E (2010-2017)

STUDIES ON CONDITIONS and RELATED ARTICLES 2010-2017

*Articles/Studies in Pre-2000 List
+Articles/Studies in 2000-2009 List


EBOLA
ECZEMA +
EDEMA*+
EHLERS-DANLOS SYNDROME + (See News Articles 2010-2017)
EMBRYOS/FETAL DEVELOPMENT/PLACENTAL DEVELOPMENT +
ENCEPHALITIS +
ENCEPHALOMYELITIS/EAE*+
ENDOMETRIOSIS +
ENTOURAGE EFFECT (See PHYTOCANNABINOIDS and ENDOCANNABINOIDS)
EPILEPSY/SEIZURES* (See Also EPIDIOLEX in PHYTOCANNABINOIDS)
EPSTEIN-BARR
ESSENTIAL TREMOR (See Also News Articles 2010-2017)
EXERCISE and the ENDOCANNABINOID SYSTEM*+


EBOLA
CBD Protective Against Ebola Virus (article–2014) http://cannabisdigest.ca/cbd-protective-ebola-virus/
Cannabidiol: a potential treatment for post Ebola syndrome? (link to PDF–2016) http://www.ijidonline.com/article/S1201-9712(16)31177-8/abstract


ECZEMA
Epigenetic Control of Skin Differentiation Genes by Phytocannabinoids (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23869687
Cannabis and Dr Piffard-A Century Ahead of the Curve (article–2016) http://archderm.jamanetwork.com/article.aspx?articleid=2547236 The Endocannabinoid System and Its Role in Eczematous Dermatoses (abst–2017) https://www.ncbi.nlm.nih.gov/pubmed/28098721


EDEMA
Palmitoylethanolamide restores myelinated-fibre function in patients with chemotherapy induced painful neuropathy (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/22229320
The cannabinoid receptor-2 is involved in allergic inflammation (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22525379
Using the endocannabinoid system as a neuroprotective strategy in perinatal hypoxicischemic brain injury (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146074/
Activation of Cannabinoid CB2 Receptor-Mediated AMPK/CREB Pathway Reduces Cerebral Ischemic Injury (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23414569
Sex differences in anti-allodynic, anti-hyperalgesic and anti-edema effects of Δ9-tetrahydrocannabinol in the rat (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23707295
Cannabinoid type 2 receptor stimulation attenuates brain edema by reducing cerebral leukocyte infiltration following subarachnoid hemorrhage in rats (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24819918
Cannabinoid type 2 receptor stimulation attenuates brain edema by reducing cerebral leukocyte infiltration following subarachnoid hemorrhage in rats (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067767/
Cannabinoid Receptor Type 2 Agonist Attenuates Apoptosis by Activation of Phosphorylated CREB-Bcl-2 Pathway After Subarachnoid Hemorrhage in Rats (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25058046
Cannabinoid Receptor Type 2 Agonist Attenuates Apoptosis by Activation of Phosphorylated CREB-Bcl-2 Pathway After Subarachnoid Hemorrhage in Rats (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194247/
Peripheral neurobiologic mechanisms of antiallodynic effect of warm water immersion therapy on persistent inflammatory pain full–2014) http://onlinelibrary.wiley.com/doi/10.1002/jnr.23461/full
Changes in cannabinoid receptors, aquaporin 4 and vimentin expression after traumatic brain injury in adolescent male mice. Association with edema and neurological deficit (full–2015) http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0128782
Cannabinoid CB2 receptor stimulation attenuates brain edema and neurological deficits in a germinal matrix hemorrhage rat model (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25625355
Minocycline Attenuates Neonatal Germinal-Matrix-Hemorrhage-Induced Neuroinflammation and Brain Edema by Activating Cannabinoid Receptor 2 (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25833102
Cannabinoid receptor 2 attenuates microglial accumulation and brain injury following germinal matrix hemorrhage via ERK dephosphorylation in vivo and in vitro (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25963415
top
A Cannabinoid Receptor 2 Agonist Prevents Thrombin-Induced Blood-Brain Barrier Damage via the Inhibition of Microglial Activation and Matrix Metalloproteinase Expression in Rats (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26376816
Cannabinoid Receptor Type 2 Agonist Attenuates Acute Neurogenic Pulmonary Edema by Preventing Neutrophil Migration after Subarachnoid Hemorrhage in Rats (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26463937
Mustard vesicants alter expression of the endocannabinoid system in mouse skin (abst–2016) http://www.sciencedirect.com/science/article/pii/S0041008X16300898
Selective modulator of cannabinoid receptor type 2 reduces memory impairment and infarct size during cerebral hypoperfusion and vascular dementia (abst–2016) http://www.ncbi.nlm.nih.gov/pubmed/27586843
Selective modulator of cannabinoid receptor type 2 (CB2) against biochemical alterations and brain damage in chronic cerebral hypoperfusion induced vascular dementia (abst–2016) http://www.ncbi.nlm.nih.gov/pubmed/27599483
Activation of Cannabinoid Receptor 2 Attenuates Mechanical Allodynia and Neuroinflammatory Responses in a Chronic Post-Ischemic Pain Model of Complex Regional Pain Syndrome Type I in Rats (abst–2016) https://www.ncbi.nlm.nih.gov/pubmed/27717112


EMBRYOS/FETAL DEVELOPMENT/PLACENTAL DEVELOPMENT 
The Maternal Lifestyle Study: Sleep Problems in Children with Prenatal Substance Exposure (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917192/?tool=pubmed
A prospective study on intrauterine cannabis exposure and fetal blood flow (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/20451334
Prenatal tobacco, marijuana, stimulant, and opiate exposure: outcomes and practice implications (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188826/?tool=pubmed
Modulation of the novel cannabinoid receptor – GPR55 – during rat fetoplacental development (full–2011) http://www.placentajournal.org/article/S0143-4004%2811%2900110-X/fulltext
N-Docosahhexanoyllethanolamide promotes development of hippocampal neurons (full–2011) http://www.biochemj.org/content/435/2/327
Uncovering a role for endocannabinoid signaling in autophagy in preimplantation mouse embryos (full–2012) http://molehr.oxfordjournals.org/content/19/2/93.full
Immunity and early pregnancy events: are endocannabinoids the missing link? (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/23177537
TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ9-tetrahydrocannabiorcol (full–2011) http://www.nature.com/ncomms/journal/v2/n11/full/ncomms1559.html
Embryonic diapause in humans: time to consider? (full–2013) http://www.rbej.com/content/11/1/92
Reduced expression of brain cannabinoid receptor 1 (Cnr1) is coupled with an increased complementary micro-RNA (miR-26b) in a mouse model of fetal alcohol spectrum disorders (full–2013) http://www.clinicalepigeneticsjournal.com/content/5/1/14
Endocannabinoid crosstalk between placenta and maternal fat in a baboon model (Papio spp) of obesity (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827983/
top
Implantation failure in mice with a disruption in Phospholipase C beta 1 gene: lack of embryonic attachment, aberrant steroid hormone signalling and defective endocannabinoid metabolism (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632219/
Long-term consequences of perinatal fatty acid amino hydrolase inhibition (abst–2013)  http://onlinelibrary.wiley.com/doi/10.1111/bph.12500/abstract
Behavioral Responses to Acute and Sub-chronic Administration of the Synthetic Cannabinoid JWH-018 in Adult Mice Prenatally Exposed to Corticosterone (abst–2013)  http://www.ncbi.nlm.nih.gov/pubmed/23296549
Fatty Acid Binding Protein-4 is expressed in the mouse placental labyrinth, yet is dispensable for placental triglyceride accumulation and fetal growth (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25096952
Programming and reprogramming neural cells by (endo-) cannabinoids: from physiological rules to emerging therapies (full–2014) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765324/
Gene-Specific Disruption of Endocannabinoid Receptor 1 (cnr1a) by Ethanol Probably Leads to the Development of Fetal Alcohol Spectrum Disorder (FASD) Phenotypes in Japanese Rice Fish (Oryzias latipes) Embryogenesis (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25251458
Lipid abundance in zebrafish embryos is regulated by complementary actions of the Endocannabinoid System and Retinoic Acid Pathway (full–2015) http://press.endocrine.org/doi/pdf/10.1210/EN.2015-1315
Fetal Alcohol Spectrum Disorder: Potential Role of Endocannabinoids Signaling (full–2015) http://www.mdpi.com/2076-3425/5/4/456/htm
Preferential epithelial expression of type-1 cannabinoid receptor (CB1R) in the developing canine embryo (full–2015) http://www.springerplus.com/content/4/1/804
Endocannabinoid signaling in female reproductive events: a potential therapeutic target? (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26126134
Gestation Related Gene Expression of the Endocannabinoid Pathway in Rat Placenta (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26229240
Long-term consequences of perinatal and adolescent cannabinoid exposure on neural and psychological processes (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25960036
Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development via PGE2 and P-selectin Activity (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25931248
Fetal endocannabinoids orchestrate the organization of pancreatic islet microarchitecture (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653226/
Cannabinoid Receptor‐2 Regulates Embryonic Hematopoietic Stem Cell Development via Prostaglandin E2 and P‐Selectin Activity (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4781665/
Use of paracetamol during pregnancy and child neurological development (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25851072
Dynamics of expression and localization of the cannabinoid system in granulosa cells during oocyte nuclear maturation (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26144572
Role of the endocannabinoid system in the mechanisms involved in the LPS-induced preterm labor (abst-2015) http://www.ncbi.nlm.nih.gov/pubmed/26347521
Lipid abundance in zebrafish embryos is regulated by complementary actions of the Endocannabinoid System and Retinoic Acid Pathway (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26181105
Progesterone and anandamide in pregnancy loss (full–2015) http://www.placentajournal.org/article/S0143-4004%2815%2900515-9/fulltext Anandamide restricts uterine stromal differentiation and is critical for complete decidualization (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25960165
Anandamide and Decidual Remodeling: COX-2 oxidative metabolism as a key regulator (abst-2015) http://www.ncbi.nlm.nih.gov/pubmed/26335727
Epigenetic Effects of Cannabis Exposure (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26546076
The endocannabinoid 2-arachidonoylglycerol dysregulates the synthesis of proteins by the human syncytiotrophoblast (abst–2015) http://www.sciencedirect.com/science/article/pii/S1388198115002309
Dose-dependent teratogenicity of the synthetic cannabinoid CP-55,940 in mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26708672
top
Maternal Caloric Restriction Implemented during the Preconceptional and Pregnancy Period Alters Hypothalamic and Hippocampal Endocannabinoid Levels at Birth and Induces Overweight and Increased Adiposity at Adulthood in Male Rat Offspring (full–2016) http://journal.frontiersin.org/article/10.3389/fnbeh.2016.00208/full
Nutritional n-3 PUFA Deficiency Abolishes Endocannabinoid Gating of Hippocampal Long-Term Potentiation (abst–2016) http://www.ncbi.nlm.nih.gov/pubmed/26946127
Dynamic of expression and localization of cannabinoid-degrading enzymes FAAH and MGLL in relation to CB1 during meiotic maturation of human oocytes (abst–2016) http://www.ncbi.nlm.nih.gov/pubmed/26948343
The endocannabinoid system: an emergent player in human placentation (abst–2016) http://www.sciencedirect.com/science/article/pii/S0890623816300260
Endocannabinoids participate in placental apoptosis induced by hypoxia inducible factor- 1 (abst–2016) http://www.ncbi.nlm.nih.gov/pubmed/27488203
Peripheral Blood Mononuclear Cells Infiltration Downregulates Decidual FAAH Activity in an LPS-Induced Embryo Resorption Model (abst–2016) https://www.ncbi.nlm.nih.gov/pubmed/27731508
Exocannabinoids effect on in vitro bovine oocyte maturation via activation of AKT and ERK1/2 (abst–2016) https://www.ncbi.nlm.nih.gov/pubmed/27798282
A role for the endocannabinoid system in premature luteal regression and progesterone withdrawal in lipopolysaccharide-induced early pregnancy loss model (abst–2016) https://www.ncbi.nlm.nih.gov/pubmed/27470501
Fetal Syndrome of Endocannabinoid Deficiency (FSECD) In Maternal Obesity (abst–2016) https://www.ncbi.nlm.nih.gov/pubmed/27959272


ENCEPHALITIS
A synthetic cannabinoid agonist promotes oligodendrogliogenesis during viral encephalitis in rats (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981070/?toolubmed
Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain: an intravital microscopy study (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034694/?toolmcentrez
Cannabinoid receptor expression in HIV encephalitis and HIV-associated neuropathologic comorbidities (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135748/
Gadolinium-HU-308-incorporated micelles (full–2011) http://www.ncbi.nlm.nih.gov/books/NBK54067/pdf/CB2R-Gd-Micelles.pdf
Prospects for cannabinoid therapies in viral encephalitis (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24021420
Prospects for cannabinoid therapies in viral encephalitis (full–2013) http://www.sciencedirect.com/science/article/pii/S0006899313011694
Anti-N-methyl-D-aspartate receptor encephalitis and drug abuse – the probable role of molecular mimicry or the overstimulation of CB receptors in a 17-year-old adolescent – case report (link to download–2016) http://www.mppt.hu/folyoirat/1/abstract/? vol=18&issue=3&elsooldal=162


ENCEPHALOMYELITIS/EAE
Cannabinoids and B cells: emerging targets for treating progressive multiple sclerosis (full–2011) http://msj.sagepub.com/content/17/3/259.long
Role of Cannabinoids in Multiple Sclerosis (link to PDF – 2011) http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.659.8269&rank=26 Endocannabinoid pathways and their role in multiple sclerosis-related muscular dysfunction (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21449854
Administration of 2-arachidonoylglycerol ameliorates both acute and chronic Experimental Autoimmune Encephalomyelitis (abst–2011) http://www.unboundmedicine.com/medline/ebm/record/21406188/abstract/Administration_of_2_arachidonoylglycerol_ameliorates_both_acute_and_chronic_Experimental_Autoimmune_Encephalomyelitis_
top
Evaluation of the Effects of Sativex (THC BDS: CBD BDS) on Inhibition of Spasticity in a Chronic Relapsing Experimental Allergic Autoimmune Encephalomyelitis: A Model of Multiple Sclerosis (full-2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423911/pdf/ISRN.NEUROLOGY2012-802649.pdf
Cannabinoid receptor-2-selective agonists improve recovery in experimental autoimmune encephalomyelitis (abst–2012) http://www.jimmunol.org/content/188/1_Supplement/116.7.abstract?sid=b1a0d6c8-40b1-4641-82a4- b6b539cebc6e
Cannabinoids ameliorate disease progression in a model of multiple sclerosis in mice, acting preferentially through CB(1) receptor-mediated anti-inflammatory effects (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22342378
The biology that underpins the therapeutic potential of cannabis-based medicines for the control of spasticity in multiple sclerosis (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/25876933
Genetic Background Can Result in a Marked or Minimal Effect of Gene Knockout (GPR55 and CB2 Receptor) in Experimental Autoimmune Encephalomyelitis Models of Multiple Sclerosis (full–2013) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0076907
Multiple sclerosis and the blood-central nervous system barrier (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562587/
Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: A role for A2A receptors (full–2013) http://www.sciencedirect.com/science/article/pii/S0969996113001939
Selective CB2 receptor activation ameliorates EAE by reducing Th17 differentiation and immune cell accumulation in the CNS (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24342422
Cannabinoids: Do they have the potential to treat the symptoms of multiple sclerosis? (full–2013) http://www.wjgnet.com/2218-6212/full/v3/i4/87.htm
R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice (full–2014) http://embomolmed.embopress.org/content/6/11/1398.long
A cannabigerol derivative suppresses immune responses and protects mice from experimental autoimmune encephalomyelitis (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984273/
Activating Cannabinoid Receptor 2 Alleviates Pathogenesis of Experimental Autoimmune Encephalomyelitis Via Activation of Autophagy and Inhibiting NLRP3 Inflammasome (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25417929
Pre- and postsynaptic type-1 cannabinoid receptors control the alterations of glutamate transmission in experimental autoimmune encephalomyelitis (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24440366
top
Cannabidiol, a non-psychoactive cannabinoid, leads to EGR2-dependent anergy in activated encephalitogenic T cells (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363052/
A new formulation of cannabidiol in cream shows therapeutic effects in a mouse model of experimental autoimmune encephalomyelitis (full-2015)
http://darujps.biomedcentral.com/articles/10.1186/s40199-015-0131-8
Activation of Cannabinoid CB2 receptors Reduces Hyperalgesia in an Experimental Autoimmune Encephalomyelitis Mouse Model of Multiple Sclerosis (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25849525
Activation of Cannabinoid CB2 receptors Reduces Hyperalgesia in an Experimental Autoimmune Encephalomyelitis Mouse Model of Multiple Sclerosis (full–2015) http://onlinelibrary.wiley.com/doi/10.1111/cns.12349/full
HU-446 and HU-465, derivatives of the non-psychoactive cannabinoid cannabidiol, decrease the activation of encephalitogenic T cells (full-2015) http://onlinelibrary.wiley.com/doi/10.1111/cbdd.12637/full
Interaction between the protective effects of cannabidiol and palmitoylethanolamide in experimental model of multiple sclerosis in C57BL/6 mice (abst–2015)  http://www.sciencedirect.com/science/article/pii/S0306452215000858
Purified Cannabidiol, the main non-psychotropic component of Cannabis sativa, alone, counteracts neuronal apoptosis in experimental multiple sclerosis (link to PDF–2015) http://www.europeanreview.org/article/10049
Neuroprotection in Experimental Autoimmune Encephalomyelitis and Progressive Multiple Sclerosis by Cannabis-Based Cannabinoids (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25537576
Activation of CB2 receptor is required for the therapeutic effect of ABHD6 inhibition in experimental autoimmune encephalomyelitis (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26189763
Neuroprotective Effect Is Driven Through the Upregulation of CB1 Receptor in Experimental Autoimmune Encephalomyelitis (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26411568
The disease-modifying effects of a Sativex-like combination of phytocannabinoids in mice with experimental autoimmune encephalomyelitis are preferentially due to Δ(9)-tetrahydrocannabinol acting through CB1 receptors (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26590655
top
Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells (full–2016) http://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-016-0603-x
Interaction between interleukin-1β and type-1 cannabinoid receptor is involved in anxiety-like behavior in experimental autoimmune encephalomyelitis (full–2016) http://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-016-0682-8
Target regulation of PI3K/Akt/mTOR pathway by cannabidiol in treatment of experimental multiple sclerosis (full–2016) http://www.sciencedirect.com/science/article/pii/S0367326X16304476
Development and Pharmacological Characterization of Selective Blockers of 2- Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain (abst–2016) http://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.5b01812
WWL70 attenuates PGE2 production derived from 2-arachidonoylglycerol in microglia by ABHD6-independent mechanism (full–2017) https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-016-0783-4


ENDOMETRIOSIS
Antiproliferative effects of cannabinoid agonists on deep infiltrating endometriosis (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993285/
Effect of palmitoylethanolamide-polydatin combination on chronic pelvic pain associated with endometriosis: preliminary observations (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/20176435
Endocannabinoid involvement in endometriosis (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/20833475
Δ9-Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells (full–2012) http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01497.x/full
The molecular connections between the cannabinoid system and endometriosis (full–2012) http://molehr.oxfordjournals.org/content/18/12/563.full
Progesterone-dependent regulation of endometrial cannabinoid receptor type 1 (CB1-R) expression is disrupted in women with endometriosis and in isolated stromal cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462249/
β-Caryophyllene causes regression of endometrial implants in a rat model of endometriosis without affecting fertility (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23353590
Administration of micronized palmitoylethanolamide (PEA)-transpolydatin in the treatment of chronic pelvic pain in women affected by endometriosis: preliminary results (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24051945
The adjuvant use of N-palmitoylethanolamine and transpolydatin in the treatment of endometriotic pain (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23415738
Magnolol inhibits LPS-induced inflammatory response in uterine epithelial cells : magnolol inhibits LPS-induced inflammatory response (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23515857
Current Therapeutic Cannabis Controversies and Clinical Trial Design Issues (full–2016) http://journal.frontiersin.org/article/10.3389/fphar.2016.00309/full
Elevated Systemic Levels of Endocannabinoids and Related Mediators Across the Menstrual Cycle in Women With Endometriosis (full–2016) http://journals.sagepub.com/doi/full/10.1177/1933719116630414
Anandamide interferes with human endometrial stromal-derived cell differentiation: An effect dependent on inhibition of cyclooxygenase-2 expression and prostaglandin E2 release (abst–2016) http://www.ncbi.nlm.nih.gov/pubmed/26945481
The cannabinoid receptor CB1 contributes to the development of ectopic lesions in a mouse model of endometriosis (abst–2016) https://www.ncbi.nlm.nih.gov/pubmed/27821707


EPILEPSY/SEIZURES
Cannabidiol Displays Antiepileptiform and Antiseizure Properties In Vitro and In Vivo (full-2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819831/?tool=pmcentrez
Cannabinoid-mediated inhibition of recurrent excitatory circuitry in the dentate gyrus in a mouse model of temporal lobe epilepsy (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871782/?tool=pubmed
AAV vector-mediated overexpression of CB1 cannabinoid receptor in pyramidal neurons of the hippocampus protects against seizure-induced excitoxicity (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006205/?tool=pubmed
Delta-Tetrahydrocannabivarin suppresses in vitro epileptiform and in vivo seizure activity in adult rats (full-2010) http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2010.02523.x/full
Dynamic changes of CB1-receptor expression in hippocampi of epileptic mice and humans (full–2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909018/
top
CB1 and CB2 cannabinoid receptor expression during development and in epileptogenic developmental pathologies (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/20621164
Endocannabinoid system protects against cryptogenic seizures (full–2011) http://www.if-pan.krakow.pl/pjp/pdf/2011/1_165.pdf
Redistribution of CB1 Cannabinoid Receptors in the Acute and Chronic Phases of Pilocarpine-Induced Epilepsy (full–2011) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0027196
In vivo activation of endocannabinoid system in temporal lobe epilepsy with hippocampal sclerosis (full–2011) http://brain.oxfordjournals.org/content/134/4/1033.long
Acetaminophen inhibits status epilepticus in cultured hippocampal neurons (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052417/
The secret “spice”: an undetectable toxic cause of seizure (full–2011) http://www.ncbi.nlm.nih.gov/pubmed/23983854
Convulsions Associated with the Use of a Synthetic Cannabinoid Product (link to PDF–2011) http://www.springerlink.com/content/9651q2672027n38g/fulltext.html
Pro-epileptic effects of the cannabinoid receptor antagonist SR141716 in a model of audiogenic epilepsy (abst-2011) http://www.ncbi.nlm.nih.gov/pubmed/21733658
Synthetic cannabinoid WIN 55,212-2 mesylate enhances the protective action of four classical antiepileptic drugs against maximal electroshock-induced seizures in mice (abst–2011) http://www.unboundmedicine.com/medline/ebm/record/21238473/abstract/Synthetic_cannabinoid_WIN_55212_2_mesylate_enhances_the_protective_action_of_four_classical_antiepileptic_drugs_against_maximal_electroshock_induced_seizures_in_mice_
Protective effects of CB1 receptor agonist WIN 55.212-2 in seizure activity in the model of temporal lobe epilepsy (abst–2011) http://www.unboundmedicine.com/medline/ebm/record/21469332/abstract/%5BProtective_effects_of_CB1_receptor_agonist_WIN_55_212_2_in_seizure_activity_in_the_model_of_temporal_lobe_epilepsy%5D_
L-Type Calcium Channel Mediates Anticonvulsant Effect of Cannabinoids in Acute and Chronic Murine Models of Seizure (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21928146
Changes in the cannabinoid (CB1) receptor expression level and G-protein activation in kainic acid induced seizures (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/22079489
Neuron to Astrocyte Communication via Cannabinoid Receptors Is Necessary for Sustained Epileptiform Activity in Rat Hippocampus (full–2012) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0037320
Cannabidivarin is anticonvulsant in mouse and rat (full–2012) http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02207.x/pdf
Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid? (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579248/
top
Cannabinoid receptor 1 inhibition causes seizures during anesthesia induction in experimental sepsis (full–2012) http://journals.lww.com/anesthesiaanalgesia/Fulltext/2012/06000/Cannabinoid_Receptor_1_Inhibition_Causes_Seizures.12.aspx
Statistical parametric mapping reveals regional alterations in cannabinoid CB1 receptor distribution and G-protein activation in the 3D reconstructed epileptic rat brain (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799958/
Cannabidiol in humans-the quest for therapeutic targets (full–2012) http://www.ncbi.nlm.nih.gov/pubmed/24281562
Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures (full–2012) http://www.seizure-journal.com/article/S1059-1311%2812%2900057-X/fulltext
Epileptiform activity in the CA1 region of the hippocampus becomes refractory to attenuation by cannabinoids in part because of endogenous γ-aminobutyric acid type B receptor activity (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350599/
Equipotent Inhibition of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase-Dual Targets of the Endocannabinoid System to Protect against Seizure Pathology (full–2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480564/
Endocannabinoids via CB₁ receptors act as neurogenic niche cues during cortical development (full–2012) http://rstb.royalsocietypublishing.org/content/367/1607/3229.long
Targeting the endocannabinoid system with cannabinoid receptor agonists: pharmacological strategies and therapeutic possibilities (full–2012) http://rstb.royalsocietypublishing.org/content/367/1607/3353.full?sid=1569c370-cd5c-4358-89ff-857201f5e069
Use of the phytocannabinoid cannabidivarin (cbdv) in the treatment of epilepsy: Patent Application 20120004251 (full–2012) http://www.freshpatents.com/-dt20120105ptan20120004251.php
Internet Highs-Seizures After Consumption of Synthetic Cannabinoids Purchased Online (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22824736
Seizure exacerbation in two patients with focal epilepsy following marijuana cessation (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/23159379
Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/23206503
Inverse relationship of cannabimimetic (R+)WIN 55, 212 on behavior and seizure threshold during the juvenile period (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22019959
Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment resistant epilepsy (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157067/
Alterations of endocannabinoids in cerebrospinal fluid of dogs with epileptic seizure disorder (full–2013) http://www.biomedcentral.com/content/pdf/1746-6148-9-262.pdf
Marijuana, endocannabinoids, and epilepsy: Potential and challenges for improved therapeutic intervention (full-2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3332149/
top
Cannabidivarin (CBDV) suppresses pentylenetetrazole (PTZ)-induced increases in epilepsy-related gene expression (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840466/
Stirring the Pot With Estrogens (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697880/
Medical Marijuana Coverage Still Lost in the Legal Weeds (article–2013) http://www.managedcaremag.com/linkout/2013/1/23
Epidiolex – GW Pharmaceuticals (drug development page–2013) http://www.gwpharm.com/Epidiolex.aspx
Therapeutic potential of cannabinoid medicines (full–2013) http://onlinelibrary.wiley.com/doi/10.1002/dta.1529/full
Cannabis and other illicit drug use in epilepsy patients (full–2013) http://onlinelibrary.wiley.com/doi/10.1111/ene.12081/full
The role of potassium BK channels in anticonvulsant effect of cannabidiol in pentylenetetrazole and maximal electroshock models of seizure in mice (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23644464
The role of α2-adrenoceptors in the anti-convulsant effects of cannabinoids on pentylenetetrazole-induced seizure threshold in mice (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23756131
The Role of CB1-Receptors in the Proconvulsant Effect of Leptin on Penicillin-Induced Epileptiform Activity in Rats (full–2013) http://onlinelibrary.wiley.com/doi/10.1111/cns.12075/full
CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/23860329
Effects of WIN 55,212-2 mesylate on the anticonvulsant action of lamotrigine, oxcarbazepine, pregabalin and topiramate against maximal electroshock-induced seizures in mice (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24161913
Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792005/
top
Whole Cannabis Extracts of High Concentration Cannabidiol May Calm Seizures in Highly Refractory Pediatric Epilepsies (abst–2013) http://hope4childrenwithepilepsy.com/wp-content/uploads/2013/11/Dr.-Gedde-Abstract.pdf
The case for medical marijuana in epilepsy (full–2014) http://onlinelibrary.wiley.com/doi/10.1111/epi.12610/full
Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders (full–2014) http://onlinelibrary.wiley.com/doi/10.1111/epi.12631/full
Effects of WIN 55,212-2 (a non-selective cannabinoid CB1 and CB 2 receptor agonist) on the protective action of various classical antiepileptic drugs in the mouse 6 Hz psychomotor seizure model (full–2014) http://download.springer.com/static/pdf/828/art%253A10.1007%252Fs00702-014-1173-7.pdf?auth66=1393191519_d7b51017bd9f9b481c18158f0312786b&ext=.pdf
Modulation of pilocarpine-induced seizures by cannabinoid receptor 1 (full–2014) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0095922
Endogenous Signaling by Omega-3 Docosahexaenoic Acid-derived Mediators Sustains Homeostatic Synaptic and Circuitry Integrity (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180614/
Physicians, Medical Marijuana, and the Law (full–2014) http://journalofethics.ama-assn.org/2014/09/hlaw1-1409.html
Phytocannabinoids and epilepsy (full–2014) http://onlinelibrary.wiley.com/doi/10.1111/jcpt.12235/full
Astrocytic expression of cannabinoid type 1 receptor in rat and human sclerotic hippocampi (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097232/
Presynaptic mechanisms of neuronal plasticity and their role in epilepsy (full–2014) http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00164/full
Selected terpenoids from medicinal plants modulate endoplasmic reticulum stress in metabolic disorders (full–2014) http://onlinelibrary.wiley.com/doi/10.1111/jphp.12267/full
The potential of antiseizure drugs and agents that act on novel molecular targets as antiepileptogenic treatments (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996125/
Cannabinoids for epilepsy (full–2014) http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD009270.pub3/full
The case for assessing cannabidiol in epilepsy (full–2014) http://onlinelibrary.wiley.com/doi/10.1111/epi.12635/full
Seizing an opportunity for the endocannabinoid system (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189640/
ABHD6 Blockade Exerts Antiepileptic Activity in PTZ-Induced Seizures and in Spontaneous Seizures in R6/2 Mice (full–2014) http://www.sciencedirect.com/science/article/pii/S0896627314005765
Anticonvulsant Effects of N-Arachidonoyl-Serotonin, a Dual FAAH Enzyme and TRPV1 Channel Blocker, on Experimental Seizures: The Roles of Cannabinoid CB1 Receptors and TRPV1 Channels (full–2014) http://onlinelibrary.wiley.com/doi/10.1111/bcpt.12232/full
Disease-Modifying Effects of RHC80267 and JZL184 in a Pilocarpine Mouse Model of Temporal Lobe Epilepsy (full–2014) http://onlinelibrary.wiley.com/doi/10.1111/cns.12302/full
Cannabidiol: Promise and Pitfalls (full–2014) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189631/
Delayed seizure-like activity following analytically confirmed use of previously unreported synthetic cannabinoid analogues (full–2014) http://journals.sagepub.com/doi/full/10.1177/0960327114550886
The Comprehensive Report on the Cannabis Extract Movement and the Use of Cannabis Extracts to Treat Diseases (link to upload-2014) http://www.slideshare.net/TheHempSolution/comprehensive-report-on-the-cannabis-extract-movement
top
A ‘spicy’ encephalopathy: synthetic cannabinoids as cause of encephalopathy and seizure (letter–2014) http://ccforum.biomedcentral.com/articles/10.1186/s13054-014-0553-6
EFFICACY AND SAFETY OF EPIDIOLEX (CANNABIDIOL) IN CHILDREN AND YOUNG ADULTS WITH TREATMENT-RESISTANT EPILEPSY: INITIAL DATA FROM AN EXPANDED ACCESS PROGRAM (abst–2014) https://www.aesnet.org/meetings_events/annual_meeting_abstracts/view/1868751#sthash.pbnOqzNG.dpuf
‘Crazy Monkey’ Poisons Man and Dog: Human and canine seizures due to PB-22, a novel synthetic cannabinoid (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24905571
Voltage-gated sodium (NaV) channel blockade by plant cannabinoids does not confer anticonvulsant effects per se (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24642454
Cannabinoids for epilepsy: is marijuana an effective treatment for epilepsy? (abst–2014) http://iospress.metapress.com/content/p50752072175783q/?p=00368d67a25c414b9e1ecc38b534bdfc&pi=14
The non-psychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25029033
Pentylenetetrazol-induced seizure-like behavior and neural hyperactivity in the medicinal leech (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25572075
Distinct modulation of the endocannabinoid system upon kainic acid-induced in vivo seizures and in vitro epileptiform bursting (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25064144
Analysis in conditional cannabinoid 1 receptor-knockout mice reveals neuronal sub-population-specific effects on epileptogenesis in the kindling paradigm (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25123336
Delayed seizure-like activity following analytically confirmed use of previously unreported synthetic cannabinoid analogues (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25233895
The interaction between ghrelin and cannabinoid systems in penicillin-induced epilepti-form activity in rats (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25256087
Cannabis, cannabidiol, and epilepsy – From receptors to clinical response (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25282526
Influence of WIN 55,212-2 on the anticonvulsant and acute neurotoxic potential of clobazam and lacosamide in the maximal electroshock-induced seizure model and chimney test in mice (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25458536
Role of CB2 receptors and cGMP pathway on the cannabinoid-dependent antiepileptic effects in an in vivo model of partial epilepsy (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25458534
top
Circumventing seizure activity in a series of G protein coupled receptor 119 (GPR119) agonists (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25286150
Involvement of PPAR receptors in the anticonvulsant effects of a cannabinoid agonist, WIN 55,212-2 (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25448777
Post-status epilepticus treatment with the cannabinoid agonist WIN 55,212-2 prevents chronic epileptic hippocampal damage in rats (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25447228
Changes and overlapping distribution in the expression of CB1/OX1-GPCRs in rat hippocampus by kainic acid-induced status epilepticus (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25446454
Medical marijuana and children (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25647865
Discriminating the effects of Cannabis sativa and Cannabis indica: a web survey of medical cannabis users (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/25191852
THE EFFECT OF EPIDIOLEX (CANNABIDIOL) ON SERUM LEVELS OF CONCOMITANT ANTI-EPILEPTIC DRUGS IN CHILDREN AND YOUNG ADULTS WITH TREATMENT-RESISTANT EPILEPSY IN AN EXPANDED ACCESS PROGRAM (abst–2014) https://www.aesnet.org/meetings_events/annual_meeting_abstracts/view/1868391#sthash.uxbwgudh.dpuf
RESOLUTION OF SEIZURES AND NORMALIZATION OF EEG AFTER INITIATION OF CBD IN A PATIENT WITH DOOSE SYNDROME (abst–2014) https://www.aesnet.org/meetings_events/annual_meeting_abstracts/view/1868186#sthash.4suBa1in.dpuf
Augmented Inhibition from Cannabinoid-Sensitive Interneurons Diminishes CA1 Output after Traumatic Brain Injury (full–2015) http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00435/full
Muscarinic M1 receptor and cannabinoid CB1 receptor do not modulate paraoxon induced seizures (full–2015) http://onlinelibrary.wiley.com/doi/10.1002/prp2.100/full
Fatty Acid Binding Proteins (FABPs) are Intracellular Carriers for Δ9-Tetrahydro-cannabinol (THC) and Cannabidiol (CBD) (full–2015)
http://www.jbc.org/content/early/2015/02/09/jbc.M114.618447.long
Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine (full–2015) http://www.hindawi.com/journals/mi/2015/523418/
top
Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423390/
Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25560837
Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284516/
Interaction between Cannabinoid Compounds and Capsazepine in Protection against Acute Pentylenetetrazole-induced Seizure in Mice (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499434/
Phytocannabinoids and epilepsy (full–2015) http://onlinelibrary.wiley.com/doi/10.1111/jcpt.12235/full
Cannabinoids and Epilepsy (full–2015) http://link.springer.com/article/10.1007%2Fs13311-015-0375-5
Impaired 2-AG signaling in hippocampal glutamatergic neurons: aggravation of anxiety-like behavior and unaltered seizure susceptibility (full–2015) http://ijnp.oxfordjournals.org/content/ijnp/early/2015/07/29/ijnp.pyv091.full.pdf
Cannabinoids: is there a potential treatment role in epilepsy? (full–2015) http://informahealthcare.com/doi/pdf/10.1517/14656566.2015.1074181
Investigational new drugs for focal epilepsy (full–2015) http://www.tandfonline.com/doi/full/10.1517/13543784.2016.1110144
Loss of Either Rac1 or Rac3 GTPase Differentially Affects the Behavior of Mutant Mice and the Development of Functional GABAergic Networks (full–2015) http://cercor.oxfordjournals.org/content/early/2015/11/17/cercor.bhv274.long
TRPV1 Channel: A Potential Drug Target for Treating Epilepsy (full-2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598436/
Narrative review of the safety and efficacy of marijuana for the treatment of commonly state-approved medical and psychiatric disorders (full-2015)
http://ascpjournal.biomedcentral.com/articles/10.1186/s13722-015-0032-7
Homer Protein-Metabotropic Glutamate Receptor Binding Regulates Endocannabinoid Signaling and Affects Hyperexcitability in a Mouse Model of Fragile X Syndrome (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25740522
The basolateral amygdala γ-aminobutyric acidergic system in health and disease (full–2015) http://onlinelibrary.wiley.com/doi/10.1002/jnr.23690/full
Enhancement of endocannabinoid signalling protects against cocaine-induced neurotoxicity (full–2015) http://www.sciencedirect.com/science/article/pii/S0041008X15001556
Drug-drug interaction between clobazam and cannabidiol in children with refractory epilepsy (full–2015) http://onlinelibrary.wiley.com/doi/10.1111/epi.13060/full
Marijuana: A Time-Honored but Untested Treatment for Epilepsy (full–2015) https://www.cambridge.org/core/journals/canadian-journal-of-neurological-sciences/article/divclasstitlemarijuana-a-time-honored-but-untested-treatment-forepilepsydiv/DDEDDD9EAA09918D3D69CC7CA047AE5C/core-reader
Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial (abst–2015) http://www.thelancet.com/journals/laneur/article/PIIS1474-4422%2815%2900379-8/abstract
Neuroprotective effects of trans-caryophyllene against kainic Acid induced seizure activity and oxidative stress in mice (abst-2015) http://www.ncbi.nlm.nih.gov/pubmed/25417010
Effects of WIN 55,212-2 (a synthetic cannabinoid CB1 and CB2 receptor agonist) on the anticonvulsant activity of various novel antiepileptic drugs against 6 Hz-induced psychomotor seizures in mice (abst-2015) http://www.ncbi.nlm.nih.gov/pubmed/25592741
Options for pharmacoresistant epilepsy in children: when medications don’t work (abst-2015) http://www.ncbi.nlm.nih.gov/pubmed/25658218
A Common Source Outbreak of Severe Delirium Associated with Exposure to the Novel Synthetic Cannabinoid ADB-PINACA (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25726258
top
Attenuation of kainic acid-induced status epilepticus by inhibition of endocannabinoid transport and degradation in guinea pigs (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25769371
Marijuana: A Time-Honored but Untested Treatment for Epilepsy (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25715711
Inhibition of monoacylglycerol lipase mediates a cannabinoid 1-receptor dependent delay of kindling progression in mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25796567
Withdrawal Seizures Seen In the Setting of Synthetic Cannabinoid Abuse (abst–2015)  http://www.ajemjournal.com/article/S0735-6757%2815%2900169-2/abstract
Parental reporting of response to oral cannabis extracts for treatment of refractory epilepsy (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25845492
The role of cannabinoids and leptin in neurological diseases (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25880465
Pure cannabidiol in the treatment of malignant migrating partial seizures in infancy: a case report (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25882081
Weeding out bad waves: towards selective cannabinoid circuit control in epilepsy (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25891509
Influence of arachidonyl-2′-chloroethylamide, a selective cannabinoid CB1 receptor agonist, on the anticonvulsant and acute side-effect potentials of clobazam, lacosamide and pregabalin in the maximal electroshock-induced seizure model and chimney test in mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25904357
Long-term disease-modifying effect of the endocannabinoid agonist WIN55,212-2 in a rat model of audiogenic epilepsy (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25933961
Perceived efficacy of cannabidiol-enriched cannabis extracts for treatment of pediatric epilepsy: A potential role for infantile spasms and Lennox-Gastaut syndrome (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25935511
JWH-018 impairs sensorimotor functions in mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25987201
Cannabinoid and nitric oxide signaling interplay in the modulation of hippocampal hyperexcitability: Study on electrophysiological and behavioral models of temporal lobe epilepsy in the rat (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26135674
Changes over time of cannabinoid receptor 1 in hippocampus of status epilepticus rats (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26168676
ACEA (a highly selective cannabinoid CB1 receptor agonist) stimulates hippocampal neurogenesis in mice treated with antiepileptic drugs (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26225920
top
Cannabidiol, a Cannabis sativa constituent, inhibits cocaine-induced seizures in mice: Possible role of the mTOR pathway and reduction in glutamate release (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26283212
Marijuana Use in Epilepsy: The Myth and the Reality (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26299273
Issues and promise in clinical studies of botanicals with anticonvulsant potential (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26341963
Cytochrome P450-mediated metabolism of the synthetic cannabinoids UR-144 and XLR-11 (abst-2015) http://www.ncbi.nlm.nih.gov/pubmed/26360322
Palmitoylethanolamide attenuates PTZ-induced seizures through CB1 and CB2 receptors (abst-2015) http://www.ncbi.nlm.nih.gov/pubmed/26370914
Cannabis and Endocannabinoid Signaling in Epilepsy (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26408165
Pentylenetetrazol-induced seizure-like behavior and neural hyperactivity in the medicinal leech (abst-2015) http://www.ncbi.nlm.nih.gov/pubmed/25572075
Polypharmacology Shakes Hands with Complex Aetiopathology (abst-2015) http://www.cell.com/trends/pharmacological-sciences/abstract/S0165-6147%2815%2900171-6?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0165614715001716%3Fshowall%3Dtrue
Cannabidiol as potential treatment in refractory pediatric epilepsy (abst-2015) http://www.ncbi.nlm.nih.gov/pubmed/26567560
The effects of adolescent cannabinoid exposure on seizure susceptibility and lethality in adult male rats (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26711091
Influence of arachidonyl‐2′‐chloroethylamide, a selective cannabinoid CB1 receptor agonist, on the anticonvulsant and acute side‐effect potentials of clobazam, lacosamide, and pregabalin in the maximal electroshock‐induced seizure model and chimney test in mice (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25904357
Convulsant effects of high efficacy synthetic cannabinoid JWH-018 in mice (abst-2015) http://www.fasebj.org/content/29/1_Supplement/614.7.abstract?sid=edf921ac-0690-4aa6-ac81-0546314dd384
The cannabinoid CB2 receptor-specific agonist AM1241 increases pentylenetetrazole induced seizure severity in Wistar rats (abst–2015) http://www.epires-journal.com/article/S0920-1211(16)30131-0/abstract
The Pharmacological Basis of Cannabis Therapy for Epilepsy (full–2016) http://jpet.aspetjournals.org/content/early/2016/01/19/jpet.115.230151.long
Cannabinoids for pediatric epilepsy? Up in smoke or real science? (full–2016) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729003/
Transient increase of interleukin-1β after prolonged febrile seizures promotes adult epileptogenesis through long-lasting upregulating endocannabinoid signaling (full–2016) http://www.nature.com/articles/srep21931
Analysis of endocannabinoid signaling elements and related proteins in lymphocytes of patients with Dravet syndrome (full–2016) http://onlinelibrary.wiley.com/doi/10.1002/prp2.220/full
ABC transporters P-gp and Bcrp do not limit the brain uptake of the novel antipsychotic and anticonvulsant drug cannabidiol in mice (full–2016) https://peerj.com/articles/2081/
CBD-enriched medical cannabis for intractable pediatric epilepsy: The current Israeli experience (full–2016) http://www.sciencedirect.com/science/article/pii/S1059131116000054
Case Series of Synthetic Cannabinoid Intoxication from One Toxicology Center (full–2016) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899060/
Synthetic cannabinoids revealing adrenoleukodystrophy (full–2016) http://www.sciencedirect.com/science/article/pii/S0967586815004567
Is the medical use of cannabis a therapeutic option for children? (full–2016) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758425/
Fatty Acid Binding Proteins are Intracellular Carriers for THC and CBD (full–2016) http://www.jbc.org/content/290/14/8711.full
Endocannabinoid control of glutamate NMDA receptors: the therapeutic potential and consequences of dysfunction (full–2016) http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path %5B%5D=10095&path%5B%5D=31745
Crucial Roles of the Endocannabinoid 2-Arachidonoylglycerol in the Suppression of Epileptic Seizures (full–2016) http://www.cell.com/cell-reports/fulltext/S2211-1247(16)30852-X
Turning Up the Heat on Endocannabinoid Signaling (full–2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106110/
Δ9-THC Intoxication by Cannabidiol-Enriched Cannabis Extract in Two Children with Refractory Epilepsy: Full Remission after Switching to Purified Cannabidiol (full–2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043219/
Medical Marijuana for Epilepsy? (full–2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911937/
Investigational new drugs for focal epilepsy (full–2016) http://www.tandfonline.com/doi/full/10.1517/13543784.2016.1110144
Cannabis and Cannabinoids (1st page–2016) http://jamanetwork.com/journals/jama/article-abstract/2592497
Cannabidiol Post-Treatment Alleviates Rat Epileptic-Related Behaviors and Activates Hippocampal Cell Autophagy Pathway Along with Antioxidant Defense in Chronic Phase of Pilocarpine-Induced Seizure (abst–2016) http://link.springer.com/article/10.1007/s12031-015-0703-6
Adverse effects after the use of JWH-210 – a case series from the EU Spice II plus project (abst–2016) http://www.ncbi.nlm.nih.gov/pubmed/26768345
Effect of JWH-250, JWH-073 and their interaction on “tetrad”, sensorimotor, neurological and neurochemical responses in mice (abst–2016) http://www.sciencedirect.com/science/article/pii/S0278584616300069
Dentate cannabinoid-sensitive interneurons undergo unique and selective strengthening of mutual synaptic inhibition in experimental epilepsy (abst–2016) http://www.sciencedirect.com/science/article/pii/S0969996116300146
Anticonvulsant activity of β-caryophyllene against pentylenetetrazol-induced seizures (abst–2016) http://www.ncbi.nlm.nih.gov/pubmed/26827298
Plant-Derived and Endogenous Cannabinoids in Epilepsy (abst–2016) http://www.ncbi.nlm.nih.gov/pubmed/26892745
Involvement of TRPV1 channels in the activity of the cannabinoid WIN 55,212-2 in an acute rat model of temporal lobe epilepsy (abst–2016) http://www.ncbi.nlm.nih.gov/pubmed/26970948
Cannabidiol and epilepsy: rationale and therapeutic potential (abst–2016) http://www.sciencedirect.com/science/article/pii/S1043661816301797
LACTIC ACIDOSIS: A RARE MANIFESTATION OF SYNTHETIC MARIJUANA INTOXICATION (abst–2016) http://www.ncbi.nlm.nih.gov/pubmed/27159480
MEDICAL CANNABIS (abst–2016) http://www.ncbi.nlm.nih.gov/pubmed/27215115
CB1 Receptor Antagonism Prevents Long-Term Hyperexcitability after Head Injury by of Dynorphin-KOR System and mGluR5 in Rat Hippocampus (abst–2016) http://www.ncbi.nlm.nih.gov/pubmed/27262683
Aberrant epilepsy-associated mutant Nav1.6 sodium channel activity can be targeted with cannabidiol (abst–2016) http://www.ncbi.nlm.nih.gov/pubmed/27267376
Current Status and Prospects for Cannabidiol Preparations as New Therapeutic Agents (abst–2016) http://www.ncbi.nlm.nih.gov/pubmed/27285147
Acute Toxicity Associated with Use of 5F-Derivations of Synthetic Cannabinoid Receptor Agonists with Analytical Confirmation (abst–2016) http://www.ncbi.nlm.nih.gov/pubmed/27456262
The cannabinoid receptor agonist WIN55.212 reduces consequences of status epilepticus in rats (abst–2016) http://www.ncbi.nlm.nih.gov/pubmed/27520083
Marijuana use in adults admitted to a Canadian epilepsy monitoring unit (abst–2016) http://www.ncbi.nlm.nih.gov/pubmed/27568641
From cannabis to cannabidiol to treat epilepsy, where are we? (abst–2016) http://www.ncbi.nlm.nih.gov/pubmed/27587196
Pharmacokinetic-pharmacodynamic influence of N-palmitoylethanolamine, arachidonyl- 2′-chloroethylamide and WIN 55,212-2 on the anticonvulsant activity of antiepileptic drugs against audiogenic seizures in DBA/2 mice (abst–2016) http://www.sciencedirect.com/science/article/pii/S0014299916306161
Effects of Marijuana on ictal and interictal EEG activity in idiopathic generalized epilepsy (abst–2016) https://www.ncbi.nlm.nih.gov/pubmed/27763968
Pharmacokinetic-pharmacodynamic influence of N-palmitoylethanolamine, arachidonyl- 2′-chloroethylamide and WIN 55,212-2 on the anticonvulsant activity of antiepileptic drugs against audiogenic seizures in DBA/2 mice (abst–2016) http://www.sciencedirect.com/science/article/pii/S0014299916306161
Endogenous cannabinoid system alterations and their role in epileptogenesis after brain injury in rat (abst–2016) https://www.ncbi.nlm.nih.gov/pubmed/27810514
Targeting brain and peripheral plasticity of the lipidome in acute kainic acid-induced epileptic seizures in mice via quantitative mass spectrometry (abst–2016) http://www.sciencedirect.com/science/article/pii/S1388198116303092
Cannabis and epilepsy: An ancient treatment returns to the fore (abst–2016) https://www.ncbi.nlm.nih.gov/pubmed/27989385
Pharmacology of cannabinoids in the treatment of epilepsy (abst–2016) https://www.ncbi.nlm.nih.gov/pubmed/28087250
Using Medical Marijuana to Stop Childhood Seizures (news & abstract–2016) http://neurosciencenews.com/thc-cbd-childhood-seizures-3618/
Synaptic Reorganization of the Perisomatic Inhibitory Network in Hippocampi of Temporal Lobe Epileptic Patients (full–2017) https://www.hindawi.com/journals/bmri/2017/7154295/
Thermolytic degradation of synthetic cannabinoids: chemical exposures and pharmacological consequences (link to download–2017) http://jpet.aspetjournals.org/content/early/2017/01/13/jpet.116.238717.long
Historical perspective on the medical use of cannabis for epilepsy: Ancient times to the 1980s (abst–2017) https://www.ncbi.nlm.nih.gov/pubmed/28089286
Neuroimaging studies towards understanding the central effects of pharmacological cannabis products on patients with epilepsy (abst–2017) https://www.ncbi.nlm.nih.gov/pubmed/28109780
Social factors in marijuana use for medical and recreational purposes (abst–2017) https://www.ncbi.nlm.nih.gov/pubmed/28132734
top


EPSTEIN-BARR
WIN55,212-2 induces cytoplasation in apoptosis-resistant MCL cells (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223692/
Microarray and Pathway Analysis Reveal Distinct Mechanisms Underlying Cannabinoid Mediated Modulation of LPS-Induced Activation of BV-2 Microglial Cells (full–2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634783/


ESSENTIAL TREMOR
Cannabinoid receptor agonism suppresses tremor, cognition disturbances and anxiety-like behaviors in a rat model of essential tremor (abst–2016) http://www.ncbi.nlm.nih.gov/pubmed/27317835 Cannabinoid type 1 receptor antagonism ameliorates harmaline-induced essential tremor in rat (abst–2016) http://www.ncbi.nlm.nih.gov/pubmed/27545646 Effect of marijuana on Essential Tremor: A case report (abst–2016) http://www.mdsabstracts.org/abstract/effect-of-marijuana-on-essential-tremor-a-case-report/


EXERCISE and the ENDOCANNABINOID SYSTEM
Endocannabinoids and voluntary activity in mice: runner’s high and long-term consequences in emotional behaviors (abst–2010) http://www.ncbi.nlm.nih.gov/pubmed/20353785
Aerobic Exercise Training Reduces Cannabis Craving and Use in Non-Treatment Seeking Cannabis-Dependent Adults (full–2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050879/?tool=pmcentrez
Adipose tissue endocannabinoid system gene expression: depot differences and effects of diet and exercise (full–2011) http://www.lipidworld.com/content/10/1/194
High-performance sport, marijuana, and cannabimimetics (full–2011) http://jat.oxfordjournals.org/content/35/9/624.long
Effects of exercise stress on the endocannabinoid system in humans under field conditions (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/22101870
Naloxone and rimonabant reduce the reinforcing properties of exercise in rats (abst–2011) http://www.ncbi.nlm.nih.gov/pubmed/21707193
Intense exercise increases circulating endocannabinoid and BDNF levels in humans-Possible implications for reward and depression (abst–2011) http://www.psyneuen-journal.com/article/PIIS0306453011002873/abstract?rss=yes
Wired to run: exercise-induced endocannabinoid signaling in humans and cursorial mammals with implications for the ‘runner’s high’ (full–2012) http://jeb.biologists.org/content/215/8/1331.long
top
The role of the endocannabinoid system in skeletal muscle and metabolic adaptations to exercise: potential implications for the treatment of obesity (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22943701
Exercise-induced endocannabinoid signaling is modulated by intensity (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/22990628
Ventral Tegmental Area Cannabinoid Type-1 Receptors Control Voluntary Exercise Performance (abst–2012) http://www.ncbi.nlm.nih.gov/pubmed/23237313
Voluntary Running in Young Adult Mice Reduces Anxiety-Like Behavior and Increases the Accumulation of Bioactive Lipids in the Cerebral Cortex (full–2013) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0081459
The effects of caffeine, nicotine, ethanol, and tetrahydrocannabinol on exercise performance (full–2013) http://www.nutritionandmetabolism.com/content/10/1/71
A role for the endocannabinoid system in exercise-induced spatial memory enhancement in mice (full–2013) http://www.ncbi.nlm.nih.gov/pubmed/24115292
Exercise Addiction- Diagnosis, Bio-Psychological Mechanisms and Treatment Issues (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24001300
Exercise increases plasma THC concentrations in regular cannabis users (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24018317
The endocannabinoid system mediates aerobic exercise-induced antinociception in rats (abst–2013) http://www.ncbi.nlm.nih.gov/pubmed/24148812
Care and Feeding of the Endocannabinoid System: A Systematic Review of Potential Clinical Interventions that Upregulate the Endocannabinoid System (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951193/
Moderate-Vigorous Physical Activity across Body Mass Index in Females: Moderating Effect of Endocannabinoids and Temperament (full–2014)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125187/
Can Physical Exercise or Food Deprivation Cause Release of Fat-Stored Cannabinoids? (full–2014) http://onlinelibrary.wiley.com/doi/10.1111/bcpt.12235/full
CB1 receptor affects cortical plasticity and response to physiotherapy in multiple sclerosis (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268035/
Acute Resistance Exercise Induces Antinociception by Activation of the Endocannabinoid System in Rats (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139418/
Mechanisms of Exercise-Induced Hypoalgesia (full–2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302052/
Molecular Basis for the Improvement in Muscle Metaboreflex and Mechanoreflex Control in Exercise-Trained Humans with Chronic Heart Failure (full–2014) http://ajpheart.physiology.org/content/307/11/H1655
Effects of Two Different Specific Neck Exercise Interventions on Palmitoylethanol-amide and Stearoylethanolamide Concentrations in the Interstitium of the Trapezius Muscle in Women with Chronic Neck Shoulder Pain (abst–2014) http://onlinelibrary.wiley.com/doi/10.1111/pme.12486/abstract
Modulation of early stress-induced neurobiological changes: a review of behavioural and pharmacological interventions in animal models (full–2014) http://www.nature.com/tp/journal/v4/n5/full/tp201431a.html
Physical activity and the endocannabinoid system: an overview (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24526057
Physical activity and cannabis cessation (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24629045
top
Fasting and exercise increase plasma cannabinoid levels in THC pre-treated rats: an examination of behavioural consequences (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24696079
Effect of dronabinol therapy on physical activity in anorexia nervosa: a randomised, controlled trial (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/24890912
The fatty acid amide hydrolase in lymphocytes from sedentary and active subjects (abst–2014) http://www.ncbi.nlm.nih.gov/pubmed/23793235
A runner’s high depends on cannabinoid receptors in mice (full–2015) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620874/
Cannabinoid Receptor 1 and Acute Resistance Exercise – In vivo and In vitro Studies in Human Skeletal Muscle (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/25796352
Deletion of G-protein coupled receptor 55 promotes obesity by reducing physical activity (abst–2015) http://www.ncbi.nlm.nih.gov/pubmed/26447738
Cannabis and Exercise Science: A Commentary on Existing Studies and Suggestions for Future Directions (abst–2015) http://link.springer.com/article/10.1007/s40279-015-0362-
3 Runner’s high linked to cannabinoid receptors in mice (news & abstract–2015) http://medicalxpress.com/news/2015-10-runner-high-linked-cannabinoid-receptors.html
Neuromodulation of Aerobic Exercise—A Review (full–2016) http://journal.frontiersin.org/article/10.3389/fpsyg.2015.01890/full
Sleep restriction alters plasma endocannabinoids concentrations before but not after exercise in humans (full–2016) http://www.psyneuen-journal.com/article/S0306-4530(16)30715-6/fulltext
Effects of chronic exercise on the endocannabinoid system in Wistar rats with high-fat diet-induced obesity (abst–2016) http://www.ncbi.nlm.nih.gov/pubmed/26880264 Exercise deprivation increases negative mood in exercise-addicted subjects and modifies their biochemical markers (abst–2016) http://www.ncbi.nlm.nih.gov/pubmed/26812592
Restricted vs. unrestricted wheel running in mice: Effects on brain, behavior and endocannabinoids (abst–2016) http://www.sciencedirect.com/science/article/pii/S0018506X16301799
Circulating levels of endocannabinoids respond acutely to voluntary exercise, are altered in mice selectively bred for high voluntary wheel running, and differ between the sexes (abst–2016) https://www.ncbi.nlm.nih.gov/pubmed/28017680
top


Advertisements