ENDOCANNABINOID SYSTEM GENETICS-ANIMAL

ENDOCANNABINOID SYSTEM GENETICS–ANIMAL
KNOCK-OUT MICE*+ (Living Examples of Severely Defective Endocannabinoid Systems)


ENDOCANNABINOID SYSTEM GENETICS–ANIMAL
Mutation of Putative GRK Phosphorylation Sites in the Cannabinoid Receptor 1 (CB1R) Confers Resistance to Cannabinoid Tolerance and Hypersensitivity to Cannabinoids in Mice (full–2014) http://www.jneurosci.org/content/34/15/5152.long
Genome-wide microarray analysis identifies a potential role for striatal retrograde endocannabinoid signaling in the pathogenesis of experimental L-DOPA-induced dyskinesia (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24599755
Strain differences in the expression of endocannabinoid genes and in cannabinoid receptor binding in the brain of Lewis and Fischer 344 rats (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24607771
Cannabinoid receptor type 1 receptors on GABAergic vs. glutamatergic neurons differentially gate sex-dependent social interest in mice (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24698342
Strain- and context-dependent effects of the anandamide hydrolysis inhibitor URB597 on social behavior in rats (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24933531
Genetic dissection of the endocannabinoid system and how it changed our knowledge of cannabinoid pharmacology and mammalian physiology (abst–2014) http://onlinelibrary.wiley.com/doi/10.1002/9781118451281.ch4/summary
Altered expression of the CB1 cannabinoid receptor in the triple transgenic mouse model of Alzheimer’s disease (abst–2014) http://iospress.metapress.com/content/j04j4362605u1464/?p=09c91830dc7947dbb9d2c0ee83a7e915&pi=5
FAAH genetic variation enhances fronto-amygdala function in mouse and human (full–2015) http://tinyurl.com/jphfuk5


KNOCK-OUT MICE
Inactivation of the cannabinoid receptor CB1 prevents leukocyte infiltration and experimental fibrosis (full–2010) http://onlinelibrary.wiley.com/doi/10.1002/art.27642/full
Genes differentially expressed in CB1 knockout mice: involvement in the depressive-like phenotype (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/20692131
CB1 receptor deficiency decreases wheel-running activity: consequences on emotional behaviours and hippocampal neurogenesis (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/20138171
WIN55212-2 ameliorates atherosclerosis associated with suppression of pro-inflammatory responses in ApoE-knockout mice (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/20868672
Effects of chronic nicotine on food intake and anxiety-like behaviour in CB(1) knockout mice (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/20189358
Role of CB1 cannabinoid receptors on GABAergic neurons in brain aging (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131310/?tool=pubmed
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Resistance to diet-induced adiposity in cannabinoid receptor-1 deficient mice is not due to impaired adipocyte function (full–2011) http://www.nutritionandmetabolism.com/content/8/1/93
The central cannabinoid CB1 receptor is required for diet-induced obesity and rimonabant’s antiobesity effects in mice (full–2011)
http://onlinelibrary.wiley.com/doi/10.1038/oby.2011.250/full
Cannabinoid type 1 receptor mediates depot-specific effects on differentiation, inflammation and oxidative metabolism in inguinal and epididymal white adipocytes (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303536/
Endocannabinoids and traumatic brain injury (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165950/?tool=pubmed
Comparative effects of chlorpyrifos in wild type and cannabinoid Cb1 receptor knockout mice (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205254/
Early onset of aging-like changes is restricted to cognitive abilities and skin structure in Cnr1(-/-) mice (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/20724033
The role of cannabinoid receptors in bone remodeling in a CB1/2 double knockout mouse (abst–2011) http://www.fasebj.org/cgi/content/meeting_abstract/25/1_MeetingAbstracts/492.5?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=160&sortspec=date&resourcetype=HWCIT
Cannabinoid-1 Receptor Protects The Brain From Aging (news–2011) http://www.medicalnewstoday.com/releases/230948.php
Bodyguard for the brain (news–2011) http://www.sciencecodex.com/bodyguard_for_the_brain
Role of CB1 cannabinoid receptors on GABAergic neurons in brain aging (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131310/?tool=pubmed
Loss of CB1 receptors leads to differential age-related changes in reward-driven learning and memory (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514639/
Acetaminophen differentially enhances social behavior and cortical cannabinoid levels in inbred mice (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389197/
Upregulation of cannabinoid type 1 receptors in dopamine D2 receptor knockout mice is reversed by chronic forced ethanol consumption (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004984/?tool=pubmed
Endocannabinoid signaling in female reproduction (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382454/
Hypothalamic CB1 Cannabinoid Receptors Regulate Energy Balance in Mice (full–2012) http://press.endocrine.org/doi/full/10.1210/en.2012-1405
Resistance to diet-induced adiposity in cannabinoid receptor-1 deficient mice is not due to impaired adipocyte function (full–2012) http://www.nutritionandmetabolism.com/content/pdf/1743-7075-8-93.pdf
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Angiotensin II induces vascular endocannabinoid release, which attenuates its vasoconstrictor effect via CB1 cannabinoid receptors (full–2012) http://www.jbc.org/content/early/2012/07/11/jbc.M112.346296.full.pdf+html
The CB1 Cannabinoid Receptor Drives Corticospinal Motor Neuron Differentiation through the Ctip2/Satb2 Transcriptional Regulation Axis (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545190/
Cannabinoid receptor 1 in the vagus nerve is dispensable for body weight homeostasis but required for normal gastrointestinal motility (full–2012) http://www.jneurosci.org/content/32/30/10331.long
Evidence for the Putative Cannabinoid Receptor (GPR55)-Mediated Inhibitory Effects on Intestinal Contractility in Mice (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548934/
How Weed Can Protect Us From Cancer and Alzheimer’s (book excerpt–2012) http://www.alternet.org/story/156269/how_weed_can_protect_us_from_cancer_and_alzheimer%27s
Impaired hippocampal glucoregulation in the cannabinoid CB(1) receptor knockout mice as revealed by an optimized in vitro experimental approach (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22155442
Cannabinoid Modulation of Midbrain Urocortin 1 Neurones During Acute and Chronic Stress (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22734681
Cannabinoid CB1 receptor deficiency increases contextual fear memory under highly aversive conditions and long-term potentiation in vivo (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22579951
Age-related changes of anandamide metabolism in CB1 cannabinoid receptor knockout mice: correlation with behaviour (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/11982628
Role of CB1 and CB2 cannabinoid receptors in the development of joint pain induced by monosodium iodoacetate (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/23199705
The cannabinoid receptor-2 is involved in allergic inflammation (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22525379
The Dual Effect of Cannabinoid Receptor-1 Deficiency on the Murine Postoperative Ileus (full–2013) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0067427
Genetic Background Can Result in a Marked or Minimal Effect of Gene Knockout (GPR55 and CB2 Receptor) in Experimental Autoimmune Encephalomyelitis Models of Multiple Sclerosis (full–2013) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0076907
Bladder function in a cannabinoid receptor type 1 knock-out mouse (full–2013) http://onlinelibrary.wiley.com/doi/10.1111/bju.12350/full
Developmental Role for Endocannabinoid Signaling in Regulating Glucose Metabolism and Growth (full–2013) http://diabetes.diabetesjournals.org/content/62/7/2359.full?sid=2f5bda2b-a9c7-432a-9588-80c99189164d
Dissociation of the Pharmacological Effects of THC by mTOR Blockade (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656376/
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The CB1 receptor mediates the peripheral effects of ghrelin on AMPK activity but not on growth hormone release (full–2013) http://www.fasebj.org/content/27/12/5112.long
Low 17beta-Estradiol Levels in Cnr1 Knock-Out Mice Affect Spermatid Chromatin Remodeling by Interfering with Chromatin Reorganization (full–2013) http://www.biolreprod.org/content/88/6/152.long
A GPR18-based signaling system regulates IOP in murine eye (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687663/
Role of cannabinoid CB2 receptor in the reinforcing actions of ethanol (full–2013) http://onlinelibrary.wiley.com/doi/10.1111/adb.12076/full
CB1 Receptor-Mediated Signaling Underlies the Hippocampal Synaptic, Learning and Memory Deficits Following Treatment with JWH-081, a New Component of Spice/K2 Preparations (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959795/
Control of spasticity in a multiple sclerosis model using central nervous system-excluded CB1 cannabinoid receptor agonists (full–2013) http://www.fasebj.org/content/28/1/117.long
Endocannabinoid system and drug addiction: new insights from mutant mice approaches (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23490550
Involvement of the opioid and cannabinoid systems in pain control: new insights from knockout studies (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23523475
Cardiorespiratory control as a function of wake-sleep behavior and diet in mice lacking CB1 cannabinoid receptors (abst–2013) http://www.fasebj.org/cgi/content/meeting_abstract/27/1_MeetingAbstracts/926.1?sid=eea722c0 -971c-4daa-8b8c-38c0c63c19ad
Synaptic plasticity alterations associated with memory impairment induced by deletion of CB2 cannabinoid receptors (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23796670
CB1 cannabinoid receptor-mediated aggressive behavior (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23916480
Characterization of bladder function in a cannabinoid receptor type 2 knockout mouse in vivo and in vitro (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23908133
Loss of CB1 receptors leads to decreased cathepsin D levels and accelerated lipofuscin accumulation in the hippocampus (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23954857
Endocannabinoids decrease neuropathic pain-related behavior in mice through the
activation of one or both peripheral CB1 and CB2 receptors (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24148808
Modulation of Strain-Specific Differences in Gene Expression by Cannabinoid Type 2
Receptor Deficiency (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24370613
Why resolutions about taking up physical activity are hard to keep (news–2013)
http://www.thefreelibrary.com/Why+resolutions+about+taking+up+physical+activity+are+hard+to+keep.-a0313904638
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New Study Finds Marijuana Could Help Treat Alzheimer’s Disease (news–2013) http://www.opposingviews.com/i/society/drug-law/new-study-marijuana-alzheimer-s-disease-cannabinoidreceptors-neurobiology-aging
Prolonged monoacylglycerol lipase blockade causes equivalent CB1-receptor mediated adaptations in FAAH wild type and knockout mice (full–2014) http://jpet.aspetjournals.org/content/early/2014/05/21/jpet.114.212753.long
CB2 Receptor Deficiency Increases Amyloid Pathology and Alters Tau Processing in a Transgenic Mouse Model of Alzheimer’s Disease (full-2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883962/
Endocannabinoid Modulation of Cortical Up-States and NREM Sleep (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919802/
Multiple sleep alterations in mice lacking cannabinoid type 1 receptors (full–2014) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0089432
Involvement of cannabinoid receptors in peripheral and spinal morphine analgesia (full–2014) http://www.sciencedirect.com/science/article/pii/S0306452213010531
Cardiorespiratory Anomalies in Mice Lacking CB1 Cannabinoid Receptors (full–2014) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0100536
Cannabinoids Alleviate Experimentally Induced Intestinal Inflammation by Acting at Central and Peripheral Receptors (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183544/
Regulatory role of the Cannabinoid-2 receptor in stress-induced neuroinflammation in mice (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243857/
Elevation of Endogenous Anandamide Impairs LTP, Learning and Memory through CB1 Receptor Signaling in Mice (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077345/
Relationships between serotonergic and cannabinoid system in depressive-like behavior: a PET study with [11C]-DASB (full–2014) http://onlinelibrary.wiley.com/doi/10.1111/jnc.12716/full
The CB1 Receptor as an Important Mediator of Hedonic Reward Processing (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24718372
Deficiency of cannabinoid receptor of type 2 worsens renal functional and structural abnormalities in streptozotocin-induced diabetic mice (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24827776
Chronic Cannabinoid Receptor 2 Activation Reverses Paclitaxel Neuropathy Without Tolerance or Cannabinoid Receptor 1-Dependent Withdrawal (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24853387
What we know and do not know about the cannabinoid receptor 2 (CB2) (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24877594
Augmented tonic pain-related behavior in knockout mice lacking monoacylglycerol lipase, a major degrading enzyme for the endocannabinoid 2-arachidonoylglycerol (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24906199
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Morphological and Behavioural Evidence for Impaired Prefrontal Cortical Function in Female CB1 Receptor Deficient Mice (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24907533
Endocannabinoid signaling modulates neurons of the pedunculopontine nucleus (PPN) via astrocytes (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25009314
Cannabinoid receptor CB2 prevents development of heart failure in a murine model of pressure overload (abst–2014) http://www.freedomwares.ca/p80cannabinoid-receptor-cb2-prevents-development-heart-failure-murinemodel-pressure-overload/
Cannabinoid type 1 (CB1) receptors on Sim1-expressing neurons regulate energy expenditure in male mice (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25456065
Genetic background modifies the effects of type 2 cannabinoid receptor deficiency on bone mass and bone turnover (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24036631
Protection from osteoarthritis may lie in our own joints, study suggests (news–2014) http://www.alphagalileo.org/ViewItem.aspx?ItemId=141814&CultureCode=en
Lack of hypophagia in CB1 null mice is associated to decreased hypothalamic POMC and CART expression (full–2015) http://ijnp.oxfordjournals.org/content/early/2015/03/09/ijnp.pyv011.long
Genetic Dissection of Behavioural and Autonomic Effects of Δ9-Tetrahydrocannabinol in Mice (full–2015) http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.0050269
Understanding Cannabinoid Psychoactivity with Mouse Genetic Models (full–2015) http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.0050280
Interactions of the opioid and cannabinoid systems in reward: Insights from knockout studies (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318341/
Diacylglycerol lipase α knockout mice demonstrate metabolic and behavioral phenotypes similar to those of cannabinoid receptor 1 knockout mice (full–2015) http://journal.frontiersin.org/article/10.3389/fendo.2015.00086/full
Inhibiting endocannabinoid biosynthesis: a novel approach to the treatment of constipation (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25684407
Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25698527
Differential Pharmacological Regulation of Sensorimotor-Gating Deficit in CB1 Knockout Mice and Associated Neurochemical and Histological Alterations (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25895455
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The type 2 cannabinoid receptor regulates susceptibility to osteoarthritis in mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25937028
Epigenetic and Proteomic Expression Changes Promoted by Eating Addictive-like Behavior (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25944409
Anxiety, Stress, and Fear Response in Mice with Reduced Endocannabinoid Levels (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25981172
Behavioral genetics: of mice, men, and internal bliss (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26035787
An endocannabinoid system is present in the mouse olfactory epithelium but does not modulate olfaction (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26037800
Role of the endocannabinoid system in the emotional manifestations of osteoarthritis pain (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26067584
Increased tonic cannabinoid CB1R activity and brain region-specific desensitization of CB1R Gi/o signaling axis in mice with global genetic knockout of monoacylglycerol lipase (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26070239
The influence of cannabinoids on learning and memory processes of the dorsal striatum (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26092091
Fever Is Mediated by Conversion of Endocannabinoid 2-Arachidonoylglycerol to Prostaglandin E2 (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26196692
The Anxiolytic Actions of 2-Arachidonoylglycerol: Converging Evidence from Two Recent Genetic Endocannabinoid Deficiency Models (abst–2015) http://www.biologicalpsychiatryjournal.com/article/S0006-3223%2815%2900532-6/abstract
Genetic deletion of monoacylglycerol lipase (MAGL) leads to impaired cannabinoid receptor CB1 R signaling and anxiety-like behavior (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26223500
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