F (2010-2018)

STUDIES ON CONDITIONS and RELATED ARTICLES 2010-2018

+Studies in 2000-2009 List
*Studies in Pre-2000 List
>Information in Another Section

>FAMILIAL MEDITERRANEAN FEVER  (See Pre-2000 List)
FASTING/FOOD/WATER DEPRIVATION and the ENDOCANNABINOID SYSTEM +
FERTILITY/SEXUAL FUNCTION*+
FETAL ALCOHOL SPECTRUM DISORDER
FEVER/TEMPERATURE CONTROL*+
FIBROMYALGIA +
FLU/INFLUENZA +
FRAGILE X SYNDROME (See Also AUTISM)


FASTING/FOOD/WATER DEPRIVATION and the ENDOCANNABINOID SYSTEM
Plasma anandamide and other N-acylethanolamines are correlated with their corresponding free fatty acid levels under both fasting and non-fasting conditions in women (full–2010) http://www.nutritionandmetabolism.com/content/7/1/49
Pharmacogenetic Trial of a Cannabinoid Agonist Shows Reduced Fasting Colonic Motility in Patients with Non-Constipated Irritable Bowel Syndrome (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202649/
TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats (full–2011) http://jpet.aspetjournals.org/content/339/1/228.long
Effect of rimonabant on oesophageal motor function in man (full-2011) http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2011.04576.x/full
Fish oil promotes survival and protects against cognitive decline in severely under-nourished mice by normalizing satiety signals (full–2011)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117120/
Plasticity in vagal afferent neurones during feeding and fasting: mechanisms and significance (abst-2011) http://www.ncbi.nlm.nih.gov/pubmed/21062423
Dietary conditions and highly palatable food access alter rat cannabinoid receptor
expression and binding density (full–2012)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621143/
The effects of fasting duration on gastric emptying in man, an exploration of the role of  the endocannabinoid system and inter-individual responsiveness (full–2012)  http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2982.2012.01954.x/full
Ibipinabant attenuates β-cell loss in male Zucker diabetic fatty rats independently of its 
effects on body weight (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22268426
Diet-dependent modulation of hippocampal expression of endocannabinoid signaling related proteins in cannabinoid antagonist-treated obese rats (abst–2012) 
http://www.ncbi.nlm.nih.gov/pubmed/23033907
Fasting induces CART down-regulation in the zebrafish nervous system in a cannabinoid  receptor 1-dependent manner (full-2013) http://press.endocrine.org/doi/full/10.1210/me.2011-1180
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Treatment with CNX-011-67, a novel GPR40 agonist, delays onset and progression of 
diabetes and improves beta cell preservation and function in male ZDF rats (full–2013) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668190/
Regulation of GPR55 in rat white adipose tissue and serum LPI by nutritional status, 
gestation, gender and pituitary factors (abst–2013)  http://www.sciencedirect.com/science/article/pii/S0303720713005261
Can Physical Exercise or Food Deprivation Cause Release of Fat-Stored Cannabinoids? (full-2014) http://onlinelibrary.wiley.com/doi/10.1111/bcpt.12235/full
Involvement of the cannabinoid CB1 receptor in modulation of dopamine output in the prefrontal cortex associated with food restriction in rats (full–2014) http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0092224
Role of corticosterone in the murine enteric nervous system during fasting (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25214399
Role of oleoylethanolamide as a feeding regulator in goldfish (full–2014) 
http://jeb.biologists.org/content/217/15/2761
Fasting and exercise increase plasma cannabinoid levels in THC pre-treated rats: an  examination of behavioural consequences (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24696079
Cannabinoid type-1 Receptors in The Paraventricular Nucleus of The Hypothalamus 
Inhibit Stimulated Food Intake (abst–2014)  http://www.ncbi.nlm.nih.gov/pubmed/24434770
The endocannabinoid system controls food intake via olfactory processes (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24509429
New insights on food intake control by olfactory processes: the emerging role of the 
endocannabinoid system (abst–2014)  http://www.sciencedirect.com/science/article/pii/S0303720714003037
Enhanced Glutamatergic Synaptic Plasticity in the Hippocampal CA1 Field of Food Restricted Rats: Involvement of CB1 Receptors (full–2015)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793114/
Quantitative analysis of performance on a progressive-ratio schedule: effects of  reinforcer type, food deprivation and acute treatment with Δ9-tetrahydrocannabinol (THC) (full–2015) http://www.sciencedirect.com/science/article/pii/S037663571500042X
Fasting stimulates 2-AG biosynthesis in the small intestine: role of cholinergic pathways (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26290104
Type 1 cannabinoid receptor modulates water deprivation-induced homeostatic responses (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26468265
Physiological roles for the subfornical organ – A dynamic transcriptome shaped by autonomic state (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26227400
Enhanced Glutamatergic Synaptic Plasticity in the Hippocampal CA1 Field of Food Restricted Rats: Involvement of CB1 Receptors (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26354043
CB1 receptors into the Prelimbic Cortex modulate food intake in rats (abst-2015) http://www.fasebj.org/content/29/1_Supplement/655.1.abstract?sid=edf921ac-0690-4aa6-ac81-0546314dd384
The Endocannabinoid System: Pivotal Orchestrator of Obesity and Metabolic Disease (abst–2015) http://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(15)00140-X
Analysis of FABP4 expression pattern in rump fat deposition and metabolism of Altay 
sheep (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25665644
Docosahexaenoic acid-supplementation prior to fasting prevents muscle atrophy in mice  (full–2016) http://onlinelibrary.wiley.com/doi/10.1002/jcsm.12103/full
A role of CB1R in inducing θ-rhythm coordination between the gustatory and  gastrointestinal insula (full–2016) http://www.nature.com/articles/srep32529
α/β-Hydrolase Domain 6 in the Ventromedial Hypothalamus Controls Energy 
Metabolism Flexibility (full–2016) http://www.cell.com/cell-reports/fulltext/S2211-1247(16)31373-0
Association between plasma endocannabinoids and appetite in hemodialysis patients: A
pilot study (full–2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919598/
Autophagy activation by novel inducers prevents BECN2-mediated drug tolerance to  cannabinoids (full–2016)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082783/
Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced 
Refeeding (abst–2016) http://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.6b01482
Insulin induces a shift in lipid and primary carbon metabolites in a model of fasting  induced insulin resistance (full–2017) http://escholarship.org/uc/item/3x70w0hv
Nongenomic Glucocorticoid Suppression of a Postsynaptic Potassium Current via 
Emergent Autocrine Endocannabinoid Signaling in Hypothalamic Neuroendocrine Cells 
following Chronic Dehydration (full–2017) 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617081/
A moderate diet restriction during pregnancy alters the levels of endocannabinoids and
endocannabinoid-related lipids in the hypothalamus, hippocampus and olfactory bulb of
rat offspring in a sex-specific manner (full–2017)  http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0174307
Pharmacological inhibition of cannabinoid receptor 1 stimulates gastric release of 
nesfatin-1 via the mTOR pathway (full–2017)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643265/
[EXPRESS] AMP-activated kinase and the endogenous endocannabinoid system might 
contribute to antinociceptive effects of prolonged moderate caloric restriction in mice 
(download–2017)  http://journals.sagepub.com/doi/pdf/10.1177/1744806917703111
Nutritional status dependent endocannabinoid signalling regulates the integration of rat 
visceral information (abst–2017) https://www.ncbi.nlm.nih.gov/pubmed/28233325
Sex-dependent effects of neonatal maternal deprivation on endocannabinoid levels in the adipose tissue: influence of diet (abst–2017) 
http://link.springer.com/article/10.1007%2Fs13105-017-0558-0
Incretin Secretion in Humans is under the Influence of Cannabinoid Receptors (abst–2017) https://www.ncbi.nlm.nih.gov/pubmed/28655715
Adolescent cannabinoid exposure effects on natural reward seeking and learning in rats (abst–2017) https://www.ncbi.nlm.nih.gov/pubmed/29022083
A Metabolomic Signature of Acute Caloric Restriction (abst–2017)  https://www.ncbi.nlm.nih.gov/pubmed/29029202
Caloric restriction lowers endocannabinoid tonus and improves cardiac function in type 2 diabetes (full–2018) https://www.nature.com/articles/s41387-017-0016-7


FERTILITY/SEXUAL FUNCTION*
Characterization of the Endocannabinoid System in Human Spermatozoa and Involvement of Transient Receptor Potential Vanilloid 1 Receptor in Their Fertilizing Ability (full–2010) http://endo.endojournals.org/content/150/10/4692.full?sid=f5b14012-9fbe-4f10-890c-386313060cf8
N-Acylethanolamine Levels and Expression of Their Metabolizing Enzymes during Pregnancy (full–2010) http://endo.endojournals.org/content/151/8/3965.full
Human sperm anatomy: ultrastructural localization of the cannabinoid1 receptor and a potential role of anandamide in sperm survival and acrosome reaction (full–2010) http://onlinelibrary.wiley.com/doi/10.1002/ar.21042/full
Cannabinoids and Reproduction: A Lasting and Intriguing History (link to PDF–2010) http://www.mdpi.com/1424-8247/3/10/3275
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From Fertilisation to Implantation in Mammalian Pregnancy—Modulation of Early Human Reproduction by the Endocannabinoid System (link to PDF–2010) http://www.mdpi.com/1424-8247/3/9/2910
Endocannabinoids and Human Sperm Cells (link to PDF-2010) http://www.mdpi.com/1424-8247/3/10/3200
Localization and function of cannabinoid receptors in the corpus cavernosum: basis for modulation of nitric oxide synthase nerve activity (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/19147270
Energetic Metabolism and Human Sperm Motility: Impact of CB1 Receptor Activation 
(full–2010) http://endo.endojournals.org/content/151/12/5882.full
Histomorphometric evaluation of cannabinoid receptor and anandamide modulating 
enzyme expression in the human endometrium through the menstrual cycle (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/20369362
Endocannabinoids and pregnancy (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/20302856
An endocannabinoid system is localized to the hypophysial pars tuberalis of Syrian hamsters and responds to photoperiodic changes (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/20165884
Dietary hempseed meal intake increases body growth and shortens the larval stage via the upregulation of cell growth and sterol levels in Drosophila melanogaster (abst–2010)  http://www.ncbi.nlm.nih.gov/pubmed/20652493
Anandamide capacitates bull spermatozoa through CB1 and TRPV1 activation (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037938/?tool=pubmed
Modulation of the novel cannabinoid receptor – GPR55 – during rat fetoplacental development (full–2011) http://www.placentajournal.org/article/S0143-4004%2811%2900110-X/fulltext
Endogenous Cannabinoid Production in the Rat Female Reproductive Tract Is Regulated by Changes in the Hormonal Milieu (link to PDF–2011) http://www.mdpi.com/1424-8247/4/6/933
Treatment with tetrahydrocannabinol (THC) prevents infertility in male cystic fibrosis mice (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/22865360
Effect of capacitation on the endocannabinoid system of mouse sperm (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21723369
Effects of the cannabinoid antagonist SR 141716 on sexual and motor behavior in receptive female rats (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21848907
Differences in the endocannabinoid system of sperm from fertile and infertile men (full–2012) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0047704
Endocannabinoid signaling in female reproduction (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382454/
Ectopic pregnancy is associated with high anandamide levels and aberrant expression of FAAH and CB1 in fallopian tubes (full–2012) http://press.endocrine.org/doi/full/10.1210/jc.2012-1780
Uncovering a role for endocannabinoid signaling in autophagy in preimplantation mouse embryos (full–2012) http://molehr.oxfordjournals.org/content/19/2/93.full
Minireview: Endocannabinoids and Gonadal Hormones: Bidirectional Interactions in Physiology and Behavior (full–2012) http://press.endocrine.org/doi/full/10.1210/en.2011-1643
Anandamide regulates the expression of GnRH1, GnRH2, and GnRH-Rs in frog testis (full–2012) http://ajpendo.physiology.org/content/303/4/E475.long
Anandamide Induces Sperm Release from Oviductal Epithelia through Nitric Oxide Pathway in Bovines (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281848/?tool=pubmed
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The role of endocannabinoids in gonadal function and fertility along the evolutionary axis (full–2012) http://www.sciencedirect.com/science/article/pii/S0303720712000445
Long-term use of HU210 adversely affects spermatogenesis in rats by modulating the endocannabinoid system (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22435752
Anandamide Transforms Noncopulating Rats into Sexually Active Animals (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22906359
Impact of reference gene selection for type 2 cannabinoid receptor gene expression studies in human spermatozoa (abst–2012) http://onlinelibrary.wiley.com/doi/10.1111/and.12006/abstract
Immunity and early pregnancy events: are endocannabinoids the missing link? (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/23177537
Impact of reference gene selection for type 2 cannabinoid receptor gene expression studies in human spermatozoa (abst–2012) http://onlinelibrary.wiley.com/doi/10.1111/and.12006/abstract
Immunity and early pregnancy events: are endocannabinoids the missing link? (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/23177537
Long-term use of HU210 adversely affects spermatogenesis in rats by modulating the 
endocannabinoid system (abst–2012) 
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2605.2012.01259.x/abstract
Implantation failure in mice with a disruption in Phospholipase C beta 1 gene: lack of embryonic attachment, aberrant steroid hormone signalling and defective endocannabinoid metabolism (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632219/
Anandamide Levels Fluctuate in the Bovine Oviduct during the Oestrous Cycle (full–2013) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0072521
Embryonic diapause in humans: time to consider? (full–2013) http://www.rbej.com/content/11/1/92
Role of the Endocannabinoid System in the Central Regulation of Nonmammalian Vertebrate Reproduction (full–2013) http://www.hindawi.com/journals/ije/2013/941237/
Estrogens and Spermiogenesis: New Insights from Type 1 Cannabinoid Receptor Knockout Mice (full–2013) http://www.hindawi.com/journals/ije/2013/501350/
Endocannabinoids as markers of sperm quality: hot spots (full–2013) http://www.frontiersin.org/Journal/10.3389/fendo.2013.00169/full
Brain Levels of Prostaglandins, Endocannabinoids, and Related Lipids Are Affected by Mating Strategies (full–2013) http://www.hindawi.com/journals/ije/2013/436252/
The Endocannabinoid System and Spermatogenesis (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864102/
Low 17beta-Estradiol Levels in Cnr1 Knock-Out Mice Affect Spermatid Chromatin Remodeling by Interfering with Chromatin Reorganization (full–2013) http://www.biolreprod.org/content/88/6/152.long
Anandamide modulates human sperm motility: implications for men with asthenozoospermia and oligoasthenoteratozoospermia (full–2013) http://humrep.oxfordjournals.org/content/28/8/2058.long
Elevated Anandamide and Related N-Acylethanolamine Levels Occur in the Peripheral Blood of Women With Ectopic Pregnancy and Are Mirrored by Changes in Peripheral Fatty Acid Amide Hydrolase Activity (full–2013) http://press.endocrine.org/doi/full/10.1210/jc.2012-3390
Synthetic cannabinoids and potential reproductive consequences (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823745/
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Of mice and (wo)men: factors influencing successful implantation including endocannabinoids (full–2013) http://humupd.oxfordjournals.org/content/20/3/415.long
Treatment with CB 2 Agonist JWH-133 Reduces Histological Features Associated with 
Erectile Dysfunction in Hypercholesterolemic Mice (full–2013) 
http://www.hindawi.com/journals/cdi/2013/263846/
Sexuality, heart and chocolate (abst–2013)  http://www.ncbi.nlm.nih.gov/pubmed/23547364
Effectiveness of vaginal adelmidrol for treating pelvic visceral discomforts and anxiety: a  prospective observational study (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24051946
β-Caryophyllene causes regression of endometrial implants in a rat model of 
endometriosis without affecting fertility (abst–2013) 
http://www.ncbi.nlm.nih.gov/pubmed/23353590
Endocannabinoids are Involved in Male Vertebrate Reproduction: Regulatory Mechanisms at Central and Gonadal Level (full–2014) http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00054/full
A role for endocannabinoids in acute stress-induced suppression of the hypothalamic-pituitary-gonadal axis in male rats (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913894/
Increased placental expression of cannabinoid receptor 1 in preeclampsia: an observational study (full–2014) http://www.ncbi.nlm.nih.gov/pubmed/25444073
The endocannabinoid anandamide induces apoptosis in cytotrophoblast cells: Involvement of cannabinoid receptor-1 activation in mitochondrial depolarizing effect of  lipopolysaccharide in human spermatozoa (full–2014) http://onlinelibrary.wiley.com/doi/10.1111/j.2047-2927.2014.00210.x/full
Endocannabinoids as biomarkers of human reproduction (full–2014) http://humupd.oxfordjournals.org/content/20/4/501.long
The biological networks in studying cell signal transduction complexity: The examples of sperm capacitation and of endocannabinoid system (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212279/
Endocannabinoid Regulation in Human Endometrium Across the Menstrual Cycle (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527420/
Low anandamide doses facilitate male rat sexual behaviour through the activation of CB1 receptors (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24671517
Endocannabinoid signaling in mammalian ovary (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24948047
Endocannabinoid Influence on Partner Preference in Female Rats (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25042777
Activity of anandamide (AEA) metabolic enzymes in rat placental bed (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25088244
Lipidomic approach towards deciphering anandamide effects in rat decidual cell (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25535694
Fenitrothion action at the endocannabinoid system leading to spermatotoxicity in Wistar rats (abst–2014)  http://www.sciencedirect.com/science/article/pii/S0041008X1400252X
The Cannabinoid Receptor 2 Q63R Variant Modulates the Relationship between Childhood Obesity and Age at Menarche (full–2015)  http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140142
Endocannabinoid signaling in female reproductive events: a potential therapeutic target? (full–2015) http://www.tandfonline.com/doi/full/10.1517/14728222.2015.1062878
Gestation Related Gene Expression of the Endocannabinoid Pathway in Rat Placenta (full–2015) http://www.hindawi.com/journals/mi/2015/850471/
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A role for GPR55 in human placental venous endothelial cells (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25869640
Dynamics of expression and localization of the cannabinoid system in granulosa cells during oocyte nuclear maturation (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26144572
Endocannabinoid signaling in the stress response of male and female songbirds (link to PDF–2015) http://press.endocrine.org/doi/10.1210/en.2015-1425?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&
Lipopolysaccharide-induced murine embryonic resorption involves changes in endocannabinoid profiling and alters progesterone secretion and inflammatory response by a CB1-mediated fashion (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25958042
Endocannabinoid signaling at the periphery: 50 years after THC (full–2015) 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420685/
Participation of the endocannabinoid system (ECS) in the weight-gain and sensitization to LPS exposure in a maternal obesity model (article–2015) http://www.placentajournal.org/article/S0143-4004%2815%2900526-3/fulltext
Type 2 cannabinoid receptor contributes to the physiological regulation of spermato-genesis (full–2015) http://www.fasebj.org/content/early/2015/12/15/fj.15-279034.long
Anandamide Reduces the Ejaculatory Threshold of Sexually Sluggish Male Rats: Possible Relevance for Human Lifelong Delayed Ejaculation Disorder (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25808995
Anandamide restricts uterine stromal differentiation and is critical for complete decidualization (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25960165
Sperm Release from the Oviductal Epithelium Depends on Ca2+ Influx Upon Activation of CB1 and TRPV1 by Anandamide (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26129689
Strain and sex differences in puberty onset and the effects of THC administration on weight gain and brain volumes (abst–2015) http://www.sciencedirect.com/science/article/pii/S0306452215006387
Biphasic effects of anandamide on behavioural responses: emphasis on copulatory behaviour (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26226145
Anandamide and Decidual Remodeling: COX-2 oxidative metabolism as a key regulator (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26335727
Anandamide acts via kisspeptin in the regulation of testicular activity of the frog, Pelophylax esculentus (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26586207
Endocannabinoid Regulation of Neuroendocrine Systems (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26638767
Progesterone and Endocannabinoid Interaction Alters Sperm Activation (full–2016) http://www.biolreprod.org/content/95/1/9.long
Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18 (full–2016) http://www.nature.com/articles/srep32255
Unconventional endocannabinoid signaling governs sperm activation via sex hormone 
progesterone (full–2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373689/
Age of Sexual Debut and Cannabis Use in the United States (full–2016) 
http://www.ncbi.nlm.nih.gov/pubmed/26881806
Role of the endocannabinoid system in the control of mouse myometrium contractility 
during the menstrual cycle (abst–2016) 
http://www.sciencedirect.com/science/article/pii/S0006295216304452
Elevated Systemic Levels of Endocannabinoids and Related Mediators Across the Menstrual Cycle in Women With Endometriosis (full–2016) http://journals.sagepub.com/doi/full/10.1177/1933719116630414
The endocannabinoid system in the human granulosa cell line KGN (abst–2016) http://www.ncbi.nlm.nih.gov/pubmed/26773729
Anandamide interferes with human endometrial stromal-derived cell differentiation: An effect dependent on inhibition of cyclooxygenase-2 expression and prostaglandin E2 release (abst–2016) http://www.ncbi.nlm.nih.gov/pubmed/26945481
Dynamic of expression and localization of cannabinoid-degrading enzymes FAAH and MGLL in relation to CB1 during meiotic maturation of human oocytes (abst–2016) http://www.ncbi.nlm.nih.gov/pubmed/26948343
The endocannabinoid anandamide impairs in vitro decidualization of human cells (abst–2016) http://www.ncbi.nlm.nih.gov/pubmed/27568210
2-arachidonoylglycerol levels are increased in leukocytospermia and correlate with seminal macrophages (abst–2016) https://www.ncbi.nlm.nih.gov/pubmed/27863106
Intra-VTA anandamide infusion produces dose-based biphasic effects on male rat sexual behavior expression (abst–2016) http://www.sciencedirect.com/science/article/pii/S0091305716302258
Endocannabinoid system in sexual motivational processes: is it a novel therapeutic horizon? (abst–2016) http://www.sciencedirect.com/science/article/pii/S1043661816312385
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The Clinical Significance of Endocannabinoids in Endometriosis Pain Management (full–2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436335/
Overactive type 2 cannabinoid receptor induces meiosis in fetal gonads and impairs 
ovarian reserve (full–2017)  http://www.nature.com/cddis/journal/v8/n10/full/cddis2017496a.html?foxtrotcallback=true
The Cannabinoid Receptor Interacting Proteins 1 of zebrafish are not required for 
morphological development, viability or fertility (full–2017) 
https://www.ncbi.nlm.nih.gov/pubmed/28687732
The Roles of Anandamide, Fatty Acid Amide Hydrolase, and Leukemia Inhibitory Factor 
on the Endometrium during the Implantation Window (full–2017) 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650704/
The correlation of anandamide with gonadotrophin and sex steroid hormones during the menstrual cycle (full–2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749362/
S100A10 identified in a genome-wide gene × cannabis dependence interaction analysis 
of risky sexual behaviours (link to download–2017) http://jpn.ca/42-4-160189/
Developmental Patterns of Adolescent Marijuana and Alcohol Use and Their Joint 
Association with Sexual Risk Behavior and Outcomes in Young Adulthood (abst–2017) https://www.ncbi.nlm.nih.gov/pubmed/28083726
Anandamide oxidative metabolism-induced endoplasmic reticulum stress and apoptosis 
(abst–2017) https://www.ncbi.nlm.nih.gov/pubmed/28220271
Individual prolactin reactivity modulates response of nucleus accumbens to erotic stimuli during acute cannabis intoxication: an fMRI pilot study (abst–2017) 
http://link.springer.com/article/10.1007%2Fs00213-017-4601-1
Demographic Characteristics, Components of Sexuality and Gender, and Minority Stress 
and Their Associations to Excessive Alcohol, Cannabis, and Illicit (Noncannabis) Drug 
Use Among a Large Sample of Transgender People in the United States (abst–2017) https://www.ncbi.nlm.nih.gov/pubmed/28405831
Spatial distribution of cannabinoid receptor 1 and fatty acid amide hydrolase in the cat 
ovary and oviduct (abst–2017) https://www.ncbi.nlm.nih.gov/pubmed/28478955
Human sperm motility, capacitation and acrosome reaction are impaired by 2-
arachidonoylglycerol endocannabinoid (abst–2017)  https://www.ncbi.nlm.nih.gov/pubmed/28585678
Investigation of changes in endocannabinoids and N-acylethanolamides in biofluids, and their correlations with female infertility (abst–2017) 
http://www.sciencedirect.com/science/article/pii/S0021967317308798?via%3Dihub
Longitudinal pathways from unconventional personal attributes in the late 20s to 
cannabis use prior to sexual intercourse in the late 30s (abst–2017) 
https://www.ncbi.nlm.nih.gov/pubmed/28648991
Participation of hypothalamic CB1 receptors in reproductive axis disruption during
immune challenge (abst–2017) https://www.ncbi.nlm.nih.gov/pubmed/28665507
The endocannabinoid system expression in the female reproductive tract is modulated by estrogen (abst–2017)  http://www.sciencedirect.com/science/article/pii/S0960076017301887
Expression and distribution of key proteins of the endocannabinoid system in the human seminal vesicles (abst–2017) https://www.ncbi.nlm.nih.gov/pubmed/28786134
Impact of dietary fats on brain functions (abst–2017) 
https://www.ncbi.nlm.nih.gov/pubmed/29046155
Song practice as a rewarding form of play in songbirds (abst–2017) 
http://www.sciencedirect.com/science/article/pii/S0376635717301894?via%3Dihub
Masturbation to Orgasm Stimulates the Release of the Endocannabinoid 2-
Arachidonoylglycerol in Humans (abst–2017)  https://www.ncbi.nlm.nih.gov/pubmed/29110806
Understanding the Role of Serotonin in Female Hypoactive Sexual Desire Disorder and 
Treatment Options (abst–2017) http://www.jsm.jsexmed.org/article/S1743-6095(17)31539-4/fulltext
Incubation of spermatozoa with Anandamide prior to cryopreservation reduces  cryocapacitation and improves post-thaw sperm quality in the water buffalo (Bubalus bubalis) (abst–2017) https://www.ncbi.nlm.nih.gov/pubmed/29277315
Association Between Marijuana Use and Sexual Frequency in the United States: A 
Population-Based Study (abst–2017) https://www.ncbi.nlm.nih.gov/pubmed/29110804


FETAL ALCOHOL SPECTRUM DISORDER
Reduced expression of brain cannabinoid receptor 1 (Cnr1) is coupled with an increased complementary micro-RNA (miR-26b) in a mouse model of fetal alcohol spectrum disorders (full-2013) http://www.clinicalepigeneticsjournal.com/content/5/1/14
Gene-Specific Disruption of Endocannabinoid Receptor 1 (cnr1a) by Ethanol Probably Leads to the Development of Fetal Alcohol Spectrum Disorder (FASD) Phenotypes in Japanese Rice Fish (Oryzias latipes) Embryogenesis (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25251458
Fetal Alcohol Spectrum Disorder: Potential Role of Endocannabinoids Signaling (full-2015) http://www.mdpi.com/2076-3425/5/4/456/htm
Prenatal exposure to recreational drugs affects global motion perception in preschool children (full-2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652269/
Maternal alcohol exposure during mid-pregnancy dilates fetal cerebral arteries via 
endocannabinoid receptors (abst–2017) https://www.ncbi.nlm.nih.gov/pubmed/28554529


FIBROMYALGIA +
The Effects of Nabilone on Sleep in Fibromyalgia: Results of a Randomized Controlled Trial (full–2010) http://journals.lww.com/anesthesiaanalgesia/Fulltext/2010/02000/The_Effects_of_Nabilone_on_Sleep_in_Fibromyalgia_.56.aspx
Information for Health Care Professionals- Marihuana (marijuana, cannabis) dried plant 
for administration by ingestion or other means (Health Canada) (full–2010) 
http://www.hc-sc.gc.ca/dhp-mps/marihuana/med/infoprof-eng.php
Emerging therapies for fibromyalgia: an update (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/20486862
Cannabis Use in Patients with Fibromyalgia: Effect on Symptoms Relief and Health-Related Quality of Life (full-2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080871/?toolubmed
Cannabinoids for Treatment of Chronic Non-Cancer Pain; a Systematic Review of Randomized Trials (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243008/
Association of herbal cannabis use with negative psychosocial parameters in patients with fibromyalgia (full–2012) http://onlinelibrary.wiley.com/doi/10.1002/acr.21732/full
Clinical implications for cannabinoid use in the rheumatic diseases: potential for help or harm? (full-2012) http://onlinelibrary.wiley.com/doi/10.1002/art.34522/full
Care and Feeding of the Endocannabinoid System: A Systematic Review of Potential Clinical Interventions that Upregulate the Endocannabinoid System (full-2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951193/
Clinical endocannabinoid deficiency (CECD) revisited: Can this concept explain the therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions? (full-2014) http://tinyurl.com/hss39v9
Fibromyalgia (abst-2014) http://www.ncbi.nlm.nih.gov/pubmed/24365316
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Efficacy, tolerability and safety of cannabinoid treatments in the rheumatic diseases: A 
systematic review of randomized controlled trials (full–2015)  http://onlinelibrary.wiley.com/doi/10.1002/acr.22727/full
β-caryophyllene-complexed in β-cyclodextrin Produces Antihyperalgesic Activity in 
Animal Model for Fibromyalgia (abst–2015) 
http://www.fasebj.org/content/29/1_Supplement/616.4.abstract?sid=edf921ac-0690-4aa6-ac81-0546314dd384
Expression of the endocannabinoid receptors in human fascial tissue (full–2016)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933831/
Cannabinoids and autoimmune diseases: A systematic review (abst–2016) 
http://www.ncbi.nlm.nih.gov/pubmed/26876387
Nabilone for the Management of Pain (abst–2016)  http://www.ncbi.nlm.nih.gov/pubmed/26923810
Medical Cannabis – another piece in the mosaic of autoimmunity? (abst–2016) https://www.ncbi.nlm.nih.gov/pubmed/27859024


FLU/INFLUENZA +
Deletion of cannabinoid receptors 1 and 2 exacerbates APC function to increase inflammation and cellular immunity during influenza infection (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206470/
Palmitoylethanolamide is a new possible pharmacological treatment for the inflammation associated with trauma (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/22697514?dopt=Abstract
Δ9-tetrahydrocannabinol impairs the inflammatory response to influenza infection: role of antigen-presenting cells and the cannabinoid receptors 1 and 2 (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551428/
Immunoregulatory Role of Cannabinoids during Infectious Disease (full–2017)  https://www.karger.com/Article/FullText/481824


FRAGILE X SYNDROME
Enhanced endocannabinoid signaling elevates neuronal excitability in fragile X syndrome (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906112/
Abnormal mGlu 5 receptor/endocannabinoid coupling in mice lacking FMRP and BC1 RNA (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055456/
Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome (full–2012) http://www.nature.com/ncomms/journal/v3/n9/full/ncomms2045.html
Pathological plasticity in fragile X syndrome (full–2012) http://www.hindawi.com/journals/np/2012/275630/
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Targeting the endocannabinoid system in the treatment of fragile X syndrome (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23542787
New insights into the molecular pathophysiology of fragile X syndrome and therapeutic perspectives from the animal model (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24831882
Therapeutic approaches for the future treatment of Fragile X (abst–2015) http://www.sciencedirect.com/science/article/pii/S2352154615000133
Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model (full-2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334917/
Homer Protein-Metabotropic Glutamate Receptor Binding Regulates Endocannabinoid Signaling and Affects Hyperexcitability in a Mouse Model of Fragile X Syndrome (abst-2015) http://www.ncbi.nlm.nih.gov/pubmed/25740522
Endocannabinoid-mediated improvement on a test of aversive memory in a mouse model of fragile X syndrome (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25979787
The basolateral amygdala γ-aminobutyric acidergic system in health and disease (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26586374
p21-activated kinase 1 restricts tonic endocannabinoid signaling in the hippocampus (full–2016) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907698/
Possible Therapeutic Doses of Cannabinoid Type 1 Receptor Antagonist Reverses Key Alterations in Fragile X Syndrome Mouse Model (full–2016) http://www.mdpi.com/2073-4425/7/9/56/htm
Endocannabinoid signaling in social functioning: an RDoC perspective (full–2016) http://www.nature.com/tp/journal/v6/n9/full/tp2016169a.html
Dissecting the signaling pathways involved in the crosstalk between mGlu5 and CB1 receptors (link to PDF–2016) http://molpharm.aspetjournals.org/content/early/2016/06/23/mol.116.104372.long Differential Adulthood Onset mGlu5 Signaling Saves Prefrontal Function in the Fragile X Mouse (abst–2016) https://www.ncbi.nlm.nih.gov/pubmed/27797833
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The Search for an Effective Therapy to Treat Fragile X Syndrome: Dream or Reality? (full–2017) https://www.frontiersin.org/articles/10.3389/fnsyn.2017.00015/full
Treating a novel plasticity defect rescues episodic memory in Fragile X model mice (abst–2017) https://www.ncbi.nlm.nih.gov/pubmed/29133950


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