D-J (Synthetics 2010+)

*Previous studies Pre-2010 List

SYNTHETICS and COMPOUNDS THAT AFFECT the ECS 2010-2015

DEXANABINOL (See HU-211)
DH-CBD / DEHYDROXYLCANNABIDIOL (Non-psychoactive Cannabinoid)
DIPYRONE / METAMIZOL (NSAID That Works by Activating CB1 Receptors)
DRONABINOL (See MARINOL)
ENP11 (Potent CB1 Antagonist, Analog of Rimonabant)
ETS-2101 (See HU-211)
[18F]MK-9470 (Radioligand With High Affinity For CB1 Receptors)
FUBIMINA (CB1 and CB2 Agonist)
GP-1a (CB2 Agonist)
GW-6471 (PPAR-α Antagonist)
GW-405833
HEXAHYDROCANNABINOLS
HU-210 (CB1 and CB2 Agonist Over 100 Times Stronger Than THC)
HU-211 / DEXANABINOL / DEXANABINONE / SINNABIDOL / ETS-2101 / PA 50211 / PRS 211007 (CB2 Agonist)
HU-239 (See Ajulemic Acid)
HU-308 (CB2 Agonist)
HU-331 (Derived From CBD, Mechanism Of Action Not Established)
HU-910 (CB2 Agonist)
IBIPINABANT / IBI (Powerful CB1 Antagonist, Causes Heart Damage in Dogs)
IBUPROFEN* (Blocks Breakdown of Anandamide [Which is What Actually Relieves Your Pain])
IR700DX-mbc94 (CB2-Targeted Photosensitizer)
JBT-101 (Ultra Purified Form of Ajulmic Acid)
JD-5037 (CB1 Agonist With Limited Brain Penetration)
JWH-015* (CB2 and GPR-55 Agonist, Mildly Activates CB1 Receptors)
JWH-018* (CB1 Agonist)
JWH-019 (CB1 and CB2 Agonist)
JWH-073* (CB1 and CB2 Agonist)
JWH-81 (CB1 Agonist)
JWH-100 / AM-678  (CB1 Agonist)
JWH-122 (CB1 Agonist)
JWH-133 / 3-(1_1_-dimethylbutyl)-1-deoxy-_8-THC* (CB2 Agonist)
JWH-150 (CB2 Agonist)
JWH-200 (CB1 Agonist)
JWH-210 (CB1 Agonist)
JWH-250 (CB1 Agonist)
JZL-184* (Blocks Breakdown of 2-AG)
JZL-195 (Stops Breakdown of Anandamide and 2-AG)


DH-CBD / DEHYDROXYLCANNABIDIOL (Non-psychoactive Cannabinoid)
Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24390226


DIPYRONE / METAMIZOL
Metamizol, a non-opioid analgesic, acts via endocannabinoids in the PAG-RVM axis during inflammation in rats (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22337336
Involvement of cannabinoid CB1 receptors in the antinociceptive effect of dipyrone (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23784345
Cannabinoid CB1 receptors mediate the effects of dipyrone (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25430877


ENP11
ENP11, a potential CB1R antagonist, induces anorexia in rats (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26072692


[18F]MK-9470
In vivo activation of endocannabinoid system in temporal lobe epilepsy with hippocampal sclerosis (full–2011) http://brain.oxfordjournals.org/content/134/4/1033.long


FUBIMINA
AB-CHMINACA, AB-PINACA, and FUBIMINA: Affinity and Potency of Novel Synthetic Cannabinoids in Producing Δ9-Tetrahydrocannabinol-Like Effects in Mice (full–2015) http://jpet.aspetjournals.org/content/early/2015/06/23/jpet.115.225326.long


GP-1a
Immunoregulation of a CB2 receptor agonist in a murine model of neuroAIDS (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109320/
Distribution and function of the endocannabinoid system in the rat and human bladder (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/23081739
Activation of Cannabinoid Receptor 2 Inhibits Experimental Cystitis (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652164/
Attenuation of HIV-1 replication in macrophages by cannabinoid receptor 2 agonists (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629438/
Functional relevance of the cannabinoid receptor 2 – heme oxygenase pathway: A novel target for the attenuation of portal hypertension (abst–2013)  http://www.ncbi.nlm.nih.gov/pubmed/24007798
Treatment with a Cannabinoid Receptor 2 Agonist Decreases Severity of Established Cystitis (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24184363
Selective CB2 receptor activation ameliorates EAE by reducing Th17 differentiation and immune cell accumulation in the CNS (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24342422
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CB2R orchestrates fibrogenesis through regulation of inflammatory response during the repair of skeletal muscle contusion (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466920/


GW-6471
Peroxisome Proliferator-Activated Receptor-α Inhibition Protects Against Doxorubicin Induced Cardiotoxicity in Mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26082188


GW-405833
Paradoxical effects of the cannabinoid CB2 receptor agonist GW405833 on rat osteoarthritic knee joint pain (full–2010) http://www.oarsijournal.com/article/S1063-4584%2810%2900315-8/fulltext
Brain cannabinoid CB2 receptors modulate cocaine’s actions in mice (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164946/
Dynamic changes to the endocannabinoid system in models of chronic pain (full-2012) http://rstb.royalsocietypublishing.org/content/367/1607/3300.full?sid=1569c370-cd5c-4358-89ff-857201f5e069
Cannabinoid Receptor 2 Protects against Acute Experimental Sepsis in Mice (full–2013) http://www.hindawi.com/journals/mi/2013/741303/
Endocannabinoid signaling in the gut mediates preference for dietary unsaturated fats (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659363/
Effects of the cannabinoid 2 receptor-selective agonist GW405833 in assays of acute pain-stimulated and paindepressed behavior in rats (abst–2013)  http://www.fasebj.org/cgi/content/meeting_abstract/27/1_MeetingAbstracts/886.9?sid=eea722c0-971c-4daa-8b8c-38c0c63c19ad
Cannabinoids as therapeutic agents in cancer: current status and future implications (link to PDF-2014) http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=2233
The cannabinoid CB2 receptor agonist GW405833 does not ameliorate brain damage induced by hypoxia-ischemia in rats (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24721671
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GW-9508
Activation of G-protein-coupled receptor 40 attenuates the cisplatin-induced apoptosis of human renal proximal tubule epithelial cells (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25092426
Dose-response estrogen promotes osteogenic differentiation via GPR40 (FFAR1) in murine BMMSCs (abst-2015)  http://www.ncbi.nlm.nih.gov/pubmed/25576830


HEXAHYDROCANNABINOLS
Involvement of NSAID-activated gene-1 in a novel synthetic hexahydrocannabinol analogue-induced growth inhibition and apoptosis of colon cancer cells (abst–2010) http://www.fasebj.org/cgi/content/meeting_abstract/24/1_MeetingAbstracts/965.8?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=Hexahydrocannabinol&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT
Induction of p53-independent apoptosis by a novel synthetic hexahydrocannabinol analog is mediated via Sp1-dependent NSAID-activated gene-1 in colon cancer cells (abst–2010) http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T4P-4YM7FF0-2&_user=10&_coverDate=07%2F01%2F2010&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1313682160&_rerunOrigin=scholar.google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=6f222e32968fcf27444674d5217dcecb
Novel hexahydrocannabinol analogs as potential anti-cancer agents inhibit cell proliferation and tumor angiogenesis (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/20950604
Anti-tumor activity of the novel hexahydrocannabinol analog LYR-8 in Human colorectal tumor xenograft is mediated through the inhibition of Akt and hypoxia-inducible factor-1α activation (full–2012) https://www.jstage.jst.go.jp/article/bpb/35/6/35_b12-00020/_pdf
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HU-210
Involvement of cannabinoid-1 and cannabinoid-2 receptors in septic ileus (full–2010) http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2982.2009.01419.x/pdf
Antitumorigenic Effects of Cannabinoids beyond Apoptosis (full–2010) http://jpet.aspetjournals.org/content/332/2/336.full?sid=af53ea87-ab4b-426e-9c7e-8f750e9c4a17
Regulation of nausea and vomiting by cannabinoids (full–2010) http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2010.01176.x/pdf
Now, There’s a Test for That — Norchem’s “Fake Marijuana” Test Reveals Significantly Increased Abuse of Spice/K2 (news–2010)http://www.marketwire.com/press-release/Now-Theres-Test-That-Norchems-Fake-Marijuana-Test-Reveals-Significantly-Increased-Abuse-1356247.htm
The potential for clinical use of cannabinoids in treatment of cardiovascular diseases (full–2011) http://onlinelibrary.wiley.com/doi/10.1111/j.1755-5922.2010.00233.x/pdf
Beyond THC: The New Generation of Cannabinoid Designer Drugs (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187647/?tool=pubmed
Investigating a not-so-natural high (full–2011) http://pubs.acs.org/doi/full/10.1021/ac900564u
Cannabinoid Receptor Type 1 Protects Nigrostriatal Dopaminergic Neurons against MPTP Neurotoxicity by Inhibiting Microglial Activation (full–2011) http://www.jimmunol.org/content/187/12/6508.full?sid=c3422dd2-7ad0-42e4-a862-845dc670f7cf
Pharmacological activation/inhibition of the cannabinoid system affects alcohol withdrawal-induced neuronal hypersensitivity to excitotoxic insults (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158793/
The effects of cannabinoid drugs on abnormal involuntary movements in dyskinetic and non-dyskinetic 6-hydroxydopamine lesioned rats (abst–2011) http://www.unboundmedicine.com/medline/ebm/record/20888328/abstract/The_effects_of_cannabinoid_drugs_on_abnormal_involuntary_movements_in_dyskinetic_and_non_dyskinetic_6_hydroxydopamine_lesioned_rats_
Increased brain metabolism after acute administration of the synthetic cannabinoid HU210: A small animal PET imaging study with (18)F-FDG (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/22155282
Cannabinoid HU210 Protects Isolated Rat Stomach against Impairment Caused by Serum of Rats with Experimental Acute Pancreatitis (full-2012) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0052921
Activation of Cannabinoid Receptor 2 reduces inflammation in acute experimental pancreatitis via intra-acinar activation of p38 and MK2-dependent mechanisms (full–2012) http://ajpgi.physiology.org/content/304/2/G181
Spice drugs are more than harmless herbal blends: A review of the pharmacology and toxicology of synthetic cannabinoids (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936256/
The anti-nausea effects of CB(1) agonists are mediated by an action at the visceral insular cortex (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492992/
The periaqueductal gray contributes to bidirectional enhancement of antinociception between morphine and cannabinoids (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959123/
Acute cannabinoids impair working memory through astroglial CB1 receptor modulation of hippocampal LTD (full–2012) http://www.sciencedirect.com/science/article/pii/S0092867412001420
Contrasting effects of different cannabinoid receptor ligands on mouse ingestive behavior (abst–2012) http://www.unboundmedicine.com/medline/ebm/record/22772336/abstract/Contrasting_effects_of_different_cannabinoid_receptor_ligands_on_mouse_ingestive_behaviour_
Long-term use of HU210 adversely affects spermatogenesis in rats by modulating the endocannabinoid system (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22435752
Simultaneous analysis of several synthetic cannabinoids, THC, CBD and CBN, in hair by ultra-high performance liquid chromatography tandem mass spectrometry. Method validation and application to real samples (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22576873
The spice in France: mixed herbs containing synthetic cannabinoids (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22796613
Analgesic effects of cannabinoids on central pain syndrome (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22359935
Synthetic Cannabinoid and Cathinone Use Among US Soldiers (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/23007932
Increased brain metabolism after acute administration of the synthetic cannabinoid HU210: a small animal PET imaging study with 18F-FDG (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22155282
Long-term use of HU210 adversely affects spermatogenesis in rats by modulating the endocannabinoid system (abst – 2012) http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2605.2012.01259.x/abstract
Cannabinoid HU210 Protects Isolated Rat Stomach against Impairment Caused by Serum of Rats with Experimental Acute Pancreatitis (full–2013) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0052921
Neuron-type specific cannabinoid-mediated G protein signalling in mouse hippocampus (full–2013) http://onlinelibrary.wiley.com/doi/10.1111/jnc.12137/full
Transdermal delivery of cannabidiol Patent 8435556 (full–2013) https://www.google.com/patents/US8435556
Getting up to speed with the public health and regulatory challenges posed by new psychoactive substances in the information age (editorial–2013) http://onlinelibrary.wiley.com/doi/10.1111/add.12287/full
Synthetic Cannabinoids -The Challenges of Testing for Designer Drugs (article–2013) (funky link- delete the “sign in”, and it comes up) http://www.aacc.org/publications/cln/2013/february/Pages/Cannabinoids.aspx?PassThru=ok&PersonID=206339#
Functional Residues Essential for the Activation of the CB1 Cannabinoid Receptor (abst-2013) http://www.ncbi.nlm.nih.gov/pubmed/23332708
Effects of cannabinoids and related fatty acids upon the viability of P19 embryonal carcinoma cells (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23552853
Cytotoxicity of synthetic cannabinoids on primary neuronal cells of the forebrain: the involvement of cannabinoid CB1 receptors and apoptotic cell death (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24211273
Simultaneous quantification of 20 synthetic cannabinoids and 21 metabolites, and semi-quantification of 12 alkyl hydroxy metabolites in human urine by liquid chromatography-tandem mass spectrometry (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24418231
Vascular targets for cannabinoids: animal and human studies (full–2014) http://onlinelibrary.wiley.com/doi/10.1111/bph.12560/full
Understanding itch: An update on mediators and mechanisms of pruritus (full–2014) http://www.ijdvl.com/article.asp?issn=0378-6323;year=2014;volume=80;issue=2;spage=106;epage=114;aulast=Hassan
Neuroprotective effects of the cannabinoid agonist HU210 on retinal degeneration (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24495949
Promising cannabinoid-based therapies for Parkinson’s disease: motor symptoms to neuroprotection (full–2015) http://www.molecularneurodegeneration.com/content/pdf/s13024-015-0012-0.pdf
Biased Agonism and Biased Allosteric Modulation at the CB1 Cannabinoid Receptor (full–2015) http://molpharm.aspetjournals.org/content/early/2015/06/04/mol.115.099192.long
A Basal Tone of 2-Arachidonoylglycerol Contributes to Early Oligodendrocyte Progenitor Proliferation by Activating Phosphatidylinositol 3-Kinase (PI3K)/AKT and the Mammalian Target of Rapamycin (MTOR) Pathways (full–2015) http://link.springer.com/article/10.1007/s11481-015-9609-x/fulltext.html
Legal highs: staying on top of the flood of novel psychoactive substances (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521440/
Cannabinoids & Stress: Impact of HU-210 on behavioral tests of anxiety in acutely stressed mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25707713
Intraperirhinal cortex administration of the synthetic cannabinoid, HU210, disrupts object recognition memory in rats (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25714419
Synthetic and endogenous cannabinoids protect retinal neurons from AMPA excitotoxicity in vivo, via activation of CB1 receptors: Involvement of PI3K/Akt and MEK/ERK signaling pathways (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25989217
Cannabinoids Regulate Intestinal Motor Function and Electrophysiological Activity of Myocytes in Rodents (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26254701


HU-211 / DEXANABINOL / DEXANABINONE / SINNABIDOL / ETS-2101 / PA 50211 / PRS 211007
Latest Studies Imply That Cannabinoids Are Protective Against Alcohol-Induced Brain Damage (news–2011) http://networkedblogs.com/mFuuX
Cannabinoid May Treat Brain Cancer (news–2012) http://www.sciencedaily.com/releases/2012/09/120925142557.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28ScienceDaily%3A+Latest+Science+News%29
Clinical trial evaluates synthetic cannabinoid as brain cancer treatment (news–2012) http://medicalxpress.com/news/2012-09-clinical-trial-synthetic-cannabinoid-brain.html
Cannabinoid May Treat Brain Cancer (news–2012) http://www.sciencedaily.com/releases/2012/09/120925142557.htm
Effects of cannabinoids and related fatty acids upon the viability of P19 embryonal carcinoma cells (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23552853
Cannabinoids in experimental stroke: a systematic review and meta-analysis (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25492113
e-Therapeutics announces continuation of ETS2101 phase I trial in brain cancer (news–2014) http://www.news-medical.net/news/20140107/e-Therapeutics-announces-continuation-of-ETS2101-phase-I-trial-in-brain-cancer.aspx
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HU-308
Gadolinium-HU-308-incorporated micelles (full–2011) http://www.ncbi.nlm.nih.gov/books/NBK54067/pdf/CB2R-Gd-Micelles.pdf
Is lipid signaling through cannabinoid 2 receptors part of a protective system? (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062638/
The Type 2 Cannabinoid Receptor Regulates Bone Mass and Ovariectomy-Induced Bone Loss by Affecting Osteoblast Differentiation and Bone Formation (full–2011) http://press.endocrine.org/doi/full/10.1210/en.2010-0930
CB2 Cannabinoid Receptors Promote Neural Progenitor Cell Proliferation via mTORC1 Signaling (full–2011) http://www.jbc.org/content/287/2/1198.full
Cannabinoid-2 Receptor Activation Protects against Infarct and Ischemia/Reperfusion Heart Injury (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/22113346
Cannabinoid receptor 2 activation reduces intestinal leukocyte recruitment and systemic inflammatory mediator release in acute experimental sepsis (full–2012) http://ccforum.com/content/16/2/R47
Cannabinoids ameliorate disease progression in a model of multiple sclerosis in mice, acting preferentially through CB(1) receptor-mediated anti-inflammatory effects (abst-2012) http://www.ncbi.nlm.nih.gov/pubmed/22342378
Effect of omega-3 polyunsaturated fatty acids on the endocannabinoid system in osteoblast-like cells and muscle (abst–2012) http://docs.lib.purdue.edu/dissertations/AAI3444794/
Characterization of bladder function in a cannabinoid receptor type 2 knockout mouse in vivo and in vitro (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23908133
Prospects for cannabinoid therapies in viral encephalitis (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24021420
Experimental cannabinoid 2 receptor-mediated immune modulation in sepsis (full–2014) http://www.hindawi.com/journals/mi/2014/978678/
2012 Division of Medicinal Chemistry Award Address: Trekking the Cannabinoid Road: A Personal Perspective (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064474/
Expression of cannabinoid receptor 2 and its inhibitory effects on synovial fibroblasts in rheumatoid arthritis (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24440992
Expression of cannabinoid receptor 2 and its inhibitory effects on synovial fibroblasts in rheumatoid arthritis (full–2014) http://rheumatology.oxfordjournals.org/content/53/5/802.long
Ultralow doses of cannabinoid drugs protect the mouse brain from inflammation-induced cognitive damage (abst–2014) http://onlinelibrary.wiley.com/doi/10.1002/jnr.23452/abstract
Protection from osteoarthritis may lie in our own joints, study suggests (news–2014) http://www.alphagalileo.org/ViewItem.aspx?ItemId=141814&CultureCode=en
Antagonism of cannabinoid receptor 2 pathway suppresses IL-6-induced immunoglobulin IgM secretion (full–2014) http://www.biomedcentral.com/2050-6511/15/30
Type-2 cannabinoid receptor regulates proliferation, apoptosis, differentiation, and OPG/RANKL ratio of MC3T3-E1 cells exposed to Titanium particles (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25292314
Activating Cannabinoid Receptor 2 Alleviates Pathogenesis of Experimental Autoimmune Encephalomyelitis Via Activation of Autophagy and Inhibiting NLRP3 Inflammasome (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25417929
Primary Macrophage Chemotaxis Induced by Cannabinoid Receptor 2 Agonists Occurs Independently of the CB2 Receptor (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451551/
Bone cell-autonomous contribution of type 2 cannabinoid receptor to breast cancer induced osteolysis (full–2015) http://www.jbc.org/content/early/2015/07/20/jbc.M115.649608.long
Activation of cannabinoid receptor 2 attenuates synovitis and joint distruction in collagen-induced arthritis (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25601571
Protective effect of paeoniflorin on the hippocampus in rats with cerebral ischemia reperfusion through activating cannabinoid receptor 2 (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25854559
Potential of the cannabinoid CB2 receptor as a pharmacological target against inflammation in Parkinson’s disease (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25863279
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The type 2 cannabinoid receptor regulates susceptibility to osteoarthritis in mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25937028
CB2 cannabinoid receptor agonist enantiomers HU-433 and HU-308: An inverse relationship between binding affinity and biological potency (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26124120


HU-331
Antitumorigenic Effects of Cannabinoids beyond Apoptosis (full-2010) http://jpet.aspetjournals.org/content/332/2/336.full?sid=af53ea87-ab4b-426e-9c7e-8f750e9c4a17
Characterization of HU-331 as a cannabinoid quinone inhibitor of topoisomerase II (abst–2014) http://www.fasebj.org/content/28/1_Supplement/549.6.abstract?sid=db987fd0-3ef0-4796-aff6-4103f0c84daf


HU-910
A new cannabinoid 2 receptor agonist HU-910 attenuates oxidative stress, inflammation, and cell death associated with hepatic ischemia/reperfusion injury (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423243/


IBIPINABANT / IBI
Pooled sample strategy in conjunction with high-resolution liquid chromatography-mass spectrometry-based background subtraction to identify toxicological markers in dogs treated with ibipinabant (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/20387806
Cannabinoid Receptor Antagonist-Induced Striated Muscle Toxicity and Ethylmalonic Adipic Aciduria in Beagle Dogs (full–2012) http://toxsci.oxfordjournals.org/content/129/2/268.full
Ibipinabant attenuates β-cell loss in male Zucker diabetic fatty rats independently of its effects on body weight (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22268426
Formulation and process design for a solid dosage form containing a spray-dried amorphous dispersion of ibipinabant (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/22268601


IBUPROFEN
Chemistry around imidazopyrazine and ibuprofen: discovery of novel fatty acid amide hydrolase (FAAH) inhibitors (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/20570023
Cannabinoid system and cyclooxygenases inhibitors (full-2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056416/
Scripps Research Scientists Discover Inflammation Is Controlled Differently in Brain and Other Tissues (news–2011) http://www.alphagalileo.org/ViewItem.aspx?ItemId=113766&CultureCode=en
Palmitoylethanolamide versus a nonsteroidal anti-inflammatory drug in the treatment of temporomandibular joint inflammatory pain (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22558609
Inhibitory properties of ibuprofen and its amide analogues towards the hydrolysis and cyclooxygenation of the endocannabinoid anandamide (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606911/
Δ9-THC-Caused Synaptic and Memory Impairments Are Mediated through COX-2 Signaling (full–2013) http://www.cell.com/cell/abstract/S0092-8674%2813%2901360-3?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867413013603%3Fshowall%3Dtrue
Preventing marijuana-induced memory problems with over-the-counter painkillers (news–2013) http://medicalxpress.com/news/2013-11-marijuana-induced-memory-problems-over-the-counterpainkillers.html
Inhibition of Endocannabinoid Metabolism by the Metabolites of Ibuprofen and Flurbiprofen (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111603/
Multitarget fatty acid amide hydrolase/cyclooxygenase blockade suppresses intestinal inflammation and protects against nonsteroidal anti-inflammatory drug-dependent gastrointestinal damage (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25757568
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The role of cannabinoids in regulation of nausea and vomiting, and visceral pain (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25715910
What ailments does medical marijuana help? (news–2015) http://www.mnn.com/health/fitness-well-being/stories/what-ailments-does-medical-marijuana-help


IR700DX-mbc94
Cannabinoid CB2 Receptor as a New Phototherapy Target for Inhibition of Tumor Growth (abst–2014) http://pubs.acs.org/doi/abs/10.1021/mp5001923


JBT-101
Ultrapure ajulemic acid has improved CB2 selectivity with reduced CB1 activity (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24856183


JD-5037
New Drug Could Help Maintain Long-Term Weight Loss (news–2012) http://www.sciencedaily.com/releases/2012/07/120726122116.htm
Peripherally restricted CB1 receptor blockers (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23902803
Hepatic cannabinoid-1 receptors mediate diet-induced insulin resistance by increasing de novo synthesis of long-chain ceramides (full–2014)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839256/


JWH-015
Protective effects of the synthetic cannabinoids CP55,940 and JWH-015 on rat brain mitochondria upon paraquat exposure (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/20514518
Now, There’s a Test for That — Norchem’s “Fake Marijuana” Test Reveals Significantly Increased Abuse of Spice/K2 (news–2010) http://www.marketwire.com/press-release/Now-Theres-Test-That-Norchems-Fake-Marijuana-Test-Reveals-Significantly-Increased-Abuse-1356247.htm
Crosstalk between Chemokine Receptor CXCR4 and Cannabinoid Receptor CB(2) in Modulating Breast Cancer Growth and Invasion (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168464/?tool=pubmed
Marijuana-based Drugs: Innovative Therapeutics or Designer Drugs of Abuse? (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139381/?tool=pubmed
The Antinociceptive Effects of JWH-015 in Chronic Inflammatory Pain Are Produced by Nitric Oxide-cGMP-PKG-KATP Pathway Activation Mediated by Opioids (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198780/?tool=pubmed
Beyond THC: The New Generation of Cannabinoid Designer Drugs (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187647/?tool=pubmed
Cannabinoids and bone: endocannabinoids modulate human osteoclast function in vitro (full–2011) http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01519.x/full
Intrathecal Administration of the Cannabinoid 2 Receptor Agonist JWH015 Can Attenuate Cancer Pain and Decrease mRNA Expression of the 2B Subunit of N-Methyl-d-Aspartic Acid (full–2011) http://journals.lww.com/anesthesia-analgesia/Fulltext/2011/08000/Intrathecal_Administration_of_the_Cannabinoid_2.33.aspx
Latest blood test detects 12 popular synthetic cannabinoids in “fake pot” (news–2011) http://www.thefreelibrary.com/Latest+blood+test+detects+12+popular+synthetic+cannabinoids+in+%22fake…-a0261876557
Chemicals Used in “Spice” and “K2” Type Products Now Under Federal Control and Regulation (news–2011) http://www.justice.g`ov/dea/pubs/pressrel/pr030111.html
Cannabinoid receptor 2 agonist ameliorates mesenteric angiogenesis and portosystemic collaterals in cirrhotic rats (full–2012) http://onlinelibrary.wiley.com/doi/10.1002/hep.25625/full
Disease modification of breast cancer-induced bone remodeling by cannabinoid 2 receptor agonists (full–2012) http://onlinelibrary.wiley.com/doi/10.1002/jbmr.1732/full
GPR18 in microglia: implications for the CNS and endocannabinoid system signaling (full–2012) http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02019.x/full
Evidence for the Putative Cannabinoid Receptor (GPR55)-Mediated Inhibitory Effects on Intestinal Contractility in Mice (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548934/
Spice drugs are more than harmless herbal blends: A review of the pharmacology and toxicology of synthetic cannabinoids (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936256/
The CB(2)-preferring agonist JWH015 also potently and efficaciously activates CB(1) in autaptic hippocampal neurons (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601544/
Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22233683
Cannabinoids and muscular pain. Effectiveness of the local administration in rat (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22354705
Acute toxicity due to the confirmed consumption of synthetic cannabinoids: Clinical and laboratory findings (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22971158
Combined antiproliferative effects of the aminoalkylindole WIN55,212-2 and radiation in breast cancer cells (full–2013) http://jpet.aspetjournals.org/content/early/2013/11/20/jpet.113.205120.long
Involvement of PPARγ in the antitumoral action of cannabinoids on hepatocellular carcinoma (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674350/
Chronic activation of cannabinoid receptors in vitro does not compromise mouse islet function (full–2013) http://www.clinsci.org/cs/124/0467/1240467.pdf
Cannabinoid CB2 receptor activation attenuates cytokine-evoked mucosal damage in a human colonic explant model without changing epithelial permeability (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23706402
Cannabinoid Effects on β Amyloid Fibril and Aggregate Formation, Neuronal and Microglial-Activated Neurotoxicity In Vitro (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24030360
Vascular targets for cannabinoids: animal and human studies (full–2014) http://onlinelibrary.wiley.com/doi/10.1111/bph.12560/full

Cannabinoids as therapeutic agents in cancer: current status and future implications (link to PDF-2014) http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=2233

Evaluation of selective cannabinoid CB1 and CB2 receptor agonists in a mouse model of lipopolysaccharide-induced interstitial cystitis (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24561047

Combined antiproliferative effects of the aminoalkylindole WIN55,212-2 and radiation in breast cancer cells (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24259678
Intrathecal Injection of JWH015 Attenuates Remifentanil-Induced Postoperative Hyperalgesia by Inhibiting Activation of Spinal Glia in a Rat Model (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24651239
Evaluation of an On-site Drug-testing Device for the Detection of Synthetic Cannabinoids in Illegal Herbal Products (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25759062
For whom the endocannabinoid tolls: Modulation of innate immune function and implications for psychiatric disorders (abst–2015) http://www.sciencedirect.com/science/article/pii/S027858461500055X
Role of cannabinoidergic system on food intake in neonatal layer-type chicken (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25902906
top


JWH-018
JWH018, a common constituent of ‘Spice’ herbal blends, is a potent and efficacious cannabinoid CB(1) receptor agonist (full-2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931559/?tool=pubmed
Involvement of cannabinoid-1 and cannabinoid-2 receptors in septic ileus (full–2010) http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2982.2009.01419.x/pdf
Monitoring of herbal mixtures potentially containing synthetic cannabinoids as psychoactive compounds (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/20857386
Chemical analysis of synthetic cannabinoids as designer drugs in herbal products (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/20117892
Pharmacological properties and dependence liabilities of synthetic cannabinoids (abst–2010) http://www.unboundmedicine.com/medline/ebm/record/20681249/abstract/%5BPharmacological_properties_and_dependence_liabilities_of_synthetic_cannabinoids%5D_
Screening for the synthetic cannabinoid JWH-018 and its major metabolites in human doping controls (abst-2010) http://www.ncbi.nlm.nih.gov/pubmed/20872894
FAQ: K2, Spice Gold, and Herbal ‘Incense’ (news–2010) http://www.webmd.com/mental-health/news/k2-spice-gold-herbal-incense-faq
THIS ISN’T YOUR MOTHER’S SPICE (news–2010) http://www.mapinc.org/drugnews/v10/n497/a07.html?1173
College students and use of K2: an emerging drug of abuse in young persons (full–2011) http://www.substanceabusepolicy.com/content/6/1/16
Quantitative measurement of JWH-018 and JWH-073 metabolites excreted in human urine (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105467/
Beyond THC: The New Generation of Cannabinoid Designer Drugs (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187647/?tool=pubmed
Investigating a not-so-natural high (full–2011) http://pubs.acs.org/doi/full/10.1021/ac900564u
Marijuana-based Drugs: Innovative Therapeutics or Designer Drugs of Abuse? (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139381/?tool=pubmed
1-Pentyl-3-phenylacetylindoles and JWH-018 share in vivo cannabinoid profiles in mice (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294131/pdf/nihms337462.pdf
Synthetic cannabinoids in oral fluid (full–2011) http://jat.oxfordjournals.org/content/35/7/424.long
Use of high-resolution accurate mass spectrometry to detect reported and previously unreported cannabinomimetics in “herbal high” products (full–2011) http://jat.oxfordjournals.org/content/34/5/252.long
Liquid chromatography-tandem mass spectrometry analysis of urine specimens for K2 (JWH-018) metabolites (full–2011) http://jat.oxfordjournals.org/content/35/7/487.long
Synthetic cannabinoid JWH-018 and psychosis: An explorative study (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21316162
Cardiotoxicity associated with the synthetic cannabinoid, K9, with laboratory confirmation (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21802885
The emergence and analysis of synthetic cannabinoids (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21337724
Comparison of “herbal highs” composition (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21318244
“Spice” girls: synthetic cannabinoid intoxication (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21167669
Three cases of “spice” exposure (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21740143
Severe toxicity following synthetic cannabinoid ingestion (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21970775
Effects of synthetic cannabinoids on electroencephalogram power spectra in rats (abst–2011) http://www.unboundmedicine.com/medline/ebm/record/21640532/abstract/Effects_of_synthetic_cannabinoids_on_electroencephalogram_power_spectra_in_rats_
Outlawing ‘Legal Highs:’ Can Emergency Bans Hinder Drug Development? (news–2011) http://healthland.time.com/2011/02/23/outlawing-legal-highs-can-emergency-bans-hinder-drug-development/
Latest blood test detects 12 popular synthetic cannabinoids in “fake pot” (news–2011) http://www.thefreelibrary.com/Latest+blood+test+detects+12+popular+synthetic+cannabinoids+in+%22fake…-a0261876557
‘Fake Marijuana’ May Trigger Heart Trouble in Teens (news–2011) http://usatoday30.usatoday.com/news/health/story/health/story/2011-11-09/Fake-marijuana-may-trigger-heart-trouble-in-teens/51133266/1
A Characterization of Synthetic Cannabinoid Exposures Reported to the National Poison Data System in 2010 (full–2012) http://www.annemergmed.com/webfiles/images/journals/ymem/FA-cohoyte.pdf
The role of CB2 receptor ligands in human eosinophil function (full–2012) http://www.biomedcentral.com/content/pdf/2050-6511-13-S1-A13.pdf
A survey study to characterize use of Spice products (synthetic cannabinoids) (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217086/
JWH-018 and JWH-073: {Delta}9-Tetrahydrocannabinol-Like Discriminative Stimulus Effects in Monkeys (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251026/pdf/zpt37.pdf
Adolescent Exposure of JWH-018 “Spice” Produces Subtle Effects on Learning and Memory Performance in Adulthood (full–2012) http://file.scirp.org/Html/2-3900080_19505.htm
Detection and disposition of JWH-018 and JWH-073 in mice after exposure to “Magic Gold” smoke (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677765/
Inhalation exposure to smoke from synthetic “marijuana” produces potent cannabimimetic effects in mice (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501554/
A major glucuronidated metabolite of JWH-018 is a neutral antagonist at CB1 receptors (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921679/
Spice drugs are more than harmless herbal blends: A review of the pharmacology and toxicology of synthetic cannabinoids (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936256/
Identification and structural characterization of the synthetic cannabinoid 3-(1-adamantoyl)-1-pentylindole as an additive in ‘herbal incense’ (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22359329
“Spice” and “k2” herbal highs: a case series and systematic review of the clinical effects and biopsychosocial implications of synthetic cannabinoid use in humans (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22691010
Simultaneous analysis of several synthetic cannabinoids, THC, CBD and CBN, in hair by ultra-high performance liquid chromatography tandem mass spectrometry. Method validation and application to real samples (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22576873
Detection and quantification of new designer drugs in human blood: part 1 – synthetic cannabinoids (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22593567
The spice in France: mixed herbs containing synthetic cannabinoids (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22796613
Prevalence of Synthetic Cannabinoids in U.S. Athletes: Initial Findings (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22872465
Acute toxicity due to the confirmed consumption of synthetic cannabinoids: Clinical and laboratory findings (abst – 2012)http://www.ncbi.nlm.nih.gov/pubmed/22971158
Determination of naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-018) in mouse blood and tissue after inhalation exposure to ‘buzz’ smoke by HPLC/MS/MS (abst–2012) http://onlinelibrary.wiley.com/doi/10.1002/bmc.2710/abstract
Synthetic Cannabinoid and Cathinone Use Among US Soldiers (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/23007932
Identification, extraction and quantification of the synthetic cannabinoid JWH-018 from commercially available herbal marijuana alternatives (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/23092847
Synthetic cannabinoids in “spice-like” herbal blends: first appearance of JWH-307 and recurrence of JWH-018 on the German market (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22748479
Synthetic marijuana was created strictly for research at Clemson (news–2012) http://www.timesnews.net/article/9042095/synthetic-marijuana-was-created-strictly-for-research-at-clemson
Wyoming kidney failure outbreak linked to designer ‘blueberry spice’ drug, aka ‘legal marijuana’ (news–2012) http://www.naturalnews.com/035181_spice_recreational_drugs_kidney_failure.html
Blueberry “spice” in Wyoming linked to cases of renal failure (news–2012) http://www.thepoisonreview.com/2012/03/03/blueberry-spice-in-wyoming-linked-to-cases-of-renal-failure/
New health concerns about ‘fake pot’ in US (news–2012) http://medicalxpress.com/news/2012-03-health-fake-pot.html
Tachycardia followed by bradycardia after smoking the synthetic cannabinoid “K9″ (news–2012) http://www.thepoisonreview.com/2012/05/22/tachycardia-followed-by-bradycardia-after-smoking-the-synthetic-cannabinoid-k9/
DIFFERENTIAL DRUG-DRUG INTERACTIONS OF THE SYNTHETIC CANNABINOIDS JWH-018 AND JWH-073: IMPLICATIONS FOR DRUG ABUSE LIABILITY AND PAIN THERAPY (full-2013) http://jpet.aspetjournals.org/content/early/2013/06/25/jpet.113.206003.long
The Directive 2010/63/EU on animal experimentation may skew the conclusions of pharmacological and behavioural studies (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737502/
“Spiceophrenia”: a systematic overview of “Spice”-related psychopathological issues and a case report (full–2013) http://onlinelibrary.wiley.com/doi/10.1002/hup.2312/full
Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptors (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685885/
Qualitative Confirmation of 9 Synthetic Cannabinoids and 20 Metabolites in Human Urine Using LC-MS/MS and Library Search (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874406/
The K2/Spice Phenomenon: emergence, identification, legislation and metabolic characterization of synthetic cannabinoids in herbal incense products (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100246/
High Times, Low Sats: Diffuse Pulmonary Infiltrates Associated with Chronic Synthetic Cannabinoid Use (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657026/
Getting up to speed with the public health and regulatory challenges posed by new psychoactive substances in the information age (editorial–2013) http://onlinelibrary.wiley.com/doi/10.1111/add.12287/full
Synthetic Cannabinoids -The Challenges of Testing for Designer Drugs (article–2013) (funky link- delete the “sign in”, and it comes up) http://www.aacc.org/publications/cln/2013/february/Pages/Cannabinoids.aspx?PassThru=ok&PersonID=206339#
Synthetic cannabis (article–2013) http://tidsskriftet.no/article/2896636/en_GB
Toxicological profiles of selected synthetic cannabinoids showing high binding affinities to the cannabinoid receptor subtype CB1 (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23494106
Driving under the influence of synthetic cannabinoids (“Spice”): a case series (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23636569
Validation of a Novel Immunoassay for the Detection of Synthetic Cannabinoids and Metabolites in Urine Specimens (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23625703
Characteristics of the designer drug and synthetic cannabinoid receptor agonist AM-2201 regarding its chemistry and metabolism (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23832945
Tolerance and cross-tolerance among high-efficacy synthetic cannabinoids JWH-018 and JWH-073 and low-efficacy phytocannabinoid 9-THC (abst–2013) http://www.fasebj.org/cgi/content/meeting_abstract/27/1_MeetingAbstracts/1097.1?sid=eea722c0-971c-4daa-8b8c-38c0c63c19ad
The omega and omega-1 monohydroxyl metabolites of the abused K2/Spice synthetic cannabinoids JWH-018 and JWH- 073 bind with high affinity and act as agonists at human cannabinoid 2 receptors (hCB2s) (abst–2013) http://www.fasebj.org/cgi/content/meeting_abstract/26/1_MeetingAbstracts/660.8?sid=eea722c0-971c-4daa-8b8c-38c0c63c19ad
Conditioned taste aversion elicited by synthetic cannabinoid JWH-018 in mice is attenuated by pretreatment with phytocannabinoid {Delta}9-THC (abst–2013) http://www.fasebj.org/cgi/content/meeting_abstract/26/1_MeetingAbstracts/660.4?sid=eea722c0-971c-4daa-8b8c-38c0c63c19ad
Structure-dependent inhibitory effects of synthetic cannabinoids against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and skin tumour promotion in mice (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23837590
A Case of Cannabinoid Hyperemesis Syndrome Caused by Synthetic Cannabinoids (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23890687
Smart drugs: green shuttle or real drug? (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23842669
Monitoring of urinary metabolites of JWH-018 and JWH-073 in legal cases (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23890611
Detection of Synthetic Cannabinoids in Oral Fluid Using ELISA and LC-MS-MS (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23946452
Blood Synthetic Cannabinoid Concentrations in Cases of Suspected Impaired Driving (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23965292
Targeted Metabolomic Approach for Assessing Human Synthetic Cannabinoid Exposure and Pharmacology (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23987522
Moving around the molecule: Relationship between chemical structure and in vivo activity of synthetic cannabinoids (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24071522
Prevalence of synthetic cannabinoids in blood samples from Norwegian drivers suspected of impaired driving during a seven weeks period (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24129318
Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24160757
Ischemic stroke after use of the synthetic marijuana “spice” (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/24212384
Cytotoxicity of synthetic cannabinoids on primary neuronal cells of the forebrain: the involvement of cannabinoid CB1 receptors and apoptotic cell death (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/24211273
Sulfaphenazole and α-Naphthoflavone Attenuate the Metabolism of the Synthetic Cannabinoids JWH-018 and AM2201 Found in K2/Spice (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/24329780
Characteristics of the designer drug and synthetic cannabinoid receptor agonist AM-2201 regarding its chemistry and metabolism (abst – 2013) http://onlinelibrary.wiley.com/doi/10.1002/jms.3229/abstract
Simultaneous quantification of 20 synthetic cannabinoids and 21 metabolites, and semi-quantification of 12 alkyl hydroxy metabolites in human urine by liquid chromatography-tandem mass spectrometry (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/24418231
Cannabinoids Found to Reduce 90% of Skin Cancer in Just 20 Weeks, According to New Study (news–2013) http://thejointblog.com/cannabinoids-found-to-reduce-90-of-skin-cancer-in-just-20-weeks-according-to-new-study/
Effects and risks associated with novel psychoactive substances: miss-labelling and sale as bath salts, spice, and research chemicals (full – 2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965957/
Analysis of new classes of recreational drugs in sewage: Synthetic cannabinoids and amphetamine-like substances (full – 2014) http://onlinelibrary.wiley.com/doi/10.1002/dta.1461/full
Hair analysis as a tool to evaluate the prevalence of synthetic cannabinoids in different populations of drug consumers (full – 2014) http://onlinelibrary.wiley.com/doi/10.1002/dta.1556/full
Screening for synthetic cannabinoids in hair by using LC-QTOF MS: A new and powerful approach to study the penetration of these new psychoactive substances in the population (full – 2014) http://msl.sagepub.com/content/54/1/22.long
Analysis of new classes of recreational drugs in sewage: Synthetic cannabinoids and amphetamine-like substances (full – 2014) http://onlinelibrary.wiley.com/doi/10.1002/dta.1461/full
Cannabinoids as therapeutic agents in cancer: current status and future implications (link to PDF-2014) http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=2233
LC-QTOF-MS as a superior strategy to immunoassay for the comprehensive analysis of synthetic cannabinoids in urine (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24424965
Driving under the influence of synthetic cannabinoids (“Spice”): a case series (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/23636569
Δ9-THC exposure attenuates aversive effects and reveals appetitive effects of K2/’Spice’ constituent JWH-018 in mice (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24625557
Characterization of in vitro metabolites of JWH-018, JWH-073 and their 4-methyl derivatives, markers of the abuse of these synthetic cannabinoids (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24657413
In vivo effects of synthetic cannabinoids JWH-018 and JWH-073 and phytocannabinoid Δ9-THC in mice: inhalation versus intraperitoneal injection (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24857780
Functional consequences of synthetic cannabinoid metabolites and CYP2C9 polymorphisms (abst–2014) http://www.fasebj.org/content/28/1_Supplement/838.4.abstract?sid=467bb529-0ecc-4ddc-af27-3f56f520a102
Intravenous Lipid Emulsion Therapy for Acute Synthetic Cannabinoid Intoxication: Clinical Experience in Four Cases (full–2015)
http://www.hindawi.com/journals/criem/2015/180921/
Legal highs: staying on top of the flood of novel psychoactive substances (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521440/
A Synthetic Cannabinoid MAM-2201 Potently Suppresses Synaptic Transmission via Activation of Presynaptic CB1 Receptors and Reduces Synaptically-Evoked Intracellular Ca2+ Transients in Cerebellar Purkinje Cells (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25747605
Detection Times of Carboxylic Acid Metabolites of the Synthetic Cannabinoids JWH-018 and JWH-073 in Human Urine (abst–2015)
http://www.ncbi.nlm.nih.gov/pubmed/25737323
Evaluation of an On-site Drug-testing Device for the Detection of Synthetic Cannabinoids in Illegal Herbal Products (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25759062
Metabolism of classical cannabinoids and the synthetic cannabinoid JWH-018 (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25788107
The effects of bioisosteric fluorine in synthetic cannabinoid designer drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135 (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25921407
JWH-018 impairs sensorimotor functions in mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25987201
How this chemist unwittingly helped spawn the synthetic drug industry (news–2015) http://www.washingtonpost.com/local/social-issues/how-a-chemist-unwittingly-helped-spawn-thesynthetic-drug-epidemic/2015/08/09/94454824-3633-11e5-9739-170df8af8eb9_story.html


JWH-019
Simultaneous quantification of 20 synthetic cannabinoids and 21 metabolites, and semi-quantification of 12 alkyl hydroxy metabolites in human urine by liquid chromatography-tandem mass spectrometry (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24418231
Hair analysis as a tool to evaluate the prevalence of synthetic cannabinoids in different populations of drug consumers (full–2014) http://onlinelibrary.wiley.com/doi/10.1002/dta.1556/fullLC-QTOF-MS as a superior strategy to immunoassay for the comprehensive analysis of synthetic cannabinoids in urine (abst–2014)http://www.ncbi.nlm.nih.gov/pubmed/24424965
Driving under the influence of synthetic cannabinoids (“Spice”): a case series (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/23636569
Development and validation of a liquid chromatography-tandem mass spectrometry method for the identification and quantification of JWH-018, JWH-073, JWH-019, and JWH-250 in human whole blood. (full–2011) http://jat.oxfordjournals.org/content/35/7/386.long
Identification of synthetic cannabinoids in herbal incense blends in the United States (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22834927
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Simultaneous quantification of 20 synthetic cannabinoids and 21 metabolites, and semi-quantification of 12 alkyl hydroxy metabolites in human urine by liquid chromatographytandem mass spectrometry (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963402/
Moving around the molecule: Relationship between chemical structure and in vivo activity of synthetic cannabinoids (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944940/
Hair analysis as a tool to evaluate the prevalence of synthetic cannabinoids in different populations of drug consumers (full–2014) http://onlinelibrary.wiley.com/doi/10.1002/dta.1556/full
Inhibitory effect of synthetic cannabinoids on CYP1A activity in mouse liver microsomes (link to PDF–2014) https://www.jstage.jst.go.jp/article/jts/39/6/39_815/_article
Could spice drugs induce psychosis with abnormal movements similar to catatonia? (1st page–2014) http://guilfordjournals.com/doi/abs/10.1521/psyc.2014.77.2.206
LC-QTOF-MS as a superior strategy to immunoassay for the comprehensive analysis of synthetic cannabinoids in urine (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24424965
Driving under the influence of synthetic cannabinoids (“Spice”): a case series (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/23636569
Evaluation of an On-site Drug-testing Device for the Detection of Synthetic Cannabinoids in Illegal Herbal Products (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25759062


JWH-073
Chemical analysis of synthetic cannabinoids as designer drugs in herbal products (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/20117892
Monitoring of herbal mixtures potentially containing synthetic cannabinoids as psychoactive compounds (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/20857386
Now, There’s a Test for That — Norchem’s “Fake Marijuana” Test Reveals Significantly Increased Abuse of Spice/K2 (news–2010) http://www.marketwire.com/press-release/Now-Theres-Test-That-Norchems-Fake-Marijuana-Test-Reveals-Significantly-Increased-Abuse-1356247.htm
College students and use of K2: an emerging drug of abuse in young persons (full–2011) http://www.substanceabusepolicy.com/content/6/1/16
Beyond THC: The New Generation of Cannabinoid Designer Drugs (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187647/?tool=pubmed
Synthetic cannabinoids in oral fluid (full–2011) http://jat.oxfordjournals.org/content/35/7/424.long
Marijuana-based Drugs: Innovative Therapeutics or Designer Drugs of Abuse? (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139381/?tool=pubmed
CP47,497-C8 and JWH073, commonly found in ‘Spice’ herbal blends, are potent and efficacious CB(1) cannabinoid receptor agonists (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094488/
Quantitative measurement of JWH-018 and JWH-073 metabolites excreted in human urine (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105467/
“Spice” girls: synthetic cannabinoid intoxication (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21167669
Three cases of “spice” exposure (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21740143
Cardiotoxicity associated with the synthetic cannabinoid, K9, with laboratory confirmation (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21802885
Synthetic cannabinoid JWH-018 and psychosis: an explorative study (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21316162
Comparison of “herbal highs” composition (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21318244
Outlawing ‘Legal Highs:’ Can Emergency Bans Hinder Drug Development? (news–2011) http://healthland.time.com/2011/02/23/outlawing-legal-highs-can-emergency-bans-hinder-drug-development/
Latest blood test detects 12 popular synthetic cannabinoids in “fake pot” (news–2011) http://www.thefreelibrary.com/Latest+blood+test+detects+12+popular+synthetic+cannabinoids+in+%22fake…-a0261876557
‘Fake Marijuana’ May Trigger Heart Trouble in Teens (news–2011) http://usatoday30.usatoday.com/news/health/story/health/story/2011-11-09/Fake-marijuana-may-trigger-heart-trouble-in-teens/51133266/1
Chemicals Used in “Spice” and “K2” Type Products Now Under Federal Control and Regulation (news–2011) http://www.justice.gov/dea/pubs/pressrel/pr030111.html
NMS Labs & Cerilliant Announce Identification Of Major Metabolite Of The Synthetic Cannabinoid JWH-073 (news–2011) http://www.medicalnewstoday.com/releases/226597.php
A Characterization of Synthetic Cannabinoid Exposures Reported to the National Poison Data System in 2010 (full–2012) http://www.annemergmed.com/webfiles/images/journals/ymem/FA-cohoyte.pdf
Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288656/
JWH-018 and JWH-073: {Delta}9-Tetrahydrocannabinol-Like Discriminative Stimulus Effects in Monkeys (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251026/pdf/zpt37.pdf
Detection and disposition of JWH-018 and JWH-073 in mice after exposure to “Magic Gold” smoke (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677765/
Spice drugs are more than harmless herbal blends: A review of the pharmacology and toxicology of synthetic cannabinoids (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936256/
A survey study to characterize use of Spice products (synthetic cannabinoids) (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217086/
Simultaneous analysis of several synthetic cannabinoids, THC, CBD and CBN, in hair by ultra-high performance liquid chromatography tandem mass spectrometry. Method validation and application to real samples (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22576873
Prevalence of Synthetic Cannabinoids in U.S. Athletes: Initial Findings (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22872465
Acute toxicity due to the confirmed consumption of synthetic cannabinoids: Clinical and laboratory findings (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22971158
Synthetic Cannabinoid and Cathinone Use Among US Soldiers (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/23007932
Synthetic marijuana was created strictly for research at Clemson (news–2012) http://www.timesnews.net/article/9042095/synthetic-marijuana-was-created-strictly-for-research-at-clemson
Tachycardia followed by bradycardia after smoking the synthetic cannabinoid “K9″ (news–2012) http://www.thepoisonreview.com/2012/05/22/tachycardia-followed-by-bradycardia-after-smoking-the-synthetic-cannabinoid-k9/
DIFFERENTIAL DRUG-DRUG INTERACTIONS OF THE SYNTHETIC CANNABINOIDS JWH-018 AND JWH-073: IMPLICATIONS FOR DRUG ABUSE LIABILITY AND PAIN THERAPY (full-2013) http://jpet.aspetjournals.org/content/early/2013/06/25/jpet.113.206003.long
The K2/Spice Phenomenon: emergence, identification, legislation and metabolic characterization of synthetic cannabinoids in herbal incense products (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100246/
Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptors (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685885/
Qualitative Confirmation of 9 Synthetic Cannabinoids and 20 Metabolites in Human Urine Using LC-MS/MS and Library Search (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874406/
“Spiceophrenia”: a systematic overview of “Spice”-related psychopathological issues and a case report (full–2013) http://onlinelibrary.wiley.com/doi/10.1002/hup.2312/full
Synthetic Cannabinoids -The Challenges of Testing for Designer Drugs (article–2013) (funky link-delete the “sign in”, and it comes up) http://www.aacc.org/publications/cln/2013/february/Pages/Cannabinoids.aspx?PassThru=ok&PersonID=206339#
Toxicological profiles of selected synthetic cannabinoids showing high binding affinities to the cannabinoid receptor subtype CB1 (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23494106
Validation of a Novel Immunoassay for the Detection of Synthetic Cannabinoids and Metabolites in Urine Specimens (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23625703
Tolerance and cross-tolerance among high-efficacy synthetic cannabinoids JWH-018 and JWH-073 and low-efficacy phytocannabinoid 9-THC (abst–2013) http://www.fasebj.org/cgi/content/meeting_abstract/27/1_MeetingAbstracts/1097.1?sid=eea722c0-971c-4daa-8b8c-38c0c63c19ad
The omega and omega-1 monohydroxyl metabolites of the abused K2/Spice synthetic cannabinoids JWH-018 and JWH- 073 bind with high affinity and act as agonists at human cannabinoid 2 receptors (hCB2s) (abst–2013) http://www.fasebj.org/cgi/content/meeting_abstract/26/1_MeetingAbstracts/660.8?sid=eea722c0-971c-4daa-8b8c-38c0c63c19ad
Smart drugs: green shuttle or real drug? (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23842669
A Case of Cannabinoid Hyperemesis Syndrome Caused by Synthetic Cannabinoids (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23890687
Monitoring of urinary metabolites of JWH-018 and JWH-073 in legal cases (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23890611
Detection of Synthetic Cannabinoids in Oral Fluid Using ELISA and LC-MS-MS (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23946452
Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24160757
Simultaneous quantification of 20 synthetic cannabinoids and 21 metabolites, and semi-quantification of 12 alkyl hydroxy metabolites in human urine by liquid chromatography-tandem mass spectrometry (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24418231
Analysis of new classes of recreational drugs in sewage: Synthetic cannabinoids and amphetamine-like substances (full–2014) http://onlinelibrary.wiley.com/doi/10.1002/dta.1461/full
Screening for synthetic cannabinoids in hair by using LC-QTOF MS: A new and powerful approach to study the penetration of these new psychoactive substances in the population (full–2014) http://msl.sagepub.com/content/54/1/22.long
Hair analysis as a tool to evaluate the prevalence of synthetic cannabinoids in different populations of drug consumers (full–2014) http://onlinelibrary.wiley.com/doi/10.1002/dta.1556/full
Cannabinoids as therapeutic agents in cancer: current status and future implications (link to PDF-2014) http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=2233
Characterization of in vitro metabolites of JWH-018, JWH-073 and their 4-methyl derivatives, markers of the abuse of these synthetic cannabinoids (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24657413
In vivo effects of synthetic cannabinoids JWH-018 and JWH-073 and phytocannabinoid Δ9-THC in mice: inhalation versus intraperitoneal injection (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24857780
Legal highs: staying on top of the flood of novel psychoactive substances (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521440/
Detection Times of Carboxylic Acid Metabolites of the Synthetic Cannabinoids JWH-018 and JWH-073 in Human Urine (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25737323
Evaluation of an On-site Drug-testing Device for the Detection of Synthetic Cannabinoids in Illegal Herbal Products (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25759062
How this chemist unwittingly helped spawn the synthetic drug industry (news–2015) http://www.washingtonpost.com/local/social-issues/how-a-chemist-unwittingly-helped-spawn-thesynthetic-drug-epidemic/2015/08/09/94454824-3633-11e5-9739-170df8af8eb9_story.html
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JWH-81
Spice drugs are more than harmless herbal blends: A review of the pharmacology and toxicology of synthetic cannabinoids (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936256/
CB1 Receptor-Mediated Signaling Underlies the Hippocampal Synaptic, Learning and Memory Deficits Following Treatment with JWH-081, a New Component of Spice/K2 Preparations (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24123667
Prevalence of synthetic cannabinoids in blood samples from Norwegian drivers suspected of impaired driving during a seven weeks period (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24129318
Simultaneous quantification of 20 synthetic cannabinoids and 21 metabolites, and semi-quantification of 12 alkyl hydroxy metabolites in human urine by liquid chromatography-tandem mass spectrometry (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24418231
Hair analysis as a tool to evaluate the prevalence of synthetic cannabinoids in different populations of drug consumers (full–2014) http://onlinelibrary.wiley.com/doi/10.1002/dta.1556/full
LC-QTOF-MS as a superior strategy to immunoassay for the comprehensive analysis of synthetic cannabinoids in urine (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24424965
Legal highs: staying on top of the flood of novel psychoactive substances (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521440/


JWH-100 / AM-678
College students and use of K2: an emerging drug of abuse in young persons (full–2011) http://www.substanceabusepolicy.com/content/6/1/16
Chemicals Used in “Spice” and “K2” Type Products Now Under Federal Control and Regulation (news–2011) http://www.justice.gov/dea/pubs/pressrel/pr030111.html


JWH-122
Spice drugs are more than harmless herbal blends: A review of the pharmacology and toxicology of synthetic cannabinoids (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936256/
Analysis of 30 synthetic cannabinoids in serum by liquid chromatography-electrospray ionization tandem mass spectrometry after liquid-liquid extraction (abst–2012) http://onlinelibrary.wiley.com/doi/10.1002/jms.3020/abstract
Acute toxicity due to the confirmed consumption of synthetic cannabinoids: Clinical and laboratory findings (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22971158
“Spiceophrenia”: a systematic overview of “Spice”-related psychopathological issues and a case report (full–2013) http://onlinelibrary.wiley.com/doi/10.1002/hup.2312/full
Qualitative Confirmation of 9 Synthetic Cannabinoids and 20 Metabolites in Human Urine Using LC-MS/MS and Library Search (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874406/
Toxicological profiles of selected synthetic cannabinoids showing high binding affinities to the cannabinoid receptor subtype CB1 (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23494106
Driving under the influence of synthetic cannabinoids (“Spice”): a case series (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23636569
Acute Psychosis Associated with Recreational Use of Benzofuran 6-(2-Aminopropyl)Benzofuran (6-APB) and Cannabis (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23733714
Structure-dependent inhibitory effects of synthetic cannabinoids against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and skin tumour promotion in mice (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23837590
Smart drugs: green shuttle or real drug? (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23842669
A Case of Cannabinoid Hyperemesis Syndrome Caused by Synthetic Cannabinoids (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23890687
Blood Synthetic Cannabinoid Concentrations in Cases of Suspected Impaired Driving (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23965292
Prevalence of synthetic cannabinoids in blood samples from Norwegian drivers suspected of impaired driving during a seven weeks period (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/24129318
Simultaneous quantification of 20 synthetic cannabinoids and 21 metabolites, and semi-quantification of 12 alkyl hydroxy metabolites in human urine by liquid chromatography-tandem mass spectrometry (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24418231
Cannabinoids Found to Reduce 90% of Skin Cancer in Just 20 Weeks, According to New Study (news–2013) http://thejointblog.com/cannabinoids-found-to-reduce-90-of-skin-cancer-in-just-20-weeks-according-to-new-study/
Identification and quantification of synthetic cannabinoids in ‘spice-like’ herbal mixtures: A snapshot of the German situation in the autumn of 2012 (full–2014) http://onlinelibrary.wiley.com/doi/10.1002/dta.1499/full
Screening for synthetic cannabinoids in hair by using LC-QTOF MS: A new and powerful approach to study the penetration of these new psychoactive substances in the population (full–2014) http://msl.sagepub.com/content/54/1/22.long
Analysis of new classes of recreational drugs in sewage: Synthetic cannabinoids and amphetamine-like substances (full–2014) http://onlinelibrary.wiley.com/doi/10.1002/dta.1461/full
LC-QTOF-MS as a superior strategy to immunoassay for the comprehensive analysis of synthetic cannabinoids in urine (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24424965
Driving under the influence of synthetic cannabinoids (“Spice”): a case series (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/23636569
Can JWH-210 and JWH-122 be detected in adipose tissue four weeks after single oral drug administration to rats? (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24474420
Characterization of in vitro metabolites of JWH-018, JWH-073 and their 4-methyl derivatives, markers of the abuse of these synthetic cannabinoids (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24657413
Legal highs: staying on top of the flood of novel psychoactive substances (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521440/
Evaluation of an On-site Drug-testing Device for the Detection of Synthetic Cannabinoids in Illegal Herbal Products (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25759062
Testing: Three Kings Day bread laced with ‘substantial’ amount of synthetic pot (news–2015) http://www.ocregister.com/articles/bread-648036-synthetic-people.html
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JWH-133 / 3-(1_1_-dimethylbutyl)-1-deoxy-_8-THC
Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition (full-2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917429/?tool=pmcentrez
Activation of cannabinoid 2 receptors protects against cerebral ischemia by inhibiting neutrophil recruitment (full–2010) http://www.fasebj.org/content/24/3/788.long
Antitumorigenic Effects of Cannabinoids beyond Apoptosis (full–2010) http://jpet.aspetjournals.org/content/332/2/336.full?sid=af53ea87-ab4b-426e-9c7e-8f750e9c4a17
Cannabinoid (JWH-133) therapy could be effective for treatment of corneal neovascularization (full–2010) http://journals.tums.ac.ir/upload_files/pdf/_/15058.pdf
Targeting the cannabinoid pathway limits the development of fibrosis and autoimmunity in a mouse model of systemic sclerosis (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893662/
Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimers’ disease (full–2011) http://molpharm.aspetjournals.org/content/early/2011/02/24/mol.111.071290.long
Is lipid signaling through cannabinoid 2 receptors part of a protective system? (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062638/
The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques (full–2011) http://eurheartj.oxfordjournals.org/content/33/7/846.full
Beneficial paracrine effects of cannabinoid receptor 2 on liver injury and regeneration (full–2011) http://onlinelibrary.wiley.com/doi/10.1002/hep.23779/full
Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating kupffer cell polarization in mice (full–2011) http://onlinelibrary.wiley.com/doi/10.1002/hep.24524/full
Brain cannabinoid CB2 receptors modulate cocaine’s actions in mice (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164946/
Cannabinoid receptor-2 (CB2) agonist ameliorates colitis in IL-10(-/-) mice by attenuating the activation of T cells and promoting their apoptosis (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117838/
Atheroprotection via cannabinoid receptor-2 is mediated by circulating and vascular cells in vivo (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21884703
Antinociceptive effects induced through the stimulation of spinal cannabinoid type 2 receptors in chronically inflamed mice (abst–2011) http://www.unboundmedicine.com/medline/ebm/record/21771590/abstract/Antinociceptive_effects_induced_through_the_stimulation_of_spinal_cannabinoid_type_2_receptors_in_chronically_inflamed_mice_
Spinal cannabinoid CB2 receptors as a target for neuropathic pain: an investigation using chronic constriction injury (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/22210507
Outlawing ‘Legal Highs:’ Can Emergency Bans Hinder Drug Development? (news–2011) http://healthland.time.com/2011/02/23/outlawing-legal-highs-can-emergency-bans-hinder-drug-development/
Can marijuana curb cocaine addiction? (news–2011) http://theweek.com/article/index/217709/can-marijuana-curb-cocaine-addiction
Prolonged oral Cannabinoid Administration prevents Neuroinflammation, lowers beta-amyloid Levels and improves Cognitive Performance in Tg APP 2576 Mice (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292807/
Cannabinoid CB(2) receptor-mediated regulation of impulsive-like behaviour in DBA/2 mice (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252982/
Cannabinoid Receptors CB1 and CB2 Form Functional Heteromers in Brain (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375509/
Cannabinoid Receptor 2-Mediated Attenuation of CXCR4-Tropic HIV Infection in Primary CD4+ T Cells (full–2012) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0033961
Spice drugs are more than harmless herbal blends: A review of the pharmacology and toxicology of synthetic cannabinoids (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936256/
The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation (full–2012) http://www.jneuroinflammation.com/content/9/1/79
Cannabinoid receptor 2 agonist ameliorates mesenteric angiogenesis and portosystemic collaterals in cirrhotic rats (full–2012) http://onlinelibrary.wiley.com/doi/10.1002/hep.25625/full
Dynamic changes to the endocannabinoid system in models of chronic pain (full–2012) http://rstb.royalsocietypublishing.org/content/367/1607/3300.full?sid=1569c370-cd5c-4358-89ff-857201f5e069
GPR18 in microglia: implications for the CNS and endocannabinoid system signaling (full–2012) http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02019.x/full
Cannabinoid receptor CB2 protects against balloon-induced neointima formation (full–2012)http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774259/
Cannabinoid type 2 receptor activation downregulates stroke-induced classic and alternative brain macrophage/microglial activation concomitant to neuroprotection (full–2012) http://stroke.ahajournals.org/content/43/1/211.long
Activation of cannabinoid receptor 2 attenuates leukocyte-endothelial cell interactions and blood-brain barrier dysfunction under inflammatory conditions (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325902/
Role of endogenous cannabinoid system in the gut (full–2013) http://www.actaps.com.cn/qikan/manage/wenzhang/2013-4-12.pdf
Attenuation of HIV-1 replication in macrophages by cannabinoid receptor 2 agonists (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629438/
Treatment with CB 2 Agonist JWH-133 Reduces Histological Features Associated with Erectile Dysfunction in Hypercholesterolemic Mice (full–2013) http://www.hindawi.com/journals/cdi/2013/263846/
Effect of Cannabinoid Receptor Activation on Spreading Depression (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586901/
Cannabinoid CB2 Receptors Regulate Central Sensitization and Pain Responses Associated with Osteoarthritis of the Knee Joint (full–2013) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0080440
Cannabinoid receptor 2 counteracts interleukin-17-induced immune and fibrogenic responses in mouse liver (full–2013) http://onlinelibrary.wiley.com/doi/10.1002/hep.26598/full
Activation of Cannabinoid Type 2 Receptor by JWH133 Protects Heart Against Ischemia/Reperfusion-Induced Apoptosis (full–2013) http://www.ncbi.nlm.nih.gov/pubmed/23711495
The cannabinoid CB2 receptor-selective phytocannabinoid beta-caryophyllene exerts analgesic effects in mouse models of inflammatory and neuropathic pain (full–2013) http://www.europeanneuropsychopharmacology.com/article/S0924-977X%2813%2900302-7/fulltext
Critical appraisal of the potential use of cannabinoids in cancer management (link to PDF–2013) http://www.dovepress.com/critical-appraisal-of-the-potential-use-of-cannabinoids-in-cancer-mana-a14216
Characterisation of cannabinoid-induced relief of neuropathic pain in a rat model of cisplatin-induced neuropathy (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23454533
CB2 Cannabinoid Receptor Agonist Ameliorates Alzheimer-Like Phenotype in AβPP/PS1 Mice (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23515018
Synaptic plasticity alterations associated with memory impairment induced by deletion of CB2 cannabinoid receptors (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23796670
Functional relevance of the cannabinoid receptor 2 – heme oxygenase pathway: A novel target for the attenuation of portal hypertension (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24007798
Increase of mesenchymal stem cell migration by Cannabidiol via activation of p42/44 MAPK (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24304686
CB2 Receptor Activation Ameliorates the Proinflammatory Activity in Acute Lung Injury Induced by Paraquat (full–2014) http://www.hindawi.com/journals/bmri/2014/971750/
CB2 Receptor Activation Inhibits Melanoma Cell Transmigration through the Blood-Brain Barrier (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057719/
Repositioning therapy for thyroid cancer: new insights on established medications (full–2014) http://erc.endocrinology-journals.org/content/21/3/R183.long
Cannabinoids as therapeutic agents in cancer: current status and future implications (link to PDF-2014) http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=2233
Regulatory role of the Cannabinoid-2 receptor in stress-induced neuroinflammation in mice (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24467609
Cannabinoids inhibit cholinergic contraction in human airways through prejunctional CB1 receptors (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24467410
Cannabinoid type 2 receptor stimulation attenuates brain edema by reducing cerebral leukocyte infiltration following subarachnoid hemorrhage in rats (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24819918
Cannabinoids inhibit angiogenic capacities of Endothelial cells via release of Tissue inhibitor of matrix metalloproteinases-1 from lung cancer cells (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24976505
Ligand Activation of Cannabinoid Receptors Attenuates Hypertrophy of Neonatal Rat Cardiomyocytes (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24979612
Cannabinoid Receptor Type 2 Agonist Attenuates Apoptosis by Activation of Phosphorylated CREB-Bcl-2 Pathway After Subarachnoid Hemorrhage in Rats (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25058046
Drugs Related to Cannabis Have Pain-Relieving Potential for Osteoarthritis (news–2014) http://www.sciencedaily.com/releases/2014/01/140107092825.htm
Synthetic cannabinoid molecule created for osteoarthritis (news–2014) http://www.news-medical.net/news/20140107/Synthetic-cannabinoid-molecule-created-for-osteoarthritis.aspx
Drugs related to cannabis have pain-relieving potential for osteoarthritis (news–2014) http://www.alphagalileo.org/ViewItem.aspx?ItemId=137809&CultureCode=en
Protective Role of CB2 Receptor Activation in Galactosamine/LPS-induced Acute Liver Failure Through Regulation of Macrophage Polarization and miRNAs (full–2015) http://jpet.aspetjournals.org/content/early/2015/03/06/jpet.114.220368.long
Primary Macrophage Chemotaxis Induced by Cannabinoid Receptor 2 Agonists Occurs Independently of the CB2 Receptor (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451551/
A Basal Tone of 2-Arachidonoylglycerol Contributes to Early Oligodendrocyte Progenitor Proliferation by Activating Phosphatidylinositol 3-Kinase (PI3K)/AKT and the Mammalian Target of Rapamycin (MTOR) Pathways (full–2015) http://link.springer.com/article/10.1007/s11481-015-9609-x/fulltext.html
CB2R orchestrates fibrogenesis through regulation of inflammatory response during the repair of skeletal muscle contusion (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466920/
Beneficial effects of cannabinoid receptor type 2 (CB2R) in injured skeletal muscle postcontusion (full–2015) http://www.hh.um.es/pdf/Vol_30/30_6/Yu-30-737-749-2015.pdf
Bone cell-autonomous contribution of type 2 cannabinoid receptor to breast cancer induced osteolysis (full–2015) http://www.jbc.org/content/early/2015/07/20/jbc.M115.649608.long
Pathogenesis of Systemic Sclerosis (full–2015) http://journal.frontiersin.org/article/10.3389/fimmu.2015.00272/full
Cannabinoid CB2 receptor stimulation attenuates brain edema and neurological deficits in a germinal matrix hemorrhage rat model (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25625355
Antidepressant-like effects of the cannabinoid receptor ligands in the forced swimming test in mice: Mechanism of action and possible interactions with cholinergic system (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25660201
2-AG promotes the expression of conditioned fear via cannabinoid receptor type 1 on GABAergic neurons (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25814137
Minocycline Attenuates Neonatal Germinal-Matrix-Hemorrhage-Induced Neuroinflammation and Brain Edema by Activating Cannabinoid Receptor 2 (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25833102
Activation of Cannabinoid CB2 receptors Reduces Hyperalgesia in an Experimental Autoimmune Encephalomyelitis Mouse Model of Multiple Sclerosis (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25849525
Role of CB2 receptors in social and aggressive behavior in male mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25921034
Cannabinoid receptor 2 attenuates microglial accumulation and brain injury following germinal matrix hemorrhage via ERK dephosphorylation in vivo and in vitro (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25963415
Neuroprotective Effect of JZL184 in MPP+-Treated SH-SY5Y Cells Through CB 2 Receptors (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25976369
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Role of the endocannabinoid system in the emotional manifestations of osteoarthritis pain (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26067584
Whole-cell biosensor for label-free detection of GPCR-mediated drug responses in personal cell lines (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26143464
Cannabinoid Use in the Treatment of Osteoarthritis Pain (news–2015) http://www.medicaljane.com/2015/01/26/cannabinoid-use-in-the-treatment-of-osteoarthritis-pain/


JWH-150
Cannabinoid Receptor 2-Mediated Attenuation of CXCR4-Tropic HIV Infection in Primary CD4+ T Cells (full–2012) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0033961


JWH-200
Outlawing ‘Legal Highs:’ Can Emergency Bans Hinder Drug Development? (news–2011) http://healthland.time.com/2011/02/23/outlawing-legal-highs-can-emergency-bans-hinder-drug-development/
Spice drugs are more than harmless herbal blends: A review of the pharmacology and toxicology of synthetic cannabinoids (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936256/
Synthetic Cannabinoids -The Challenges of Testing for Designer Drugs (article–2013) (funky link-delete the “sign in” and it comes up) http://www.aacc.org/publications/cln/2013/february/Pages/Cannabinoids.aspx?PassThru=ok&PersonID=206339#
Detection of Synthetic Cannabinoids in Oral Fluid Using ELISA and LC-MS-MS (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23946452
In vivo and in vitro metabolism of the synthetic cannabinoid JWH-200 (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23943333
Simultaneous quantification of 20 synthetic cannabinoids and 21 metabolites, and semi-quantification of 12 alkyl hydroxy metabolites in human urine by liquid chromatography-tandem mass spectrometry (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24418231
Spice/K2 drugs – more than innocent substitutes for marijuana (full–2013) http://ijnp.oxfordjournals.org/content/17/3/509
Detection of Synthetic Cannabinoids in Oral Fluid Using ELISA and LC-MS-MS (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23946452
In vivo and in vitro metabolism of the synthetic cannabinoid JWH-200 (abst–2013)  http://www.ncbi.nlm.nih.gov/pubmed/23943333
Urinary prevalence, metabolite detection rates, temporal patterns and evaluation of suitable LC-MS/MS targets to document synthetic cannabinoid intake in US military urine specimens. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/25263309
Evaluation of an On-site Drug-testing Device for the Detection of Synthetic Cannabinoids in Illegal Herbal Products (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25759062
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How this chemist unwittingly helped spawn the synthetic drug industry (news–2015) http://www.washingtonpost.com/local/social-issues/how-a-chemist-unwittingly-helped-spawn-thesynthetic-drug-epidemic/2015/08/09/94454824-3633-11e5-9739-170df8af8eb9_story.html


JWH-210
Spice drugs are more than harmless herbal blends: A review of the pharmacology and toxicology of synthetic cannabinoids (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936256/
Analysis of 30 synthetic cannabinoids in serum by liquid chromatography-electrospray ionization tandem mass spectrometry after liquid-liquid extraction (abst–2012) http://onlinelibrary.wiley.com/doi/10.1002/jms.3020/abstract
Acute toxicity due to the confirmed consumption of synthetic cannabinoids: Clinical and laboratory findings (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22971158
Analysis of synthetic cannabinoids in “spice-like” herbal highs: snapshot of the German market in summer 2011 (abst-2012) http://www.ncbi.nlm.nih.gov/pubmed/22710567
Identification of synthetic cannabinoids in herbal incense blends in the United States (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22834927
Qualitative Confirmation of 9 Synthetic Cannabinoids and 20 Metabolites in Human Urine Using LC-MS/MS and Library Search (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874406/
Simultaneous quantification of 20 synthetic cannabinoids and 21 metabolites, and semi-quantification of 12 alkyl hydroxy metabolites in human urine by liquid chromatographytandem mass spectrometry (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963402/
Identification and Structural Elucidation of Four Cannabimimetic Compounds (RCS-4, AM-2201, JWH-203 and JWH-210) in Seized Products (full–2013) http://jat.oxfordjournals.org/content/37/2/56.full.pdf+html
Toxicological profiles of selected synthetic cannabinoids showing high binding affinities to the cannabinoid receptor subtype CB1 (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23494106
Driving under the influence of synthetic cannabinoids (“Spice”): a case series (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23636569
Structure-dependent inhibitory effects of synthetic cannabinoids against 12-Otetradecanoylphorbol-13-acetate-induced inflammation and skin tumour promotion in mice (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23837590
Blood Synthetic Cannabinoid Concentrations in Cases of Suspected Impaired Driving (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23965292
Cytotoxicity of synthetic cannabinoids on primary neuronal cells of the forebrain: the involvement of cannabinoid CB1 receptors and apoptotic cell death. (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24211273
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Cannabinoids Found to Reduce 90% of Skin Cancer in Just 20 Weeks, According to New Study (news–2013) http://thejointblog.com/cannabinoids-found-to-reduce-90-of-skin-cancer-in-just-20-weeks-according-tonew-study/
Hair analysis as a tool to evaluate the prevalence of synthetic cannabinoids in different populations of drug consumers (full–2014)
http://onlinelibrary.wiley.com/doi/10.1002/dta.1556/full
Dependence Potential of the Synthetic Cannabinoids JWH-073, JWH-081, and JWH-210: In Vivo and In Vitro Approaches (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131522/
Cannabinoids as therapeutic agents in cancer: current status and future implications (link to PDF-2014) http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=2233
LC-QTOF-MS as a superior strategy to immunoassay for the comprehensive analysis of synthetic cannabinoids in urine (abst–2014)
http://www.ncbi.nlm.nih.gov/pubmed/24424965
Driving under the influence of synthetic cannabinoids (“Spice”): a case series (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/23636569
Can JWH-210 and JWH-122 be detected in adipose tissue four weeks after single oral drug administration to rats? (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24474420
Urinary prevalence, metabolite detection rates, temporal patterns and evaluation of suitable LC-MS/MS targets to document synthetic cannabinoid intake in US military urine specimens (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25263309
A case of law-evading herbs poisoning that induced shock and myocardial damage (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25771668
Legal highs: staying on top of the flood of novel psychoactive substances (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521440/


JWH-250
Spice drugs are more than harmless herbal blends: A review of the pharmacology and toxicology of synthetic cannabinoids (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936256/
“Spiceophrenia”: a systematic overview of “Spice”-related psychopathological issues and a case report (full–2013) http://onlinelibrary.wiley.com/doi/10.1002/hup.2312/full
Qualitative Confirmation of 9 Synthetic Cannabinoids and 20 Metabolites in Human Urine Using LC-MS/MS and Library Search (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874406/
Validation of a Novel Immunoassay for the Detection of Synthetic Cannabinoids and Metabolites in Urine Specimens (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23625703
Smart drugs: green shuttle or real drug? (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23842669
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Blood Synthetic Cannabinoid Concentrations in Cases of Suspected Impaired Driving (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23965292
Prevalence of synthetic cannabinoids in blood samples from Norwegian drivers suspected of impaired driving during a seven weeks period (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24129318
Simultaneous quantification of 20 synthetic cannabinoids and 21 metabolites, and semi-quantification of 12 alkyl hydroxy metabolites in human urine by liquid chromatography-tandem mass spectrometry (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24418231
Screening for synthetic cannabinoids in hair by using LC-QTOF MS: A new and powerful approach to study the penetration of these new psychoactive substances in the population (full–2014) http://msl.sagepub.com/content/54/1/22.long
Hair analysis as a tool to evaluate the prevalence of synthetic cannabinoids in different populations of drug consumers (full–2014) http://onlinelibrary.wiley.com/doi/10.1002/dta.1556/full
LC-QTOF-MS as a superior strategy to immunoassay for the comprehensive analysis of synthetic cannabinoids in urine (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24424965
Urinary prevalence, metabolite detection rates, temporal patterns and evaluation of suitable LC-MS/MS targets to document synthetic cannabinoid intake in US military urine specimens (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25263309
Legal highs: staying on top of the flood of novel psychoactive substances (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521440/


JZL-184
Inhibition of COX-2 expression by endocannabinoid 2-arachidonoylglycerol is mediated via PPAR-γ (full–2011) http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01444.x/full
Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224879/
Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249428/
Inhibition of monoacylglycerol lipase (MAGL) attenuates NSAID-induced gastric hemorrhages in mice (full–2011) http://jpet.aspetjournals.org/content/early/2011/06/09/jpet.110.175778.long
Spinal administration of the monoacylglycerol lipase inhibitor JZL184 produces robust inhibitory effects on nociceptive processing and the development of central sensitization in the rat (full–2012) http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02179.x/full
Monoacylglycerol lipase is a new therapeutic target for Alzheimer’s disease (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513645/
Monoacylglycerol Lipase (MAGL) Inhibition Attenuates Acute Lung Injury in Mice (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808422/
Dynamic changes to the endocannabinoid system in models of chronic pain (full–2012) http://rstb.royalsocietypublishing.org/content/367/1607/3300.full?sid=1569c370-cd5c-4358-89ff-857201f5e069
The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717616/
Dual Inhibition of Endocannabinoid Catabolic Enzymes Produces Enhanced Anti-Withdrawal Effects in Morphine-Dependent Mice (full–2013) http://www.ncbi.nlm.nih.gov/pubmed/23303065
Repeated Low Dose Administration of the Monoacylglycerol Lipase Inhibitor JZL184 Retains CB1 Receptor Mediated Antinociceptive and Gastroprotective Effects (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657109/
Peripheral and Spinal Activation of Cannabinoid Receptors by Joint Mobilization Alleviates Postoperative Pain in Mice (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24120553
The endocannabinoid system mediates aerobic exercise-induced antinociception in rats (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24148812
Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24384256
Study: Cannabinoids Offer Treatment For Severe Lung Disease (news–2013) http://www.leafscience.com/2013/11/21/study-cannabinoids-offer-treatment-severe-lung-disease/
Experimental cannabinoid 2 receptor-mediated immune modulation in sepsis (full–2014) http://www.hindawi.com/journals/mi/2014/978678/
The influence of monoacylglycerol lipase inhibition upon the expression of epidermal growth factor receptor in human PC-3 prostate cancer cells (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109781/
Prolonged monoacylglycerol lipase blockade causes equivalent CB1-receptor mediated adaptations in FAAH wild type and knockout mice (full-2014) http://jpet.aspetjournals.org/content/early/2014/05/21/jpet.114.212753.long
Monoacylglycerol Lipase Inhibition Blocks Chronic Stress-Induced Depressive-Like Behaviors via Activation of mTOR Signaling (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24476943
Prior stimulation of the endocannabinoid system prevents methamphetamine-induced dopaminergic neurotoxicity in the striatum through activation of CB2 receptors (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24709540
Hemopressin, an inverse agonist of cannabinoid receptors, inhibits neuropathic pain in rats (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24703998
Endocannabinoid contribution to Δ9-tetrahydrocannabinol discrimination in rodents (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24858366
Augmented tonic pain-related behavior in knockout mice lacking monoacylglycerol lipase, a major degrading enzyme for the endocannabinoid 2-arachidonoylglycerol (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24906199
The dual FAAH/MAGL inhibitor JZL195 has enhanced effects on endocannabinoid transmission and motor behavior in rats as compared to those of the MAGL inhibitor JZL184 (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24911644
Attenuation of serotonin-induced itch responses by inhibition of endocannabinoid degradative enzymes, fatty acid amide hydrolase and monoacylglycerol lipase (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24915981
The monoacylglycerol lipase inhibitor JZL184 is neuroprotective and alters glial cell phenotype in the chronic MPTP mouse model (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24973119
Endocannabinoid modulation by FAAH and MAGL within the analgesic circuitry of the periaqueductal grey (abst–2014)http://www.ncbi.nlm.nih.gov/pubmed/25041240
Inhibition of monoacylglycerol lipase reduces nicotine withdrawal (full–2015) http://onlinelibrary.wiley.com/doi/10.1111/bph.12948/full
Blockade of monoacylglycerol lipase inhibits oligodendrocyte excitotoxicity and prevents demyelination in vivo (full–2015) http://onlinelibrary.wiley.com/doi/10.1002/glia.22742/full
Selective monoacylglycerol lipase inhibitors: Antinociceptive vs. cannabimimetic effects in mice (full–2015) http://jpet.aspetjournals.org/content/early/2015/03/11/jpet.114.222315.long
Blockade of 2-arachidonoylglycerol hydrolysis produces antidepressant-like effects and enhances adult hippocampal neurogenesis and synaptic plasticity (full–2015) http://onlinelibrary.wiley.com/doi/10.1002/hipo.22344/full
Monoacylglycerol lipase inhibitor JZL184 reduces neuroinflammatory response in APdE9 mice and in adult mouse glial cells (full–2015) http://www.jneuroinflammation.com/content/12/1/81
Full FAAH inhibition combined with partial monoacylglycerol lipase inhibition: Augmented and sustained antinociceptive effects with negligible cannabimimetic side effects in mice (full–2015) http://jpet.aspetjournals.org/content/early/2015/05/20/jpet.115.222851.long
A Basal Tone of 2-Arachidonoylglycerol Contributes to Early Oligodendrocyte Progenitor Proliferation by Activating Phosphatidylinositol 3-Kinase (PI3K)/AKT and the Mammalian Target of Rapamycin (MTOR) Pathways (full–2015) http://link.springer.com/article/10.1007/s11481-015-9609-x/fulltext.html
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Endocannabinoid Catabolic Enzymes Play Differential Roles in Thermal Homeostasis in Response to Environmental or Immune Challenge (full–2015) http://tinyurl.com/otbun2q
Multiple Forms of Endocannabinoid and Endovanilloid Signaling Regulate the Tonic Control of GABA Release (full–2015)
http://www.jneurosci.org/content/35/27/10039.full?sid=7e769d1b-9b77-42fe-92d0-8b337b34b9b6
Endocannabinoid-mediated modulation of Gq/11 protein-coupled receptor signalinginduced vasoconstriction and hypertension (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25595485
Combined inhibition of monoacylglycerol lipase and cyclooxygenases synergistically reduces neuropathic pain in mice (abst–2015) http://onlinelibrary.wiley.com/doi/10.1111/bph.13012/abstract
[16-OR]: Vasoactive lipid mediators control uterine vascular reactivity at early pregnancy in the transgenic hAGNxhREN rat (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25787366
Simultaneous inhibition of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) shares discriminative stimulus effects with ∆9-THC in mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25711338
For whom the endocannabinoid tolls: Modulation of innate immune function and implications for psychiatric disorders (abst–2015) http://www.sciencedirect.com/science/article/pii/S027858461500055X
Inhibition of monoacylglycerol lipase mediates a cannabinoid 1-receptor dependent delay of kindling progression in mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25796567
Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25698527
2-AG promotes the expression of conditioned fear via cannabinoid receptor type 1 on GABAergic neurons (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25814137
The effect of FAAH, MAGL, and Dual FAAH/MAGL inhibition on inflammatory and colorectal distension-induced visceral pain models in Rodents (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25869205
The monoacylglycerol lipase inhibitor JZL184 decreases inflammatory response in skeletal muscle contusion in rats (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25912803
Modulatory effects by CB1 receptors on rat spinal locomotor networks after sustained application of agonists or antagonists (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26126926
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JZL-195
Astroglial CB1 cannabinoid receptors regulate leptin signaling in mouse brain astrocytes (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854987/
Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24384256
The dual FAAH/MAGL inhibitor JZL195 has enhanced effects on endocannabinoid transmission and motor behavior in rats as compared to those of the MAGL inhibitor JZL184 (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24911644
Endocannabinoid modulation by FAAH and MAGL within the analgesic circuitry of the periaqueductal grey (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25041240
Opposite control of frontocortical 2-arachidonoylglycerol turnover rate by cannabinoid type-1 (CB1 ) receptors located on glutamatergic neurons and on astrocytes (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25626460
Simultaneous inhibition of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) shares discriminative stimulus effects with ∆9-THC in mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25711338
Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25698527
The effect of FAAH, MAGL, and Dual FAAH/MAGL inhibition on inflammatory and colorectal distension-induced visceral pain models in Rodents (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25869205
Distinct roles of the endocannabinoids anandamide and 2-arachidonoylglycerol in social behavior and emotionality at different developmental ages in rats (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25914159