ECS GENETICS (2000-2009)


ATT / (ATT)n GENES
CB1 GENES
CB2 GENES
COMT GENES
FAAH GENES (RS324420 / C385A , RS324419 Etc.)
KNOCK-OUT MICE* (Living Examples of Severely Defective Endocannabinoid Systems)
RS GENES POLYMORPHISMS (Various)


ATT / (ATT)n GENES
(AAT)n repeat in the cannabinoid receptor gene (CNR1): association with cocaine addiction in an African-Caribbean population (full–2006) http://www.nature.com/tpj/journal/v6/n2/full/6500352a.html
Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa (full-2008) http://www.capmh.com/content/2/1/33
Association of the Cannabinoid Receptor Gene (CNR1) With ADHD and Post-Traumatic Stress Disorder (full-2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685476/?tool=pubmed
Cannabinoid receptor 1 gene (CNR1) and susceptibility to a quantitative phenotype for hebephrenic schizophrenia (abst–2008) http://www.ncbi.nlm.nih.gov/pubmed/18186055


CB1 GENES
Association study of a cannabinoid receptor gene (CNR1) polymorphism and schizophrenia (abst–2000) http://www.ncbi.nlm.nih.gov/pubmed/11204352
Association of a CB1 cannabinoid receptor gene (CNR1) polymorphism with severe alcohol dependence (abst–2002) http://www.ncbi.nlm.nih.gov/pubmed/11841893
Marijuana receptor gene abnormality in schizophrenia (news–2002) http://www.eurekalert.org/pub_releases/2002-07/mp-mrg061802.php
Human cannabinoid receptor 1: 5′ exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse (full–2004) http://www.nature.com/mp/journal/v9/n10/full/4001560a.html
Association study of cannabinoid receptor gene (CNR1) alleles and anorexia nervosa: differences between restricting and binging/purging subtypes (abst–2004) http://www.ncbi.nlm.nih.gov/pubmed/14755457
Depression in Parkinson’s disease is related to a genetic polymorphism of the cannabinoid receptor gene (CNR1) (full-2005) http://www.nature.com/tpj/journal/v5/n2/full/6500301a.html
Moderation of the Effect of Adolescent-Onset Cannabis Use on Adult Psychosis by a Functional Polymorphism in the Catechol-O-Methyltransferase Gene: Longitudinal Evidence of a Gene X Environment Interaction (full–2006) http://www.ukcia.org/research/COMTgene.pdf
Genetic variations at the endocannabinoid type 1 receptor gene (CNR1) are associated with obesity phenotypes in men (full–2007) http://jcem.endojournals.org/content/92/6/2382.long
Genotype effects of CHRNA7, CNR1 and COMT in schizophrenia: interactions with tobacco and cannabis use (full–2007) http://bjp.rcpsych.org/content/191/5/402.long
No evidence for an involvement of variants in the cannabinoid receptor gene (CNR1) in obesity in German children and adolescents (abst–2007) http://www.ncbi.nlm.nih.gov/pubmed/17292652
Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations (full–2008) http://hmg.oxfordjournals.org/content/17/13/1916.long
Marijuana withdrawal and craving: influence of the cannabinoid receptor 1 (CNR1) and fatty acid amide hydrolase (FAAH) genes (full-2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873690/
Cannabinoid type-1 receptor gene polymorphisms are associated with central obesity in a Southern Brazilian population (link to PDF–2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827795/
Cannabinoid receptor 1 (CNR1) gene: impact on antidepressant treatment response and emotion processing in major depression (abst–2008) http://www.ncbi.nlm.nih.gov/pubmed/18579347
Genetic variation may influence obesity only under conditions of diet: Analysis of three candidate genes (abst–2008) http://www.mgmjournal.com/article/S1096-7192%2808%2900201-1/abstract
Association of CNR1 and FAAH endocannabinoid gene polymorphisms with anorexia nervosa and bulimia nervosa: evidence for synergistic effects (full–2009) http://onlinelibrary.wiley.com/doi/10.1111/j.1601-183X.2009.00518.x/full
Variations in the cannabinoid receptor 1 gene predispose to migraine (abst–2009) http://www.ncbi.nlm.nih.gov/pubmed/19539700
Altered pattern of cannabinoid type 1 receptor expression in adipose tissue of dysmetabolic and overweight patients (abst–2009) http://www.metabolismjournal.com/article/S0026-0495%2808%2900398-3/abstract
The use and misuse of alcohol and marijuana can be traced to a common set of genes (news–2009) http://www.eurekalert.org/pub_releases/2009-12/ace-tua121209.php
Cannabis and smoking gene links to schizophrenia ‘unfounded’ (news–2009) http://www.medwirenews.com/47/71003/Psychiatry/Cannabis_and_smoking_gene_links_to_schizophrenia_%E2%80%98unfounded%E2%80%99.html


CB2 GENES
Reduced endocannabinoid immune modulation by a common cannabinoid 2 (CB2) receptor gene polymorphism: possible risk for autoimmune disorders (full–2005) http://www.jleukbio.org/content/78/1/231.long
Cannabinoid receptor type 2 gene is associated with human osteoporosis (full-2005) http://hmg.oxfordjournals.org/cgi/content/full/14/22/3389?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=400&resourcetype=HWCIT
Comparison Analysis of Gene Expression Patterns between Sporadic Alzheimer’s and Parkinson’s Disease (abst–2007) http://www.ncbi.nlm.nih.gov/pubmed/18198416
Common polymorphisms in the cannabinoid CB2 receptor gene (CNR2) are not associated with myocardial infarction and cardiovascular risk factors (link to PDF-2008) http://www.spandidos-publications.com/ijmm/22/2/165
The cannabinoid receptor type 2 (CNR2) gene is associated with hand bone strength phenotypes in an ethnically homogeneous family sample (abst-2009) http://www.ncbi.nlm.nih.gov/pubmed/19565271
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COMT GENES
Genotype effects of CHRNA7, CNR1 and COMT in schizophrenia: interactions with tobacco and cannabis use (full–2007) http://bjp.rcpsych.org/content/191/5/402.long
Cannabis and smoking gene links to schizophrenia ‘unfounded’ (news–2009) http://www.medwirenews.com/47/71003/Psychiatry/Cannabis_and_smoking_gene_links_to_schizophrenia_%E2%80%98unfounded%E2%80%99.html


FAAH GENES
A second fatty acid amide hydrolase with variable distribution among placental mammals (full–2006) http://www.jbc.org/content/281/48/36569.long
Genetic variation in endocannabinoid metabolism, gastrointestinal motility, and sensation (full-2007) http://ajpgi.physiology.org/cgi/content/full/294/1/G13?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=1120&resourcetype=HWCIT
The fatty acid amide hydrolase C385A (P129T) missense variant in cannabis users: studies of drug use and dependence in Caucasians (abst–2007) http://www.ncbi.nlm.nih.gov/pubmed/17290447
Genetic Loss of Faah Compromises Male Fertility in Mice (full-2008) http://www.biolreprod.org/content/80/2/235.long
Marijuana withdrawal and craving: influence of the cannabinoid receptor 1 (CNR1) and fatty acid amide hydrolase (FAAH) genes (full-2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873690/
Genetic deletion of Fatty Acid Amide Hydrolase results in improved long-term outcome in chronic autoimmune encephalitis (abst–2008) http://www.ncbi.nlm.nih.gov/pubmed/18501510
The role of fatty acid hydrolase gene variants in inflammatory bowel disease (full–2009) http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2008.03910.x/pdf
Association of CNR1 and FAAH endocannabinoid gene polymorphisms with anorexia nervosa and bulimia nervosa: evidence for synergistic effects (full–2009) http://onlinelibrary.wiley.com/doi/10.1111/j.1601-183X.2009.00518.x/full


KNOCK-OUT MICE
Are Cannabinoid Receptor Knockout Mice Animal Models for Schizophrenia? (abst-2000) http://www.medical-hypotheses.com/article/S0306-9877%2800%2991261-1/abstract
Anandamide degradation and N-acylethanolamines level in wild-type and CB1 cannabinoid receptor knockout mice of different ages (full–2001) http://onlinelibrary.wiley.com/doi/10.1046/j.1471-4159.2001.00413.x/full
The Central Cannabinoid Receptor Inactivation Suppresses Endocrine Reproductive Functions (abst–2001) http://www.ncbi.nlm.nih.gov/pubmed/11394887
Increased Severity of Stroke in CB1 Cannabinoid Receptor Knock-Out Mice (full-2002) http://www.jneurosci.org/cgi/content/full/22/22/9771?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=80&resourcetype=HWCIT#Top
Lack of CB1 cannabinoid receptors modifies nicotine behavioural responses, but not nicotine abstinence (abst–2002) http://www.ncbi.nlm.nih.gov/pubmed/12384171
Natural High Erases Bad Memories (news-2002) http://www.cbsnews.com/news/natural-high-erases-bad-memories/
Cannabinoid Cb1 Receptor Knockout Mice Exhibit Markedly Reduced Voluntary Alcohol Consumption and Lack Alcohol-induced Dopamine Release in the Nucleus Accumbens (full–2003) http://onlinelibrary.wiley.com/doi/10.1046/j.1471-4159.2003.01576.x/full
Milk intake and survival in newborn cannabinoid CB1 receptor knockout mice: evidence for a “CB3” receptor (abst–2003) http://www.ncbi.nlm.nih.gov/pubmed/12568912
The endogenous cannabinoid, anandamide, activates the hypothalamo-pituitary-adrenal
axis in CB1 cannabinoid receptor knockout mice (abst–2003) http://www.ncbi.nlm.nih.gov/pubmed/14688442?dopt=Abstract
Cannabinoid receptor type 1 (CB1) affects hypothalamic-pituitary-adrenal (HPA) axis activity at cerebral and pituitary level (abst–2003) https://www.thieme-connect.com/ejournals/abstract/10.1055/s-2003-817562
Keeping the Brain’s Activity under Control (news–2003) http://www.mpg.de/481862/pressRelease20031022?filter_order=L
Defective adult neurogenesis in CB1 cannabinoid receptor knockout mice (full-2004) http://molpharm.aspetjournals.org/content/66/2/204.long
CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity (full-2004)
http://www.nature.com/ijo/journal/v28/n4/full/0802583a.html
Context-dependent effects of CB1 cannabinoid gene disruption on anxiety-like and social behaviour in mice (abst–2004) http://onlinelibrary.wiley.com/doi/10.1111/j.1460-9568.2004.03293.x/abstract;jsessionid=15C92BB3498FAF0EE40394675E8B1800.d01t01
Cannabinoids and Reward: Interactions with the Opioid System (abst–2004) http://dl.begellhouse.com/journals/7b004699754c9fe6,54f83f6510f9db32,479134412f4ae4d5.html
Cannabinoid/Opioid Crosstalk in the Central Nervous System (abst–2004) http://dl.begellhouse.com/journals/7b004699754c9fe6,54f83f6510f9db32,25c26f6e4b594ae3.html
Overeating, Alcohol and Sucrose Consumption Decrease in Cb1 Receptor Deleted Mice (abst–2004) http://www.ncbi.nlm.nih.gov/pubmed/12770700
Cannabinoids spell relief in colon inflammation (news–2004) http://www.mpg.de/496761/pressRelease20040506?filter_order=L
Ethanol Induces Higher Bec in Cb1 Cannabinoid Receptor Knockout Mice While Decreasing Ethanol Preference (full–2005) http://alcalc.oxfordjournals.org/content/40/1/54.long
Early age-related cognitive impairment in mice lacking cannabinoid CB1 receptors (full–2005) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1266095/?tool=pubmed
Cannabinoid-receptor 1 null mice are susceptible to neurofilament damage and caspase 3 activation (abst–2005) http://www.ncbi.nlm.nih.gov/pubmed/15953683
Involvement of Neuronal Cannabinoid Receptor CB1 in Regulation of Bone Mass and Bone Remodeling (full-2006) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2238031/?tool=pmcentrez
The Endocannabinoids: Functional Roles and Therapeutic Opportunities (news–2007) http://www.alphagalileo.org/ViewItem.aspx?ItemId=11344&CultureCode=en
Neural Substrates Underlying the Effects of Cannabinoids, and More (news–2007) http://www.alphagalileo.org/ViewItem.aspx?ItemId=11623&CultureCode=en
Loss of Cannabinoid Receptor CB1 Induces Preterm Birth (full-2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553193/?tool=pmcentrez
The peripheral cannabinoid receptor knockout mice: an update (full–2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219525/?tool=pubmed
Involvement of central cannabinoid CB2 receptor in reducing mechanical allodynia in a mouse model of neuropathic pain (abst–2008) http://www.sciencedirect.com/science/article/pii/S0014299908000630
Endocannabinoid and serotonergic systems are needed for acetaminophen-induced analgesia (abst–2008) http://www.ncbi.nlm.nih.gov/pubmed/18485596?dopt=Abstract&holding=f1000,f1000m,isrctn
Anandamide effects on 5-HT(3) receptors in vivo (abst–2008) http://www.frontiersin.org/publications/18775693
Turned-Off Cannabinoid Receptor Turns On Colorectal Tumor Growth (news-2008) http://www.sciencedaily.com/releases/2008/08/080801074056.htm
CB2 receptor activation attenuates microcirculatory dysfunction during cerebral ischemic / reperfusion injury (full-2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319431/
Altered CB1 receptor and endocannabinoid levels precede motor symptom onset in a transgenic mouse model of Huntington’s disease (abst–2009) http://www.ncbi.nlm.nih.gov/pubmed/19524019
Bidirectional regulation of novelty-induced behavioral inhibition by the endocannabinoid system (abst–2009) http://www.ncbi.nlm.nih.gov/pubmed/19607846
Sex differences in the cannabinoid regulation of energy homeostasis (abst–2009) http://www.psyneuen-journal.com/article/S0306-4530%2809%2900123-1/abstract
Cannabinoids produced in the human body have an anti-inflammatory effect (news–2009) http://www.alphagalileo.org/ViewItem.aspx?ItemId=14530&CultureCode=en


RS GENES POLYMORPHISMS
Cannabinoid type-1 receptor gene polymorphisms are associated with central obesity in a Southern Brazilian population (link to PDF–2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827795/
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