F-H [ECS]

*Older Studies 2000-2009

FAAH / FATTY ACID AMIDE HYDROLASE* (Breaks down Anandamide)
FABP / FATTY ACID BINDING PROTEINS (Deliver Cannabinoids to FAAH for Destruction)
HEMOPRESIN* (CB1 Inverse Agonist)


FAAH / FATTY ACID AMIDE HYDROLASE
Enhancement of endocannabinoid signaling by fatty acid amide hydrolase inhibition: a neuroprotective therapeutic modality (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848893/?tool=pubmed
Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828288/?report=classic
Arachidonoyl ethanolamide (AEA)-induced apoptosis is mediated by J-series prostaglandins and is enhanced by fatty acid amide hydrolase (FAAH) blockade (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134573/pdf/nihms275514.pdf
Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227620/?tool=pubmed
A catalytically silent FAAH-1 variant drives anandamide transport in neurons (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245783/
The activity of the endocannabinoid metabolising enzyme fatty acid amide hydrolase in subcutaneous adipocytes correlates with BMI in metabolically healthy humans (full–2011) http://www.lipidworld.com/content/10/1/129
Dual inhibition of alpha/beta hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons (full–2011) http://www.jbc.org/content/early/2011/06/10/jbc.M110.202853.long
Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21740924
Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227620/?tool=pubmed
A role for the ventral hippocampal endocannabinoid system in fear-conditioned analgesia and fear responding in the presence of nociceptive tone in rats (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21864979
Pharmacological characterization of the peripheral FAAH inhibitor URB937 in female rodents: interaction with the Abcg2 transporter in the blood-placenta barrier (full–2012) http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02098.x/full
A polymorphism in the gene of the endocannabinoid-degrading enzyme FAAH (FAAH C385A) is associated with emotional–motivational reactivity (full–2012) http://link.springer.com/article/10.1007/s00213-012-2785-y/fulltext.html
The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action (full–2012) http://www.biomedcentral.com/1471-2407/12/92
Endocannabinoid signaling in female reproduction (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382454/
The endocannabinoid system: an overview (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303140/
Inhibiting fatty acid amide hydrolase normalizes endotoxin-induced enhanced gastrointestinal motility in mice (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372737/
Changes of Blood Endocannabinoids during Anaesthesia: a Special Case for Fatty Acid Amide Hydrolase Inhibition by Propofol? (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394128/
The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423256/
Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525790/
β−Amyloid exacerbates inflammation in astrocytes lacking fatty acid amide hydrolase through a mechanism involving PPAR-α, PPAR-γ and TRPV1, but not CB1 or CB2 receptors (full–2012) http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.01889.x/pdf
Ectopic pregnancy is associated with high anandamide levels and aberrant expression of FAAH and CB1 in fallopian tubes (full–2012) http://press.endocrine.org/doi/full/10.1210/jc.2012-1780
Lack of effect of chronic pre-treatment with the FAAH inhibitor URB597 on inflammatory pain behaviour: evidence for plastic changes in the endocannabinoid system (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449266/
Endocannabinoids at the synapse a decade after the Dies Mirabilis (29 March 2001): what we still do not know (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424745/
Equipotent Inhibition of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase – Dual Targets of the Endocannabinoid System to Protect against Seizure Pathology (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480564/
The FAAH inhibitor URB597 efficiently reduces tyrosine hydroxylase expression through CB1 and FAAH-independent mechanisms (full–2012) http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02208.x/full
Acute reduction of anandamide-hydrolase (FAAH) activity is coupled with a reduction of nociceptive pathways facilitation in medication-overuse headache subjects after withdrawal treatment (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22670561?dopt=Abstract
Genetic variability in the endocannabinoid system and 12-week clinical response to citalopram treatment: the role of the CNR1, CNR2 and FAAH genes (abst–2012) http://jop.sagepub.com/content/26/10/1391
Spinal Cord Fatty Acid Amide Hydrolase (FAAH) in Normal Micturition Control and Bladder Overactivity in Awake Rats (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/23219540
Endothelium-dependent mechanisms of the vasodilatory effect of the endocannabinoid, anandamide, in the rat pulmonary artery (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22627170
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Inhibition of FAAH and activation of PPAR: New approaches to the treatment of cognitive dysfunction and drug addiction (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662489/
Astroglial CB1 cannabinoid receptors regulate leptin signaling in mouse brain astrocytes (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854987/
Elevated Anandamide and Related N-Acylethanolamine Levels Occur in the Peripheral Blood of Women With Ectopic Pregnancy and Are Mirrored by Changes in Peripheral Fatty Acid Amide Hydrolase Activity (full–2013) http://press.endocrine.org/doi/full/10.1210/jc.2012-3390
Parsing the players: 2-AG synthesis and degradation in the CNS (full–2013) http://onlinelibrary.wiley.com/doi/10.1111/bph.12411/full
Cannabinoid signaling and liver therapeutics (full–2013) http://www.journal-of-hepatology.eu/article/S0168-8278%2813%2900212-2/fulltext
Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788575/
Expression of fatty acid amide hydrolase (FAAH) in human, mouse, and rat urinary bladder and effects of FAAH inhibition on bladder function in awake rats (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/21930339
Full Inhibition of Spinal FAAH Leads to TRPV1-Mediated Analgesic Effects in Neuropathic Rats and Possible Lipoxygenase-Mediated Remodeling of Anandamide Metabolism (full–2013) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0060040
Dual Inhibition of Endocannabinoid Catabolic Enzymes Produces Enhanced Anti-Withdrawal Effects in Morphine-Dependent Mice (full–2013) http://www.ncbi.nlm.nih.gov/pubmed/23303065
Fatty acid amide hydrolase deficiency enhances intraplaque neutrophil recruitment in atherosclerotic mice (full–2013) http://atvb.ahajournals.org/content/33/2/215.long
Effects of C358A polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) on weight loss, adipocytokines levels, and insulin resistance after a high polyunsaturated fat diet in obese patients (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24445122
FAAH selectively influences placebo effects (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24042479
The effects of anandamide signaling enhanced by the FAAH inhibitor URB597 on coping styles in rats (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23743650
Long-term consequences of perinatal fatty acid amino hydrolase inhibition (abst–2013) http://onlinelibrary.wiley.com/doi/10.1111/bph.12500/abstract
Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24384256
Impulsivity, Variation in the Cannabinoid Receptor (CNR1) and Fatty Acid Amide Hydrolase (FAAH) Genes, and Marijuana-Related Problems (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24172113
Decreased Enteric Fatty Acid Amide Hydrolase Activity is Associated with Colonic Inertia in Slow Transit Constipation (abst–2013) http://onlinelibrary.wiley.com/doi/10.1111/jgh.12346/abstract
Inhibition of fatty acid amide hydrolase (FAAH) as a novel therapeutic strategy in the treatment of pain and inflammatory diseases in the gastrointestinal tract (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24275607
Fatty acid amide hydrolase but not monoacyl glycerol lipase controls cell death induced by the endocannabinoid 2-arachidonoyl glycerol in hepatic cell populations (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23806692
Amygdala FAAH and anandamide: mediating protection and recovery from stress (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24325918
Differential expression of endocannabinoid system in normal and preeclamptic placentas: effects on nitric oxide synthesis (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23122699
(4-Phenoxyphenyl)tetrazolecarboxamides and related compounds as dual inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23455058
Mechanisms of endothelium-dependent relaxation evoked by anandamide in isolated human pulmonary arteries (full–2014) http://download.springer.com/static/pdf/387/art%253A10.1007%252Fs00210-014-0961-9.pdf?auth66=1396559334_2a7771f3b0767a5092c7c4a570374992&ext=.pdf
Getting high on the endocannabinoid system (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997295/
Inhibition of Fatty Acid binding proteins elevates brain anandamide levels and produces analgesia (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976407/
FAAH inhibition enhances anandamide mediated anti-tumorigenic effects in non-small cell lung cancer by downregulating the EGF/EGFR pathway (full–2014) http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=1723&path%5B%5D=2142
Prolonged monoacylglycerol lipase blockade causes equivalent CB1-receptor mediated adaptations in FAAH wild type and knockout mice (full–2014) http://jpet.aspetjournals.org/content/early/2014/05/21/jpet.114.212753.long
Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation (full–2014) http://www.nature.com/tp/journal/v4/n7/full/tp201453a.html
Localization of the cannabinoid CB1 receptor and the 2-AG synthesizing (DAGLα) and degrading (MAGL, FAAH) enzymes in cells expressing the Ca(2+)-binding proteins calbindin, calretinin, and parvalbumin in the adult rat hippocampus (full–2014) http://journal.frontiersin.org/Journal/10.3389/fnana.2014.00056/full
The First Dual ChE/FAAH Inhibitors: New Perspectives for Alzheimer’s Disease? (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025825/
2012 Division of Medicinal Chemistry Award Address: Trekking the Cannabinoid Road: A Personal Perspective (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064474/
Association of the c.385C>A (p.Pro129Thr) polymorphism of the fatty acid amide hydrolase gene with anorexia nervosa in the Japanese population (full–2014) http://onlinelibrary.wiley.com/doi/10.1002/mgg3.69/full
Involvement of Fatty Acid Amide Hydrolase and Fatty Acid Binding Protein 5 in the Uptake of Anandamide by Cell Lines with Different Levels of Fatty Acid Amide Hydrolase Expression: A Pharmacological Study (full–2014) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0103479
The expression of cannabinoid receptor 1 is significantly increased in atopic patients (full–2014) http://www.jacionline.org/article/S0091-6749%2813%2902936-9/fulltext
Ketoconazole Inhibits the Cellular Uptake of Anandamide via Inhibition of FAAH at Pharmacologically Relevant Concentrations (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900727/
Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788575/
The effects of obesity, diabetes and metabolic syndrome on the hydrolytic enzymes of the endocannabinoid system in animal and human adipocytes (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995979/
Influence of dietary fat intake on the endocannabinoid system in lean and obese subjects (full–2014) http://onlinelibrary.wiley.com/doi/10.1002/oby.20728/full
Cannabinoids as therapeutic agents in cancer: current status and future implications (link to PDF-2014) http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=2233
Selective inhibition of FAAH produces antidiarrheal and antinociceptive effect mediated by endocannabinoids and cannabinoid-like fatty acid amides (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24460851
No more pain upon Gq -protein-coupled receptor activation: role of endocannabinoids (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24494686
Anandamide in primary sensory neurons: too much of a good thing? (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24494681
Organophosphate agents induce plasma hypertriglyceridemia in mouse via single or dual inhibition of the endocannabinoid hydrolyzing enzyme(s) (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24361246
Dexamethasone alleviates motion sickness in rats in part by enhancing the endocannabinoid system (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24508383
Switching cannabinoid response from CB2 agonists to FAAH inhibitors (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24508127
Targeting the cannabinoid system for pain relief? (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24529672
1-Aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase (abst-2014) http://www.ncbi.nlm.nih.gov/pubmed/24513048
Effects of the fatty acid amide hydrolase inhibitor URB597 on pain-stimulated and pain depressed behavior in rats (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24583930
Endocannabinoid-Hydrolysing Enzymes in the Post-Mortem Cerebellum of Humans Affected by Hereditary Autosomal Dominant Ataxias (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24642775
Toward modulation of the endocannabinoid system for treatment of gastrointestinal disease: FAAHster but not “higher” (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24641009
Elevation of Endogenous Anandamide Impairs LTP, Learning and Memory through CB1 Receptor Signaling in Mice (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24648181
Anticonvulsant Effects of N-Arachidonoyl-Serotonin, a Dual FAAH Enzyme and TRPV1 Channel Blocker, on Experimental Seizures: The Roles of Cannabinoid CB1 Receptors and TRPV1 Channels (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24674273
Inhibition of Peripheral Fatty Acid Amide Hydrolase Depresses Activities of Bladder Mechanosensitive Nerve Fibers of the Rat (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24746881
New players in the fatty acyl ethanolamide metabolism (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24747663
Endocannabinoid Regulation in Human Endometrium Across the Menstrual Cycle (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24819878
Endocannabinoid signaling in Alzheimer’s disease: current knowledge and future directions (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24813316
Functionalization of β-Caryophyllene Generates Novel Polypharmacology in the Endocannabinoid System. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24831513
Endocannabinoid contribution to Δ9-tetrahydrocannabinol discrimination in rodents (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24858366
The dual blocker of FAAH/TRPV1 N-arachidonoylserotonin reverses the behavioral despair induced by stress in rats and modulates the HPA-axis (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24861565
The dual FAAH/MAGL inhibitor JZL195 has enhanced effects on endocannabinoid transmission and motor behavior in rats as compared to those of the MAGL inhibitor JZL184 (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24911644
Attenuation of serotonin-induced itch responses by inhibition of endocannabinoid degradative enzymes, fatty acid amide hydrolase and monoacylglycerol lipase (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24915981
PET Imaging of Fatty Acid Amide Hydrolase with [18F]DOPP in Non-Human Primates (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25004399
The endocannabinoid system is altered in the post-mortem prefrontal cortex of alcoholic subjects (abst–2014) http://onlinelibrary.wiley.com/doi/10.1111/adb.12160/abstract
Anticancer effects of anandamide on head and neck squamous cell carcinoma cells via the production of receptor-independent reactive oxygen species (abst–2014) http://onlinelibrary.wiley.com/doi/10.1002/hed.23727/abstract
Endocannabinoid modulation by FAAH and MAGL within the analgesic circuitry of the periaqueductal grey (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25041240
Inhibition of FAAH enzyme by pterostilbene: potential mechanism of anxiolytic action (abst–2014) http://www.fasebj.org/content/28/1_Supplement/1144.10.abstract?sid=db987fd0-3ef0-4796-aff6-4103f0c84daf
The FAAH inhibitor PF-04457845 has THC-like rewarding and reinstatement effects in squirrel monkeys and increases dopamine levels in the nucleus accumbens shell in rats (abst–2014) http://www.fasebj.org/content/28/1_Supplement/838.6.abstract?sid=db987fd0-3ef0-4796-aff6-4103f0c84daf
Synthesis of Phenoxyacyl-Ethanolamides and Their Effects on Fatty Acid Amide Hydrolase Activity (abst–2014) http://www.jbc.org/content/289/13/9340.abstract?sid=58027e04-8d1d-47c5-b6d3-49611e578de4
Endocannabinoid-hydrolysing enzymes in the post-mortem cerebellum of humans affected by hereditary autosomal dominant ataxias (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24642775
Endocannabinoid Regulation in Human Endometrium Across the Menstrual Cycle (abst–2014) http://rsx.sagepub.com/content/early/2014/05/09/1933719114533730.abstract
Fenitrothion action at the endocannabinoid system leading to spermatotoxicity in Wistar rats. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24998969
The Role of Endocannabinoid Signaling in the Molecular Mechanisms of Neuro-degeneration in Alzheimer’s Disease (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25147120
Role of the basolateral amygdala in mediating the effects of the fatty acid amide hydrolase inhibitor URB597 on HPA axis response to stress (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25106694
Consequences of early life stress on the expression of endocannabinoid-related genes in the rat brain (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25083571
Inhibition of endocannabinoid neuronal uptake and hydrolysis as strategies for developing anxiolytic drugs (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25083569
Computational insights into function and inhibition of fatty acid amide hydrolase (abst-2014) http://www.ncbi.nlm.nih.gov/pubmed/25240419
Activity of anandamide (AEA) metabolic enzymes in rat placental bed (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25088244
JZL184 is anti-hyperalgesic in a murine model of cisplatin-induced peripheral neuropathy (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25304184
Attenuation of Cystitis and Pain Sensation in Mice Lacking Fatty Acid Amide Hydrolase (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25374388
N-Acylethanolamine-hydrolyzing acid amidase inhibition increases colon Npalmitoylethanolamine levels and counteracts murine colitis (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25384424
Cannabinoid CB1 receptors mediate the effects of dipyrone (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25430877
“Disease Modifying Nutricals” for multiple sclerosis (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25435020
Normal aging in rats and pathological aging in human Alzheimer disease decrease FAAH activity: Modulation by cannabinoid agonists (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25456842
The cannabinoid receptor antagonist AM251 increases paraoxon and chlorpyrifos oxon toxicity in rats (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25447325
Attenuation of persistent pain-related behavior by fatty acid amide hydrolase (FAAH) inhibitors in a rat model of HIV sensory neuropathy (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25486617
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Inhibition of anandamide hydrolysis attenuates nociceptor sensitization in a murine model of chemotherapy-induced peripheral neuropathy (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25505113
Increased angiotensin II contraction of the uterine artery at early gestation in a transgenic model of hypertensive pregnancy is reduced by inhibition of endocannabinoid hydrolysis (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24935942
Enhanced microglial activity in FAAH-/- animals (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25534441
The fatty acid amide hydrolase in lymphocytes from sedentary and active subjects (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/23793235
Substrate-selective COX-2 inhibition as a novel strategy for therapeutic endocannabinoid augmentation (abst–2014) http://www.cell.com/trends/pharmacological-sciences/abstract/S0165-6147%2814%2900068-6
The Endocannabinoid Anandamide Mediates Hypoxic Pulmonary Vasoconstriction And Pulmonay Hypertension (abst–2014) http://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2014.189.1_MeetingAbstracts.A5558
Local uterine Ang-(1-7) infusion augments the expression of cannabinoid receptors and differentially alters endocannabinoid metabolizing enzymes in the decidualized uterus of pseudopregnant rats (full–2015) http://www.rbej.com/content/13/1/5
Regulation of cannabinoid receptor gene expression and endocannabinoid levels in lymphocyte subsets by interferon-β: a longitudinal study in multiple sclerosis patients (full–2015) http://onlinelibrary.wiley.com/doi/10.1111/cei.12443/full
Cocaine-induced endocannabinoid release modulates behavioral and neurochemical sensitization in mice (full–2015) http://onlinelibrary.wiley.com/doi/10.1111/adb.12080/full
Fatty Acid Binding Proteins (FABPs) are Intracellular Carriers for Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD) (full–2015) http://www.jbc.org/content/early/2015/02/09/jbc.M114.618447.long
Full FAAH inhibition combined with partial monoacylglycerol lipase inhibition: Augmented and sustained antinociceptive effects with negligible cannabimimetic side effects in mice (full–2015) http://jpet.aspetjournals.org/content/early/2015/05/20/jpet.115.222851.long
Turning Over a New Leaf: Cannabinoid and Endocannabinoid Modulation of Immune Function (full–2015) http://link.springer.com/article/10.1007/s11481-015-9615-z/fulltext.html
Increased contextual fear conditioning in iNOS knockout mice: additional evidence for the involvement of nitric oxide in stress-related disorders and contribution of the endocannabinoid system (full–2015) http://ijnp.oxfordjournals.org/content/18/8/pyv005.long
Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423390/
Perturbations of the endocannabinoid system in mantle cell lymphoma: correlations to clinical and pathological features (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278325/
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Endocannabinoid Catabolic Enzymes Play Differential Roles in Thermal Homeostasis in Response to Environmental or Immune Challenge (full–2015) http://tinyurl.com/q8uqfrd
Changes in the endocannabinoid signaling system in CNS structures of TDP-43 transgenic mice: relevance for a neuroprotective therapy in TDP-43-related disorders (full–2015) http://tinyurl.com/jcs8lgr
Homeostatic regulation of brain functions by endocannabinoid signaling (full–2015)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468750/
Pathogenesis of Systemic Sclerosis (full–2015)
http://journal.frontiersin.org/article/10.3389/fimmu.2015.00272/full
FAAH genetic variation enhances fronto-amygdala function in mouse and human (full–2015) http://tinyurl.com/jphfuk5
Multiple Forms of Endocannabinoid and Endovanilloid Signaling Regulate the Tonic Control of GABA Release (full–2015) http://www.jneurosci.org/content/35/27/10039.full?sid=7e769d1b -9b77-42fe-92d0-8b337b34b9b6
Elevated Levels of Endocannabinoids in Chronic Hepatitis C May Modulate Cellular Immune Response and Hepatic Stellate Cell Activation (link to PDF-2015) http://www.mdpi.com/1422-0067/16/4/7057
Endocannabinoids (article–2015) http://emedicine.medscape.com/article/1361971-overview#showall
Novel associations between FAAH genetic variants and postoperative central opioidrelated adverse effects (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25558980
Activation of cannabinoid receptor 1 inhibits increased bladder activity induced by nerve growth factor (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25575795
Inhibition of anandamide hydrolysis enhances noradrenergic and GABAergic transmission in the prefrontal cortex and basolateral amygdala of rats subjected to acute swim stress (abst-2015) http://www.ncbi.nlm.nih.gov/pubmed/25581607
Effects of peripheral FAAH blockade on NTG-induced hyperalgesia-evaluation of URB937 in an animal model of migraine (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25608877
N-stearoyltyrosine protects primary cortical neurons against Aβ(1-40)-induced injury
through inhibiting endocannabinoid degradation (abst–2015) http://www.sciencedirect.com/science/article/pii/S0024320515000521
Inhibition of anandamide hydrolysis enhances noradrenergic and GABAergic transmission in the prefrontal cortex and basolateral amygdala of rats subjected to acute swim stress (abst–2015) http://onlinelibrary.wiley.com/doi/10.1002/jnr.23539/abstract
Effects of Fatty Acid Amide Hydrolase (FAAH) Inhibitors in Non-Human Primate Models of Nicotine Reward and Relapse (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25754762
Loratadine analogues as MAGL inhibitors (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25752982
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Multitarget fatty acid amide hydrolase/cyclooxygenase blockade suppresses intestinal inflammation and protects against nonsteroidal anti-inflammatory drug-dependent gastrointestinal damage (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25757568
Attenuation of kainic acid-induced status epilepticus by inhibition of endocannabinoid transport and degradation in guinea pigs (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25769371
[268-POS]: Placental expression of the endocannabinoid system in preeclampsia (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25787618
Spinal neuronal cannabinoid receptors mediate urodynamic effects of systemic fatty acid amide hydrolase (FAAH) inhibition in rats (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25788026
[16-OR]: Vasoactive lipid mediators control uterine vascular reactivity at early pregnancy in the transgenic hAGNxhREN rat (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25787366
Corticotropin-Releasing Hormone Drives Anandamide Hydrolysis in the Amygdala to Promote Anxiety (abst-2015) http://www.ncbi.nlm.nih.gov/pubmed/25740517
N-stearoyltyrosine protects primary cortical neurons against Aβ(1-40)-induced injury
through inhibiting endocannabinoid degradation (abst–2015)
http://www.ncbi.nlm.nih.gov/pubmed/25637682
The role of cannabinoids in regulation of nausea and vomiting, and visceral pain (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25715910
Simultaneous inhibition of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) shares discriminative stimulus effects with ∆9-THC in mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25711338
A multi-target approach for pain treatment – dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25719612
Effects of URB597 as an inhibitor of fatty acid amide hydrolase on WIN55, 212-2-induced learning and memory deficits in rats (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25689415
Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25698527
The effect of FAAH, MAGL, and Dual FAAH/MAGL inhibition on inflammatory and colorectal distension-induced visceral pain models in Rodents (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25869205
Inhibition of FAAH reduces nitroglycerin-induced migraine-like pain and trigeminal neuronal hyperactivity in mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25910421
Endocannabinoids regulate the activity of astrocytic hemichannels and the microglial response against an injury: In vivo studies (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25917763
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Enhancement of endocannabinoid signalling protects against cocaine-induced neurotoxicity (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25933444
Endocannabinoid and ceramide levels are altered in patients with colorectal cancer (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25975960
Endocannabinoid-mediated improvement on a test of aversive memory in a mouse model
of fragile X syndrome (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25979787
Repeated forced swim stress differentially affects formalin-evoked nociceptive behaviour and the endocannabinoid system in stress normo-responsive and stress hyper-responsive rat strains (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25988529
A highly selective, reversible inhibitor identified by comparative chemoproteomics
modulates diacylglycerol lipase activity in neurons (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26083464
Blocking of fatty acid amide hydrolase activity with PF-04457845 in human brain: a positron emission tomography study with the novel radioligand [11C]CURB (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26082009
Dynamics of expression and localization of the cannabinoid system in granulosa cells during oocyte nuclear maturation (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26144572
Phytocannabinoids for Cancer Therapeutics: Recent Updates and Future Prospects (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26179998
URB937, a peripherally-restricted inhibitor for fatty acid amide hydrolase, reduces
prostaglandin E2 -induced bladder overactivity and hyperactivity of bladder mechanoafferent nerve fibers in rats (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26189783
COMPARATIVE EFFECTS OF PARATHION AND CHLORPYRIFOS ON ENDOCANNABINOID AND ENDOCANNABINOID-LIKE LIPID METABOLITES IN RAT STRIATUM (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26215119
Inhibition of fatty-acid amide hydrolyse (FAAH) exerts cognitive improvements in male but not female rats (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26238495


FABP / FATTY ACID BINDING PROTEINS
Inhibition of Fatty Acid binding proteins elevates brain anandamide levels and produces analgesia (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976407/
Involvement of Fatty Acid Amide Hydrolase and Fatty Acid Binding Protein 5 in the Uptake of Anandamide by Cell Lines with Different Levels of Fatty Acid Amide Hydrolase Expression: A Pharmacological Study (full–2014) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0103479
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Fatty Acid-binding Protein 5 (FABP5) Regulates Cognitive Function Both by Decreasing Anandamide Levels and by Activating the Nuclear Receptor Peroxisome Proliferator activated Receptor β/δ (PPARβ/δ) in the Brain (abst–2014) http://www.jbc.org/content/289/18/12748.abstract?sid=58027e04-8d1d-47c5-b6d3-49611e578de4
Fatty Acid Binding Protein-4 is expressed in the mouse placental labyrinth, yet is dispensable for placental triglyceride accumulation and fetal growth (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25096952
Plasma-Free Fatty Acids, Fatty Acid-Binding Protein 4, and Mortality in Older Adults (from the Cardiovascular Health Study) (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25073566
Impaired Neurogenesis by HIV-1-Gp120 is Rescued by genetic deletion of Fatty Acid
Amide Hydrolase Enzyme (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24571443
Fatty Acid Binding Proteins (FABPs) are Intracellular Carriers for Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD) (full–2015)
http://www.jbc.org/content/early/2015/02/09/jbc.M114.618447.long
Increased Plasma Levels of FABP4 and PTEN Is Associated with More Severe Insulin
Resistance in Women with Gestational Diabetes Mellitus (full–2015)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329941/
Fatty Acid-Binding Protein 4 (FABP4): Pathophysiological Insights and Potent Clinical Biomarker of Metabolic and Cardiovascular Diseases (full–2015)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315049/
Bile salt recognition by human liver fatty acid binding protein (abst–2015)
http://www.ncbi.nlm.nih.gov/pubmed/25639618
Fatty acid binding protein 5 (FABP5) regulates diet-induced obesity (DIO) via GIP
secretion from enteroendocrine K-cells in response to fat ingestion (abst–2015)
http://www.ncbi.nlm.nih.gov/pubmed/25628425
Urinary early kidney injury molecules in children with beta-thalassemia major (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25656833
Analysis of FABP4 expression pattern in rump fat deposition and metabolism of Altay sheep (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25665644
Angiotensin II receptor blockers decrease serum concentration of fatty acid-binding protein 4 in patients with hypertension (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25672659
Point-of-care heart-type fatty acid binding protein versus high-sensitivity troponin T testing in emergency patients at high risk for acute coronary syndrome (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25666938
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HEMOPRESIN
The Peptide Hemopressin Acts through CB1 Cannabinoid Receptors to Reduce Food Intake in Rats and Mice (full–2010) http://www.jneurosci.org/content/30/21/7369.full
Binding of the hemopressin peptide to the cannabinoid CB1 receptor: structural insights (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/21062041
The effects of peptide and lipid endocannabinoids on arthritic pain at the spinal level (full–2012) http://journals.lww.com/anesthesiaanalgesia/Fulltext/2012/06000/The_Effects_of_Peptide_and_Lipid_Endocannabinoids.30.aspx
Identification and quantification of a new family of peptide endocannabinoids (Pepcans) showing negative allosteric modulation at CB1 receptors (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481297/
Modulation of the cannabinoid receptors by hemopressin peptides (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594051/
Central functional response to the novel peptide cannabinoid, hemopressin (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23542442
Modulation of subventricular zone oligodendrogenesis: a role for hemopressin? (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936357/
Hemopressin, an inverse agonist of cannabinoid receptors, inhibits neuropathic pain in rats (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24703998
Analgesic tolerance and cross-tolerance to the cannabinoid receptors ligands hemopressin, VD-hemopressin(α) and WIN55,212-2 at the supraspinal level in mice (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25010019
Role of cannabinoid receptors in hepatic fibrosis and apoptosis associated with bile duct ligation in rats (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25179573
Anxiogenic-like effects induced by hemopressin in rats (abst–2014)
http://www.ncbi.nlm.nih.gov/pubmed/25462856
The hypotensive effect of intrathecally injected (m)VD-hemopressin(α) in urethane anesthetized rats (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24681436
The Endocannabinoid System in Renal Cell: Regulation of Na+ Transport by CB1 Receptors Through Distinct Cell Signaling Pathways (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25537261
The endocannabinoid system in renal cell: Regulation of Na+ transport by CB1 receptors through distinct cell signaling pathways (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26177675
Mitochondrial CB1 receptor is involved in ACEA-induced protective effects on neurons and mitochondrial functions (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26215450
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