rat (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24746881
Cannabinoid type 2 receptor stimulation attenuates brain edema by reducing cerebral leukocyte infiltration following subarachnoid hemorrhage in rats (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24819918
Attenuation of serotonin-induced itch responses by inhibition of endocannabinoid degradative enzymes, fatty acid amide hydrolase and monoacylglycerol lipase (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24915981
Ultralow doses of cannabinoid drugs protect the mouse brain from inflammation-induced cognitive damage (abst–2014) http://onlinelibrary.wiley.com/doi/10.1002/jnr.23452/abstract


SURINABANT / SR 147778
Efficacy of a dose range of surinabant, a cannabinoid receptor blocker, for smoking cessation: a randomized controlled clinical trial (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22219220
Surinabant, a selective CB(1) antagonist, inhibits THC-induced central nervous system and heart rate effects in humans (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703229/
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