A-C (Synthetics 2010+)

SYNTHETICS and COMPOUNDS THAT AFFECT the ECS 2010-2015

AB-CHMINACA (Very Strong CB1 and 2 Agonist)
AB-PINACA (Strong CB1 and 2 Agonist)
ABN-CBD / ABNORMAL CANNABIDIOL / CAY10429 (GPR-18 / GPR-55 Agonist)
ACEA / ARACHIDONYL-2′-CHLOROETHYLAMIDE (CB1 Agonist)
ACETAMINOPHEN / PARACETAMOL
ACPA / ARACHIDONYLCYCLOPROPYLAMIDE (Potent CB1 Agonist)
AJULEMIC ACID / AjA / IP-751 / HU-239 / CT-3
AM-111 / D-JNKI-1 / XG-102 (Blocks MAPK-JNK Signal Pathway)
AM-251 (GPR 55 Agonist, CB1 Antagonist / Inverse Agonist)
AM-281 (CB1 Antagonist and Inverse Agonist)
AM-374 / HEXADECYL SULFONYLFLUORIDE
AM-404 (Cannabinoid Transport Inhibitor, Made in the Body From Acetaminophen, See Also ACETAMINOPHEN)
AM-630 (CB2 Inverse Agonist)
AM-694 (CB1 and 2 Agonist)
AM-841
AM-1172 (Anandamide Transport Inhibitor)
AM-1220 (Potent CB1 Agonist, Weak CB2 Agonist)
AM-1241 (CB 2 Agonist)
AM-1346 (CB1 Agonist)
AM-1710 (CB2 Agonist)
AM-2201 (CB1 Agonist)
AM-2233 (CB1 Agonist)
AM-2389 (CB1 Agonist)
AM-3506 (Blocks Breakdown of Anandamide)
AM-4054
AM-4113 (CB1 Antagonist)
AM-6545 (Peripherally Restricted CB1 Antagonist, No ‘High’ [Previous studies 2010-2014])
AM-6546 (CB1 Antagonist [Previous studies 2013])
AM-6701 (Equally Blocks Breakdown of 2-AG and Anandamide)
AM-6702 (Strongly Blocks Breakdown of Anandamide and Weakly, 2-AG)
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ARN-258 (Blocks Breakdown of Anandamide)
AS-1535907 (GPR119 Agonist)
AS-1907417 (GPR119 Agonist)
CANNABINOR (CB2 Agonist)
3 CARBOXAMIDO-5-ARYL-ISOXAZOLES (CB 2 Agonists)
CB-13 (CB1/CB2 Dual Agonist With Limited Brain Penetration)
CB-65 (CB2 Agonist)
CID16020046 (GPR-55 Antagonist)
COMPOUND A (CB1/CB2 Agonist That Is Excluded From The Brain)
COMPOUND 39 (CB2 Agonist)
CP-47,497 (CB1 and CB2 Agonist)
CP-50,556-1 / LEVONANTRADOL (CB1 and CB2 Agonist)
CP-55,940 (CB1, CB2 and GPR55 Agonist)


AB-CHMINACA
AB-CHMINACA, AB-PINACA, and FUBIMINA: Affinity and Potency of Novel Synthetic Cannabinoids in Producing Δ9-Tetrahydrocannabinol-Like Effects in Mice (full–2015) http://jpet.aspetjournals.org/content/early/2015/06/23/jpet.115.225326.long
In vitro and in vivo human metabolism of the synthetic cannabinoid AB-CHMINACA (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25865117


AB-PINACA
AB-CHMINACA, AB-PINACA, and FUBIMINA: Affinity and Potency of Novel Synthetic Cannabinoids in Producing Δ9-Tetrahydrocannabinol-Like Effects in Mice (full–2015) http://jpet.aspetjournals.org/content/early/2015/06/23/jpet.115.225326.long


ABN-CBD / ABNORMAL CANNABIDIOL / CAY10429
N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor (full–2010) http://www.biomedcentral.com/1471-2202/11/44
Nonpsychotropic Cannabinoids, Abnormal Cannabidiol and Canabigerol-Dimethyl Heptyl, Act at Novel Cannabinoid Receptors to Reduce Intraocular Pressure (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21770780
The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55 (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21683763
siRNA knockdown of GPR18 receptors in BV-2 microglia attenuates N-arachidonoyl glycine-induced cell migration (full–2012) http://www.jmolecularsignaling.com/content/7/1/10
GPR18 in microglia: implications for the CNS and endocannabinoid system signaling (full–2012) http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02019.x/full
Involvement of a non-CB1/CB2 cannabinoid receptor in the aqueous humor outflow-enhancing effects of abnormal-cannabidiol (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22580290
A GPR18-based signaling system regulates IOP in murine eye (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687663/
Mechanism of Central Atypical Cannabinoid Receptor GPR18-Mediated Hypotension in Conscious Rats (abst–2013) http://www.fasebj.org/cgi/content/meeting_abstract/27/1_MeetingAbstracts/654.15?sid=eea722c0-971c-4daa-8b8c-38c0c63c19ad
Role of Central Atypical Cannabinoid Receptor GPR18 in Modulating Cardiovascular Function (abst–2013) http://www.fasebj.org/cgi/content/meeting_abstract/26/1_MeetingAbstracts/663.10?sid=eea722c0-971c-4daa-8b8c-38c0c63c19ad
Evaluation of the insulin releasing and antihyperglycaemic activities of GPR55 lipid agonists using clonal beta-cells, isolated pancreatic islets and mice (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23992544
Cannabinoid Effects on β Amyloid Fibril and Aggregate Formation, Neuronal and Microglial-Activated Neurotoxicity In Vitro (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24030360
Neuronal Nitric Oxide Synthase Dependent Elevation in Adiponectin in the Rostral Ventrolateral Medulla Underlies GPR18-mediated Hypotension in Conscious Rats (full–2014) http://jpet.aspetjournals.org/content/early/2014/08/06/jpet.114.216036.long
The Novel Endocannabinoid Receptor GPR18 is Expressed in the Rostral Ventrolateral Medulla and Exerts Tonic Restraining Influence on Blood Pressure (full–2014) http://jpet.aspetjournals.org/content/early/2014/01/15/jpet.113.209213.long
Vascular targets for cannabinoids: animal and human studies (full – 2014) http://onlinelibrary.wiley.com/doi/10.1111/bph.12560/full
Cannabinoid and lipid-mediated vasorelaxation in retinal microvasculature (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24751709
Activation of GPR18 by Cannabinoid compounds: A tale of biased agonism (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24762058
Role of Endothelium in Abnormal Cannabidiol-Induced Vasoactivity in Retinal Arterioles (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26098470
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ACEA / ARACHIDONYL-2′-CHLOROETHYLAMIDE
Regulatory Role of Cannabinoid Receptor 1 in Stress-Induced Excitotoxicity and Neuroinflammation (full-2010) http://www.nature.com/npp/journal/vaop/ncurrent/full/npp2010214a.html
Alkamides and a neolignan from Echinacea purpurea roots and the interaction of alkamides with G-protein-coupled cannabinoid receptors (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21764086
The Effect of Hypoxia on G Protein Coupled (CB1) Receptor Gene Expression in Cortical B50 Neurons in Culture (abst–2011) http://www.maxwellsci.com/jp/abstract.php?jid=BJPT&no=92&abs=05
Inhibition of basal and ultraviolet B-induced melanogenesis by cannabinoid CB(1) receptors: a keratinocyte-dependent effect (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21298280
L-Type Calcium Channel Mediates Anticonvulsant Effect of Cannabinoids in Acute and Chronic Murine Models of Seizure (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21928146
Changes in the cannabinoid (CB1) receptor expression level and G-protein activation in kainic acid induced seizures (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/22079489
Opposing Roles for Cannabinoid Receptor Type-1 (CB(1)) and Transient Receptor Potential Vanilloid Type-1 Channel (TRPV1) on the Modulation of Panic-Like Responses in Rats (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242309/
Cannabinoid Receptors CB1 and CB2 Form Functional Heteromers in Brain (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375509/
Contrasting effects of different cannabinoid receptor ligands on mouse ingestive behavior (abst–2012) http://www.unboundmedicine.com/medline/ebm/record/22772336/abstract/Contrasting_effects_of_different_cannabinoid_receptor_ligands_on_mouse_ingestive_behaviour_
CB1 Agonist ACEA Protects Neurons and Reduces the Cognitive Impairment of AβPP/PS1 Mice (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22451318
Protective effect of cannabinoid CB1 receptor activation against altered intrinsic repetitive firing properties induced by Aβ neurotoxicity (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22172925
CB1 cannabinoid receptor activation rescues amyloid β-induced alterations in behaviour and intrinsic electrophysiological properties of rat hippocampal CA1 pyramidal neurones (abst-2012) http://www.ncbi.nlm.nih.gov/pubmed/22508047
Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22233683
Cannabinoids and muscular pain. Effectiveness of the local administration in rat (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22354705
Revisiting CB1 Receptor as Drug Target in Human Melanoma (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22447182
Photoperiodic Changes in Endocannabinoid Levels and Energetic Responses to Altered Signalling at CB1 Receptors in Siberian Hamsters (abst–2012) http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2826.2012.02312.x/abstract
Effect of ACEA-a selective cannabinoid CB1 receptor agonist on the protective action of different antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22789660
Evaluation of Anti-invasion Effect of Cannabinoids on Human Hepatocarcinoma Cells (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22978792
Distribution and function of the endocannabinoid system in the rat and human bladder (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/23081739
Study: Cannabis Agonists Produce Anti-Cancer Effects In Human Liver Cancer Cells (news–2012) http://norml.org/news/2012/10/11/study-cannabis-agonists-produce-anti-cancer-effects-in-human-liver-cancer-cells
Anti-Cancer Effects In Human Liver Cancer Cells Produced By Cannabis Agonists (news–2012) http://www.imarijuana.com/tag/cannabinoid-agonists
Negative Regulation of Leptin-induced ROS Formation by CB1 Receptor Activation in Hypothalamic Neurons (full–2015) http://www.jbc.org/content/early/2015/04/13/jbc.M115.646885.full.pdf+html
Intrathecal cannabinoid-1 receptor agonist prevents referred hyperalgesia in acute acrolein-induced cystitis in rats (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446380/
A Basal Tone of 2-Arachidonoylglycerol Contributes to Early Oligodendrocyte Progenitor Proliferation by Activating Phosphatidylinositol 3-Kinase (PI3K)/AKT and the Mammalian Target of Rapamycin (MTOR) Pathways (full–2015) http://link.springer.com/article/10.1007/s11481-015-9609-x/fulltext.html
Interaction between Cannabinoid Compounds and Capsazepine in Protection against Acute Pentylenetetrazole-induced Seizure in Mice (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499434/
Cannabinoid-induced autophagy regulates suppressor of cytokine signaling-3 in intestinal epithelium (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101681/
Pharmacological profiling of the hemodynamic effects of cannabinoid ligands: a combined in vitro and in vivo approach (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492759/
Activation of cannabinoid receptor 1 inhibits increased bladder activity induced by nerve growth factor (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25575795
Further Evidence for the Neuroplastic Role of Cannabinoids: A Study in Organotypic Hippocampal Slice Cultures (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25645684
CB 1Cannabinoid Receptor Agonist Inhibits Matrix Metalloproteinase Activity in Spinal Cord Injury: A Possible Mechanism of Improved Recovery (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25881484
Influence of arachidonyl-2′-chloroethylamide, a selective cannabinoid CB1 receptor agonist, on the anticonvulsant and acute side-effect potentials of clobazam, lacosamide and pregabalin in the maximal electroshock-induced seizure model and chimney test in mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25904357
Enhancement of endocannabinoid signalling protects against cocaine-induced neurotoxicity (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25933444
Role of the endocannabinoid system in the emotional manifestations of osteoarthritis pain (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26067584
Mitochondrial CB1 receptor is involved in ACEA-induced protective effects on neurons and mitochondrial functions (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26215450
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ACEA (a highly selective cannabinoid CB1 receptor agonist) stimulates hippocampal neurogenesis in mice treated with antiepileptic drugs (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26225920


ACETAMINOPHEN / PARACETAMOL
Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system (full–2005) http://www.jbc.org/content/280/36/31405.long
The analgesic activity of paracetamol is prevented by the blockade of cannabinoid CB1 receptors (abst–2005) http://www.ncbi.nlm.nih.gov/pubmed/16438952
Paracetamol: New Vistas of an Old Drug (full–2006) http://onlinelibrary.wiley.com/doi/10.1111/j.1527-3458.2006.00250.x/full
The local antinociceptive effects of paracetamol in neuropathic pain are mediated by cannabinoid receptors (abst–2007) http://www.sciencedirect.com/science/article/pii/S0014299907007935
The acetaminophen-derived bioactive N-acylphenolamine AM404 inhibits NFAT by targeting nuclear regulatory events (abst–2007) http://www.ncbi.nlm.nih.gov/pubmed/17196940
Pro-drugs for indirect cannabinoids as therapeutic agents (abst–2008) http://www.ncbi.nlm.nih.gov/pubmed/18855592
Endocannabinoid and serotonergic systems are needed for acetaminophen-induced analgesia (abst–2008) http://www.ncbi.nlm.nih.gov/pubmed/18485596?dopt=Abstract&holding=f1000,f1000m,isrctn
Endocannabinoids mediate anxiolytic-like effect of acetaminophen via CB1 receptors (abst–2009) http://www.ncbi.nlm.nih.gov/pubmed/19580839
Cannabinoid receptor-mediated antinociception with acetaminophen drug combinations in rats with neuropathic spinal cord injury pain (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826109/?tool=pubmed
Can autism be triggered by acetaminophen activation of the endocannabinoid system? (link to PDF–2010) http://www.ncbi.nlm.nih.gov/pubmed/20628445
Paracetamol-induced hypothermia is independent of cannabinoids and transient receptor potential vanilloid-1 and is not mediated by AM404 (full–2011) http://dmd.aspetjournals.org/content/39/9/1689.full
Acetaminophen inhibits status epilepticus in cultured hippocampal neurons (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052417/
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TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ9-tetrahydrocannabiorcol (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/22109525
Acetaminophen differentially enhances social behavior and cortical cannabinoid levels in inbred mice (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389197/
Acetaminophen, pesticide, and diethylhexyl phthalate metabolites, anandamide, and fatty acids in deciduous molars: potential biomarkers of perinatal exposure (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22805989
Inhibition of fatty acid amide hydrolase by URB597 attenuates the anxiolytic-like effect of acetaminophen in the mouse elevated plus-maze test (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22750843
Intraocular pressure-lowering effect of oral paracetamol and its in vitro corneal penetration properties (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564461/
Care and Feeding of the Endocannabinoid System: A Systematic Review of Potential Clinical Interventions that Upregulate the Endocannabinoid System (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951193/
Blockade of cannabinoid CB1 and CB2 receptors does not prevent the antipruritic effect of systemic paracetamol (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24399199
Arsenic decreases antinociceptive activity of paracetamol: Possible involvement of serotonergic and endocannabinoid receptors (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25128769
Terpenes and Lipids of the Endocannabinoid and Transient Receptor Potential-channel Biosignaling Systems (abst–2014) http://pubs.acs.org/doi/abs/10.1021/cn5000875
Paracetamol potentiates the antidepressant-like and anticompulsive-like effects of fluoxetine (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25340977
Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine (full–2015) http://www.hindawi.com/journals/mi/2015/523418/
Use of paracetamol during pregnancy and child neurological development (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25851072
Association between paracetamol use in infancy or childhood with body mass index (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25864407


ACPA / ARACHIDONYLCYCLOPROPYLAMIDE
Anxiolytic-like effect induced by the cannabinoid CB1 receptor agonist, arachydonilcyclopropylamide (ACPA), in the rat amygdala is mediated through the D1 and D2 dopaminergic systems (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/20685770
Effects of gonadal hormones on the peripheral cannabinoid receptor 1 (CB1R) system under a myositis condition in rats (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578305/
Endocannabinoids in the Brainstem Modulate Dural Trigeminovascular Nociceptive Traffic via CB1 and “Triptan” Receptors: Implications in Migraine (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771033/
Cannabinoids inhibit energetic metabolism and induce AMPK-dependent autophagy in pancreatic cancer cells (full–2013) http://www.nature.com/cddis/journal/v4/n6/pdf/cddis2013151a.pdf
Comparative proteomic and phosphoproteomic profiling of pancreatic adenocarcinoma cells treated with CB1 or CB2 agonists (abst–2013)  http://www.ncbi.nlm.nih.gov/pubmed/23463621
Cannabinoids as therapeutic agents in cancer: current status and future implications (link to PDF-2014) http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=2233
Effects of cannabinoids on tension induced by acetylcholine and choline in slow skeletal muscle fibers of the frog (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24218022
Cannabinoid receptor type 1 activation by arachidonylcyclopropylamide in rat aortic rings causes vasorelaxation involving calcium-activated potassium channel subunit alpha-1 and calcium channel, voltage-dependent, L type, alpha 1C subunit (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24561046
Modulation of the effects of the cannabinoid agonist, ACPA, on spatial and non-spatial novelty detection in mice by dopamine D1 receptor drugs infused into the basolateral amygdala (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25476564
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Involvement of the serotonergic system of the ventral hippocampus (CA3) on amnesia induced by ACPA in mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25771207
The dual effect of CA1 NMDA receptor modulation on ACPA-induced amnesia in stepdown passive avoidance learning task (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25680309
The hippocampal NMDA receptors may be involved in acquisition, but not expression of ACPA-induced place preference (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26072736


ADELMIDROL
Topical adelmidrol 2% emulsion, a novel aliamide, in the treatment of mild atopic dermatitis in pediatric subjects: a pilot study (abst–2007) http://www.ncbi.nlm.nih.gov/pubmed/17631786
Effect of a mucoadhesive gel and dental scaling on gingivitis in dogs (abst–2008) http://www.ncbi.nlm.nih.gov/pubmed/18512623
Adelmidrol, a palmitoylethanolamide analogue, reduces chronic inflammation in a carrageenin-granuloma model in rats (full–2009) http://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2008.00353.x/full
Inhibitory effect of topical adelmidrol on antigen-induced skin wheal and mast cell behavior in a canine model of allergic dermatitis (full–2012) http://www.biomedcentral.com/1746-6148/8/230
Adelmidrol: a new ALIAmide for chronic inflammation (news–2012) http://www.neuropathie.nu/research-development/adelmidrol-a-new-aliamide-for-chronic-inflamm.html
Effectiveness of vaginal adelmidrol for treating pelvic visceral discomforts and anxiety: a prospective observational study (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24051946


AJULEMIC ACID / AjA / IP-751 / HU-239 / CT-3
Synthetic cannabinoid ajulemic acid exerts potent antifibrotic effects in experimental models of systemic sclerosis (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22492781
In vitro metabolism and metabolic effects of ajulemic acid, a synthetic cannabinoid agonist (full–2013) http://onlinelibrary.wiley.com/doi/10.1002/prp2.17/full
In vitro metabolism and metabolic effects of ajulemic acid, a synthetic cannabinoid agonist (full–2013) http://onlinelibrary.wiley.com/doi/10.1002/prp2.17/full
Control of spasticity in a multiple sclerosis model using central nervous system-excluded CB1 cannabinoid receptor agonists (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24121462
The cannabinoid acids, analogs and endogenous counterparts (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24731541
Inhibition of Voltage-Gated Na+ Channels by the Synthetic Cannabinoid Ajulemic Acid (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24755846
Ultrapure ajulemic acid has improved CB2 selectivity with reduced CB1 activity (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24856183


AM-111 / D-JNKI-1 / XG-102
CONTROLLED-RELEASE APOPTOSIS MODULATING COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS Patent application number: 20100016218 (full–2010) http://www.faqs.org/patents/app/20100016218
Otoprotective Effect of AM-111 Also Shown In Model of Cochlear Ischemia (news–2010) http://www.biospace.com/news_story.aspx?StoryID=192710
JNK plays a key role in tau hyperphosphorylation in Alzheimer’s disease models (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21628793
Protection against ischemic cochlear damage by intratympanic administration of AM-111 (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/22089955
The JNK inhibitor XG-102 protects against TNBS-induced colitis (full-2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302790/
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Neuroprotection by inhibiting the c-Jun N-terminal kinase pathway after cerebral ischemia occurs independently of interleukin-6 and keratinocyte-derived chemokine (KC/CXCL1) secretion (full–2012) http://www.jneuroinflammation.com/content/9/1/76
Inhibition of JNK by a peptide inhibitor reduces traumatic brain injury-induced tauopathy in transgenic mice (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268782/
Specific inhibition of the JNK pathway promotes locomotor recovery and neuroprotection after mouse spinal cord injury (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22426389
The JNK inhibitor D-JNKI-1 blocks apoptotic JNK signaling in brain mitochondria (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22206897
Analysis: Drugmakers step up search for hearing loss medicines (news–2012) http://www.reuters.com/article/2012/12/02/us-hearing-medicines-idUSBRE8B102H20121202
Molecular mechanisms involved in cochlear implantation trauma and the protection of hearing and auditory sensory cells by inhibition of c-Jun-N-terminal kinase signaling (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23382052
Mitochondrial JNK phosphorylation as a novel therapeutic target to inhibit neuro-inflammation and apoptosis after neonatal ischemic brain damage (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23376684
Implication of JNK pathway on tau pathology and cognitive decline in a senescence accelerated mouse model (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23501261
c-Jun N-terminal kinase has a key role in Alzheimer disease synaptic dysfunction in vivo (full–2014) http://www.nature.com/cddis/journal/v5/n1/full/cddis2013559a.html
The impact of JNK inhibitor D-JNKI-1 in a murine model of chronic colitis induced by dextran sulfate sodium (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650567/
Efficacy and safety of AM-111 in the treatment of acute sensorineural hearing loss: a double-blind, randomized, placebo-controlled phase II study (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24979398


AM-251
Regulation of the Hypothalamic-Pituitary-Adrenal Axis Circadian Rhythm by Endocannabinoids Is Sexually Diergic (full-2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964781/?tool=pmcentrez
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2 (full–2010) http://pharmrev.aspetjournals.org/content/62/4/588.full.pdf+html
Cannabinoids excite circadian clock neurons (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927117/?tool=pubmed
GPR55 ligands promote receptor coupling to multiple signalling pathways (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931561/?tool=pubmed
Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898685/?tool=pubmed
Spinal and peripheral analgesic effects of the CB cannabinoid receptor agonist AM1241 in two models of bone cancer-induced pain (full-2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931557/?tool=pubmed
The Neuroprotective Effect of Cannabinoid Receptor Agonist (WIN55,212-2) in Paraoxon Induced Neurotoxicity in PC12 Cells and N-methyl-D-aspartate Receptor Interaction (full–2010) http://celljournal.org/library/upload/article/af_4334422Hashemi.pdf
Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone (SAB378), a peripherally restricted cannabinoid CB1/CB2 receptor agonist, inhibits gastrointestinal motility but has no effect on experimental colitis in mice (full – 2010) http://jpet.aspetjournals.org/content/334/3/973.long
The Endocannabinoid System Tonically Regulates Inhibitory Transmission and Depresses the Effect of Ethanol in Central Amygdala (full – 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904853/
Pharmacological characterization of GPR55, a putative cannabinoid receptor (full – 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874616/pdf/nihms189321.pdf
Anandamide and AM251, via water, modulate food intake at central and peripheral level in fish (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/19800340
Involvement of ERK 1/2 activation in electroacupuncture pretreatment via cannabinoid CB1 receptor in rats (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/20654595
The endocannabinoid system modulates the valence of the emotion associated to food ingestion (abst–2010) http://onlinelibrary.wiley.com/doi/10.1111/j.1369-1600.2010.00271.x/abstract
Cannabidiol (CBD) as an Anti-Arrhythmic – the Role of the CB1 Receptors (news–2010) http://cannabisclinicians.org/2011/cannabidiol-cbd-as-an-anti-arrhythmic-the-role-of-the-cb1-receptors/
AM251, cannabinoids receptors ligand, improves recognition memory in rats (full–2011) http://www.if-pan.krakow.pl/pjp/pdf/2011/3_670.pdf
A Pilot Study into the Effects of the CB1 Cannabinoid Receptor Agonist WIN55,212-2 or the Antagonist/Inverse Agonist AM251 on Sleep in Rats (full–2011) http://www.hindawi.com/journals/sd/2011/178469/
CB(1) -independent mechanisms of Δ(9) -THCV, AM251 and SR141716 (rimonabant)(full–2011) http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2710.2011.01284.x/full
Cannabinoids prevent the development of behavioral and endocrine alterations in a rat model of intense stress (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242307/
Cannabinoid receptor-mediated regulation of neuronal activity in the main olfactory bulb full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397690/
α-Tocopherol and α-tocopheryl phosphate interact with the cannabinoid system in the rodent hippocampus (abst-2011)http://www.ncbi.nlm.nih.gov/pubmed/21843633
Cannabidiol as an anti-arrhythmic, the role of the CB1 receptors (abst–2011) http://heart.bmj.com/content/97/24/e8.9.abstract
Effects of repeated electroacupuncture on gene expression of cannabinoid receptor-1 and dopamine 1 receptor in nucleus accumbens-caudate nucleus region in inflammatory-pain rats (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21585053
Endocannabinoid CB1 receptors modulate visual output from the thalamus (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21773721
The effects of cannabinoid drugs on abnormal involuntary movements in dyskinetic and non-dyskinetic 6-hydroxydopamine lesioned rats (abst–2011) http://www.unboundmedicine.com/medline/ebm/record/20888328/abstract/The_effects_of_cannabinoid_drugs_on_abnormal_involuntary_movements_in_dyskinetic_and_non_dyskinetic_6_hydroxydopamine_lesioned_rats_
Cannabinoid receptor type 2 activation yields delayed tolerance to focal cerebral ischemia (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21443454
Pot and Pumpkin Pie: Endocannabinoid System Enhanced by Vitamin E (news–2011) http://www.examiner.com/medical-marijuana-in-philadelphia/pot-and-pumpkin-pie-endocannabinoid-system-enhanced-by-vitamin-e
Cannabinoid Receptor Type 1 (CB1) Activation Inhibits Small GTPase RhoA Activity and Regulates Motility of Prostate Carcinoma Cells (full–2012) http://endo.endojournals.org/content/153/1/29.full
Differences in Spontaneously Avoiding or Approaching Mice Reflect Differences in CB1-Mediated Signaling of Dorsal Striatal Transmission (full–2012) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0033260
A Role for the Cannabinoid 1 Receptor in Neuronal Differentiation of Adult Spinal Cord Progenitors in vitro is Revealed through Pharmacological Inhibition and Genetic Deletion (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265030/?tool=pubmedCannabinoid HU210 Protects Isolated Rat Stomach against Impairment Caused by Serum of Rats with Experimental Acute Pancreatitis (full-2012) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0052921
The cannabinoid receptor CB1 modulates the signaling properties of the lysophosphatidylinositol receptor GPR55 (full – 2012) http://www.jbc.org/content/early/2012/11/16/jbc.M112.364109.long
Medial prefrontal cortex endocannabinoid system modulates baroreflex activity through CB1 receptors (full–2012) http://ajpregu.physiology.org/content/302/7/R876
The anti-nausea effects of CB(1) agonists are mediated by an action at the visceral insular cortex (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492992/
So what do we call GPR18 now? (full–2012) http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01731.x/full
Opposing Roles for Cannabinoid Receptor Type-1 (CB(1)) and Transient Receptor Potential Vanilloid Type-1 Channel (TRPV1) on the Modulation of Panic-Like Responses in Rats (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242309/
Nicotine-induced anxiety-like behavior in a rat model of the novelty-seeking phenotype is associated with long-lasting neuropeptidergic and neuroplastic adaptations in the amygdala: Effects of the cannabinoid receptor 1 antagonist AM251 (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697052/
Neuron to Astrocyte Communication via Cannabinoid Receptors Is Necessary for Sustained Epileptiform Activity in Rat Hippocampus (full–2012) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0037320
Effects of gonadal hormones on the peripheral cannabinoid receptor 1 (CB1R) system under a myositis condition in rats (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578305/
Cannabinoid Receptors CB1 and CB2 Form Functional Heteromers in Brain (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375509/
Involvement of the Endocannabinoid System in Ethanol-Induced Corticostriatal Synaptic Depression (full–2012) https://www.jstage.jst.go.jp/article/jphs/120/1/120_12118FP/_pdf
The cannabinoid CB1 receptor antagonists rimonabant (SR141716) and AM251 directly potentiate GABAA receptors (full–2012) http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01405.x/full
The effects of peptide and lipid endocannabinoids on arthritic pain at the spinal level (full–2012) http://journals.lww.com/anesthesia-analgesia/Fulltext/2012/06000/The_Effects_of_Peptide_and_Lipid_Endocannabinoids.30.aspx
Diet-dependent modulation of hippocampal expression of endocannabinoid signaling-related proteins in cannabinoid antagonist-treated obese rats (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/23033907
Bidirectional regulation of endocannabinoid signaling in the amygdala contributes to activation and adaptation of the stress response (abst–2012) http://www.journaldatabase.org/articles/bidirectional_regulation.html
Cannabinoid type 1 receptor ligands WIN 55,212-2 and AM 251 alter anxiety-like behaviors of marmoset monkeys in an open-field test (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/23183218
The cannabinoid receptor CB₁ inverse agonist AM251 potentiates the anxiogenic activity of urocortin I in the basolateral amygdala (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/21736884
Cannabinoids and muscular pain. Effectiveness of the local administration in rat (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/22354705
Endocannabinoid analogues exacerbate marble-burying behavior in mice via TRPV1 receptor (abst–2012 )http://www.ncbi.nlm.nih.gov/pubmed/22248639
WIN55212-2 attenuates amyloid-beta-induced neuroinflammation in rats through activation of cannabinoid receptors and PPAR-γ pathway (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22634229
Revisiting CB1 Receptor as Drug Target in Human Melanoma (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22447182
Stimulation of acumbens shell cannabinoid CB(1) receptors by noladin ether, a putative endocannabinoid, modulates food intake and dietary selection in rats (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22728691
Mechanism of the Interaction of Cannabinoid System in Central Amygdale with Opioid System (abst–2012) http://journal.muq.ac.ir/en/index.php/jmuqen/article/view/29
The interaction between intrathecal administration of low doses of palmitoylethanolamide and AM251 in formalin-induced pain related behavior and spinal cord IL1-β expression in rats (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22201038
Endothelium-dependent mechanisms of the vasodilatory effect of the endocannabinoid, anandamide, in the rat pulmonary artery (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22627170
Anti-Inflammatory Effect of the Endocannabinoid Anandamide in Experimental Periodontitis and Stress in the Rat (abst–2012) http://content.karger.com/produktedb/produkte.asp?doi=339113
The cannabinoid Δ(9)-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671751/
Role of endocannabinoids and cannabinoid-1 receptors in cerebrocortical blood flow regulation (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537620/
A role for the endocannabinoid system in exercise-induced spatial memory enhancement in mice (full–2013) http://www.ncbi.nlm.nih.gov/pubmed/24115292
Activation of Type 1 Cannabinoid Receptor (CB1R) Promotes Neurogenesis in Murine Subventricular Zone Cell Cultures (full-2013) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0063529
Electroacupuncture inhibition of hyperalgesia in rats with adjuvant arthritis: involvement of cannabinoid receptor 1 and dopamine receptor subtypes in striatum (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677619/
Insulin induces long-term depression of VTA dopamine neurons via endocannabinoids (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072656/
A role for O-1602 and G protein-coupled receptor GPR55 in the control of colonic motility in mice (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677091/
A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes in vitro and in situ (full–2013) https://peerj.com/articles/40/
Phencyclidine-induced social withdrawal results from deficient stimulation of cannabinoid CB1 receptors: implications for schizophrenia (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717536/
CB1 and CB2 Cannabinoid Receptor Agonists Induce Peripheral Antinociception by Activation of the Endogenous Noradrenergic System (full–2013) http://journals.lww.com/anesthesia-analgesia/Fulltext/2013/02000/CB1_and_CB2_Cannabinoid_Receptor_Agonists_Induce.31.aspx
Long-term CB1 receptor blockade enhances vulnerability to anxiogenic-like effects of cannabinoids (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691020/
Expression and functional relevance of cannabinoid receptor 1 in hodgkin lymphoma (full–2013) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0081675
Inhibitory effects of endocannabinoid on the action potential of pacemaker cells in sinoatrial nodes of rabbits (full–2013) http://www.actaps.com.cn/qikan/manage/wenzhang/2013-2-03.pdf
Evaluation of the role of striatal cannabinoid CB1 receptors on movement activity of parkinsonian rats induced by reserpine (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730975/
Rapid Glucocorticoid-Induced Activation of TRP and CB1 Receptors Causes Biphasic Modulation of Glutamate Release in Gastric-Related Hypothalamic Preautonomic Neurons (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560102/
Cannabinoids ameliorate impairments induced by chronic stress to synaptic plasticity and short-term memory (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682147/
Cannabinoid HU210 Protects Isolated Rat Stomach against Impairment Caused by Serum of Rats with Experimental Acute Pancreatitis (full–2013) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0052921
Working memory- and anxiety-related behavioral effects of repeated nicotine as a stressor: the role of cannabinoid receptors (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599339/
Cannabinoid CB1 Receptors Mediate the Gastroprotective Effect of Neurotensin (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586888/
Behavioral effects of the novel potent cannabinoid CB1 agonist AM 4054 (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015344/
Endocannabinoid/GABA interactions in the entopeduncular nucleus modulates alcohol intake in rats (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/23291357
Signaling cross-talk between cannabinoid and muscarinic systems actives Rho-kinase and increases the contractile responses of the bovine ciliary muscle (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23396229
Role of cannabinoid and vanilloid receptors in invasion of human breast carcinoma cells (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23394450
Characterisation of cannabinoid-induced relief of neuropathic pain in a rat model of cisplatin-induced neuropathy (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23454533
Neuroprotective effects of topical CB1 agonist WIN 55212-2 on Retinal ganglion cells after acute rise in intraocular pressure induced ischemia in rat (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23454099
Cannabinoid receptor 1 controls human mucosal-type mast cell degranulation and maturation in situ (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23453134
Role of TRPV1 receptors on panic-like behaviors mediated by the dorsolateral periaqueductal gray in rats (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23474373
Role of intra-accumbal cannabinoid CB1 receptors in the potentiation, acquisition and expression of morphine-induced conditioned place preference (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23523958
The Role of CB1-Receptors in the Proconvulsant Effect of Leptin on Penicillin-Induced Epileptiform Activity in Rats (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23521910
Involvement of prelimbic medial prefrontal cortex in panic-like elaborated defensive behaviour and innate fear-induced antinociception elicited by GABAA receptor blockade in the dorsomedial and ventromedial hypothalamic nuclei: role of the endocannabinoid CB1 receptor (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23521775
Central functional response to the novel peptide cannabinoid, hemopressin (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23542442
Entopeduncular nucleus endocannabinoid system modulates sleep-waking cycle and mood in rats (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23584096
2-AG into the lateral hypothalamus increases REM sleep and cFos expression in melanin concentrating hormone neurons in rats (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23603032
CB1 receptor signaling regulates social anxiety and memory (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23647582
Impact of omega-6 polyunsaturated fatty acid supplementation and γ-aminobutyric acid on astrogliogenesis through the endocannabinoid system (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23633391
Endocannabinoids mediate hyposalivation induced by inflammogens in the submandibular glands and hypothalamus (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/23684250
Effects of compounds that interfere with the endocannabinoid system on behaviors predictive of anxiolytic and panicolytic activity in the elevated T-maze (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23711591
Modulation of anxiety-like behaviour by the endocannabinoid 2-arachidonoylglycerol (2-AG) in the dorsolateral periaqueductal gray (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23714073
The role of α2-adrenoceptors in the anti-convulsant effects of cannabinoids on pentylenetetrazole-induced seizure threshold in mice (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23756131
Regulation of cell proliferation by GPR55/cannabinoid receptors using (R,R’)-4’-methoxy-1-naphthylfenoterol in rat C6 glioma cell line (abst–2013) http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=695437a2-7613-4bef-8697-2294df2da859&cKey=18ba6eb0-2c5f-4004-a56f-2d1f450e2ed1&mKey=9b2d28e7-24a0-466f-a3c9-07c21f6e9bc9
(R,R’)-4’-methoxy-1-naphthylfenoterol Inhibits GPR55 signaling and the modulation of motility in human cancer cells (abst–2013) http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=25370896-7d13-4f15-be76-f664d79b577d&cKey=87b7fec1-45cc-42b7-aca7-48c6b1d42773&mKey=9b2d28e7-24a0-466f-a3c9-07c21f6e9bc9
CB1 Cannabinoid Receptor Agonist Prevents NGF-Induced Sensitization of TRPV1 in Sensory Neurons (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23850608
CB1 and CB2 contribute to antinociceptive and anti-inflammatory effects of electro-acupuncture on experimental arthritis of the rat temporomandibular joint (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23181276
Anandamide modulates the neuroendocrine responses induced by extracellular volume expansion (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23875874
Activation of spinal cannabinoid cb2 receptors inhibits neuropathic pain in streptozotocin-induced diabetic mice (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23892011
Complex interaction between anandamide and the nitrergic system in the dorsolateral periaqueductal gray to modulate anxiety-like behavior in rats (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23899460
Comparative effects of parathion and chlorpyrifos on extracellular endocannabinoid levels in rat hippocampus: Influence on cholinergic toxicity (abst–2013 http://www.ncbi.nlm.nih.gov/pubmed/23933531
Novel effects of the cannabinoid inverse agonist AM 251 on parameters related to metabolic syndrome in obese Zucker rats (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23932644
CB1 and CB2 Cannabinoid Receptor Antagonists Prevent Minocycline-Induced Neuroprotection Following Traumatic Brain Injury in Mice (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23960212
The endocannabinoid anandamide induces apoptosis of rat decidual cells through a mechanism involving ceramide synthesis and p38 MAPK activation (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24048885
The endocannabinoid system mediates aerobic exercise-induced antinociception in rats (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24148812
Endocannabinoids decrease neuropathic pain-related behavior in mice through the activation of one or both peripheral CB1 and CB2 receptors (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24148808
Angiotensin II-induced activation of central AT1 receptors exerts endocannabinoid-mediated gastroprotective effect in rats (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24145131
Cannabinoid Receptor Activation Prevents the Effects of Chronic Mild Stress on Emotional Learning and LTP in a Rat Model of Depression (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24141570
Cytotoxicity of synthetic cannabinoids on primary neuronal cells of the forebrain: the involvement of cannabinoid CB1 receptors and apoptotic cell death (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24211273
(R,R’)-4′-Methoxy-1-naphthylfenoterol Targets GPR55-mediated Ligand Internalization and Impairs Cancer Cell Motility (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24355564
Organophosphate agents induce plasma hypertriglyceridemia in mouse via single or dual inhibition of the endocannabinoid hydrolyzing enzyme(s) (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24361246
Concurrent pharmacological modification of cannabinoid-1 and glucagon-like peptide-1 receptor activity affects feeding behavior and body weight in rats fed a free-choice, high-carbohydrate diet (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24370558
Differential expression of endocannabinoid system in normal and preeclamptic placentas: effects on nitric oxide synthesis (abst-2013) http://www.ncbi.nlm.nih.gov/pubmed/23122699
Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24384256
Prophylactic cannabinoid administration blocks the development of paclitaxel-induced neuropathic nociception during analgesic treatment and following cessation of drug delivery (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998744/
Involvement of cannabinoid receptors in peripheral and spinal morphine analgesia (full–2014)http://www.sciencedirect.com/science/article/pii/S0306452213010531
Effect of intermittent cold exposure on brown fat activation, obesity, and energy homeostasis in mice (full–2014)http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895006/
CB1 cannabinoid receptors are involved in neuroleptic-induced enhancement of brain neurotensin (full–2014)http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016688/
2012 Division of Medicinal Chemistry Award Address: Trekking the Cannabinoid Road: A Personal Perspective (full–2014)http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064474/
Cannabinoids as therapeutic agents in cancer: current status and future implications (link to PDF-2014)http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=2233
Blockade of cannabinoid CB1 and CB2 receptors does not prevent the antipruritic effect of systemic paracetamol (abst–2014)http://www.ncbi.nlm.nih.gov/pubmed/24399199
Cannabinoid modulation of predator fear: involvement of the dorsolateral periaqueductal gray (abst–2014)http://www.ncbi.nlm.nih.gov/pubmed/24438603
Anti-depressive mechanism of repetitive transcranial magnetic stimulation in rat: The role of the endocannabinoid system (abst–2014)http://www.ncbi.nlm.nih.gov/pubmed/24479995
Anandamide activation of CB1 receptors increases spontaneous bursting and oscillatory activity in the thalamus (abst–2014)http://www.ncbi.nlm.nih.gov/pubmed/24508153
Anticonvulsant Effects of N-Arachidonoyl-Serotonin, a Dual FAAH Enzyme and TRPV1 Channel Blocker, on Experimental Seizures: The Roles of Cannabinoid CB1 Receptors and TRPV1 Channels (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24674273
Low anandamide doses facilitate male rat sexual behaviour through the activation of CB1 receptors (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24671517
Hemopressin, an inverse agonist of cannabinoid receptors, inhibits neuropathic pain in rats (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24703998
Vagal anandamide signaling via cannabinoid receptor 1 contributes to luminal 5-HT modulation of visceral nociception in rats (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24813296
Augmented tonic pain-related behavior in knockout mice lacking monoacylglycerol lipase, a major degrading enzyme for the endocannabinoid 2-arachidonoylglycerol (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24906199
Attenuation of serotonin-induced itch responses by inhibition of endocannabinoid degradative enzymes, fatty acid amide hydrolase and monoacylglycerol lipase (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24915981
Endocannabinoid modulation by FAAH and MAGL within the analgesic circuitry of the periaqueductal grey (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25041240
The interaction between serotonergic and cannabinoidergic modulations involved in the fear extinction (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25069241
The spinal anti-inflammatory mechanism of motor cortex stimulation: cause of success and refractoriness in neuropathic pain? (full–2015)
http://www.jneuroinflammation.com/content/pdf/s12974-014-0216-1.pdf
Cannabinoid Receptor CB2 Is Involved in Tetrahydrocannabinol-Induced Anti-Inflammation against Lipopolysaccharide in MG-63 Cells (full–2015)
http://www.hindawi.com/journals/mi/2015/362126/
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Role for Endogenous BDNF in Endocannabinoid-Mediated Long-Term Depression at Neocortical Inhibitory Synapses (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415885/
Interaction between orexin A and cannabinoid system in the lateral hypothalamus of rats and effects of subchronic intraperitoneal administration of cannabinoid receptor inverse agonist on food intake and the nutritive utilization of protein (full–2015) http://www.jpp.krakow.pl/journal/archive/04_15/pdf/181_04_15_article.pdf
Role of the endocannabinoid system in obesity induced by neuropeptide Y overexpression in noradrenergic neurons (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423197/
Bi-directional CB1 receptor-mediated cardiovascular effects of cannabinoids in anaesthetized rats: role of the paraventricular nucleus (full–2015) http://www.jpp.krakow.pl/journal/archive/06_15/pdf/343_06_15_article.pdf
Tonic endocannabinoid-mediated modulation of GABA release is independent of the CB1 content of axon terminals (full–2015) http://www.nature.com/ncomms/2015/150420/ncomms7557/full/ncomms7557.html
Coadministration of indomethacin and minocycline attenuates established paclitaxelinduced neuropathic thermal hyperalgesia: Involvement of cannabinoid CB1 receptors (full–2015) http://www.nature.com/srep/2015/150618/srep10541/pdf/srep10541.pdf
Pharmacological profiling of the hemodynamic effects of cannabinoid ligands: a combined in vitro and in vivo approach (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492759/
Multiple Forms of Endocannabinoid and Endovanilloid Signaling Regulate the Tonic Control of GABA Release (full–2015) http://www.jneurosci.org/content/35/27/10039.full?sid=7e769d1b-9b77-42fe-92d0-8b337b34b9b6
Activation of cannabinoid receptor 1 inhibits increased bladder activity induced by nerve growth factor (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25575795
The role of AMP-activated protein kinase (AMPK) in the androgenic potentiation of cannabinoid-induced changes in energy homeostasis (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25550281
Intra-visceral insular cortex 2-arachidonoylglycerol, but not Narachidonoylethanolamide, suppresses acute nausea-induced conditioned gaping in rats (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25499318
Role of endocannabinoid signalling in the dorsolateral periaqueductal grey in the modulation of distinct panic-like responses (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25601395
Modulation of sweet taste sensitivities by endogenous leptin and endocannabinoids in mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25728242
Attenuation of kainic acid-induced status epilepticus by inhibition of endocannabinoid transport and degradation in guinea pigs (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25769371
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Spinal neuronal cannabinoid receptors mediate urodynamic effects of systemic fatty acid amide hydrolase (FAAH) inhibition in rats (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25788026
Acute administration of a cannabinoid CB1 receptor antagonist impairs stress-induced antinociception in fish (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25656689
Effects of cannabinoid and glutamate receptor antagonists and their interactions on learning and memory in male rats (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25684318
Further Evidence for the Neuroplastic Role of Cannabinoids: A Study in Organotypic Hippocampal Slice Cultures (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25645684
The GPR55 agonist lysophosphatidylinositol mediates vasorelaxation of the rat mesenteric resistance artery and induces calcium release in rat mesenteric artery endothelial cells (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25652040
Antidepressant-like effects of the cannabinoid receptor ligands in the forced swimming test in mice: Mechanism of action and possible interactions with cholinergic system (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25660201
A multi-target approach for pain treatment – dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25719612
Anandamide Reduces the Ejaculatory Threshold of Sexually Sluggish Male Rats: Possible Relevance for Human Lifelong Delayed Ejaculation Disorder (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25808995
Chronic administration with AM251 improves albuminuria and renal tubular structure in obese rats (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25804605
The dual effect of CA1 NMDA receptor modulation on ACPA-induced amnesia in stepdown passive avoidance learning task (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25680309
Cannabinoid-Induced Changes in the Activity of Electron Transport Chain Complexes of Brain Mitochondria (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25820672
Major urinary protein 1 interacts with cannabinoid receptor type 1 in fatty acid-induced hepatic insulin resistance in a mouse hepatocyte model (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25843798
Possible inhibitory role of endogenous 2-arachidonoylglycerol as an endocannabinoid in (±)-epibatidine-induced activation of central adrenomedullary outflow in the rat (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25882827
Enhanced function of inhibitory presynaptic cannabinoid CB1 receptors on sympathetic nerves of DOCA-salt hypertensive rats (abst–2015) http://www.sciencedirect.com/science/article/pii/S0024320515002155
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Enhancement of endocannabinoid signalling protects against cocaine-induced neuro-toxicity (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25933444
Cannabinoid functions in the amygdala contribute to conditioned fear memory in streptozotocin-induced diabetic mice: interaction with glutamatergic functions (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25929688
Differential Pharmacological Regulation of Sensorimotor-Gating Deficit in CB1 Knockout Mice and Associated Neurochemical and Histological Alterations (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25895455
Chronic ethanol exposure decreases CB1 receptor function at GABAergic synapses in the rat central amygdala (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25940135
AM251 induces apoptosis and G2/M cell cycle arrest in A375 human melanoma cells (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25974027
Endocannabinoid-mediated improvement on a test of aversive memory in a mouse model of fragile X syndrome (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25979787
JWH-018 impairs sensorimotor functions in mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25987201
Involvement of cannabinoid receptors in infrasonic noise-induced neuronal impairment (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26058582
Evidence against a critical role of CB1 receptors in adaptation of the hypothalamic pituitary-adrenal axis and other consequences of daily repeated stress (abst– 2015) http://www.ncbi.nlm.nih.gov/pubmed/26092203
A pivotal role for enhanced brainstem orexin receptor 1 signaling in the central cannabinoid receptor 1-mediated pressor response in conscious rats (abst-2015) http://www.ncbi.nlm.nih.gov/pubmed/26096126
Cannabinoid and nitric oxide signaling interplay in the modulation of hippocampal hyperexcitability: Study on electrophysiological and behavioral models of temporal lobe epilepsy in the rat (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26135674
Modulatory effects by CB1 receptors on rat spinal locomotor networks after sustained application of agonists or antagonists (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26126926
Enhanced vasorelaxation effect of endogenous anandamide on thoracic aorta in renal vascular hypertension rats (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26173564
Mitochondrial CB1 receptor is involved in ACEA-induced protective effects on neurons and mitochondrial functions (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26215450
Cannabinoids Regulate Intestinal Motor Function and Electrophysiological Activity of Myocytes in Rodents (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26254701
Microinjection of orexin-A into the rat locus coeruleus nucleus induces analgesia via cannabinoid type-1 receptors (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26254729
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AM-281
GPR55 ligands promote receptor coupling to multiple signalling pathways (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931561/?tool=pubmed
Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics and role in influencing neurochemical phenotype (full–2010) http://ajpgi.physiology.org/content/299/1/G63.full?sid=fc6948f0-78cf-405c-981b-afaa05ee417c
Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930808/?tool=pubmed
Cannabinoids inhibit peptidoglycan-induced phosphorylation of NF-κB and cell growth in U87MG human malignant glioma cells (full–2012) http://www.spandidos-publications.com/or/28/4/1176;jsessionid=52ED17697BFDC92E6F5F848306023474?text=fulltext
Angiotensin II induces vascular endocannabinoid release, which attenuates its vasoconstrictor effect via CB1 cannabinoid receptors (full–2012) http://www.jbc.org/content/early/2012/07/11/jbc.M112.346296.full.pdf+html
Early Endogenous Activation of CB1 and CB2 Receptors after Spinal Cord Injury Is a Protective Response Involved in Spontaneous Recovery (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496738/
The cannabinoid receptor CB1 modulates the signaling properties of the lysophosphatidylinositol receptor GPR55 (full–2012) http://www.jbc.org/content/early/2012/11/16/jbc.M112.364109.long
Regulation of endocannabinoid release by G proteins: A paracrine mechanism of G protein-coupled receptor action (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22075205
Peripheral antinociceptive effect of anandamide and drugs that affect the endocannabinoid system on the formalin test in normal and streptozotocin-diabetic rats (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/22959964
Endogenous cannabinoid receptor CB1 activation promotes vascular smooth muscle cell proliferation and neointima formation (full–2013) http://www.jlr.org/content/early/2013/03/11/jlr.M035147.long
Monoacylglycerol Lipase (MAGL) Inhibition Attenuates Acute Lung Injury in Mice (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808422/
Acetaldehyde as a drug of abuse: insight into AM281 administration on operant-conflict paradigm in rats (full–2013) http://www.frontiersin.org/Behavioral_Neuroscience/10.3389/fnbeh.2013.00064/full
AM281, Cannabinoid Antagonist/Inverse agonist, Ameliorates Scopolamine-Induced Cognitive Deficit (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586915/
Cannabinoid receptor activation in the nucleus tractus solitaries produces baroreflex-like responses in the rat (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614708/
GPR55 and its interaction with membrane lipids: comparison with other endocannabinoid-binding receptors (link to PDF-2013) http://www.eurekaselect.com/105678/article
Cannabinoid Receptors as Therapeutic Targets for Dialysis-Induced Peritoneal Fibrosis (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23296044
The non-selective cannabinoid receptor agonist WIN 55,212-2 attenuates responses of C-fiber nociceptors in a murine model of cancer pain (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23673278
Dysregulation of Cannabinoid CB1 Receptor and Associated Signaling Networks in Brains of Cocaine Addicts and Cocaine-Treated Rodents (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23727505
Peripheral and Spinal Activation of Cannabinoid Receptors by Joint Mobilization Alleviates Postoperative Pain in Mice (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24120553
The effect of AM281, a cannabinoid antagonist, on memory performance during spontaneous morphine withdrawal in mice (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895301/
2012 Division of Medicinal Chemistry Award Address: Trekking the Cannabinoid Road: A Personal Perspective (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064474/
Effects of cannabinoids on tension induced by acetylcholine and choline in slow skeletal muscle fibers of the frog (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24218022
Tonic Modulation of Nociceptive Behavior and Allodynia by Cannabinoid Receptors in Formalin Test in Rats (full–2015) http://www.cps.org.tw/files/201503160252300.pdf
Increased contextual fear conditioning in iNOS knockout mice: additional evidence for the involvement of nitric oxide in stress-related disorders and contribution of the endocannabinoid system (full–2015) http://ijnp.oxfordjournals.org/content/18/8/pyv005.long
Palmitoylethanolamide Inhibits Glutamate Release in Rat Cerebrocortical Nerve Terminals (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394492/
A Basal Tone of 2-Arachidonoylglycerol Contributes to Early Oligodendrocyte Progenitor Proliferation by Activating Phosphatidylinositol 3-Kinase (PI3K)/AKT and the Mammalian Target of Rapamycin (MTOR) Pathways (full–2015) http://link.springer.com/article/10.1007/s11481-015-9609-x/fulltext.html
Pathogenesis of Systemic Sclerosis (full–2015) http://journal.frontiersin.org/article/10.3389/fimmu.2015.00272/full
Cannabinoid agonists rearrange synaptic vesicles at excitatory synapses and depress motoneuron activity in vivo (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25595101
Phenotype-dependent inhibition of glutamatergic transmission on nucleus accumbens medium spiny neurons by the abused inhalant toluene (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25752326
The monoacylglycerol lipase inhibitor JZL184 decreases inflammatory response in skeletal muscle contusion in rats (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25912803
The endocannabinoid system and associative learning and memory in zebrafish (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25956869
The role of the peripheral cannabinoid system in the pathogenesis of detrusor over-activity evoked by increased intravesical osmolarity in rats (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26243021


AM–374 / HEXADECYL SULFONYLFLUORIDE
Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington’s disease (full–2003) http://onlinelibrary.wiley.com/doi/10.1046/j.1471-4159.2003.01595.x/full
Behavioral effects of inhibition of cannabinoid metabolism: The amidase inhibitor AM374 enhances the suppression of lever pressing produced by exogenously administered anandamide (abst–2004) http://www.ncbi.nlm.nih.gov/pubmed/14672756
Dual modulation of endocannabinoid transport and fatty acid amide hydrolase protects against excitotoxicity (full–2005) http://www.jneurosci.org/content/25/34/7813.long
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Endocannabinoid enhancement protects against kainic acid-induced seizures and associated brain damage (full–2007) http://jpet.aspetjournals.org/content/322/3/1059.long
Sulfonyl Fluoride Inhibitors of Fatty Acid Amide Hydrolase (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678964/


AM-404
Pharmacological elevation of anandamide impairs short-term memory by altering the neurophysiology in the hippocampus (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156972/
The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine-induced dopamine elevations in the nucleus accumbens shell in rats (full–2011) http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01467.x/full
Role of endocannabinoid and glutamatergic systems in DOI-induced head-twitch response in mice (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21504759
Acetaminophen differentially enhances social behavior and cortical cannabinoid levels in inbred mice (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389197/
Involvement of the Endocannabinoid System in Ethanol-Induced Corticostriatal Synaptic Depression (full–2012) https://www.jstage.jst.go.jp/article/jphs/120/1/120_12118FP/_pdf
Endocannabinoid analogues exacerbate marble-burying behavior in mice via TRPV1 receptor (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22248639
Effects of the anandamide uptake blocker AM404 on food intake depend on feeding status and route of administration (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22133635
Inhibition of fatty acid amide hydrolase by URB597 attenuates the anxiolytic-like effect of acetaminophen in the mouse elevated plus-maze test (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22750843
Peripheral antinociceptive effect of anandamide and drugs that affect the endocannabinoid system on the formalin test in normal and streptozotocin-diabetic rats (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22959964
Diuretic effects of cannabinoids (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533417/
Effects of cannabinoid drugs on the deficit of prepulse inhibition of startle in an animal model of schizophrenia: the SHR strain (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915876/
AM404 attenuates reinstatement of nicotine seeking induced by nicotine-associated cues and nicotine priming but does not affect nicotine- and food-taking (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058760/
Diuretic effects of cannabinoid agonists in mice (abst–2013) http://www.sciencedirect.com/science/article/pii/S0014299913007176
2012 Division of Medicinal Chemistry Award Address: Trekking the Cannabinoid Road: A Personal Perspective (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064474/
Sterol Carrier Protein-2: Binding Protein for Endocannabinoids (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24510313
Targeting the cannabinoid system for pain relief? (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24529672
Effects of cannabinoid and vanilloid drugs on positive and negative-like symptoms on an animal model of schizophrenia: The SHR strain (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24556469
Attenuation of serotonin-induced itch responses by inhibition of endocannabinoid degradative enzymes, fatty acid amide hydrolase and monoacylglycerol lipase (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24915981
Attenuation of kainic acid-induced status epilepticus by inhibition of endocannabinoid transport and degradation in guinea pigs (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25769371
For whom the endocannabinoid tolls: Modulation of innate immune function and implications for psychiatric disorders (abst–2015) http://www.sciencedirect.com/science/article/pii/S027858461500055X
2-AG promotes the expression of conditioned fear via cannabinoid receptor type 1 on GABAergic neurons (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25814137
Possible inhibitory role of endogenous 2-arachidonoylglycerol as an endocannabinoid in (±)-epibatidine-induced activation of central adrenomedullary outflow in the rat (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25882827


AM-630
Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930808/?tool=pubmed
Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone (SAB378), a peripherally restricted cannabinoid CB1/CB2 receptor agonist, inhibits gastrointestinal motility but has no effect on experimental colitis in mice (full–2010) http://jpet.aspetjournals.org/content/334/3/973.long
A nonsynonymous polymorphism in cannabinoid CB2 receptor gene is associated with eating disorders in humans and food intake is modified in mice by its ligands (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/19768813
Brain cannabinoid CB2 receptors modulate cocaine’s actions in mice (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164946/
annabinoid receptor-2 (CB2) agonist ameliorates colitis in IL-10(-/-) mice by attenuating the activation of T cells and promoting their apoptosis (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117838/
Cannabinoid-2 Receptor Activation Protects against Infarct and Ischemia/Reperfusion Heart Injury (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/22113346
The role of central CB2 cannabinoid receptors on food intake in neonatal chicks (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21927979
Cannabinoid receptor type 2 activation yields delayed tolerance to focal cerebral ischemia (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21443454
Effects of a Selective Cannabinoid CB2 Agonist and Antagonist on Intravenous Nicotine Self Administration and Reinstatement of Nicotine Seeking (full – 2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266883/?tool=pubmed
Early Endogenous Activation of CB1 and CB2 Receptors after Spinal Cord Injury Is a Protective Response Involved in Spontaneous Recovery (full – 2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496738/
Cannabinoid CB(2) receptor-mediated regulation of impulsive-like behaviour in DBA/2 mice (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252982/
The role of CB2 receptor ligands in human eosinophil function (full–2012) http://www.biomedcentral.com/content/pdf/2050-6511-13-S1-A13.pdf
Cannabinoid receptor 2 agonist ameliorates mesenteric angiogenesis and portosystemic collaterals in cirrhotic rats (full–2012) http://onlinelibrary.wiley.com/doi/10.1002/hep.25625/full
Cannabinoid Receptors CB1 and CB2 Form Functional Heteromers in Brain (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375509/
The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CB2 receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy (full–2012) http://www.molecularpain.com/content/8/1/71
Effect of omega-3 polyunsaturated fatty acids on the endocannabinoid system in osteoblast-like cells and muscle (abst–2012) http://docs.lib.purdue.edu/dissertations/AAI3444794/
Cannabinoids and muscular pain. Effectiveness of the local administration in rat (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22354705
Cannabinoids ameliorate disease progression in a model of multiple sclerosis in mice, acting preferentially through CB(1) receptor-mediated anti-inflammatory effects (abst-2012) http://www.ncbi.nlm.nih.gov/pubmed/22342378
Peripheral antinociceptive effect of anandamide and drugs that affect the endocannabinoid system on the formalin test in normal and streptozotocin-diabetic rats (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22959964
Anandamide enhances expression of heat shock protein 72 to protect against ischemia-reperfusion injury in rat heart (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/23007622
Endothelium-dependent mechanisms of the vasodilatory effect of the endocannabinoid, anandamide, in the rat pulmonary artery (abst-2012) http://www.ncbi.nlm.nih.gov/pubmed/22627170
Acute toxicity due to the confirmed consumption of synthetic cannabinoids: clinical and laboratory findings (abst–2012) http://onlinelibrary.wiley.com/doi/10.1111/j.1360-0443.2012.04078.x/abstract
Anti-Inflammatory Effect of the Endocannabinoid Anandamide in Experimental Periodontitis and Stress in the Rat (abst–2012) http://content.karger.com/produktedb/produkte.asp?doi=339113
Electroacupuncture reduces the expression of proinflammatory cytokines in inflamed skin tissues through activation of cannabinoid CB2 receptors (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22337285
Monoacylglycerol Lipase (MAGL) Inhibition Attenuates Acute Lung Injury in Mice (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808422/
CB1 and CB2 Cannabinoid Receptor Agonists Induce Peripheral Antinociception by Activation of the Endogenous Noradrenergic System (full–2013) http://journals.lww.com/anesthesia-analgesia/Fulltext/2013/02000/CB1_and_CB2_Cannabinoid_Receptor_Agonists_Induce.31.aspx
Activation of Cannabinoid Receptor 2 Inhibits Experimental Cystitis (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652164/
Diuretic effects of cannabinoids (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533417/
Inhibitory effects of endocannabinoid on the action potential of pacemaker cells in sinoatrial nodes of rabbits (full–2013) http://www.actaps.com.cn/qikan/manage/wenzhang/2013-2-03.pdf
Targeting the Endocannabinoid System to Treat Sepsis (review–2013) http://www.signavitae.com/articles/review-articles/222-targeting-the-endocannabinoid-system-to-treat-sepsis
Inhibition of endocannabinoid degradation in experimental endotoxemia reduces leukocyte adhesion and improves capillary perfusion in the gut (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23382309
Activation of Cannabinoid CB2 Receptor-Mediated AMPK/CREB Pathway Reduces Cerebral Ischemic Injury (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23414569
The complex effects of cannabinoids on insulin secretion from rat isolated islets of Langerhans (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23499687
Mechanisms Of Cannabidiol Neuroprotection In Hypoxic-Ischemic Newborn Pigs: Role Of 5HT1A And CB2 Receptors (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23587650
The fatty acid amide hydrolase inhibitor, URB597, promotes retinal ganglion cell neuroprotection in a rat model of optic nerve axotomy (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23643752
The non-selective cannabinoid receptor agonist WIN 55,212-2 attenuates responses of C-fiber nociceptors in a murine model of cancer pain (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23673278
Modulation of anxiety-like behaviour by the endocannabinoid 2-arachidonoylglycerol (2-AG) in the dorsolateral periaqueductal gray (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23714073
Synaptic plasticity alterations associated with memory impairment induced by deletion of CB2 cannabinoid receptors (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23796670
CB1 and CB2 contribute to antinociceptive and anti-inflammatory effects of electroacupuncture on experimental arthritis of the rat temporomandibular joint (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23181276
Activation of spinal cannabinoid cb2 receptors inhibits neuropathic pain in streptozotocin-induced diabetic mice (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23892011
Characterization of bladder function in a cannabinoid receptor type 2 knockout mouse in vivo and in vitro (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23908133
CB1 and CB2 Cannabinoid Receptor Antagonists Prevent Minocycline-Induced Neuroprotection Following Traumatic Brain Injury in Mice (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23960212
The oral administration of trans-caryophyllene attenuates acute and chronic pain in mice (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24055516
PPARγ mediates the effects of WIN55,212-2, an synthetic cannabinoid, on the proliferation and apoptosis of the BEL-7402 hepatocarcinoma cells (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24062073
Peripheral and Spinal Activation of Cannabinoid Receptors by Joint Mobilization Alleviates Postoperative Pain in Mice (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24120553
The endocannabinoid system mediates aerobic exercise-induced antinociception in rats (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24148812
Cytotoxicity of synthetic cannabinoids on primary neuronal cells of the forebrain: the involvement of cannabinoid CB1 receptors and apoptotic cell death (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24211273
Endocannabinoids underlie reconsolidation of hedonic memories in Wistar rats (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24247477
Increase of mesenchymal stem cell migration by Cannabidiol via activation of p42/44 MAPK (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24304686
The inhibitory effect of anandamide on oxytocin and vasopressin secretion from neurohypophysis is mediated by nitric oxide (abst–2013)  http://www.ncbi.nlm.nih.gov/pubmed/24342802
Cytotoxicity of synthetic cannabinoids on primary neuronal cells of the forebrain: the involvement of cannabinoid CB1 receptors and apoptotic cell death (abst–2013) http://www.sciencedirect.com/science/article/pii/S0041008X13004766
Diuretic effects of cannabinoid agonists in mice (abst–2013) http://www.sciencedirect.com/science/article/pii/S0014299913007176
Cannabinoid Trans-Caryophyllene Protects Brain Cells From Ischemia (news–2013) http://www.medicalnewstoday.com/articles/256799.php
Activation of cortical type 2 cannabinoid receptors ameliorates ischemic brain injury (news–2013) http://www.sciencedaily.com/releases/2013/02/130221141140.htm
Docosahexaenoyl ethanolamide improves glucose uptake and alters endocannabinoid system gene expression in proliferating and differentiating C2C12 myoblasts (full–2014) http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00100/full
Experimental cannabinoid 2 receptor-mediated immune modulation in sepsis (full–2014) http://www.hindawi.com/journals/mi/2014/978678/
Prophylactic cannabinoid administration blocks the development of paclitaxel-induced neuropathic nociception during analgesic treatment and following cessation of drug delivery (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998744/
Cannabinoids as therapeutic agents in cancer: current status and future implications (link to PDF-2014) http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=2233
Cannabinoid receptor antagonists and fatty acids alter endocannabinoid system gene expression and COX activity (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24854955
Chronic Cannabinoid Receptor 2 Activation Reverses Paclitaxel Neuropathy Without Tolerance or Cannabinoid Receptor 1-Dependent Withdrawal (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24853387
β-Caryophyllene, a CB2 Receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24930711
Anti-atherosclerosis role of N-oleoylethanolamine in CB2 (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24961101
The cannabinoid receptor 2 agonist, β-Caryophyllene, reduced voluntary alcohol intake and attenuated ethanol-induced place preference and sensitivity in mice (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24999220
Differential Activation of Intracellular vs Plasmalemmal CB2 Cannabinoid Receptors (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25033246
Peripheral neurobiologic mechanisms of antiallodynic effect of warm water immersion therapy on persistent inflammatory pain (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25079058
Cannabinoid Receptor CB2 Is Involved in Tetrahydrocannabinol-Induced Anti-Inflammation against Lipopolysaccharide in MG-63 Cells (full–2015) http://www.hindawi.com/journals/mi/2015/362126/
Tonic Modulation of Nociceptive Behavior and Allodynia by Cannabinoid Receptors in Formalin Test in Rats (full–2015) http://www.cps.org.tw/files/201503160252300.pdf
Cannabinoid CB2 Receptors in a Mouse Model of Aβ Amyloidosis: Immunohistochemical Analysis and Suitability as a PET Biomarker of
Neuroinflammation (full-2015) http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0129618
A Basal Tone of 2-Arachidonoylglycerol Contributes to Early Oligodendrocyte Progenitor Proliferation by Activating Phosphatidylinositol 3-Kinase (PI3K)/AKT and the Mammalian Target of Rapamycin (MTOR) Pathways (full–2015) http://link.springer.com/article/10.1007/s11481-015-9609-x/fulltext.html
CB2R orchestrates fibrogenesis through regulation of inflammatory response during the repair of skeletal muscle contusion (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466920/
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Beneficial effects of cannabinoid receptor type 2 (CB2R) in injured skeletal muscle post contusion (full–2015) http://www.hh.um.es/pdf/Vol_30/30_6/Yu-30-737-749-2015.pdf
Pathogenesis of Systemic Sclerosis (full–2015) http://journal.frontiersin.org/article/10.3389/fimmu.2015.00272/full
Activation of murine microglial N9 cells is attenuated through cannabinoid receptor CB2 signaling (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25637536
Antidepressant-like effects of the cannabinoid receptor ligands in the forced swimming test in mice: Mechanism of action and possible interactions with cholinergic system (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25660201
2-AG promotes the expression of conditioned fear via cannabinoid receptor type 1 on GABAergic neurons (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25814137
Minocycline Attenuates Neonatal Germinal-Matrix-Hemorrhage-Induced Neuro-inflammation and Brain Edema by Activating Cannabinoid Receptor 2 (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25833102
Activation of Cannabinoid CB2 receptors Reduces Hyperalgesia in an Experimental Autoimmune Encephalomyelitis Mouse Model of Multiple Sclerosis. (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25849525
Protective effect of paeoniflorin on the hippocampus in rats with cerebral ischemia reperfusion through activating cannabinoid receptor 2 (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25854559
Role of cannabinoidergic system on food intake in neonatal layer-type chicken (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25902906
The monoacylglycerol lipase inhibitor JZL184 decreases inflammatory response in skeletal muscle contusion in rats (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25912803
Role of CB2 receptors in social and aggressive behavior in male mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25921034
Cannabinoid functions in the amygdala contribute to conditioned fear memory in streptozotocin-induced diabetic mice: interaction with glutamatergic functions (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25929688
Cannabinoid receptor 2 attenuates microglial accumulation and brain injury following germinal matrix hemorrhage via ERK dephosphorylation in vivo and in vitro (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25963415
Neuroprotective Effect of JZL184 in MPP+-Treated SH-SY5Y Cells Through CB 2 Receptors (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25976369
Endocannabinoid and nitric oxide interaction mediates food intake in neonatal chicken (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26053311
Whole-cell biosensor for label-free detection of GPCR-mediated drug responses in personal cell lines (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26143464
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Enhanced vasorelaxation effect of endogenous anandamide on thoracic aorta in renal vascular hypertension rats (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26173564
A synergistic interaction of 17-β-estradiol with specific cannabinoid receptor type 2 antagonist/inverse agonist on proliferation activity in primary human osteoblasts (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26171165
The role of the peripheral cannabinoid system in the pathogenesis of detrusor overactivity evoked by increased intravesical osmolarity in rats (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26243021
Cannabinoids Regulate Intestinal Motor Function and Electrophysiological Activity of Myocytes in Rodents (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26254701


AM-694
Beyond THC: The New Generation of Cannabinoid Designer Drugs (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187647/?tool=pubmed
The impact of changes in UK classification of the synthetic cannabinoid receptor agonists in ‘Spice’ (abst–2011)http://www.ncbi.nlm.nih.gov/pubmed/21482092
The detection of the urinary metabolites of 1-[(5-fluoropentyl)-1H-indol-3-yl]-(2-iodophenyl)methanone (AM-694), a high affinity cannabimimetic, by gas chromatography – mass spectrometry (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22522907
Acute toxicity due to the confirmed consumption of synthetic cannabinoids: clinical and laboratory findings (abst–2012)http://onlinelibrary.wiley.com/doi/10.1111/j.1360-0443.2012.04078.x/abstract
Synthetic Cannabinoids -The Challenges of Testing for Designer Drugs (article–2013) (funky link- delete the “sign in”, and it comes up) http://www.aacc.org/publications/cln/2013/february/Pages/Cannabinoids.aspx?PassThru=ok&PersonID=206339#
Toxicological profiles of selected synthetic cannabinoids showing high binding affinities to the cannabinoid receptor subtype CB1 (abst–2013)http://www.ncbi.nlm.nih.gov/pubmed/23494106
A Case of Cannabinoid Hyperemesis Syndrome Caused by Synthetic Cannabinoids (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23890687
Simultaneous quantification of 20 synthetic cannabinoids and 21 metabolites, and semi-quantification of 12 alkyl hydroxy metabolites in human urine by liquid chromatography-tandem mass spectrometry (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24418231
Effects and risks associated with novel psychoactive substances: mislabeling and sale as bath salts, spice, and research chemicals (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965957/
Cannabinoids as therapeutic agents in cancer: current status and future implications (link to PDF-2014) http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=2233
Intravenous Lipid Emulsion Therapy for Acute Synthetic Cannabinoid Intoxication: Clinical Experience in Four Cases (full–2015) http://www.hindawi.com/journals/criem/2015/180921/
Legal highs: staying on top of the flood of novel psychoactive substances (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521440/
Evaluation of an On-site Drug-testing Device for the Detection of Synthetic Cannabinoids in Illegal Herbal Products (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25759062


AM-841
(-)-7′-Isothiocyanato-11-hydroxy-1′,1′-dimethylheptylhexahydrocannabinol (AM841), a high-affinity electrophilic ligand, interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptor (full–2005) http://molpharm.aspetjournals.org/content/68/6/1623.long
Cannabinoids Alleviate Experimentally Induced Intestinal Inflammation by Acting at Central and Peripheral Receptors (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183544/
AM841, a covalent cannabinoid ligand, powerfully slows gastrointestinal motility in normal and stressed mice in a peripherally-restricted manner (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25572435
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AM-1172
2012 Division of Medicinal Chemistry Award Address: Trekking the Cannabinoid Road: A Personal Perspective (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064474/


AM-1220
Hair analysis as a tool to evaluate the prevalence of synthetic cannabinoids in different populations of drug consumers (full–2014) http://onlinelibrary.wiley.com/doi/10.1002/dta.1556/full
Evaluation of an On-site Drug-testing Device for the Detection of Synthetic Cannabinoids in Illegal Herbal Products (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25759062


AM-1241
Spinal and peripheral analgesic effects of the CB cannabinoid receptor agonist AM1241 in two models of bone cancer-induced pain (full-2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931557/?tool=pubmed
A cannabinoid 2 receptor agonist attenuates bone cancer-induced pain and bone loss (full-2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871326/
Cannabinoids attenuate cancer pain and proliferation in a mouse model (full-2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099480/?tool=pubmed
Self-medication of a cannabinoid CB(2) agonist in an animal model of neuropathic pain (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157548/pdf/nihms285774.pdf
Regulation of hematopoietic stem cell trafficking and mobilization by the endocannabinoid system (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/22074629
Antinociceptive effects induced through the stimulation of spinal cannabinoid type 2 receptors in chronically inflamed mice (abst–2011) http://www.unboundmedicine.com/medline/ebm/record/21771590/abstract/Antinociceptive_effects_induced_through_the_stimulation_of_spinal_cannabinoid_type_2_receptors_in_chronically_inflamed_mice_
Effects of a Selective Cannabinoid CB2 Agonist and Antagonist on Intravenous Nicotine Self Administration and Reinstatement of Nicotine Seeking (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266883/?tool=pubmed
Prevention of Fibrosis Progression in CCl4-Treated Rats: Role of the Hepatic Endocannabinoid and Apelin Systems (full–2012) http://jpet.aspetjournals.org/content/340/3/629.full
Dynamic changes to the endocannabinoid system in models of chronic pain (full–2012) http://rstb.royalsocietypublishing.org/content/367/1607/3300.full?sid=1569c370-cd5c-4358-89ff-857201f5e069
Therapeutic modulation of cannabinoid lipid signaling: Metabolic profiling of a novel antinociceptive cannabinoid-2 receptor agonist (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493696/
Electroacupuncture reduces the expression of proinflammatory cytokines in inflamed skin tissues through activation of cannabinoid CB2 receptors (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22337285
Diuretic effects of cannabinoids (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533417/
Cannabinoid Receptors as Therapeutic Targets for Dialysis-Induced Peritoneal Fibrosis (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23296044
Pharmacology of Cannabinoid Receptor Agonists and a Cyclooxygenase-2 Inhibitor in Rat Bone Tumor Pain (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24008428
CB2 cannabinoid agonist enhanced neurogenesis in GFAP/Gp120 transgenic mice displaying deficits in neurogenesis (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24148086
Diuretic effects of cannabinoid agonists in mice (abst–2013) http://www.sciencedirect.com/science/article/pii/S0014299913007176
Activation of CB2 receptors as a potential therapeutic target for migraine: evaluation in an animal model (full–2014) http://www.thejournalofheadacheandpain.com/content/pdf/1129-2377-15-14.pdf
2012 Division of Medicinal Chemistry Award Address: Trekking the Cannabinoid Road: A Personal Perspective (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064474/
Effects of cannabinoid receptor type 2 on endogenous myocardial regeneration by activating cardiac progenitor cells in mouse infarcted heart (link to PDF–2014) http://life.scichina.com:8082/sciCe/EN/abstract/abstract513395.shtml#
Terpenes and Lipids of the Endocannabinoid and Transient Receptor Potential-channel Biosignaling Systems (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24866555
Drugs of Abuse in HIV infection and neurotoxicity (full–2015) http://journal.frontiersin.org/article/10.3389/fmicb.2015.00217/full
Time-Dependent Protection of CB2 Receptor Agonist in Stroke (full–2015) http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132487
Activation of murine microglial N9 cells is attenuated through cannabinoid receptor CB2 signaling (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25637536
Influence of nitric oxide synthase or cyclooxygenase inhibitors on cannabinoids activity in streptozotocin-induced neuropathy (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25712641
Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development via PGE2 and P-selectin Activity (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25931248
A synergistic interaction of 17-β-estradiol with specific cannabinoid receptor type 2 antagonist/inverse agonist on proliferation activity in primary human osteoblasts (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26171165


AM-1346
2012 Division of Medicinal Chemistry Award Address: Trekking the Cannabinoid Road: A Personal Perspective (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064474/


AM-1710 
Pharmacological characterization of AM1710, a putative cannabinoid CB(2) agonist from the cannabilactone class: Antinociception without central nervous system side-effects (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089437/pdf/nihms280008.pdf
The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CB2 receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy (full–2012) http://www.molecularpain.com/content/8/1/71
Intrathecal cannabilactone CB(2)R agonist, AM1710, controls pathological pain and restores basal cytokine levels (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603341/
Prophylactic cannabinoid administration blocks the development of paclitaxel-induced neuropathic nociception during analgesic treatment and following cessation of drug delivery (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998744/
2012 Division of Medicinal Chemistry Award Address: Trekking the Cannabinoid Road: A Personal Perspective (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064474/
Chronic Cannabinoid Receptor 2 Activation Reverses Paclitaxel Neuropathy Without Tolerance or Cannabinoid Receptor 1-Dependent Withdrawal (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24853387
An alternative to medical marijuana for pain? (news–2015) http://medicalxpress.com/news/2015-03-alternative-medical-marijuana-pain.html


AM-2201
Spice drugs are more than harmless herbal blends: A review of the pharmacology and toxicology of synthetic cannabinoids (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936256/
Analysis of 30 synthetic cannabinoids in serum by liquid chromatography-electrospray ionization tandem mass spectrometry after liquid-liquid extraction (abst–2012) http://onlinelibrary.wiley.com/doi/10.1002/jms.3020/abstract
First European case of convulsions related to analytically confirmed use of the synthetic cannabinoid receptor agonist AM-2201 (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22936123
Qualitative Confirmation of 9 Synthetic Cannabinoids and 20 Metabolites in Human Urine Using LC-MS/MS and Library Search (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874406/
High Times, Low Sats: Diffuse Pulmonary Infiltrates Associated with Chronic Synthetic Cannabinoid Use (full–2013)http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657026/
Identification and Structural Elucidation of Four Cannabimimetic Compounds (RCS-4, AM-2201, JWH-203 and JWH-210) in Seized Products (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23339188
Driving under the influence of synthetic cannabinoids (“Spice”): a case series (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23636569
Validation of a Novel Immunoassay for the Detection of Synthetic Cannabinoids and Metabolites in Urine Specimens (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23625703
K2 Toxicity: Fatal Case of Psychiatric Complications Following AM2201 Exposure (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23822805
Identification and Structural Elucidation of Four Cannabimimetic Compounds (RCS-4, AM-2201, JWH-203 and JWH-210) in Seized Products (abst–2013) http://jat.oxfordjournals.org/content/37/2/56.abstract?sid=7be65428-0ff8-4917-884b-c35f5a2819af
A Case of Cannabinoid Hyperemesis Syndrome Caused by Synthetic Cannabinoids (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23890687
Detection of Synthetic Cannabinoids in Oral Fluid Using ELISA and LC-MS-MS (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23946452
Toxicological Findings of Synthetic Cannabinoids in Recreational Users (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23970540
Blood Synthetic Cannabinoid Concentrations in Cases of Suspected Impaired Driving (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23965292
Targeted Metabolomic Approach for Assessing Human Synthetic Cannabinoid Exposure and Pharmacology (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23987522
Prevalence of synthetic cannabinoids in blood samples from Norwegian drivers suspected of impaired driving during a seven weeks period (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24129318
Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24160757
Detection of urinary metabolites of AM-2201 and UR-144, two novel synthetic cannabinoids (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23042760
Sulfaphenazole and α-Naphthoflavone Attenuate the Metabolism of the Synthetic Cannabinoids JWH-018 and AM2201 Found in K2/Spice (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24329780
Characteristics of the designer drug and synthetic cannabinoid receptor agonist AM-2201 regarding its chemistry and metabolism (abst–2013) http://onlinelibrary.wiley.com/doi/10.1002/jms.3229/abstract
Analysis of AM-2201 and metabolites in a drugs and driving case (abst – 2013) http://onlinelibrary.wiley.com/doi/10.1002/dta.1535/abstract
Cytotoxicity of synthetic cannabinoids on primary neuronal cells of the forebrain: the involvement of cannabinoid CB1 receptors and apoptotic cell death (abst–2013) http://www.sciencedirect.com/science/article/pii/S0041008X13004766
Simultaneous quantification of 20 synthetic cannabinoids and 21 metabolites, and semi-quantification of 12 alkyl hydroxy metabolites in human urine by liquid chromatography-tandem mass spectrometry (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24418231
Identification and quantification of synthetic cannabinoids in ‘spice-like’ herbal mixtures: A snapshot of the German situation in the autumn of 2012 (full–2014) http://onlinelibrary.wiley.com/doi/10.1002/dta.1499/full
Analysis of new classes of recreational drugs in sewage: Synthetic cannabinoids and amphetamine-like substances (full–2014) http://onlinelibrary.wiley.com/doi/10.1002/dta.1461/full
Analysis of new classes of recreational drugs in sewage: Synthetic cannabinoids and amphetamine-like substances (full–2014) http://onlinelibrary.wiley.com/doi/10.1002/dta.1461/full
LC-QTOF-MS as a superior strategy to immunoassay for the comprehensive analysis of synthetic cannabinoids in urine (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24424965
Driving under the influence of synthetic cannabinoids (“Spice”): a case series (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/23636569
Legal highs: staying on top of the flood of novel psychoactive substances (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521440/
Evaluation of an On-site Drug-testing Device for the Detection of Synthetic Cannabinoids in Illegal Herbal Products (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25759062
Genotoxic properties of representatives of alkylindazoles and aminoalkyl-indoles which are consumed as synthetic cannabinoids (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25792264
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The effects of bioisosteric fluorine in synthetic cannabinoid designer drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135 (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25921407
Cluster of Acute Toxicity from Ingestion of Synthetic Cannabinoid-Laced Brownies (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25967137


AM-2233
Another nail in coffin of synthetic cannabis (news–2011) http://tvnz.co.nz/national-news/another-nail-in-coffin-synthetic-cannabis-4666168?ref=rss
Characteristics of the designer drug and synthetic cannabinoid receptor agonist AM-2201 regarding its chemistry and metabolism (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23832945


AM-2389
Cannabinoid withdrawal in mice: inverse agonist vs neutral antagonist (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25772338


AM-3506
Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003779/
Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549323/
Sulfonyl fluoride inhibitors of Fatty Acid amide hydrolase (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/23083016
Acute reduction of anandamide-hydrolase (FAAH) activity is coupled with a reduction of nociceptive pathways facilitation in medication-overuse headache subjects after withdrawal treatment (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22670561?dopt=Abstract
Modulating the endocannabinoid system in human health and disease: successes and failures (full–2013) http://onlinelibrary.wiley.com/doi/10.1111/febs.12260/pdf
Role of endogenous cannabinoid system in the gut (full–2013) http://www.actaps.com.cn/qikan/manage/wenzhang/2013-4-12.pdf
2012 Division of Medicinal Chemistry Award Address: Trekking the Cannabinoid Road: A Personal Perspective (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064474/


AM-4054
Diuretic effects of cannabinoids (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533417/
Behavioral effects of the novel potent cannabinoid CB1 agonist AM 4054 (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015344/
Effects of anandamide and other CB1 ligands on cognitive function (abst–2013) http://www.fasebj.org/cgi/content/meeting_abstract/27/1_MeetingAbstracts/1097.10?sid=eea722c0-971c-4daa-8b8c-38c0c63c19ad
Diuretic effects of cannabinoid agonists in mice (abst–2013) http://www.sciencedirect.com/science/article/pii/S0014299913007176
Effects of a novel CB1 agonist on visual attention in male rats: Role of strategy and expectancy in task accuracy (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24099361


AM-4113 
The neutral cannabinoid CB₁ receptor antagonist AM4113 regulates body weight through changes in energy intake in the rat (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023913/
The CB(1) Receptor-Mediated Endocannabinoid Signaling and NGF: The Novel Targets of Curcumin (turmeric) (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22311129
2012 Division of Medicinal Chemistry Award Address: Trekking the Cannabinoid Road: A Personal Perspective (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064474/
Cannabinoid withdrawal in mice: inverse agonist vs neutral antagonist (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25772338


AM-6545
Rehashing endocannabinoid antagonists: can we selectively target the periphery to safely treat obesity and type 2 diabetes? (full–2010) http://www.jci.org/articles/view/44099?search[abstract_text]=&search[article_text]=cannabinoid&search[authors_text]=&search[fpage]=&search[title_text]=&search[volume]=
A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990160/
The novel cannabinoid CB1 antagonist AM6545 suppresses food intake and food-reinforced behavior (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522179/
Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912197/
Peripherally restricted CB1 receptor blockers (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23902803
2012 Division of Medicinal Chemistry Award Address: Trekking the Cannabinoid Road: A Personal Perspective (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064474/
Bi-directional CB1 receptor-mediated cardiovascular effects of cannabinoids in anaesthetized rats: role of the paraventricular nucleus (full–2015) http://www.jpp.krakow.pl/journal/archive/06_15/pdf/343_06_15_article.pdf
Cannabinoid withdrawal in mice: inverse agonist vs neutral antagonist (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25772338
Peripheral Targeting of CB1 Cannabinoid Receptors Protects from Radiation-Induced Pulmonary Fibrosis (abst–2015)
http://www.atsjournals.org/doi/abs/10.1165/rcmb.2014-0331OC#.VcgfrvlwtB8


AM-6546
Endocannabinoid signaling in the gut mediates preference for dietary unsaturated fats (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659363/
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AM-6701
Equipotent Inhibition of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase -Dual Targets of the Endocannabinoid System to Protect against Seizure Pathology (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480564/


AM-6702
Equipotent Inhibition of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase -Dual Targets of the Endocannabinoid System to Protect against Seizure Pathology (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480564/


ARN-2508
Multitarget fatty acid amide hydrolase/cyclooxygenase blockade suppresses intestinal inflammation and protects against nonsteroidal anti-inflammatory drug-dependent gastrointestinal damage (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25757568


AS-1535907
The role of small molecule GPR119 agonist, AS1535907, in glucose-stimulated insulin secretion and pancreatic β-cell function (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/21114601
Novel GPR119 agonist AS1535907 contributes to first-phase insulin secretion in rat perfused pancreas and diabetic db/db mice (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/20937249


AS-1907417 
AS1907417, a novel GPR119 agonist, as an insulinotropic and β-cell preservative agent for the treatment of type 2 diabetes (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/20816753
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CANNABINOR 
Cannabinor, a selective cannabinoid-2 receptor agonist, improves bladder emptying in rats with partial urethral obstruction (full–2010) http://www.jurology.com/article/S0022-5347%2810%2904713-0/fulltext
Effects of cannabinor, a novel selective cannabinoid 2 receptor agonist, on bladder function in normal rats (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/20207474


3 CARBOXAMIDO-5-ARYL-ISOXAZOLES
3-Carboxamido-5-aryl-isoxazoles as new CB2 agonists for the treatment of colitis (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23849204
Switching cannabinoid response from CB2 agonists to FAAH inhibitors (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24508127


CB-13
Cannabinoids Alleviate Experimentally Induced Intestinal Inflammation by Acting at Central and Peripheral Receptors (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183544/
Cannabinoids Alleviate Experimentally Induced Intestinal Inflammation by Acting at Central and Peripheral Receptors (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183544/
Ligand Activation of Cannabinoid Receptors Attenuates Hypertrophy of Neonatal Rat Cardiomyocytes (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24979612
Dual agonism of peripheral cannabinoid CB1/CB2 receptors suppresses cardiac myocyte hypertrophy (abst–2014) http://www.fasebj.org/content/28/1_Supplement/652.9.abstract?sid=db987fd0-3ef0-4796-aff6-4103f0c84daf
Evaluation of an On-site Drug-testing Device for the Detection of Synthetic Cannabinoids in Illegal Herbal Products (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25759062
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Lipid nanoparticles as an emerging platform for cannabinoid delivery: physicochemical optimization and biocompatibility (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25996463
6B.09: EFFECT OF CANNABINOID RECEPTOR ACTIVATION ON ABERRANT MITOCHONDRIAL BIOENERGETICS IN HYPERTROPHIED CARDIAC MYOCYTE (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26102932


CB-65 
The role of central CB2 cannabinoid receptors on food intake in neonatal chicks (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21927979
Evaluation of Anti-invasion Effect of Cannabinoids on Human Hepatocarcinoma Cells (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22978792
Study: Cannabis Agonists Produce Anti-Cancer Effects In Human Liver Cancer Cells (news–2012) http://norml.org/news/2012/10/11/study-cannabis-agonists-produce-anti-cancer-effects-in-human-liver-cancer-cells
Anti-Cancer Effects In Human Liver Cancer Cells Produced By Cannabis Agonists (news–2012) http://www.imarijuana.com/tag/cannabinoid-agonists
Role of cannabinoid and vanilloid receptors in invasion of human breast carcinoma cells (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23394450
Endocannabinoid and nitric oxide interaction mediates food intake in neonatal chicken (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26053311


CID16020046
A selective antagonist reveals a potential role of G protein-coupled receptor 55 in platelet and endothelial cell function (full–2013) http://jpet.aspetjournals.org/content/346/1/54.long
TRPV1 mediates cellular uptake of anandamide and thus promotes endothelial cell proliferation and network-formation (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265754/
The G-protein coupled receptor 55-agonist L-α-lysophosphatidylinositol mediates ovarian carcinoma cell induced angiogenesis (full–2015) http://www.actaps.com.cn/qikan/manage/wenzhang/2014-3-10.pdf
The GPR55 antagonist CID16020046 protects against intestinal inflammation (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26227635
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COMPOUND A
An Effective Prodrug Strategy to Selectively Enhance Ocular Exposure of a Cannabinoid Receptor (CB1/2) Agonist (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23738526


COMPOUND 39
Novel Triazolopyrimidine-Derived Cannabinoid Receptor 2 Agonists As Potential Treatment for Inflammatory Kidney Diseases (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26228928


CP-47,497 
Pharmacological properties and dependence liabilities of synthetic cannabinoids (abst–2010) http://www.unboundmedicine.com/medline/ebm/record/20681249/abstract/%5BPharmacological_properties_and_dependence_liabilities_of_synthetic_cannabinoids%5D_
Monitoring of herbal mixtures potentially containing synthetic cannabinoids as psychoactive compounds (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/20857386
THIS ISN’T YOUR MOTHER’S SPICE (news–2010) http://www.mapinc.org/drugnews/v10/n497/a07.html?1173
Now, There’s a Test for That — Norchem’s “Fake Marijuana” Test Reveals Significantly Increased Abuse of Spice/K2 (news–2010) http://www.marketwire.com/press-release/Now-Theres-Test-That-Norchems-Fake-Marijuana-Test-Reveals-Significantly-Increased-Abuse-1356247.htm
College students and use of K2: an emerging drug of abuse in young persons (full–2011) http://www.substanceabusepolicy.com/content/6/1/16
Marijuana-based Drugs: Innovative Therapeutics or Designer Drugs of Abuse? (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139381/?tool=pubmed
Beyond THC: The New Generation of Cannabinoid Designer Drugs (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187647/?tool=pubmed
Investigating a not-so-natural high (full–2011) http://pubs.acs.org/doi/full/10.1021/ac900564u
CP47,497-C8 and JWH073, commonly found in ‘Spice’ herbal blends, are potent and efficacious CB(1) cannabinoid receptor agonists (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094488/
Synthetic cannabinoids in oral fluid (full–2011) http://jat.oxfordjournals.org/content/35/7/424.long
Use of high-resolution accurate mass spectrometry to detect reported and previously unreported cannabinomimetics in “herbal high” products (full–2011) http://jat.oxfordjournals.org/content/34/5/252.long
A method for CP 47, 497 a synthetic non-traditional cannabinoid in human urine using liquid chromatography tandem mass spectrometry (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21233028
Cytotoxicity of synthetic cannabinoids found in “Spice” products: The role of cannabinoid receptors and the caspase cascade in the NG 108-15 cell line (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21907772
Effects of synthetic cannabinoids on electroencephalogram power spectra in rats (abst–2011) http://www.unboundmedicine.com/medline/ebm/record/21640532/abstract/Effects_of_synthetic_cannabinoids_on_electroencephalogram_power_spectra_in_rats_
The emergence and analysis of synthetic cannabinoids (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21337724
Chemicals Used in “Spice” and “K2” Type Products Now Under Federal Control and Regulation (news–2011) http://www.justice.gov/dea/pubs/pressrel/pr030111.html
Outlawing ‘Legal Highs:’ Can Emergency Bans Hinder Drug Development? (news–2011) http://healthland.time.com/2011/02/23/outlawing-legal-highs-can-emergency-bans-hinder-drug-development/
Characterization of In Vitro Metabolites of CP 47,497, a Synthetic Cannabinoid, in Human Liver Microsomes by LC-MS/MS (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22931239
Detection and quantification of new designer drugs in human blood: part 1 – synthetic cannabinoids (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22593567
The spice in France: mixed herbs containing synthetic cannabinoids (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22796613
Acute toxicity due to the confirmed consumption of synthetic cannabinoids: Clinical and laboratory findings (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22971158
“Spiceophrenia”: a systematic overview of “Spice”-related psychopathological issues and a case report (full–2013) http://onlinelibrary.wiley.com/doi/10.1002/hup.2312/full
The K2/Spice Phenomenon: emergence, identification, legislation and metabolic characterization of synthetic cannabinoids in herbal incense products (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100246/
Getting up to speed with the public health and regulatory challenges posed by new psychoactive substances in the information age (editorial–2013) http://onlinelibrary.wiley.com/doi/10.1111/add.12287/full
Synthetic Cannabinoids -The Challenges of Testing for Designer Drugs (article–2013) (funky link- delete the “sign in”, and it comes up) http://www.aacc.org/publications/cln/2013/february/Pages/Cannabinoids.aspx?PassThru=ok&PersonID=206339#
Cytotoxicity of synthetic cannabinoids on primary neuronal cells of the forebrain: the involvement of cannabinoid CB1 receptors and apoptotic cell death (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24211273
Simultaneous quantification of 20 synthetic cannabinoids and 21 metabolites, and semi-quantification of 12 alkyl hydroxy metabolites in human urine by liquid chromatography-tandem mass spectrometry (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24418231
Investigation of the in vitro toxicological properties of the synthetic cannabimimetic drug CP-47,497-C8 (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24686252
Impact of a synthetic cannabinoid (CP-47,497-C8) on protein expression in human cells: evidence for induction of inflammation and DNA damage (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26194647


CP-50,556-1 / LEVONANTRADOL
Marijuana-based Drugs: Innovative Therapeutics or Designer Drugs of Abuse? (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139381/?tool=pubmed
Transdermal delivery of cannabidiol Patent 8435556 (full–2013) https://www.google.com/patents/US8435556
Levonantradol: asymmetric synthesis and structural analysis (abst–2013) http://pubs.rsc.org/en/Content/ArticleLanding/2013/CC/c3cc41388h


CP-55,940 
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2 (full–2010) http://pharmrev.aspetjournals.org/content/62/4/588.full.pdf+html
Attenuation of morphine antinociceptive tolerance by a CB(1) receptor agonist and an NMDA receptor antagonist: Interactive effects (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813317/?tool=pubmed
Cannabinoid inhibition of macrophage migration to the trans-activating (Tat) protein of HIV-1 is linked to the CB(2) cannabinoid receptor (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846023/?tool=pubmed
The expression level of CB1 and CB2 receptors determines their efficacy at inducing apoptosis in astrocytomas (full-2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806825/?tool=pubmed
Rimonabant-induced Delta9-tetrahydrocannabinol withdrawal in rhesus monkeys: discriminative stimulus effects and other withdrawal signs (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912042/pdf/zpt347.pdf
Protective effects of the synthetic cannabinoids CP55,940 and JWH-015 on rat brain mitochondria upon paraquat exposure (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/20514518
Sex Differences in Cannabinoid 1 vs. Cannabinoid 2 Receptor-Selective Antagonism of Antinociception Produced by Δ9-Tetrahydrocannabinol and CP55,940 in the Rat (full–2011) http://jpet.aspetjournals.org/content/340/3/787.full
Cannabinoids and bone: endocannabinoids modulate human osteoclast function in vitro (full–2011) http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01519.x/full
Chronic Δ⁹-tetrahydrocannabinol treatment in rhesus monkeys: differential tolerance and cross-tolerance among cannabinoids (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051379/pdf/bph0162-1060.pdf
Mouse models for studying pain in sickle disease: effects of strain, age, and acuteness (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779783/
Effects of cannabinoid CB(1) receptor agonism and antagonism on SKF81297-induced dyskinesia and haloperidol-induced dystonia in Cebus apella monkeys (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21029743
Cytotoxicity of synthetic cannabinoids found in “Spice” products: The role of cannabinoid receptors and the caspase cascade in the NG 108-15 cell line (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21907772
The schizophrenia susceptibility gene neuregulin 1 modulates tolerance to the effects of cannabinoids (abst–2011) http://www.unboundmedicine.com/medline/ebm/record/20701826/abstract/The_schizophrenia_susceptibility_gene_neuregulin_1_modulates_tolerance_to_the_effects_of_cannabinoids
A synthetic cannabinoid, CP55940, inhibits lipopolysaccharide-induced cytokine mRNA expression in a cannabinoid receptor-independent mechanism in rat cerebellar granule cells (abst–2011) http://www.unboundmedicine.com/medline/ebm/record/21492165/abstract/A_synthetic_cannabinoid_CP55940_inhibits_lipopolysaccharide_induced_cytokine_mRNA_expression_in_a_cannabinoid_receptor_independent_mechanism_in_rat_cerebellar_granule_cells
Allosteric modulator ORG27569 induces a CB1 Cannabinoid receptor high affinity agonist binding state, receptor internalization and Gi-independent ERK1/2 activation (full–2012) http://www.jbc.org/content/early/2012/02/16/jbc.M111.316463.long
Biphasic Effects of Cannabinoids in Anxiety Responses: CB1 and GABA(B) Receptors in the Balance of GABAergic and Glutamatergic Neurotransmission (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473327/
GPR18 in microglia: implications for the CNS and endocannabinoid system signaling (full–2012) http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02019.x/full
Acetaminophen differentially enhances social behavior and cortical cannabinoid levels in inbred mice (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389197/
Effects of CP 55,940–agonist of CB1 cannabinoid receptors on ghrelin and somatostatin producing cells in the rat pancreas (full–2012) http://czasopisma.viamedica.pl/fhc/article/view/18705/14714
Neural Circuit in the Dorsal Raphe Nucleus Responsible for Cannabinoid-Mediated Increases in 5-HT Efflux in the Nucleus Accumbens of the Rat Brain (full–2012) http://www.hindawi.com/isrn/pharmacology/2012/276902/
Contrasting effects of different cannabinoid receptor ligands on mouse ingestive behavior (abst–2012) http://www.unboundmedicine.com/medline/ebm/record/22772336/abstract/Contrasting_effects_of_different_cannabinoid_receptor_ligands_on_mouse_ingestive_behaviour_
Pharmacological effects of cannabinoids on the reference and working memory functions in mice (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22903389
Interactions between mu opioid receptor agonists and cannabinoid receptor agonists in rhesus monkeys: antinociception, drug discrimination, and drug self-administration (full–2013) http://jpet.aspetjournals.org/content/early/2013/03/27/jpet.113.204099.long
Novel Insights Into CB1 Cannabinoid Receptor Signaling: A Key Interaction Identified Between EC3-Loop and TMH2 (full–2013) http://jpet.aspetjournals.org/content/early/2013/02/21/jpet.112.201046.long
Long-term CB1 receptor blockade enhances vulnerability to anxiogenic-like effects of cannabinoids (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691020/
Working memory- and anxiety-related behavioral effects of repeated nicotine as a stressor: the role of cannabinoid receptors (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599339/
Stabilization of Functional Recombinant Cannabinoid Receptor CB2 in Detergent Micelles and Lipid Bilayers (full–2013) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0046290
Phencyclidine-induced social withdrawal results from deficient stimulation of cannabinoid CB1 receptors: implications for schizophrenia (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717536/
Distinct roles of β-arrestin 1 and β-arrestin 2 in ORG27569-induced biased signaling and internalization of the cannabinoid receptor one (CB1) (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617280/
Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptors (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685885/
G-Protein Receptor Kinase 5 Regulates the Cannabinoid Receptor 2-Induced Upregulation of Serotonin 2A Receptors (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668730/
Cannabinoid receptor activation in the nucleus tractus solitaries produces baroreflex-like responses in the rat (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614708/
An investigation into “two hit” effects of BDNF deficiency and young-adult cannabinoid receptor stimulation on prepulse inhibition regulation and memory in mice (full–2013) http://www.frontiersin.org/Journal/10.3389/fnbeh.2013.00149/full
Transdermal delivery of cannabidiol Patent 8435556 (full–2013) https://www.google.com/patents/US8435556
Multitarget Cannabinoids as Novel Strategy for Alzheimer Disease (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23369066
Interactions between mu opioid receptor agonists and cannabinoid receptor agonists CP55940 and WIN55212-2 in rhesus monkeys: evaluation of treatment- and abuse-related effects (abst–2013) http://www.fasebj.org/cgi/content/meeting_abstract/27/1_MeetingAbstracts/1097.3?sid=7a3e6978-9a8c-4319-bca1-9f80fed2445f
Changes in cannabinoid CB1 receptor functionality in the female rat prefrontal cortex following a high fat diet (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23454443
Regulation of cell proliferation by GPR55/cannabinoid receptors using (R,R’)-4’-methoxy-1-naphthylfenoterol in rat C6 glioma cell line (abst – 2013) http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=695437a2-7613-4bef-8697-2294df2da859&cKey=18ba6eb0-2c5f-4004-a56f-2d1f450e2ed1&mKey=9b2d28e7-24a0-466f-a3c9-07c21f6e9bc9
Real-time characterisation of Cannabinoid Receptor 1 (CB1) allosteric modulators reveals novel mechanism of action (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23937487
Cytotoxicity of synthetic cannabinoids on primary neuronal cells of the forebrain: the involvement of cannabinoid CB1 receptors and apoptotic cell death (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/24211273
The agonist binding mechanism of human CB2 receptor studied by molecular dynamics simulation, free energy calculation and 3D-QSAR studies (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24358778
Cannabinoid neuromodulation in the adult early visual cortex (full–2014) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0087362
The influence of monoacylglycerol lipase inhibition upon the expression of epidermal growth factor receptor in human PC-3 prostate cancer cells (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109781/
Vascular targets for cannabinoids: animal and human studies (full–2014) http://onlinelibrary.wiley.com/doi/10.1111/bph.12560/full
Early increase of cannabinoid receptor density after experimental traumatic brain injury in the newborn piglet (link to PDF–2014) http://www.ncbi.nlm.nih.gov/pubmed/24993629
Cannabinoids inhibit cholinergic contraction in human airways through prejunctional CB1 receptors (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24467410
Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24742657
Allosteric Modulation of a Cannabinoid G Protein-coupled Receptor BINDING SITE ELUCIDATION AND RELATIONSHIP TO G PROTEIN SIGNALING (abst–2014) http://www.jbc.org/content/289/9/5828.abstract?sid=9a3f2c47-b737-4ecc-b47c-2f6edbe16774
Combined antiproliferative effects of the aminoalkylindole WIN55,212-2 and radiation in breast cancer cells (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24259678
The therapeutic efficacy of cannabinoid receptor type 1 ligands in Huntington’s disease may depend on their functional selectivity (abst–2014) http://www.fasebj.org/content/28/1_Supplement/846.6.abstract?sid=467bb529-0ecc-4ddc-af27-3f56f520a102
Biased Agonism and Biased Allosteric Modulation at the CB1 Cannabinoid Receptor (full–2015) http://molpharm.aspetjournals.org/content/early/2015/06/04/mol.115.099192.long
Bi-directional CB1 receptor-mediated cardiovascular effects of cannabinoids in anaesthetized rats: role of the paraventricular nucleus (full–2015) http://www.jpp.krakow.pl/journal/archive/06_15/pdf/343_06_15_article.pdf
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Effects of acute and repeated dosing of the synthetic cannabinoid CP55,940 on intracranial self-stimulation in mice (abst–2015) http://www.sciencedirect.com/science/article/pii/S0376871615000423
The effects of beta-arrestin1 deletion on acute cannabinoid activity, brain cannabinoid receptors and tolerance to cannabinoids in mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25779032
The effect of phytocannabinoids on airway hyper-responsiveness, airway inflammation, and cough (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25655949
For whom the endocannabinoid tolls: Modulation of innate immune function and implications for psychiatric disorders (abst-2015) http://www.sciencedirect.com/science/article/pii/S027858461500055X
2-AG promotes the expression of conditioned fear via cannabinoid receptor type 1 on GABAergic neurons (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25814137
A potential role for cannabinoid receptors in the therapeutic action of fenofibrate (abst–2015) http://www.fasebj.org/content/29/4/1446
The effect of FAAH, MAGL, and Dual FAAH/MAGL inhibition on inflammatory and colorectal distension-induced visceral pain models in Rodents (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25869205
CB1 Knockout Mice Unveil Sustained CB2-Mediated Anti-Allodynic Effects of the Mixed CB1/CB2 Agonist CP55,940 in a Mouse Model of Paclitaxel-Induced Neuropathic Pain (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25904556
Enhanced function of inhibitory presynaptic cannabinoid CB1 receptors on sympathetic nerves of DOCA-salt hypertensive rats (abst–2015) http://www.sciencedirect.com/science/article/pii/S0024320515002155
Effects of amphetamine, morphine, and CP 55, 940 on Go/No-Go task performance in rhesus monkeys (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26061355
On the effects of CP 55-940 and other cannabinoid receptor agonists in C6 and U373 cell lines (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26255146
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