P-V (ECS 2000-2009)

PEA-PALMITOYLETHANOLAMIDE (CB2, GPR55 & GPR119 Agonist. Limits FAAH. See Also GLAUCOMA, RETINITIS PIGMENTOSA)
VIRODHAMINE (GPR-55 & CB2 Agonist; CB 1 Agonist / Antagonist Depending on Dose)
VITAMIN E / D α-TOCOPHEROL (Modulator of Endocannabinoid System)


PEA-PALMITOYLETHANOLAMIDE
Differences in the pharmacological properties of rat and chicken brain fatty acid amidohydrolase (full–2000) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1572338/
Endocannabinoids and fatty acid amides in cancer, inflammation and related disorders (abst–2000) http://www.ncbi.nlm.nih.gov/pubmed/11106791
Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells (full–2001) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222054/pdf/11485574.pdf/?tool=pmcentrez
Administration of Endocannabinoids Prevents a Referred Hyperalgesia Associated With Inflammation of the Urinary Bladder (full–2001) http://journals.lww.com/anesthesiology/Fulltext/2001/03000/Administration_of_Endocannabinoids_Prevents_a.23.aspx
Anandamide degradation and N-acylethanolamines level in wild-type and CB1 cannabinoid receptor knockout mice of different ages (full–2001) http://onlinelibrary.wiley.com/doi/10.1046/j.1471-4159.2001.00413.x/full
Effects of homologues and analogues of palmitoylethanolamide upon the inactivation of the endocannabinoid anandamide (full-2001) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1621151/
Characterization of palmitoylethanolamide transport in mouse Neuro-2a neuroblastoma and rat RBL-2H3 basophilic leukaemia cells: comparison with anandamide (full-2001) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1572744/
Anticonvulsant activity of N-palmitoylethanolamide, a putative endocannabinoid, in mice (abst-2001) http://www.ncbi.nlm.nih.gov/pubmed/11442148
Clinical and histological evaluation of an analogue of palmitoylethanolamide, PLR 120 (comicronized Palmidrol INN) in cats with eosinophilic granuloma and eosinophilic plaque: a pilot study (abst-2001) http://www.ncbi.nlm.nih.gov/pubmed/11301536
Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat (full-2002) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1573125&tool=pmcentrez
Endocannabinoids and related fatty acid derivatives in pain modulation (abst-2002) http://www.ncbi.nlm.nih.gov/pubmed/12505698
N-Acylethanolamines in human reproductive fluids (abst–2002) http://www.ncbi.nlm.nih.gov/pubmed/12505702
Effect on cancer cell proliferation of palmitoylethanolamide, a fatty acid amide interacting with both the cannabinoid and vanilloid signalling systems (abst–2002) http://www.ncbi.nlm.nih.gov/pubmed/12570018
Endocannabinoids in the immune system and cancer (abst–2002) http://www.ncbi.nlm.nih.gov/pubmed/12052046
Idiopathic infertility: susceptibility of spermatozoa to in‐vitro capacitation, in the presence and the absence of palmitylethanolamide (a homologue of anandamide), is strongly correlated with membrane polarity studied by Laurdan fluorescence (full–2003) http://molehr.oxfordjournals.org/content/9/7/381.full
The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity (full–2005) http://www.jlr.org/content/46/2/342.long
The search for the palmitoylethanolamide receptor (abst–2005) http://www.ncbi.nlm.nih.gov/pubmed/15963531
Finding of endocannabinoids in human eye tissues: implications for glaucoma (abst–2005) http://www.ncbi.nlm.nih.gov/pubmed/15823551
Selective antiepileptic effects of N-palmitoylethanolamide, a putative endocannabinoid (abst–2005) http://www.ncbi.nlm.nih.gov/pubmed/15461672
Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of patients with diabetic retinopathy and age-related macular degeneration (abst–2006) http://www.ncbi.nlm.nih.gov/pubmed/17011761
Synergistic antinociceptive effects of anandamide, an endocannabinoid, and nonsteroidal anti-inflammatory drugs in peripheral tissue: a role for endogenous fatty-acid ethanolamides? (abst–2006) http://www.ncbi.nlm.nih.gov/pubmed/17027744
STUDIES OF ANANDAMIDE ACCUMULATION INHIBITORS IN CEREBELLAR GRANULE NEURONS (full–2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248273/
Effects of palmitoylethanolamide on signaling pathways implicated in the development of spinal cord injury (full–2008) http://jpet.aspetjournals.org/content/326/1/12.long
Endocannabinoids and nutrition (full–2008) http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2826.2008.01687.x/full
‘Entourage’ effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors (full–2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597234/?tool=pubmed
An endocannabinoid signaling system modulates anxiety-like behavior in male Syrian hamsters (full–2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694060/
Evaluation of fatty acid amides in the carrageenan-induced paw edema model (full–2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2200792/
Cannabinomimetic Control of Mast Cell Mediator Release: New Perspective in Chronic Inflammation (full–2008) http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2826.2008.01674.x/full
Adjuvant treatment of atopic eczema: assessment of an emollient containing Npalmitoylethanolamine (ATOPA study) (abst–2008) http://www.ncbi.nlm.nih.gov/pubmed/18181976
Overview of the chemical families of fatty acid amide hydrolase and monoacylglycerol lipase inhibitors (abst–2008) http://www.ncbi.nlm.nih.gov/pubmed/18289091
Endocannabinoids mediate neuroprotection after transient focal cerebral ischemia (abst–2008) http://www.ncbi.nlm.nih.gov/pubmed/18823959
Abnormalities in the cerebrospinal fluid levels of endocannabinoids in multiple sclerosis (abst–2008) http://www.ncbi.nlm.nih.gov/pubmed/18535023
The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and antihyperalgesic effects in a murine model of neuropathic pain: involvement of CB(1), TRPV1 and PPARgamma receptors and neurotrophic factors (abst–2008) http://www.ncbi.nlm.nih.gov/pubmed/18602217
Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress (full–2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716432/?tool=pubmed
Receptors for acylethanolamides-GPR55 and GPR119 (full–2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751869/?tool=pubmed
Minocycline treatment inhibits microglial activation and alters spinal levels of endocannabinoids in a rat model of neuropathic pain (full–2009) http://www.molecularpain.com/content/5/1/35
The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities (full–2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757311/
Anti-inflammatory effect of palmitoylethanolamide on human adipocytes (abst–2009) http://www.ncbi.nlm.nih.gov/pubmed/19131941
Plasma endocannabinoid levels in multiple sclerosis (abst–2009) http://www.ncbi.nlm.nih.gov/pubmed/19695579
N-acylethanolamines, anandamide and food intake (abst–2009) http://www.ncbi.nlm.nih.gov/pubmed/19413995
Enhancement of the hypotensive effects of intrathecally injected endocannabinoids by the entourage compound palmitoylethanolamide (abst–2009)
http://www.ncbi.nlm.nih.gov/pubmed/19289116
Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase (abst–2009) http://www.ncbi.nlm.nih.gov/pubmed/19095868


VIRODHAMINE
Phytocannabinoids (news–undated) http://www.news-medical.net/health/Phytocannabinoids.aspx
Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor (full–2002) http://jpet.aspetjournals.org/content/301/3/1020.long
Endocannabinoids and related fatty acid derivatives in pain modulation (abst–2002) http://www.ncbi.nlm.nih.gov/pubmed/12505698
Vasorelaxant activities of the putative endocannabinoid virodhamine in rat isolated small mesenteric artery (abst–2004) http://www.ncbi.nlm.nih.gov/pubmed/15233865
Role of the endocannabinoid system in the development of tolerance to alcohol (full–2005) http://alcalc.oxfordjournals.org/content/40/1/15.long
Fatty acid amidohydrolase in human neocortex-activity in epileptic and non-epileptic brain tissue and inhibition by putative endocannabinoids (abst–2005) http://www.ncbi.nlm.nih.gov/pubmed/15923084
Binding affinity and agonist activity of putative endogenous cannabinoids at the human neocortical CB1 receptor (abst–2005) http://www.ncbi.nlm.nih.gov/pubmed/15588725
GPR55: a new member of the cannabinoid receptor clan? (full-2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2095104/?tool=pubmed
The orphan receptor GPR55 is a novel cannabinoid receptor (full-2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2095107/?tool=pubmed
GPR55 and the vascular receptors for cannabinoids (full–2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190021/?tool=pubmed
Virodhamine and CP55,940 modulate cAMP production and IL-8 release in human bronchial epithelial cells (full–2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2042924/?tool=pubmed
Nicotine (NC)-induced “depressive” behavioral symptoms and effects of antidepressants including cannabinoids (CBs) (full–2008) https://www.jstage.jst.go.jp/article/jts/33/5/33_5_555/_pdf
Role of endocannabinoids in cardiovascular shock (full-2008) http://www.jpp.krakow.pl/journal/archive/12_08_s8/pdf/91_12_08_s8_article.pdf
Inhibition of human neutrophil chemotaxis by endogenous cannabinoids and phytocannabinoids: evidence for a site distinct from CB1 and CB2 (full-2008) http://molpharm.aspetjournals.org/content/73/2/441.long
Virodhamine relaxes the human pulmonary artery through the endothelial cannabinoid receptor and indirectly through a COX product (full-2008) http://www.ncbi.nlm.nih.gov/pubmed/18806815
The role of the CB1 receptor in the regulation of sleep (abst–2008) http://www.ncbi.nlm.nih.gov/pubmed/18514375
Unconventional neurotransmitters, neurodegeneration and neuroprotection (full–2009) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000100011&lng=en&nrm=iso


VITAMIN E / D α-TOCOPHEROL
Inhibition of Rat C6 Glioma Cell Proliferation by Endogenous and Synthetic Cannabinoids. Relative Involvement of Cannabinoid and Vanilloid Receptors (full-2001) http://jpet.aspetjournals.org/content/299/3/951.full
Amyloid precursor protein 96-110 and beta-amyloid 1-42 elicit developmental anomalies in sea urchin embryos and larvae that are alleviated by neurotransmitter analogs for acetylcholine, serotonin and cannabinoids (full–2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579926/?tool=pubmed
Virgin hemp seed oil: An interesting niche product (abst–2008) http://onlinelibrary.wiley.com/doi/10.1002/ejlt.200700311/abstract;jsessionid=3D837473A3139F03ECE86C45085E4B8F.f01t04


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