L-M [ECS]

*Previous Articles/Studies 2000-2009

L-a-LYSOPHOSPHATIDYLINOSITOL* (GPR55 Agonist)
MAGL / MGL / MONOACYLGLYCEROL LIPASE* (Breaks down 2-AG)


L-a-LYSOPHOSPHATIDYLINOSITOL
The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation (full–2009) http://www.fasebj.org/content/23/1/183.long
GPR55 ligands promote receptor coupling to multiple signalling pathways (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931561/?tool=pubmed
A role for L-alpha-lysophosphatidylinositol and GPR55 in the modulation of migration, orientation and polarization of human breast cancer cells (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931574/
Pharmacology of GPR55 in yeast and identification of GSK494581A as a mixed-activity glycine transporter subtype 1 inhibitor and GPR55 agonist (full–2011) http://jpet.aspetjournals.org/content/337/1/236.long
Lipid bilayer molecular dynamics study of lipid-derived agonists of the putative cannabinoid receptor, GPR55 (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086297/?tool=pubmed
L-α-lysophosphatidylinositol meets GPR55: a deadly relationship (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21367464
The L-α-lysophosphatidylinositol/GPR55 system and its potential role in human obesity (full–2012) http://diabetes.diabetesjournals.org/content/61/2/281.long
Modulation of L-α-lysophosphatidylinositol/GPR55 mitogen-activated protein kinase (MAPK) signaling by cannabinoids (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22027819
The G protein-coupled receptor 55 ligand l-α-lysophosphatidylinositol exerts microgliadependent neuroprotection after excitotoxic lesion (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24038453
(R,R’)-4′-Methoxy-1-naphthylfenoterol Targets GPR55-mediated Ligand Internalization and Impairs Cancer Cell Motility (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24355564
The G protein-coupled receptor 55 ligand l-α-lysophosphatidylinositol exerts microgliadependent neuroprotection after excitotoxic lesion (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24038453
The G-protein coupled receptor 55-agonist L-α-lysophosphatidylinositol mediates ovarian carcinoma cell induced angiogenesis (full–2015)
http://www.actaps.com.cn/qikan/manage/wenzhang/2014-3-10.pdf


MAGL / MGL / MONOACYLGLYCEROL LIPASE
Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828288/?report=classic
Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224879/
Inhibition of monoacylglycerol lipase (MAGL) attenuates NSAID-induced gastric hemorrhages in mice (full–2011) http://jpet.aspetjournals.org/content/early/2011/06/09/jpet.110.175778.long
The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2‐arachidonoylglycerol signalling through cannabinoid receptors (full–2011) http://onlinelibrary.wiley.com/doi/10.1111/j.1748-1716.2011.02280.x/full
Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249428/
Scripps Research Scientists Discover Inflammation Is Controlled Differently in Brain and Other Tissues (news–2011) http://www.alphagalileo.org/ViewItem.aspx?ItemId=113766&CultureCode=en
Intrinsic Up-Regulation of 2-AG Favors an Area Specific Neuronal Survival in Different In Vitro Models of Neuronal Damage (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527460/
Dynamic changes to the endocannabinoid system in models of chronic pain (full–2012) http://rstb.royalsocietypublishing.org/content/367/1607/3300.full?sid=1569c370-cd5c-4358-89ff-857201f5e069
Inhibition of recombinant human carboxylesterase 1 and 2 and monoacylglycerol lipase by chlorpyrifos oxon, paraoxon and methyl paraoxon (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345137/
The endocannabinoid system: an overview (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303140/
Monoacylglycerol lipase is a new therapeutic target for Alzheimer’s disease (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513645/
Endocannabinoid signaling in female reproduction (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382454/
Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525790/
Spinal administration of the monoacylglycerol lipase inhibitor JZL184 produces robust inhibitory effects on nociceptive processing and the development of central sensitization in the rat (full–2012) http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02179.x/full
Monoacylglycerol lipase – a target for drug development? (full–2012) http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.01950.x/pdf
Activation of Type 5 Metabotropic Glutamate Receptors and Diacylglycerol Lipase-α Initiates 2-Arachidonoylglycerol Formation and Endocannabinoid-Mediated Analgesia (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652685/
Equipotent Inhibition of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase – Dual Targets of the Endocannabinoid System to Protect against Seizure Pathology (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480564/
Expression and function of monoacylglycerol lipase in mouse β-cells and human islets of Langerhans (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22739267
Dual inhibition of MAGL and type II topoisomerase by N-phenylmaleimides as a potential strategy to reduce neuroblastoma cell growth (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22127371
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Monoacylglycerol Lipase (MAGL) Inhibition Attenuates Acute Lung Injury in Mice (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808422/
Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation. (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788575/
Parsing the players: 2-AG synthesis and degradation in the CNS (full–2013) http://onlinelibrary.wiley.com/doi/10.1111/bph.12411/full
Neuregulin-1 Impairs the Long-term Depression of Hippocampal Inhibitory Synapses by Facilitating the Degradation of Endocannabinoid 2-AG (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776056/
The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717616/
Astroglial CB1 cannabinoid receptors regulate leptin signaling in mouse brain astrocytes (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854987/
Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6 (full–2013) http://www.pnas.org/content/110/43/17558.long
Dual Inhibition of Endocannabinoid Catabolic Enzymes Produces Enhanced Anti-Withdrawal Effects in Morphine-Dependent Mice (full–2013) http://www.ncbi.nlm.nih.gov/pubmed/23303065
Therapeutic potential of monoacylglycerol lipase inhibitors (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594462/
Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model. (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24384256
In vivo characterization of the highly selective monoacylglycerol lipase inhibitor KML29: Antinociceptive activity without cannabimimetic side effects (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23848221
(4-Phenoxyphenyl)tetrazolecarboxamides and related compounds as dual inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23455058
Aging modifies the enzymatic activities involved in 2-arachidonoylglycerol metabolism (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23281018
Acute inhibition of diacylglycerol lipase blocks endocannabinoid-mediated retrograde synaptic suppression: evidence for on-demand biosynthesis of 2-arachidonoylglycerol. (abst-2013) http://www.ncbi.nlm.nih.gov/pubmed/23858009
Vascular targets for cannabinoids: animal and human studies (full–2014) http://onlinelibrary.wiley.com/doi/10.1111/bph.12560/full
Prefrontal deficits in a murine model overexpressing the down syndrome candidate gene dyrk1a (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953590/
2012 Division of Medicinal Chemistry Award Address: Trekking the Cannabinoid Road: A Personal Perspective (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064474/
Heterogeneous presynaptic distribution of monoacylglycerol lipase, a multipotent regulator of nociceptive circuits in the mouse spinal cord (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979158/
The influence of monoacylglycerol lipase inhibition upon the expression of epidermal growth factor receptor in human PC-3 prostate cancer cells (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109781/
The effects of obesity, diabetes and metabolic syndrome on the hydrolytic enzymes of the endocannabinoid system in animal and human adipocytes (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995979/
The expression of cannabinoid receptor 1 is significantly increased in atopic patients (full–2014) http://www.jacionline.org/article/S0091-6749%2813%2902936-9/fulltext
Localization of the cannabinoid CB1 receptor and the 2-AG synthesizing (DAGLα) and degrading (MAGL, FAAH) enzymes in cells expressing the Ca(2+)-binding proteins calbindin, calretinin, and parvalbumin in the adult rat hippocampus (full–2014) http://journal.frontiersin.org/Journal/10.3389/fnana.2014.00056/full
Cannabinoids as therapeutic agents in cancer: current status and future implications (link to PDF-2014) http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=2233
Monoacylglycerol Lipase Inhibition Blocks Chronic Stress-Induced Depressive-Like Behaviors via Activation of mTOR Signaling (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24476943
Brain regional cannabinoid CB1 receptor signalling and alternative enzymatic pathways for 2-arachidonoylglycerol generation in brain sections of diacylglycerol lipase deficient mice (abst–2014) http://www.sciencedirect.com/science/article/pii/S0928098713003497
Mutation of cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1-and 2-monoacylglycerols and selectively impairs inhibitor potency (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24368842
No more pain upon Gq -protein-coupled receptor activation: role of endocannabinoids. (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24494686
Organophosphate agents induce plasma hypertriglyceridemia in mouse via single or dual inhibition of the endocannabinoid hydrolyzing enzyme(s) (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24361246
Dexamethasone alleviates motion sickness in rats in part by enhancing the endocannabinoid system (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24508383
Targeting the cannabinoid system for pain relief? (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24529672
Endocannabinoid-Hydrolysing Enzymes in the Post-Mortem Cerebellum of Humans Affected by Hereditary Autosomal Dominant Ataxias (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24642775
The Role of Monoacylglycerol Lipase (MAGL) in the Cancer Progress (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24633487
Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24676249
Functionalization of β-Caryophyllene Generates Novel Polypharmacology in the Endocannabinoid System. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24831513
Identification and characterization of a new reversible MAGL inhibitor (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24853323
Endocannabinoid contribution to Δ9-tetrahydrocannabinol discrimination in rodents (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24858366
Augmented tonic pain-related behavior in knockout mice lacking monoacylglycerol lipase, a major degrading enzyme for the endocannabinoid 2-arachidonoylglycerol (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24906199
The dual FAAH/MAGL inhibitor JZL195 has enhanced effects on endocannabinoid transmission and motor behavior in rats as compared to those of the MAGL inhibitor JZL184 (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24911644
Attenuation of serotonin-induced itch responses by inhibition of endocannabinoid degradative enzymes, fatty acid amide hydrolase and monoacylglycerol lipase (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24915981
Endocannabinoid-hydrolysing enzymes in the post-mortem cerebellum of humans affected by hereditary autosomal dominant ataxias (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24642775
The endocannabinoid system is altered in the post-mortem prefrontal cortex of alcoholic subjects (abst–2014) http://onlinelibrary.wiley.com/doi/10.1111/adb.12160/abstract
Endocannabinoid modulation by FAAH and MAGL within the analgesic circuitry of the periaqueductal grey (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25041240
Endocannabinoid Regulation in Human Endometrium Across the Menstrual Cycle (abst–2014) http://rsx.sagepub.com/content/early/2014/05/09/1933719114533730.abstract
The Role of Endocannabinoid Signaling in the Molecular Mechanisms of Neurodegeneration in Alzheimer’s Disease (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25147120
Consequences of early life stress on the expression of endocannabinoid-related genes in the rat brain (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25083571
Effect of selective inhibition of monoacylglycerol lipase (MAGL) on acute nausea, anticipatory nausea, and vomiting in rats and Suncus murinus (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25085768
Inhibition of endocannabinoid neuronal uptake and hydrolysis as strategies for developing anxiolytic drugs (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25083569
A Reversible and Selective Inhibitor of Monoacylglycerol Lipase Ameliorates Multiple Sclerosis (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25298214
Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25282655
Dual inhibition of monoacylglycerol lipase and cyclooxygenases synergistically reduces neuropathic pain in mice (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25393148
The cannabinoid receptor antagonist AM251 increases paraoxon and chlorpyrifos oxon toxicity in rats (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25447325
Inhibition of monoacylglycerol lipase prevents chronic traumatic encephalopathy-like neuropathology in a mouse model of repetitive mild closed head injury (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25492114
Comparative biochemical characterization of the monoacylglycerol lipase inhibitor KML29 in brain, spinal cord, liver, spleen, fat and muscle tissue (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25497453
Increased angiotensin II contraction of the uterine artery at early gestation in a transgenic model of hypertensive pregnancy is reduced by inhibition of endocannabinoid hydrolysis (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24935942
Cannabinoid receptor-dependent metabolism of 2-arachidonoylglycerol during aging (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24768821
Substrate-selective COX-2 inhibition as a novel strategy for therapeutic endocannabinoid augmentation (abst–2014) http://www.cell.com/trends/pharmacological-sciences/abstract/S0165-6147%2814%2900068-6
Marijuana for Alzheimer’s Disease (news–2014) https://www.psychologytoday.com/blog/your-brain-food/201411/marijuana-alzheimer-s-disease
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Local uterine Ang-(1-7) infusion augments the expression of cannabinoid receptors and differentially alters endocannabinoid metabolizing enzymes in the decidualized uterus of pseudopregnant rats (full–2015) http://www.rbej.com/content/13/1/5
Inhibition of monoacylglycerol lipase reduces nicotine withdrawal (full–2015) http://onlinelibrary.wiley.com/doi/10.1111/bph.12948/full
Blockade of monoacylglycerol lipase inhibits oligodendrocyte excitotoxicity and prevents demyelination in vivo (full–2015) http://onlinelibrary.wiley.com/doi/10.1002/glia.22742/full
Blockade of 2-arachidonoylglycerol hydrolysis produces antidepressant-like effects and enhances adult hippocampal neurogenesis and synaptic plasticity (full–2015) http://onlinelibrary.wiley.com/doi/10.1002/hipo.22344/full
Global deletion of monoacylglycerol lipase in mice delays lipid absorption and alters energy homeostasis and diet-induced obesity (full–2015)
http://www.jlr.org/content/early/2015/04/04/jlr.M058586.long
Selective monoacylglycerol lipase inhibitors: Antinociceptive vs. cannabimimetic effects in mice (full–2015) http://jpet.aspetjournals.org/content/early/2015/03/11/jpet.114.222315.long
Monoacylglycerol lipase inhibitor JZL184 reduces neuroinflammatory response in APdE9 mice and in adult mouse glial cells (full–2015) http://www.jneuroinflammation.com/content/12/1/81
Full FAAH inhibition combined with partial monoacylglycerol lipase inhibition: Augmented and sustained antinociceptive effects with negligible cannabimimetic side effects in mice (full–2015) http://jpet.aspetjournals.org/content/early/2015/05/20/jpet.115.222851.long
Turning Over a New Leaf: Cannabinoid and Endocannabinoid Modulation of Immune Function (full–2015) http://link.springer.com/article/10.1007/s11481-015-9615-z/fulltext.html
Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284516/
Task-specific enhancement of hippocampus-dependent learning in mice deficient in monoacylglycerol lipase, the major hydrolyzing enzyme of the endocannabinoid 2-arachidonoylglycerol (full–2015) http://journal.frontiersin.org/article/10.3389/fnbeh.2015.00134/full
A Basal Tone of 2-Arachidonoylglycerol Contributes to Early Oligodendrocyte Progenitor Proliferation by Activating Phosphatidylinositol 3-Kinase (PI3K)/AKT and the Mammalian Target of Rapamycin (MTOR) Pathways (full–2015) http://link.springer.com/article/10.1007/s11481-015-9609-x/fulltext.html
Endocannabinoid Catabolic Enzymes Play Differential Roles in Thermal Homeostasis in Response to Environmental or Immune Challenge (full–2015) http://tinyurl.com/q8uqfrd
Homeostatic regulation of brain functions by endocannabinoid signaling (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468750/
Pathogenesis of Systemic Sclerosis (full–2015) http://journal.frontiersin.org/article/10.3389/fimmu.2015.00272/full
Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action (full–2015) http://www.cell.com/cell-reports/fulltext/S2211-1247%2815%2900725-1
Impaired 2-AG signaling in hippocampal glutamatergic neurons: aggravation of anxietylike behavior and unaltered seizure susceptibility (full–2015) http://ijnp.oxfordjournals.org/content/ijnp/early/2015/07/29/ijnp.pyv091.full.pdf
Multiple Forms of Endocannabinoid and Endovanilloid Signaling Regulate the Tonic Control of GABA Release (full–2015) http://www.jneurosci.org/content/35/27/10039.full?sid=7e769d1b-9b77-42fe-92d0-8b337b34b9b6
Elevated Levels of Endocannabinoids in Chronic Hepatitis C May Modulate Cellular Immune Response and Hepatic Stellate Cell Activation (link to PDF-2015) http://www.mdpi.com/1422-0067/16/4/7057
Combined inhibition of monoacylglycerol lipase and cyclooxygenases synergistically reduces neuropathic pain in mice (abst–2015) http://onlinelibrary.wiley.com/doi/10.1111/bph.13012/abstract
Loratadine analogues as MAGL inhibitors (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25752982
[16-OR]: Vasoactive lipid mediators control uterine vascular reactivity at early pregnancy in the transgenic hAGNxhREN rat (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25787366
The role of cannabinoids in regulation of nausea and vomiting, and visceral pain (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25715910
Simultaneous inhibition of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) shares discriminative stimulus effects with ∆9-THC in mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25711338
The potential of inhibitors of endocannabinoid metabolism as anxiolytic and antidepressive drugs-A practical view (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25791296
For whom the endocannabinoid tolls: Modulation of innate immune function and implications for psychiatric disorders (abst–2015) http://www.sciencedirect.com/science/article/pii/S027858461500055X
Inhibition of monoacylglycerol lipase mediates a cannabinoid 1-receptor dependent delay of kindling progression in mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25796567
Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25698527
Monoacylglycerol Lipase Inhibitor Protects Primary Cultured Neurons Against Homocysteine-induced Impairments in Rat Caudate Nucleus through COX-2 signaling (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25818189
Postnatal ethanol exposure alters levels of 2-arachidonylglycerol-metabolizing enzymes and pharmacological inhibition of monoacylglycerol (MAGL) does not cause neurodegeneration in neonatal mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25857698
The effect of FAAH, MAGL, and Dual FAAH/MAGL inhibition on inflammatory and colorectal distension-induced visceral pain models in Rodents (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25869205
Possible inhibitory role of endogenous 2-arachidonoylglycerol as an endocannabinoid in (±)-epibatidine-induced activation of central adrenomedullary outflow in the rat (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25882827
Inhibition of FAAH reduces nitroglycerin-induced migraine-like pain and trigeminal neuronal hyperactivity in mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25910421
The monoacylglycerol lipase inhibitor JZL184 decreases inflammatory response in skeletal muscle contusion in rats (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25912803
Neuroprotective Effect of JZL184 in MPP+-Treated SH-SY5Y Cells Through CB 2 Receptors (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25976369
Repeated forced swim stress differentially affects formalin-evoked nociceptive behaviour and the endocannabinoid system in stress normo-responsive and stress hyper-responsive rat strains (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25988529
Peroxide-Dependent MGL Sulfenylation Regulates 2-AG-Mediated Endocannabinoid Signaling in Brain Neurons (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26000748
Increased tonic cannabinoid CB1R activity and brain region-specific desensitization of CB1R Gi/o signaling axis in mice with global genetic knockout of monoacylglycerol lipase (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26070239
A highly selective, reversible inhibitor identified by comparative chemoproteomics modulates diacylglycerol lipase activity in neurons (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26083464
Dynamics of expression and localization of the cannabinoid system in granulosa cells during oocyte nuclear maturation (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26144572
Phytocannabinoids for Cancer Therapeutics: Recent Updates and Future Prospects (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26179998
COMPARATIVE EFFECTS OF PARATHION AND CHLORPYRIFOS ON ENDOCANNABINOID AND ENDOCANNABINOID-LIKE LIPID METABOLITES IN RAT STRIATUM (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26215119
Genetic deletion of monoacylglycerol lipase (MAGL) leads to impaired cannabinoid receptor CB1 R signaling and anxiety-like behavior (abst–2015)
http://www.ncbi.nlm.nih.gov/pubmed/26223500
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